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development of a novel imaging method for cancer therapy based on alteration of mitochondriafunction

Research Project

Project/Area Number 22390232
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

MAGATA Yasuhiro  浜松医科大学, メディカルフォトニクス研究センター, 教授 (20209399)

Co-Investigator(Kenkyū-buntansha) SAKAHARA Harumi  浜松医科大学, 医学部, 教授 (10187031)
MATSUSHIMA Yoshitaka  浜松医科大学, 医学部, 准教授 (20282816)
OGAWA Mikako  浜松医科大学, メディカルフォトニクス研究センター, 准教授 (20344351)
TAKASHIMA Misato  浜松医科大学, メディカルフォトニクス研究センター, 助教 (70525592)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords放射性医薬品 / 腫瘍 / PET / SPECT / ミトコンドリア / ミトコンドリア膜電位 / イメージングプローブ / 放射性薬品 / 分子イメージング / アポトーシス
Research Abstract

For the purpose of selection of cancer therapy, prediction of therapeutic effectandearlyjudgment of the therapy, weexplored development of a novel method to estimate mitochondria function which relates "apoptosis", or "oxygen". We obtained a radioiodinated labeled compound IDPP which accumulatesto a cell depending on mitochondrial membrane potential. On the other hand, the relationship between photodynamic therapy and alteration of cell function after PDT was estimated usinguptake value of FDG and MIBI as a marker. High PDT therapeuticeffect isexpected in case of high FDG uptake in tumor cells. And it was indicated thatthe decreasing ratio of MIBI uptake linearly relatedto PDT effect.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2013 2012 2011

All Journal Article (1 results) Presentation (8 results)

  • [Journal Article] Differentiation of tumor sensitivity to photodynamic therapy and early evaluation of treatment effect by nuclear medicine techniques2013

    • Author(s)
      Jie Liu,Mikako Ogawa, Toshihiro Sakai, Misato Takashima, Shigetoshi Okazaki, Yasuhiro Magata.
    • Journal Title

      Ann.Nucl.Med

    • NAID

      10031194489

    • Related Report
      2012 Final Research Report
  • [Presentation] ミトコンドリア膜電位依存的に集積を示すイメージング薬剤の開発2012

    • Author(s)
      堺俊博、小川美香子、齋藤有里子、高島好聖、間賀田泰寛
    • Organizer
      第51回日本核医学会
    • Place of Presentation
      札幌
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Differentiation of Tumor Sensitivity to Photo Dynamic Therapyand Early Evaluation of Treatment Effect by Nuclear Medicine Technique2012

    • Author(s)
      Jie Liu, Mikako Ogawa, Toshihiro Sakai, Mutsumi Kosugi, Shigetoshi Okazaki and Yasuhiro Magata
    • Organizer
      第51回日本核医学会
    • Place of Presentation
      札幌
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] EarlyEvaluation of Treatment Effect on Photo Dynamic Therapy by Nuclear Medicine Technique2012

    • Author(s)
      Jie Liu, Mikako Ogawa, Toshihiro Sakai, Mutsumi Kosugi, Yasuhiro Magata
    • Organizer
      第7回日本分子イメージング学会
    • Place of Presentation
      浜松
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] ミトコンドリア膜電位依存的に集積する脂溶性カチオンイメージング剤の開発2012

    • Author(s)
      堺俊博、齋藤有里子、高島好聖、小川美香子、間賀田泰寛
    • Organizer
      第7回日本分子イメージング学会
    • Place of Presentation
      浜松
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] ミトコンドリア膜電位依存的に集積を示すイメージング薬剤の開発2012

    • Author(s)
      堺 俊博(間賀田 泰寛)
    • Organizer
      第52回日本核医学会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミトコンドリア膜電位に依存した集積を示す薬剤の開発2011

    • Author(s)
      堺俊博、齋藤有里子、小川美香子、間賀田泰寛
    • Organizer
      第50回日本核医学学会
    • Place of Presentation
      筑波
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 脂溶性カチオン構造を有する新規イメージング剤の開発2011

    • Author(s)
      間賀田泰寛, 他
    • Organizer
      第6回日本分子イメージング学会
    • Place of Presentation
      神戸市
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミトコンドリア膜電位に依存した集積を示す薬剤の開発2011

    • Author(s)
      間賀田泰寛, 他
    • Organizer
      第50回日本核医学会
    • Place of Presentation
      つくば市
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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