Targeted radionuclide therapy for malignant neuroendcrine tumors based on biological and pathohistological characteristics

• Project/Area Number: 22390230
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: KINUYA Seigo 金沢大学, 医学系, 教授 (20281024)
• Research Collaborator: KAYANO Daiki 金沢大学, 大学病院, 助教 (10547152) ; INAKI Anri 金沢大学, 医学系, 助教 (40645131) ; WAKABAYASHI Hiroshi 金沢大学, 大学病院, 助教 (60622818)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 内照射療法 / 放射性医薬品 / 内用療法 / 悪性神経内分泌腫瘍 / 褐色細胞腫 / 神経芽腫 / I-131 MIBG / 放射線増感作用 / I131-MIBG / 放射線管理 / アイソトープ

Outline of Final Research Achievements

Targeted radiotherapy with I-131 MIBG was conducted for patients with malignant neuroendocrine tumors. Objective response was observed approximately 60% of adult cases. Responders to the first treatment tended to have good prognosis. In addition, repeated treatments were likely related with good prognosis. High dose treatment followed by bone marrow support may induce complete remission in patients with neuroblastoma refractory to chemotherapy. Diagnostic performance was best with scintigrams of therapeutic doses of I-131 MIBG at late time points. SPECT acquisition further improved diagnosis of lesion location. Caffeine may intensify the efficacy of I-131 MIBG therapy although further investigation is required.

Research Products

• [Journal Article] Draft guidelines regarding appropriate use of 131I-MIBG radiotherapy for neuroendocrine tumors : Guideline Drafting Committee for Radiotherapy with 131I-MIBG, Committee for Nuclear Oncology and Immunology, The Japanese Society of Nuclear Medicine. (2015)
  • Author(s): Kinuya S, Yoshinaga K, Higuchi T, Jinguji M, Kurihara H, Kawamoto H.
  • Journal Title: Annals of Nuclear Medicine Volume: 29 Issue: 6 Pages: 543-552
  • DOI: 10.1007/s12149-015-0960-z
  • Peer Reviewed
• [Journal Article] Iodine-131 Metaiodobenzylguanidine Therapy for (2015)
  • Author(s): Kayano D, Kinuya S
  • Journal Title: Scientific World Journal Volume: 2015 Issue: 1 Pages: 189135-189135
  • DOI: 10.1155/2015/189135
  • Peer Reviewed / Open Access
• [Journal Article] Effects and safety of ¹³¹I-metaiodobenzylguanidine (MIBG) radiotherapy in malignant neuroendocrine tumors: Results from a multicenter observational registry (2014)
  • Author(s): Yoshinaga K, Oriuchi N, Wakabayashi H, Tomiyama Y, Jinguji M, Higuchi T, Kayano D, Fukuoka M, Inaki A, Toratani A, Okamoto S, Shiga T, Ito YM, Nakajo M, Nakajo M, Kinuya S.
  • Journal Title: Endocrine Journal Volume: 61 Issue: 12 Pages: 1171-1180
  • DOI: 10.1507/endocrj.EJ14-0211
  • NAID: 130004687425
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Prototype imaging protocols for monitoring the efficacy of iodine-131 ablation in differentiated thyroid cancer. (2013)
  • Author(s): Kobayashi M, Wakabayashi H, Kojima H, Konishi T, Okuda K, Yoneyama H, Kayano D, Tobisaka M, Tsushima H, Onoguchi M, Kawai K, Kinuya S
  • Journal Title: Hell J Nucl Med Volume: 16 Pages: 175-180
  • Peer Reviewed
• [Journal Article] Prognostic values of initial responses to low-dose (131)I-MIBG therapy in patients with malignant pheochromocytoma and paraganglioma. (2013)
  • Author(s): Wakabayashi H, Taki J, Inaki A, Nakamura A, Kayano D, Fukuoka M, Matsuo S, Nakajima K, Kinuya S
  • Journal Title: Ann Nucl Med Volume: 27 Issue: 9 Pages: 839-846
  • DOI: 10.1007/s12149-013-0755-z
  • Peer Reviewed
• [Journal Article] アイソトープ内用療法（内照射療法）の進むべき方向 (2013)
  • Author(s): 絹谷清剛
  • Journal Title: 癌と化学療法 Volume: 40 Pages: 133-138
  • NAID: 120005253907
• [Journal Article] Sensitive immunodetection of radiotoxicity after iodine-131 therapy for thyroid cancer using γ-H2AX foci of DNA damage in lymphocytes (2013)
  • Author(s): Doai M
  • Journal Title: Annals of Nuclear Medicine Volume: 27 Issue: 3 Pages: 233-238
  • DOI: 10.1007/s12149-012-0678-0
  • Peer Reviewed
• [Journal Article] I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma (2012)
  • Author(s): Sato Y
  • Journal Title: Italian Journal of Pediatrics Volume: 38 Issue: 1 Pages: 53-53
  • DOI: 10.1186/1824-7288-38-53
  • Peer Reviewed
• [Journal Article] Thallium-201 scintigraphy for the assessment of long-term prognosis in patients with osteosarcoma (2012)
  • Author(s): Inaki A
  • Journal Title: Annals of Nuclear Medicine Volume: 26 Issue: 7 Pages: 545-550
  • DOI: 10.1007/s12149-012-0608-1
  • NAID: 10031033817
  • Peer Reviewed
• [Journal Article] 褐色細胞腫の核医学画像診断 (2012)
  • Author(s): 絹谷清剛
  • Journal Title: 医学のあゆみ Volume: 240 Pages: 147-152
• [Journal Article] Low-dose (123)I-metaiodobenzylguanidine diagnostic scan is inferior to (131)I-metaiodobenzylguanidine posttreatment scan in detection of malignant pheochromocytoma and paraganslioma (2011)
  • Author(s): Kayano D, Taki J, Fukuoka M, Wakabayashi H, Inaki A, Nakamura A, Kinuya S
  • Journal Title: Nuclear Medicine Communications Volume: 32 Issue: 10 Pages: 941-946
  • DOI: 10.1097/mnm.0b013e32834a4445
  • Peer Reviewed
• [Journal Article] Double-phase (131)I whole body scan and (131)I SPECT-CT images in patients with differentiated thyroid cancer : their effectiveness for accurate identification (2011)
  • Author(s): Wakabayashi H, Nakajima K, Fukuoka M, Inaki A, Nakamura A, Kayano D, Kinuya S
  • Journal Title: Annals of Nuclear Medicine Volume: 25 Issue: 9 Pages: 609-615
  • DOI: 10.1007/s12149-011-0513-z
  • NAID: 10030232928
  • Peer Reviewed
• [Journal Article] 神経芽腫に対する^<131>I-MIBG内用療法 (2011)
  • Author(s): 滝淳一、萱野大樹、福岡誠、絹谷清剛
  • Journal Title: Pharma Medica Volume: 29 Pages: 67-71
• [Journal Article] Comparison of diagnostic value of I-123 MIBG and high-dose I-131 MIBG scintig raphy including incremental value of SPECT/CT over planar image in patients with malignant pheochromocytoma/paraganglioma and neuroblastoma (2011)
  • Author(s): Fukuoka M, Taki J, Mochizuki T, Kinuya S
  • Journal Title: Clin Nucl Med Volume: 36 Pages: 1-7
  • NAID: 120003141440
  • Peer Reviewed
• [Presentation] Toward Individualized Evidence Based Medicine (2014)
  • Author(s): Kinuya S
  • Organizer: The 15th Asian Oceanian Congress of Radiology
  • Place of Presentation: 神戸市・神戸国際会議場
  • Year and Date: 2014-09-23
  • Invited
• [Presentation] Repeated low dose I-131 MIBG therapy for a malignant pheochromocytoma patient with catecholamine cardiomyopathy. (2014)
  • Author(s): H. Wakabayashi, A. Inaki, N. Akatani, D. Kayano, S. Matsuo, T. Takamura, S. Kinuya, Y. Kunita.
  • Organizer: International Symposium on Pheochromocytoma and Paraganglioma
  • Place of Presentation: 京都市・国立京都国際会館
  • Year and Date: 2014-09-19
• [Presentation] Targeted radionuclide therapy for malignant neuroendocrine tumors: Current status and future perspective in Japan (2014)
  • Author(s): Kinuya S
  • Organizer: International Symposium on Pheochromocytoma and Paraganglioma
  • Place of Presentation: 京都市・国立京都国際会館
  • Year and Date: 2014-09-19
  • Invited
• [Presentation] 神経芽腫の131I-MIBG内照射療法 (2013)
  • Author(s): 絹谷清剛
  • Organizer: 第２７回日本がん看護学会学術集会
  • Place of Presentation: 石川県立音楽堂（石川県）
  • Invited
• [Presentation] 褐色細胞腫、傍神経節腫が疑われる症例でのI-123 MIBGシンチグラフィ (2012)
  • Author(s): 萱野大樹
  • Organizer: 第８５回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] Comparison of 6, 24, and 48 hours of I-123 MIBG SPECT/CT in malignant pheochromocytoma and paraganglioma (2012)
  • Author(s): Kayano D
  • Organizer: 59th Society of Nuclear Medicine Annual Meeting
  • Place of Presentation: Miami convention center (米国)
• [Presentation] 悪性褐色細胞腫および悪性傍神経節腫患者によけるI-123 MIBG SPECT/CTの最適撮像時期の検討 (2012)
  • Author(s): 萱野大樹
  • Organizer: 第５２回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] Targeted radionuclide therapy as an ideal form of theranostics (2012)
  • Author(s): Kinuya S
  • Organizer: The 11th Asian Regional Cooperative Council for Nuclear Medcine
  • Place of Presentation: Hoam Faculty House Convention Center Mugunghwa（韓国）
  • Invited
• [Presentation] The Prognostic Value of Hormonal Responses after Initial Low Dose I-131 MIBG Therapy in Patients with Malignant Pheochromocytoma and Paraganglioma (2012)
  • Author(s): Wakabayashi H
  • Organizer: European Association of Nuclear Medicine Congress 2012
  • Place of Presentation: MiCo - Milano Congressi（イタリア）
• [Presentation] 悪性褐色細胞腫における診断的I-123 MIBGシンチと治療時I-131 MIBGシンチの比較 (2011)
  • Author(s): 萱野大樹
  • Organizer: 第84回日本内分泌学会総会
  • Place of Presentation: 神戸コンベンションセンター、兵庫県
  • Year and Date: 2011-04-21
• [Presentation] A clinician's demand on targeted radionuclide therapy (2010)
  • Author(s): Kinuya S
  • Organizer: PACIFICHEM 2010
  • Place of Presentation: Hawaii Convention Center, USA 招待講演
  • Year and Date: 2010-12-17
• [Presentation] 神経芽腫の131I-MIBG内用療法 (2010)
  • Author(s): 絹谷清剛
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ、埼玉県
  • Year and Date: 2010-11-11
• [Presentation] 国内における悪性神経内分泌腫瘍に対する131I-MIBG内用療法の実態:131I-MIBG内照射療法検討委員会報告 (2010)
  • Author(s): 絹谷清剛、中條政敬、織内昇、吉永恵一郎
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ、埼玉県
  • Year and Date: 2010-11-11
• [Presentation] Diagnostic scan with low dose I-123 MIBG is inferior to I-131 MIBG post-treatment scan in malignant pheochromocytoma and malignant paraganglioma (2010)
  • Author(s): Kayano D, Inaki A, Nakamura A, Wakabayashi H, Fukuoka M, Mochizuki T, Taki J, Kinuya S
  • Organizer: Annual Congress of the European Association of Nuclear Medicine
  • Place of Presentation: Austria Center Vienna, Austria
  • Year and Date: 2010-10-11
• [Presentation] Low dose I-123 MIBG diagnostic scan is inferior to I-131 MIBG post-treatment scan in detection of neuroblastoma (2010)
  • Author(s): Kayano D, Inaki A, Nakamura A, Wakabayashi H, Fukuoka M, Mochizuki T.Taki J.Kinuva S
  • Organizer: Annual Meeting of the Society of Nuclear Medicine 2010
  • Place of Presentation: Salt Palace Convention Center, USA
  • Year and Date: 2010-06-07
• [Presentation] 悪性神経内分泌腫瘍患者における診断的I-123MIBGシンチと治療量I-131 MIBGシンチの比較 (2010)
  • Author(s): 萱野大樹、稲木杏吏、中村文音、若林大志、福岡誠、望月孝史, 他2名
  • Organizer: 第47回腫瘍免疫核医学研究会
  • Place of Presentation: タワーホール船堀、東京都
  • Year and Date: 2010-05-08
• [Presentation] Targeted radionuclide therapy with 131I-MIBG for malignant neuroendocrine tumors: Institutional experience for 12 years.
  • Author(s): Kinuya S
  • Organizer: 2013 Conference of the Federation of Asian Societies for
  • Place of Presentation: Taipei Veterans General Hospital (台湾)
  • Invited
• [Presentation] Nuclear Medicine is Targeted Radionuclide Theranostics
  • Author(s): Kinuya S
  • Organizer: Cross-strait and International Conference of Therapeutic Nuclear Medicine
  • Place of Presentation: Changhua Christian Hospital (台湾)
  • Invited
• [Presentation] これからの10年間の核医学の動向「内用療法は発展します」
  • Author(s): 絹谷清剛
  • Organizer: 第33回日本核医学技術学会学術総会
  • Place of Presentation: 福岡国際会議場（福岡県）
  • Invited
• [Presentation] 神経芽腫内照射療法におけるカフェイン併用抗腫瘍効果の基礎的検討
  • Author(s): 若林 大志、萱野 大樹、稲木 杏吏、滝 淳一、福岡 誠、絹谷 清剛、小林 正和、柴 和弘
  • Organizer: 第53回日本核医学総会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] 神経芽腫のI-131 MIBG療法におけるカフェイン併用抗腫瘍効果の基礎的検討
  • Author(s): 若林 大志、萱野 大樹、稲木 杏吏、滝 淳一、福岡 誠、絹谷 清剛、小林 正和、柴 和弘
  • Organizer: 第77回日本核医学会中部地方会
  • Place of Presentation: 金沢大学（石川県）
• [Presentation] RI内用療法の今後の展開「I-131 MIBG」
  • Author(s): 萱野大樹、稲木杏吏、若林大志、赤谷憲一、福岡誠、絹谷清剛
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡国際会議場（福岡県）
  • Invited
• [Presentation] 「教えて！小児がんの最新治療」I-131 MIBG内用療法
  • Author(s): 萱野大樹、絹谷清剛
  • Organizer: 第18回公益財団法人がんの子どもを守る会公開シンポジウム(第55回日本小児血液・がん学会学術集会、第11回日本小児がん看護学会との共同開催)
  • Place of Presentation: ヒルトン福岡シーホーク（福岡県)
  • Invited
• [Presentation] アイソトープ内用療法：最近の変化と将来
  • Author(s): 絹谷清剛
  • Organizer: 第４２回多摩核医学技術検討会
  • Place of Presentation: 立川グランドホテル（東京都）
  • Invited
• [Presentation] 放射線治療における最近の話題：アイソトープ内用療法
  • Author(s): 絹谷清剛
  • Organizer: 第１３回臨床腫瘍夏期セミナー
  • Place of Presentation: 東商ホール（東京都）
• [Book] 内分泌画像検査・診断マニュアル(編集成瀬光栄、織内昇、平田結喜緒) (2011)
  • Author(s): 絹谷清剛
  • Total Pages: 235
  • Publisher: 診断と治療社