Elucidation of Molecular Mechanism of Cell Death induced by Radiation, Hyperthermia and Ultrasound for Cancer Therapy
| Project/Area Number |
22390229
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Toyama |
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Principal Investigator |
KONDO Takashi 富山大学, 大学院・医学薬学研究部(医学), 教授 (40143937)
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| Co-Investigator(Kenkyū-buntansha) |
TABUCHI Yoshiaki 富山大学, 生命科学先端研究センター, 准教授 (20322109)
ZHAO Qing-li 富山大学, 大学院・医学薬学研究部(医学), 助教 (90313593)
TAKASAKI Ichro 富山大学, 生命科学先端研究センター, 助教 (00397176)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 放射線腫瘍学 / 超音波治療学 / 温熱治療学 / ハイパーサーミア / アポトーシス / 放射線 / 超音波 / TAK1 / Chk1 / 遺伝子発現 / がん / 細胞死 / 治療 |
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| Research Abstract |
Molecular mechanism of cell death induced by ionizing radiation, heat or ultrasound was examined. Stable knockdown of TAK1 caused increase in subG1 fraction and apoptosis induced by X-rays in HeLa cells. Inhibition of DNA-PK increased heat-induced apoptosis in HeLa cells and the knockdown of an identified gene, NR1D1, also enhanced apoptosis. For the cell death induced by ultrasound, cell death signal is modulated by the balance between p53 and Akt via ATM and DNA-PK and the pathway of DNA-PK/Akt is predominant in sonicated cells.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] TGF-beta-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray-irradiated HeLa cells dependent on p21 induction but independent of NF-kB, p38 MAPK and ERK phosphorylations2012
Author(s)
Furusawa Y, Wei ZL, Sakurai H, Tabuchi Y, Li P, Zhao Q-L, Zhao, Nomura T, Saiki I, and Kondo T
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Journal Title
Radiat Res
Volume: 177
Issue: 6
Pages: 766-774
DOI
Related Report
Peer Reviewed
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[Journal Article] Mitochondria-Targeted Superoxide Dismutase (SOD2) Regulates Radiation Resistance and Radiation Stress Response in HeLa Cells2012
Author(s)
Hosoki, A., S. Yonekura, Q-L. Zhao, Z-L. Wei, I. Takasaki, Y. Tabuchi, L-L. Wang, S. Hasuike, T. Nomura, A. Tachibana, K. Hashiguchi, S. Yonei, T. Kondo and Q-M. Zhang-Akiyama
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Journal Title
Journal of Radiation Research
Volume: 53
Issue: 1
Pages: 58-71
DOI
NAID
ISSN
0449-3060, 1349-9157
Related Report
Peer Reviewed
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[Book] Ultrasound-induced DNA damage and signal transductions indicated by gamma H2AX2011
Author(s)
Furusawa Y, Fijiwara Y, Zhao Q-L, Hassan MA, Ogawa R, Tabuchi Y, Takasaki I,Takahashi A, Ohnishi T, and Kondo T
Publisher
10th International Symposium on Therapeutic Ultrasound (ISTU2010) Editors, Matsumoto Y, Crum LA, and ter Haar GR, 322-325, AIP Conf Proc 1359, American Institute of Physics
Related Report
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