Elucidation of mesenchymal to epithelial transition mechanism of bone marrow mesenchymal stem cells and application to regenerative medicine.

• Project/Area Number: 22390217
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Osaka University
• Principal Investigator: TAMAI Katsuto 大阪大学, 医学系研究科, 寄附講座教授 (20236730)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: 骨髄間葉系幹細胞 / 間葉上皮転換(MET) / HMGB1 / CXCL12 / CXCR4 / 間葉系幹細胞 / 表皮水疱症 / VII型コラーゲン / SDF-1α / 間葉-上皮転換 / SSEA3 / ケラチン5 / 再生誘導 / 皮膚損傷

Research Abstract

Previously, we had shown that bone marrow-derived mesenchymal stem/progenitor cells contribute regeneration of detached epithelia in the skin of epidermolysis bullosa (EB), a intractable genetic skin disease. With such background, in this study, we aimed to investigate precise mechanism of mesenchymal to epithelial transition (MET) of bone marrow-derived mesenchymal cells in the EB skin, and to apply the obtained results for developing novel regenerative medicine. In 2012, we found that injured epithelia of EB skin release abundant high mobility group box 1 (HMGB1) to stimulate and mobilize lineage-/PDGFR.+/c-kit- (L-P+K-) bone marrow cells into the circulation, and the circulating L-P+K- cells are then accumulate to the injured skin via CXCR4/SDF-1. axis to provide bone marrow-derived epithelial cells by MET. In 2013, we further investigated particular cell surface marker for identifying MET-capable cell in L-P+K- population, and clarified that SSEA3 is an exclusive maker for specifically identifying the MET-capable cells in the L-P+K- cell population. We also proved that L-P+K- bone marrow-derived cells are essential for regeneration of EB skin by blocking accumulation of those cells by systemic inoculating CXCR4 antagonist in EB mouse model, resulting in persistent severe cutaneous injury. In 2014, we examined efficacy of systemic administration of HMGB1 on regeneration processes of cutaneous injury, and found that HMGB1 administration significantly accelerate tissue regeneration by inducing accumulation of L-P+K- cells in the injury, which then provide potent anti-inflammatory molecules and regenerate the injured epithelia by MET.

Research Products

• [Journal Article] Systemic Circulation and Bone Recruitment of Osteoclast Precursors Tracked by Using Fluorescent Imaging Techniques. (2013)
  • Author(s): Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M
  • Journal Title: J Immunol Volume: 190(2) Pages: 605-612
• [Journal Article] Systemic administration of a novel immune-stimulatory pseudovirion suppresses lung metastatic melanoma by regionally enhancing IFN-γ production. (2013)
  • Author(s): Saga K, Tamai K, Yamazaki T, Kaneda Y
  • Journal Title: Clin Cancer Res Volume: 19(3) Pages: 668-679
• [Journal Article] The combination of chemistry with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma (2012)
  • Author(s): Kiyohara E.
  • Journal Title: Gene Therapy Volume: 19 Issue: 7 Pages: 731-741
  • DOI: 10.1038/gt.2011.123
  • Peer Reviewed
• [Journal Article] Early intra-amniotic gene transfer using lentiviral vector improves skin blistering phenotype in a murine model of Herlitz junctional epidermolysis bullosa. (2012)
  • Author(s): Endo M, Zoltick PW, Radu A, Qiujie J, Matsui C, Marinkovich PM, McGrath J, Tamai K, Uitto J, Flake AW
  • Journal Title: Gene Ther Volume: 19(5) Issue: 5 Pages: 561-9
  • DOI: 10.1038/gt.2011.135
• [Journal Article] HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function. (2012)
  • Author(s): Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
  • Journal Title: FASEB J Volume: 26(6) Pages: 2306-2317
• [Journal Article] Two cases of recessive dystrophic epidermolysis bullosa diagnosed as severe generalized. (2012)
  • Author(s): Ohashi M, Shu E, Nagai M, Murase K, Nakano H, Tamai K, Sawamura D, Hiroka T, Seishima M, Kitajima Y, Aoyama Y
  • Journal Title: J Dermatol Volume: 38 Pages: 893-9
  • NAID: 10030728065
• [Journal Article] The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa. (2012)
  • Author(s): Hanafusa T, Tamai K, Umegaki N, Yamaguchi Y, Fukuda S, Nishikawa Y, Yaegashi N, Okuyama R, McGrath JA, Katayama I
  • Journal Title: Clin Exp Dermatol Volume: 37 Pages: 10-4
• [Journal Article] Systemic administration of a novel immune-stimulatory pseudovirion suppresses lung metastatic melanoma by regionally enhancing IFN-γ production. (2012)
  • Author(s): Saga K, Tamai K, Yamazaki T, Kaneda Y.
  • Journal Title: Clin Cancer Res Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Systemic Circulation and Bone Recruitment of Osteoclast Precursors Tracked by Using Fluorescent Imaging Techniques. (2012)
  • Author(s): Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M
  • Journal Title: J Immunol. Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Two cases of recessive dystrophic epidermolysis bullosa diagnosed as severe generalized. (2012)
  • Author(s): Ohashi M, Shu E, Nagai M, Murase K, Nakano H, Tamai K, Sawamura D, Hiroka T, Seishima M, Kitajima Y, Aoyama Y.
  • Journal Title: J Dermatol Volume: 38 Pages: 893-899
  • NAID: 10030728065
• [Journal Article] The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa. (2012)
  • Author(s): Hanafusa T, Tamai K, Umegaki N, Yamaguchi Y, Fukuda S, Nishikawa Y, Yaegashi N, Okuyama R, McGrath JA, Katayama I.
  • Journal Title: Clin Exp Dermatol. Volume: 37 Pages: 10-4
  • Peer Reviewed
• [Journal Article] The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa (2012)
  • Author(s): Hanafusa T, Tamai K, Umegaki N, Yamaguchi Y, Fukuda S, Nishikawa Y, Yaegashi N, Okuyama R, McGrath JA, Katayama I
  • Journal Title: Clin Exp Dermatol Volume: 37 Issue: 1 Pages: 10-14
  • DOI: 10.1111/j.1365-2230.2011.04179.x
  • Peer Reviewed
• [Journal Article] Exon 87 skipping of the COL7A1 gene in dominant dystrophic epidermolysis bullosa. (2011)
  • Author(s): Koga H, Hamada T, Ishii N, Fukuda S, Sakaguchi S, Nakano H, Tamai K, Sawamura D, Hashimoto T
  • Journal Title: J Dermatol Volume: 38 Pages: 489-492
• [Journal Article] Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus (2011)
  • Author(s): Fujita H, Tamai K, Kawachi M, Saga K, Shimbo T, Yamazaki T, Kaneda Y
  • Journal Title: Arch Virol Volume: 156 Pages: 995-1005
• [Journal Article] Vorner type palmoplantar keratoderma: novel KRT9 mutation associated with knuckle pad-like lesion and recurrent mutation causing digital mutilation. (2011)
  • Author(s): Umegaki N, Nakano H, Tamai K, Mitsuhashi Y, Akasaka E, Sawamura D, Katayama I
  • Journal Title: Br J Dermatol Volume: 165 Pages: 199-201
• [Journal Article] PDGFR.-positive cells in bone marrow are mobilized by HMGB1 to regenerate injured epithelia. (2011)
  • Author(s): Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, Umegaki N, Katayama I, Miyazaki J, Takeda J, McGrath JA, Uitto J, Kaneda Y
  • Journal Title: Proc Natl Acd Sci USA Volume: 108 Pages: 6609-6614
• [Journal Article] Modification of a novel angiogenic peptide, AG30, for the development of novel therapeutic agents. (2011)
  • Author(s): Nakagami H, Nishikawa T, Tamura N, Maeda A, Hibino H, Mochizuki M, Shimosato T, Moriya T, Morishita R, Tamai K, Tomono K, Kaneda Y
  • Journal Title: J Cell Mol Med Volume: - Issue: 7 Pages: 1629-1639
  • DOI: 10.1111/j.1582-4934.2011.01406.x
  • Peer Reviewed
• [Journal Article] PDGFRα-positive cells in bone marrow are mobilized by HMGB1 to regenerate injured epithelia (2011)
  • Author(s): Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, Umegaki N, Katayama I, Miyazaki J, Takeda J, McGrath JA, Uitto J, Kanda Y
  • Journal Title: Proc Natl Acd Sci USA Volume: 108 Pages: 6609-6614
  • Peer Reviewed
• [Journal Article] Exon 87 skipping of the COL7A1 gene in dominant dystrophic epidermolysis bullosa (2011)
  • Author(s): Koga H, Hamada T, Ishii N, Fukuda S, Sakaguchi S, Nakano H, Tamai K, Sawamura D, Hashimoto T.Exon 87 skipping of the COL7A1 gene in domin ant dystrophic epidermolysis bullosa
  • Journal Title: J Dermatol Volume: 38 Pages: 489-492
  • Peer Reviewed
• [Journal Article] Vorner type palmoplantar keratoderma : novel KRT9 mutation associated with knuckle pad-like lesion and recurrent mutation causing digital mutilation (2011)
  • Author(s): Umegaki N, Nakano H, Tamai K, Mitsuhashi Y, Akasaka E, Sawamura D, Katayama I
  • Journal Title: Br J Dermatol Volume: 165 Pages: 199-201
  • Peer Reviewed
• [Journal Article] Two cases of recessive dystrophic epidermolysis bullosa diagnosed as severe generalized (2011)
  • Author(s): Ohashi M, Shu E, Nagai M, Murase K, Nakano H, Tamai K, Sawamura D, Hiroka T, Seishima M, Kitajima Y, Aoyama Y
  • Journal Title: J Dermatol Volume: 38 Pages: 893-839
  • NAID: 10030728065
  • Peer Reviewed
• [Journal Article] Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus. (2011)
  • Author(s): Fujita H, Tamai K, Kawachi M, Saga K, Shimbo T, Yamazaki T, Kaneda Y.
  • Journal Title: Arch Virol. Volume: (Epub)
  • Peer Reviewed
• [Journal Article] Controlled release of bone morphogenetic protein-2 enhances recruitment of osteogenic progenitor cells for de novo generation of bone tissue. (2010)
  • Author(s): Kimura Y, Miyazaki N, Hayashi N, Otsuru S, Tamai K, Kaneda Y, Tabata Y
  • Journal Title: Tissue Eng Part A Volume: 16 Pages: 1263-1270
• [Journal Article] Serum anti-BPAG1 auto-antibody is a novel marker for human melanoma. (2010)
  • Author(s): Shimbo T, Tanemura A, Yamazaki T, Tamai K, Katayama I, Kaneda Y
  • Journal Title: PLoS One Volume: 5
• [Journal Article] Relation between the expression of level of the POU transcription factor Skn-1a and Skn-1n and keratinocyte differentiation. (2010)
  • Author(s): Takemoto H, Tamai K, Akasaka E, Rokunohe D, Takiyoshi N, Umegaki N, Nakajima K, Aizu T, Kaneko T, Nakano H, Sawamura D
  • Journal Title: J Dermatol Sci Volume: 60 Pages: 203-205
  • NAID: 10027841207
• [Journal Article] Controlled release of bone morphogenetic protein-2 enhances recruitment of osteogenic progenitor cells for de novo generation of bone tissue. (2010)
  • Author(s): Kimura Y, Miyazaki N, Hayashi N, Otsuru S, Tamai K, Kaneda Y, Tabata Y.
  • Journal Title: Tissue Eng Part A. Volume: 16 Pages: 1263-1270
  • Peer Reviewed
• [Journal Article] Relation between expression levels of the POU transcriptional factor Skn-1a and Skn-1n and keratinocyte differentiation. (2010)
  • Author(s): Takemoto H, Tamai K, Akasaka E, Rokunohe D, Takiyoshi N, Umegaki N, Nakajima K, Aizu T, Kaneko T, Nakano H, Sawamura D.
  • Journal Title: J Dermatol Sci Volume: 60 Pages: 203-205
  • NAID: 10027841207
  • Peer Reviewed
• [Presentation] 他家骨髄間葉系幹細胞移植による表皮水疱症治療研究：基礎と臨床 (2013)
  • Author(s): 玉井克人
  • Organizer: 第12回日本再生医療学会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 幹細胞研究の展望:末梢循環性間葉系幹細胞の皮膚集積による病態変化. (2012)
  • Author(s): 玉井克人
  • Organizer: 日本皮膚科学会中部支部学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-10-13
• [Presentation] 水疱症に対する骨髄間葉系幹細胞移植治療の可能性 (2012)
  • Author(s): 玉井克人、飯沼晋、菊池康、飯塚一、金田安史、片山一朗
  • Organizer: 第34回水疱症研究会
  • Place of Presentation: 弘前
  • Year and Date: 2012-10-06
• [Presentation] Injured tissue releases HMGB1 to recruit bone marrow mesenchymal stem cells for inducing regeneration of the injury (2012)
  • Author(s): Katsuto Tamai, Yasushi Kikuchi, Shin Iinuma, Yasufumi Kaneda
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Sapporo,Japan
  • Year and Date: 2012-09-20
• [Presentation] アトピー性皮膚炎に対するNFkBデコイDNA軟膏の展望 (2012)
  • Author(s): 玉井克人
  • Organizer: 第42回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 軽井沢
  • Year and Date: 2012-07-14
• [Presentation] 教育講演49 遙かにひろがる皮膚イメージング宇宙の旅:皮膚イメージング宇宙を旅する宇宙船皮膚号にようこそ (2012)
  • Author(s): 玉井克人
  • Organizer: 第111回日本皮膚科学会総会・学術大会
  • Place of Presentation: 京都
  • Year and Date: 2012-06-03
• [Presentation] 教育講演6 研究を目指す若手皮膚科医のために 臨床医にとって研究とは? 臨床と研究は皮膚科学一卵性双生児である. (2012)
  • Author(s): 玉井克人
  • Organizer: 第111回日本皮膚科学会総会・学術大会
  • Place of Presentation: 京都
  • Year and Date: 2012-06-01
• [Presentation] 骨髄間葉系幹細胞による皮膚再生機序を利用した表皮水疱症治療 (2012)
  • Author(s): 玉井克人
  • Organizer: 第2回国際遺伝病遺伝子治療フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2012-01-19
• [Presentation] Crosstalk mechanism between injured epithelia and bone marrow (2012)
  • Author(s): Katsuto Tamai
  • Organizer: Experimental Biology 2012
  • Place of Presentation: SanDiego
  • Invited
• [Presentation] Mesenchymal stem cell transplantation for epidermolysis bullosa (2012)
  • Author(s): Katsuto Tamai
  • Organizer: 75th annnual meeting of Society of Investigative Dermatology
  • Place of Presentation: Raleigh, North Carolina
  • Invited
• [Presentation] Injured tissue releases HMGB1 (2012)
  • Author(s): Katsuto Tamai
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Association,
  • Place of Presentation: Sapporo, Japan
• [Presentation] 末梢循環性間葉系幹細胞の皮膚集積による病態変化 (2012)
  • Author(s): 玉井克人
  • Organizer: 第63回日本皮膚科学会中部支部学術集会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] High mobility group box 1 (HMGB1) mobilizes mesenchymal stem cells from bone marrow to regenerate injured epithelia (2011)
  • Author(s): Katsuto Tamai
  • Organizer: 日本研究皮膚科学会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2011-12-09
• [Presentation] 骨髄と皮膚のクロストークを利用した皮膚病治療 (2011)
  • Author(s): 玉井克人
  • Organizer: 第63回日本皮膚科学会西部支部学術集会
  • Place of Presentation: 沖縄県那覇市
  • Year and Date: 2011-10-08
• [Presentation] 骨髄と皮膚のクロストークを利用した皮膚病治療 (2011)
  • Author(s): 玉井克人
  • Organizer: 第63回日本皮膚科学会西部支部学術集会
  • Place of Presentation: 沖縄県那覇市(招待講演)
  • Year and Date: 2011-10-08
• [Presentation] 表皮水疱症の剥離表皮再生メカニズムを利用した新しい治療戦略 (2011)
  • Author(s): 玉井克人
  • Organizer: 第35回日本小児皮膚科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-07-23
• [Presentation] 表皮水疱症の剥離表皮再生メカニズムを利用した新しい治療戦略 (2011)
  • Author(s): Katsuto Tamai
  • Organizer: 第35回日本小児皮膚科学会
  • Place of Presentation: 横浜市(招待講演)
  • Year and Date: 2011-07-23
• [Presentation] HMGB1 mobilized PDGFRa-positive cells from bone marrow to regenerate injured epithelia (2011)
  • Author(s): Katsuto Tamai
  • Organizer: Japan Society of Gene Therapy 2011 17th Annual Meeting
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2011-07-17
• [Presentation] HMGB1 mobilized PDGFRa-positive cells from bone marrow to regenerate injured epithelia (2011)
  • Author(s): Katsuto Tamai
  • Organizer: Japan Society of Gene Therapy 2011 17^<th> Annual Meeting
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2011-07-17
• [Presentation] 皮膚と骨髄のクロストーク (2011)
  • Author(s): 玉井克人
  • Organizer: 日本皮膚科学会第357回福岡地方会
  • Place of Presentation: 福岡県久留米市
  • Year and Date: 2011-06-19
• [Presentation] 皮膚と骨髄のクロストーク (2011)
  • Author(s): 玉井克人
  • Organizer: 日本皮膚科学会第357回福岡地方会
  • Place of Presentation: 福岡県久留米市(招待講演)
  • Year and Date: 2011-06-19
• [Presentation] 損傷組織と骨髄細胞のクロストークを利用した体内再生誘導医療開発 (2011)
  • Author(s): 玉井克人、飯沼晋、菊池康、金田安史
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-12
• [Presentation] Plenary lecture: Skin regeneration and repair by bone marrow-derived stem/progenitor cells. (2011)
  • Author(s): Katsuto Tamai
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-05-24
• [Presentation] Successful treatment of severe facial atopic dermatitis with topical NF-kappa B decoy ointment (2011)
  • Author(s): Katsuto Tamai
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-05-24
• [Presentation] Problems and future perspectives for gene therapy of genetic skin diseases (2011)
  • Author(s): Katsuto Tamai
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-05-24
• [Presentation] Plenary lecture : Skin regeneration and repair by bone marrow-derived stem/progenitor cells (2011)
  • Author(s): Katsuto Tamai
  • Organizer: 22^<nd> World Congress of Dermatology
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2011-05-24
• [Presentation] Successful treatment of severe facial atopic dermatitis with topical NF-kappa B decoy ointment (2011)
  • Author(s): Katsuto Tamai
  • Organizer: 22^<nd> World Congress of Dermatology
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2011-05-24
• [Presentation] Problems and future perspectives for gene therapy of genetic skin diseases (2011)
  • Author(s): Katsuto Tamai
  • Organizer: 22^<nd> World Congress of Dermatology
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2011-05-24
• [Presentation] Cross-talk between skin and bone marrow (2011)
  • Author(s): Katsuto Tamai
  • Organizer: British Society of Investigative Dermatology Annual meeting
  • Place of Presentation: Manchester, UK
  • Year and Date: 2011-04-11
• [Presentation] Cross-talk between skin and bone marrow (2011)
  • Author(s): Katsuto Tamai
  • Organizer: British Society of Investigative Dermatology Annual meeting
  • Place of Presentation: Manchester, UK(招待講演)
  • Year and Date: 2011-04-11
• [Presentation] 骨髄由来細胞による表皮水疱症皮膚再生医療 (2011)
  • Author(s): 玉井克人
  • Organizer: 第10回日本再生医療学会
  • Place of Presentation: 東
  • Year and Date: 2011-03-01
• [Presentation] 骨髄由来細胞による表皮水疱症皮膚再生医療 (2011)
  • Author(s): 玉井克人
  • Organizer: 第10回日本再生医療学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-03-01
• [Presentation] 骨髄由来幹細胞による表皮再生 (2011)
  • Author(s): 玉井克人
  • Organizer: 第74回日本皮膚科学会東京支部学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-02-11
• [Presentation] 骨髄由来幹細胞による表皮再生 (2011)
  • Author(s): 玉井克人
  • Organizer: 第74回日本皮膚科学会東京支部学術大会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-02-11
• [Presentation] 表皮水疱症の病態 (2010)
  • Author(s): 玉井克人
  • Organizer: 第42回日本臨床分子形態学会
  • Place of Presentation: 三島
  • Year and Date: 2010-09-24
• [Presentation] 表皮水疱症の病態 (2010)
  • Author(s): 玉井克人
  • Organizer: 第42回日本臨床分子形態学会
  • Place of Presentation: 三島(招待講演)
  • Year and Date: 2010-09-24
• [Presentation] 移植皮膚片における表皮恒常性維持機構 (2010)
  • Author(s): 玉井克人、知野剛直、飯沼晋、金田安史、梅垣知子、片山一朗
  • Organizer: 第25回角化症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-31
• [Presentation] Contribution of PDGFRα-positive bone marrow cells for epithelial regeneration in genetic blistering skin disease, RDEB. (2010)
  • Author(s): Katsuto Tamai, Takehiko Yamazaki, Takenao Chino, Yasuhumi Kaneda.
  • Organizer: 13th Annual Meeting, American Society of Gene and Cell Therapy
  • Place of Presentation: Washington, DC, USA.
  • Year and Date: 2010-05-19
• [Presentation] Contribution of PDGFRα-positive bone marrow cells for epithelial regeneration in genetic blistering skin disease, RDEB.
  • Author(s): Katsuto Tamai, Takehiko Yamazaki, Takenao Chino and Yasuhumi Kaneda
  • Organizer: 3th Annual Meeting, American Society of Gene and Cell Therapy
  • Place of Presentation: Washington, DC, USA
• [Book] The Color Atlas of Disorders of Keratinization (2011)
  • Author(s): Katsuto Tamai
  • Publisher: Kyowa Kikaku, LTD
• [Patent(Industrial Property Rights)] 組織再生を誘導するためのペプチドとその利用 (2012)
  • Inventor(s): 玉井克人 他
  • Industrial Property Rights Holder: 大阪大学、株式会社ジェノミックス
  • Filing Date: 2012-04-03
  • Overseas
• [Patent(Industrial Property Rights)] 組織再生を誘導するためのペプチドとその利用 (2012)
  • Inventor(s): 玉井克人
  • Industrial Property Rights Holder: 玉井克人
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-04-03
  • Overseas
• [Patent(Industrial Property Rights)] 骨髄間葉系および/または多能性幹細胞の血中動員による組織再生促進剤 (2010)
  • Inventor(s): 玉井克人 他
  • Industrial Property Rights Holder: 大阪大学、株式会社ジェノミックス
  • Filing Date: 2010-10-28
  • Overseas
• [Patent(Industrial Property Rights)] 骨髄間葉系および/または多能性幹細胞の血中動員による組織再生促進剤 (2010)
  • Inventor(s): 玉井克人、金田安史、知野剛直
  • Industrial Property Rights Holder: 大阪大学、株式会社ジェノミックス
  • Filing Date: 2010-10-28
  • Overseas