Development of a total microreactor system for radiosynthesis of^<18>F-labeled PET probes
| Project/Area Number |
22390228
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
IWATA Ren 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (60143038)
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| Co-Investigator(Kenkyū-buntansha) |
FURUMOTO Shozo 東北大学, 大学院・医学系研究科, 准教授 (00375198)
TAKAHASHI Kazuhiro 理化学研究所, 分子イメージング科学研究センター, ユニットリーダー (20370257)
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| Co-Investigator(Renkei-kenkyūsha) |
OZEKI Eiichi 島津製作所, 基盤技術研究所, 主幹研究員 (30192529)
SAIKI Hidekazu 島津製作所, 基盤技術研究所, 主任 (70466382)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 分子イメージング / マイクロリアクター / 標識合成 / PET / 標識プローブ / F-18 / 放射性薬剤 / 自動合成 |
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| Research Abstract |
In order to utilize electrochemically concentrated [^<18>F]fluoride in microreactor radiosynthesis of ^<18>F-labeled probes, we developed a total system for carrying out the whole procedures from separation of [^<18>F]fluoride to purification of a ^<18>F-labeled probe based on the following techniques: to improve the concentration of [^<18>F]fluoride with a newly designed chip; to develop a new evaporation chip for on-line concentration of a reaction product solution; to develop a rapid, efficient method for purifying a final product with a solid phase extraction column. We demonstrated that the decrease in concentration of [^<18>F]fluoride in acetonitrile was mainly caused by diffusion in transfer tubing and that the evaporation chip worked efficiently under optimized conditions.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] A modified method of 3D-SSP analysis for amyloid PET imaging using [^<11>C]BF-2272011
Author(s)
Kaneta T, Okamuia N, Minoshima S, Furukawa K, Tashiro M, Furumoto S, Iwata R, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H
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Journal Title
Ann Nucl Med.
Volume: 25
Issue: 10
Pages: 643-649
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Imaging of hypoxic lesions in patients with glioma by using positron emission tomography with 1-(2-[^<18>F]fluoro-1-[hydrohymethyl]ethoxy)-methyl-2- nitroimidazole, a new ^<18>F-labeled2-nitroimidazole analog2010
Author(s)
Shibahara I., Kumabe T., KanamoriM., Saito R., Sonoda Y., Watanabe M., Iwata R., Higano S., Takanami K., Takai Y., Tominaga T.
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Journal Title
J. Neurosurg
Volume: 11
Pages: 358-368
Related Report
Peer Reviewed
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[Journal Article] Imaging of hypoxic lesions in patients with glioma by using positron emission tomography with 1-(2-[^<18>F]fluoro-1-[hydrohymethyl]ethoxy)-methyl-2-nitroimidazole, a new ^<18>F-labeled 2-nitroimidazole analog2010
Author(s)
I.Shibahara, T.Kumabe, M.Kanamori, R.Saito, Y.Sonoda, M.Watanabe, R.Iwata, S.Higano, K.Takanami, Y.Takai, T.Tominaga
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Journal Title
J.Neurosurgery
Volume: 11
Pages: 358-368
Related Report
Peer Reviewed
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