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Molecular mechanism of D-serine for pathophysiology of schizophrenia

Research Project

Project/Area Number 22390220
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionChiba University

Principal Investigator

HASHIMOTO Kenji  千葉大学, 社会精神保健教育研究センター, 教授 (10189483)

Co-Investigator(Renkei-kenkyūsha) IYO Masaomi  千葉大学, 大学院・医学研究院, 教授 (50191903)
MORI Hisashi  富山大学, 大学院・医学薬学研究部(医学), 教授 (00239617)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords統合失調症 / D型セリン / NMDA受容体 / D型サイクロセリン / セリンラセマーゼ / D型アミノ酸 / D型アミノ酸酸化酵素 / グルタミン酸受容体
Research Abstract

D-serine in the brain is known to be synthesized from serine racemase (SRR). In the methamphetamine model of schizophrenia, we found that methamphetamine-induced behavioral sensitization was not detected in the SRR knock-out mice. This study suggests that SRR plays a role in the development of behavioral sensitization by methamphetamine treatment.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (8 results) (of which Invited: 1 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders2013

    • Author(s)
      Hashimoto, K., Malchow, B., Falkai, P., and Schmitt, A
    • Journal Title

      Eur. Arch. Psychiatry Clin. Neurosci

      Volume: (in press) Issue: 5 Pages: 367-377

    • DOI

      10.1007/s00406-013-0399-y

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Is D-cycloserine a prodrug forD-serine in the brain? Biol2013

    • Author(s)
      Horio, M., Mori, H., and Hashimoto, K
    • Journal Title

      Psychiatry

      Volume: (in press) Issue: 12 Pages: e33-e34

    • DOI

      10.1016/j.biopsych.2012.07.013

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal disruption of serine racemase causes schizophrenia-like behavioral abnormalities in adulthood: Clinical rescue by D-serine2013

    • Author(s)
      Hagiwara, H., Iyo, M., and Hashimoto, K
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased levels of D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice2013

    • Author(s)
      Horio, M., Ishima, T., Fujita, Y., Inoue, R., Mori, H., and Hashimoto, K
    • Journal Title

      Neurochem. Int

      Volume: 62 Issue: 6 Pages: 843-847

    • DOI

      10.1016/j.neuint.2013.02.015

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine2012

    • Author(s)
      Horio, M., Kohno, M., Fujita, Y., Ishima, T., Inoue, R., Mori, H., and Hashimoto, K
    • Journal Title

      PLoS One

      Volume: 7 Issue: 4 Pages: e35494-e35494

    • DOI

      10.1371/journal.pone.0035494

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Levels of D-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice2011

    • Author(s)
      Horio, M., Kohno, M., Fujita, Y., Ishima, T., Inoue, R., Mori, H., and Hashimoto, K
    • Journal Title

      Neurochem. Int

      Volume: 59 Issue: 6 Pages: 853-859

    • DOI

      10.1016/j.neuint.2011.08.017

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance spectroscopy study of the antioxidant defense system in schizophrenia2011

    • Author(s)
      Matsuzawa D, Hashimoto K
    • Journal Title

      Antioxidants & Redox Signaling

      Volume: 15 Issue: 7 Pages: 2057-2065

    • DOI

      10.1089/ars.2010.3453

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Levels of D-serine in the brain and periphery organs of serine racemase (Srr) knock-out mice2011

    • Author(s)
      Horio M, et al.
    • Journal Title

      Neurochemistry International

      Volume: 59 Pages: 853-859

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comments to"The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia"2010

    • Author(s)
      K.Hashimoto
    • Journal Title

      J.Psychopharmacol.

      Volume: 24 Pages: 1133-1134

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analyses of mechanism for mouse strain-dependent prepulse inhibition point toarole of Shmtl(SHMTI)in mice and schizophrenia.2010

    • Author(s)
      T.Maekawa, et al.
    • Journal Title

      J.Neurochem.

      Volume: 115 Pages: 1374-1385

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Therapeutic effects of metabotropic glutamate receptor 5positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice2012

    • Author(s)
      Hashimoto, K., Horio, M., and Fujita, Y
    • Organizer
      22^<nd> Neuropharmacology Conference "Cognitive Enhancers"
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] D-サイクロセリンは、脳においてD-セリンのプロドラッグか?2012

    • Author(s)
      堀尾菜央、森寿、橋本謙二
    • Organizer
      第8回D-アミノ酸研究会学術講演会
    • Place of Presentation
      滋賀県大津市
    • Related Report
      2012 Final Research Report
  • [Presentation] D-サイクロセリンは、脳においてD-セリンのプロドラッグか?2012

    • Author(s)
      堀尾菜央(橋本謙二)
    • Organizer
      第8回D-アミノ酸研究会学術講演会
    • Place of Presentation
      滋賀県大津市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ペンチレンテトラゾール誘発痙攣発作におけるDセリンの機能解析2011

    • Author(s)
      井上蘭, ら
    • Organizer
      第7回D-アミノ酸研究会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lack of behavioral sensitization in serine racemase knock-out mice after administration of methamphetamine2011

    • Author(s)
      Horio, M., Fujita, Y., Kohno, M., Inoue, R., Mori, H., and Hashimoto, K
    • Organizer
      The 41th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] セリンラセマーゼ遺伝子欠損マウスでの覚せい剤投与による行動感作の欠如2011

    • Author(s)
      堀尾菜央、河野眞美、藤田有子、井上蘭、森寿、橋本謙二
    • Organizer
      第7回D-アミノ酸研究会学術講演会
    • Place of Presentation
      東京都
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Lack of behavioral sensitization in serine racemase knock-out mice after administration of methamphetamine2011

    • Author(s)
      Horio M, et al.
    • Organizer
      The 41th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      米国ワシントンDC市
    • Related Report
      2011 Annual Research Report
  • [Presentation] セリンラセマーゼ遺伝子欠損マウスの脳および末梢臓器におけるDセリン濃度2010

    • Author(s)
      堀尾菜央, ら
    • Organizer
      第6回D-アミノ酸研究会学術講演会
    • Place of Presentation
      富山市
    • Related Report
      2010 Annual Research Report
  • [Book] The Handbook of Behavior, Diet and Nutrition2011

    • Author(s)
      K.Hashimoto
    • Publisher
      Springer Publishers In press
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/shakai/jp/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/shakai/jp/byoutai/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/shakai/jp/byoutai/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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