| Project/Area Number |
22390228
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
IWATA Ren 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (60143038)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FURUMOTO Shozo 東北大学, 大学院・医学系研究科, 准教授 (00375198)
TAKAHASHI Kazuhiro 理化学研究所, 分子イメージング科学研究センター, ユニットリーダー (20370257)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OZEKI Eiichi 島津製作所, 基盤技術研究所, 主幹研究員 (30192529)
SAIKI Hidekazu 島津製作所, 基盤技術研究所, 主任 (70466382)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
|
|---|
| Keywords | 分子イメージング / マイクロリアクター / 標識合成 / PET / 標識プローブ / F-18 / 放射性薬剤 / 自動合成 |
|---|
| Research Abstract |
In order to utilize electrochemically concentrated [^<18>F]fluoride in microreactor radiosynthesis of ^<18>F-labeled probes, we developed a total system for carrying out the whole procedures from separation of [^<18>F]fluoride to purification of a ^<18>F-labeled probe based on the following techniques: to improve the concentration of [^<18>F]fluoride with a newly designed chip; to develop a new evaporation chip for on-line concentration of a reaction product solution; to develop a rapid, efficient method for purifying a final product with a solid phase extraction column. We demonstrated that the decrease in concentration of [^<18>F]fluoride in acetonitrile was mainly caused by diffusion in transfer tubing and that the evaporation chip worked efficiently under optimized conditions.
|
