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Development of cancer diagnosis method based on the quantitative measurement of DNA synthesis rate by means of positron emission tomography.

Research Project

Project/Area Number 22390241
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

TOYOHARA Jun  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 専門副部長 (50425659)

Co-Investigator(Kenkyū-buntansha) KUBOTA Kazuo  独立行政法人国立国際医療研究センター, 放射線科核医学室, 医長 (40161674)
YAMAMOTO Yuka  香川大学, 医学部付属病院, 講師 (30335872)
Co-Investigator(Renkei-kenkyūsha) ISHIWATA Kiichi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター, 研究部長 (50143037)
ISHII Kenji  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター, 研究部長 (10231135)
ODA Keiichi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター, 研究員 (70224235)
SAKATA Muneyuki  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター, 研究員 (00403329)
NARIAI Tadashi  東京医科歯科大学, 医学部付属病院, 准教授 (00228090)
Research Collaborator ELSINGA Philip  University Medical Center Groningen, Faculty of Medical Sciences, Professor
SCHWARTZ Jeffrey L.  University of Washington Medical Center, Department of Radiation Oncology, Associate Professor
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords核医学(PETを含む) / 放射性医薬品 / 分析化学 / 放射線 / 核酸 / 癌 / 薬学 / がん / 分析科学
Research Abstract

4DST is a newly developed PET tracer that can be used to image DNA synthesis, and its application in clinical settings is being studied at many facilities. 4DST will be applied to more types of cancer. Establishment of the clinical significance is needed.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (78 results)

All 2013 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (59 results) (of which Invited: 3 results) Book (5 results)

  • [Journal Article] Longitudinal observation of ^<11>C-4DST uptake in turpentine-induced inflammatory tissue.2013

    • Author(s)
      Toyohara, J., Sakata, M., Oda, K., Ishii, K. and Ishiwata, K.
    • Journal Title

      Nucl. Med. Biol.

      Volume: 40 Issue: 2 Pages: 240-244

    • DOI

      10.1016/j.nucmedbio.2012.10.008

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of[^<11>C]SA4503 to selection of novel sigmal selective agonists.2012

    • Author(s)
      Toyohara, J., Kobayashi, T., Mita, S. and Ishiwata, K.
    • Journal Title

      Nucl. Med. Biol.

      Volume: 39 Issue: 8 Pages: 1117-1121

    • DOI

      10.1016/j.nucmedbio.2012.06.004

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Re-evaluation of in vivo selectivity of [^<11>C]SA4503 to sigmal receptors in the brain : contributions of emopamil binding protein.2012

    • Author(s)
      Toyohara, J., Sakata, M. and Ishiwata, K
    • Journal Title

      Nucl. Med. Biol.

      Volume: 39 Issue: 7 Pages: 1049-1052

    • DOI

      10.1016/j.nucmedbio.2012.03.002

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of sigmal receptors in the mechanisms of action of CNS drugs.2012

    • Author(s)
      Toyohara, J., Sakata, M. and Ishiwata, K.
    • Journal Title

      Trans. Neurosci.

      Volume: 3 Issue: 3 Pages: 294-299

    • DOI

      10.2478/s13380-012-0030-0

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of 4'-[methyl-^<11>C]thiothymidine (^<11>C-4DST) in a rodent tumor and inflammation model.2012

    • Author(s)
      Toyohara, J., Elsinga, P. H., Ishiwata, K., Sijbesma, J. W. A. Dierckx, R. A. J. 0. and van Waarde, A.
    • Journal Title

      J. Nucl. Med.

      Volume: 53 Issue: 3 Pages: 488-494

    • DOI

      10.2967/jnumed.111.098426

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ^<11>C-4DST PET/CT for proliferation imaging in non-small-cell-lung cancer.2012

    • Author(s)
      Minamimoto, R., Toyohara, J., Seike, A., Ito, H., Endo, H., Mooorka, M., Nakajima, K., Mitsumoto, T., Ito, K., Okasaki, M., Ishiwata, K. and Kubota K.
    • Journal Title

      J. Nucl. Med.

      Volume: 53 Issue: 2 Pages: 199-206

    • DOI

      10.2967/jnumed.111.095539

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腫瘍イメージング剤 DNA合成イメージング剤 4DST. 特集 PET 薬剤と合成装置の進歩2012

    • Author(s)
      豊原潤
    • Journal Title

      PETジャーナル

      Volume: 20 Pages: 39-41

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Animal tumor models for PET in drug development.2011

    • Author(s)
      Toyohara, J. and Ishiwata, K.
    • Journal Title

      Ann. Nucl. Med.

      Volume: 25 Pages: 717-731

    • NAID

      10030233402

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Whole-body distribution and brain tumor imaging with ^<11>C-4DST : a pilot study.2011

    • Author(s)
      Toyohara, J., Nariai, T., Sakata, M., Oda, K., Ishii, K., Kawabe, T., Irie, T., Saga, T., Kubota, K. and Ishiwata, K.
    • Journal Title

      J. Nucl. Med.

      Volume: 52 Pages: 1322-1328

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Whole-body distribution and brain tumor imaging with ^<11>C-4DST : a pilot study2011

    • Author(s)
      Toyohara J, et al
    • Journal Title

      The Journal of Nuclear Medicine

      Volume: 52 Issue: 8 Pages: 1322-1325

    • DOI

      10.2967/jnumed.111.088435

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Animal tumor models for PET in drug development2011

    • Author(s)
      Toyohara J, et al
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 25 Issue: 10 Pages: 717-731

    • DOI

      10.1007/s12149-011-0531-x

    • NAID

      10030233402

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-body distributiona dn brain tumor imaging with ^<11>C-4DST : a pilot study.2011

    • Author(s)
      Toyohara J, Nariai T, Sakata M, Oda K, Ishii K, Kawabe T, Irie T, Saga T, Kubota K, Ishiwata K.
    • Journal Title

      The Journal of Nuclear Medicine

      Volume: in press Pages: 52-52

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヌクレオシド誘導体プローブとそれによる腫瘍イメージング 特集1腫瘍のイメージング2011

    • Author(s)
      豊原潤
    • Journal Title

      PETジャーナル

      Volume: 13 Pages: 15-16

    • Related Report
      2010 Annual Research Report
  • [Journal Article] FDG以外のPET製剤2010

    • Author(s)
      豊原潤
    • Journal Title

      臨床泌尿器科

      Volume: 64 Pages: 751-756

    • Related Report
      2010 Annual Research Report
  • [Presentation] FDG以外の腫瘍PETイメージングプローブ2013

    • Author(s)
      豊原潤
    • Organizer
      第7回四国PET勉強会
    • Place of Presentation
      高松
    • Year and Date
      2013-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Imaging of DNA synthesis rate of malignant brain tumor with newly developed PET molecular imaging probe ^<11>C-4DST2013

    • Author(s)
      Inaji, M.
    • Organizer
      Joint neurosurgical convention 2013 (the 6^<th> international Mt. Bandai symposium for neuroscience and the 7^<th> Pan-pacific neurosurgery congress)
    • Place of Presentation
      Hawaii (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Imaging of DNA synthesis rate of malignant brain tumor with newly developed PET molecular imaging probe 11C-4DST2013

    • Author(s)
      Inaji, M., Nariai, T., Tanaka, Y., Oda, K., Sakata, M., Toyohara, J., Ishii, K., Ishiwata, K., Maehara, T. and Ohno, K
    • Organizer
      Joint Neurosurgical Convention 2013 (the 6th International Mt. Bandai Symposium for Neuroscience and the 7th Pan-Pacific Neurosurgery Congress)
    • Place of Presentation
      Hawaii
    • Related Report
      2012 Annual Research Report
  • [Presentation] FDG以外の腫瘍PETイメージングプローブ2013

    • Author(s)
      豊原潤
    • Organizer
      第7回四国 PET 勉強会
    • Place of Presentation
      高松
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] DNA合成の分子イメージング-4DST研究の現状と展望-2012

    • Author(s)
      豊原潤
    • Organizer
      第77回日本核医学会関東甲信越地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical use of 4DST as a new PET molecular imaging probe to measure DNA synthesis of brain tumor.2012

    • Author(s)
      Nariai, T.
    • Organizer
      The 4^<th> International symposium of brain tumor pathology
    • Place of Presentation
      Nagova
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] ^<11>C-4DST PETを用いた悪性脳腫瘍のDNA合成能評価法の検討2012

    • Author(s)
      成相直
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 多発性骨髄腫のFDG-PET、メチオニンPET、4DST-PETの比較検討2012

    • Author(s)
      岡崎百子
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] PET薬剤の被曝線量評価における小動物実験とヒト全身PETの比較2012

    • Author(s)
      坂田宗之
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] ^<11>C-4DSTの炎症集積に関する検討2012

    • Author(s)
      豊原潤
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA合成診断薬剤11C-4DSTによる肺癌リンパ節転移の検出能力に関する検討2012

    • Author(s)
      南本亮吾
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規PET薬剤からfirst-in-human studyまで-多施設共同研究への取り組み-2012

    • Author(s)
      豊原潤
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] ^<11>C-4DST PETを用いたDNA合成能イメージングによる悪性脳腫瘍診断2012

    • Author(s)
      稲次基希
    • Organizer
      第13回日本分子脳神経外科学会、
    • Place of Presentation
      熊本
    • Related Report
      2012 Final Research Report
  • [Presentation] A molecular imaging study of multiple myeloma : comparison of ^<18>F-FDG, ^<11>C-methionine (MET), and ^<11>C-thiothymidine (4DST) PET.2012

    • Author(s)
      Okasaki, M.
    • Organizer
      59^<th> Annual meeting of the society of nuclear medicine
    • Place of Presentation
      Miami (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Proliferation imaging by ^<11>C-4DST PET/CT for differentiation of malignant and benign lesion.2012

    • Author(s)
      Minamimoto, R.
    • Organizer
      59th Annual meeting of the society of nuclear medicine
    • Place of Presentation
      Miami (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA合成能のPET分子イメージングによる脳腫瘍増殖能の画像診断-新規診断薬剤^<11>C-4DSTの臨床応用-2012

    • Author(s)
      成相直
    • Organizer
      第35回日本脳神経CI学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Clinical use of 4DST as a new PET molecular imaging probe to measure DNA synthesis of brain tumor2012

    • Author(s)
      Nariai, T., Inaji, M., Toyohara, J., Ishiwata, K., Tanaka, Y., Aoyagi, M. and Ohno, K.
    • Organizer
      The 4th International Symposium of Brain Tumor pathology
    • Place of Presentation
      Nagoya
    • Related Report
      2012 Annual Research Report
  • [Presentation] Proliferation imaging by 11C-4DST PET/CT for differentiation of malignant and benign lesion2012

    • Author(s)
      Minamimoto, R., Toyohara, J., Morooka, M., Okasaki, M., Ito, K., Miyata, Y., Mitsumoto, T., Nakajima, K. and Kubota, K.
    • Organizer
      59th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Miami Beach
    • Related Report
      2012 Annual Research Report
  • [Presentation] A molecular imaging study of multiple myeloma: Comparison of 18F-FDG, 11C-methionine (MET), and 11C-thiothymidine (4DST) PET2012

    • Author(s)
      Okasaki, M., Kubota, K., Minamimoto, R., Morooka, M., Miyata, Y., Ito, K., Toyohara, J., Ishiwata, K., Hirai, R. and Miwa, A.
    • Organizer
      59th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Miami Beach
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA合成の分子イメージングー4DST研究の現状と展望ー2012

    • Author(s)
      豊原潤
    • Organizer
      第77回日本核医学会関東甲信越地方会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 11C-4DST PETを用いたDNA合成能イメージングによる悪性脳腫瘍診断2012

    • Author(s)
      稲次基希、成相直、田中洋次、坂田宗之、豊原潤、石渡喜一、石井賢二、青柳傑
    • Organizer
      第13回日本分子脳神経外科学会
    • Place of Presentation
      熊本
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規PET薬剤開発からfirst-in-human studyまでー多施設共同研究への取り組みー2012

    • Author(s)
      豊原潤、坂田宗之、織田圭一、石井賢二、石渡喜一
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] DNA合成診断薬剤11C-4DSTによる肺癌リンパ節移転の検出能力に関する検討2012

    • Author(s)
      南本亮吾、窪田和雄、豊原潤、伊藤秀幸、諸岡都、岡崎百子、宮田陽子、中島和彦、伊藤公輝、三本拓也、石渡喜一
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 11C-4DSTの炎症集積に関する検討2012

    • Author(s)
      豊原潤、林薫平、石渡喜一
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] PET薬剤の被曝線量評価における小動物実験とヒト全身PETとの比較2012

    • Author(s)
      坂田宗之、織田圭一、豊原潤、石井賢二、石渡喜一
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 11C-4DST PETを用いた悪性脳腫瘍のDNA合性能評価法の検討2012

    • Author(s)
      成相直、稲次基希、豊原潤、石渡喜一、坂田宗之、石井賢二、織田圭一、田中洋次、青柳傑
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] [^<11>C]4DST as novel PET tracer for imaging DNA synthesis in non-small cell lung cancer.2011

    • Author(s)
      Minamimoto, R.
    • Organizer
      Radiological society of north America 97^<th> scientific assemble and annual meeting.
    • Place of Presentation
      Chicago (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Initial clinical trials of carbon-11-labeled 4DST for malignant brain tumors as a PET molecular imaging probe to measure DNA synthesis rate.2011

    • Author(s)
      Nariai, T.
    • Organizer
      16^<th> Annual scientific meeting of the society for neuro-oncology,
    • Place of Presentation
      Orange County (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの非小細胞肺癌における有用性の検討2011

    • Author(s)
      南本亮吾
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Final Research Report
  • [Presentation] ^<11>C-4DST PETの腫瘍と炎症の鑑別診断に関する基礎的検討2011

    • Author(s)
      豊原潤
    • Organizer
      第51回目本核医学会学術総会、
    • Place of Presentation
      つくば市
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA合成診断薬剤^<11>C-4DSTの悪性脳腫瘍治療効果モニターリングへの応用2011

    • Author(s)
      成相直
    • Organizer
      第51回日本核医学会学術総会、
    • Place of Presentation
      つくば市
    • Related Report
      2012 Final Research Report
  • [Presentation] ^<11>C-4DST動態解析に関する基礎的検討2011

    • Author(s)
      豊原潤
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of 4'-[methyl-^<11>C]thiothymidine in a rodent model of tumor and inflammation.2011

    • Author(s)
      Toyohara, J.
    • Organizer
      Annual congress of the European association of nuclear medicine
    • Place of Presentation
      Birmingham (UK)
    • Related Report
      2012 Final Research Report
  • [Presentation] PET分子イメージングの有用性と可能性2011

    • Author(s)
      稲次基希
    • Organizer
      第70回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical use of molecular imaging for the treatment of malignant brain tumor.2011

    • Author(s)
      Nariai, T.
    • Organizer
      Annual meeting of congress of neurological surgeons
    • Place of Presentation
      Washington DC (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Initial clinical trials of carbon-11-labeled 4DST in brain tumors2011

    • Author(s)
      Toyohara, J.
    • Organizer
      58th Annual meeting of the society of nuclear medicine
    • Place of Presentation
      San Antonio (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA synthesis imaging of non-small-cell lung cancer using a new PET tracer [^<11>C]4DST.2011

    • Author(s)
      Minamimoto, R.
    • Organizer
      58^<th> Annual meeting of the society of nuclear
    • Place of Presentation
      San Antonio (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Kinetic modeling of [^<11>C]4DST PET imaging DNA synthesis rate : initial clinical trials in brain tumors.2011

    • Author(s)
      Sakata, M.
    • Organizer
      10^<th> International conference of quantification of brain function with PET
    • Place of Presentation
      Barcelona(Spain)
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価-安全性評価と代謝分析2011

    • Author(s)
      豊原潤
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮
    • Related Report
      2012 Final Research Report
  • [Presentation] Kinetic modeling of [^<11>C]4DST PET imaging DNA synthesis rate. Initial clnical trials in brain tumors2011

    • Author(s)
      Sakata M
    • Organizer
      10th International Conference of Quantification of Brain Function with PET (BrainPET '11)
    • Place of Presentation
      バルセロナ(スペイン)
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA synthesis imaging of non-small-cell lung cancer using a new PET tracer [^<11>C]4DST2011

    • Author(s)
      Minamimoto R
    • Organizer
      SNM 2011 Annual Meeting
    • Place of Presentation
      サンアントニオ(米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Initial clinical trials of carbon-11-labeled 4DST in brain tumors2011

    • Author(s)
      Toyohara J
    • Organizer
      SNM 2011 Annual Meeting
    • Place of Presentation
      サンアントニオ(米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Clinical use of molecular imaging for the treatment of malignant brain tumor2011

    • Author(s)
      Nariai T
    • Organizer
      Annual Meeting of Congress of Neurological Surgeons
    • Place of Presentation
      ワシントンDC(米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of 4'-[methyl-^<11>C]thiothymidine in a rodent model of tumor and inflammation2011

    • Author(s)
      Toyohara J
    • Organizer
      Annual Congress of the European Association of Nuclear Medicine (EANM'11)
    • Place of Presentation
      バーミンガム(英国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ^<11>C-4DST動態解析に関する基礎的検討2011

    • Author(s)
      豊原潤
    • Organizer
      第51回日本核医学会総会
    • Place of Presentation
      つくば
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA合成診断薬剤^<11>C-4DSTの悪性脳腫瘍治療効果モニターリングへの臨床応用2011

    • Author(s)
      成相直
    • Organizer
      第51回日本核医学会総会
    • Place of Presentation
      つくば
    • Related Report
      2011 Annual Research Report
  • [Presentation] ^<11>C-4DST PETの腫瘍と炎症の鑑別診断に関する基礎的検討2011

    • Author(s)
      豊原潤
    • Organizer
      第51回日本核医学会総会
    • Place of Presentation
      つくば
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの非小細胞肺癌における有用性の検討2011

    • Author(s)
      南本亮吾
    • Organizer
      第51回日本核医学会総会
    • Place of Presentation
      つくば
    • Related Report
      2011 Annual Research Report
  • [Presentation] Initial clinical trials of carbon-11-Labeled 4DST for malignant brain tumors as a PET molecular imaging probe to measure DNA synthesis rate2011

    • Author(s)
      Nariai T
    • Organizer
      16th Annual Scientific Meeting of the Society for Neuro-Oncology
    • Place of Presentation
      オレンジカウンティ(米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] [^<11>C]4DST as novel PET tracer for imaging DNA synthesis in non-small cell lung cancer2011

    • Author(s)
      Minamimoto R
    • Organizer
      Radiological Society of North America 97th Scientific Assemble and Annual Meeting
    • Place of Presentation
      シカゴ(米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] てびき第4版解説4チミジン[^<11>C]チオチミジン2011

    • Author(s)
      豊原潤
    • Organizer
      第20回PET化学ワークショップ
    • Place of Presentation
      湯沢町
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価-悪性脳腫瘍への臨床応用2010

    • Author(s)
      成相直
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価一脳腫瘍での動態解析2010

    • Author(s)
      坂田宗之
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価-全身PET画像の評価2010

    • Author(s)
      窪田和雄
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム画像診断の進歩と展望悪性脳腫瘍に対するPETマルチトレーサーイメージングの臨床活用-新しいDNA合成イメージング法の採用による今後の展望-2010

    • Author(s)
      成相直、田中洋次、稲次基希、武川麻紀、百瀬俊也、川邊拓也、山本昌昭、窪田和雄、石渡喜一、豊原潤、大野喜久郎
    • Organizer
      第69回日本脳神経外科学会学術総会
    • Place of Presentation
      福岡市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価安全性評価と代謝分析2010

    • Author(s)
      豊原潤、成相直、坂出宗之、川邊拓也、織田圭一、窪田和雄、諸岡都、石井賢二、石渡喜一
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価全身PET両像の評価2010

    • Author(s)
      窪田和雄、諸岡都、南本亮吾、伊藤公輝、宮田陽子、中島和彦、成相直、豊原潤、坂田宗之、石渡喜一
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価脳腫瘍での動態解析2010

    • Author(s)
      坂田宗之、豊原潤、成相直、川邊拓也、織田圭一、石井賢二、窪田和雄、石渡喜一
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価悪性脳腫瘍への臨床応用2010

    • Author(s)
      成相直、豊原潤、坂田宗之、川邊拓也、織田圭一、窪田和雄、武川麻紀、大野喜久郎、石井賢二、石渡喜一
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮市
    • Related Report
      2010 Annual Research Report
  • [Book] Trends on the role of PET in drug development 7682012

    • Author(s)
      Toyohara, J. and Ishiwata, K.
    • Publisher
      World Scientific Publishing Co.
    • Related Report
      2012 Final Research Report
  • [Book] Trends on the role of PET in drug development2012

    • Author(s)
      Toyohara, J. and Ishiwata, K.
    • Total Pages
      768
    • Publisher
      World Scientific Publishing Co.
    • Related Report
      2012 Annual Research Report
  • [Book] Animal models-Overview of animal models for tumors, brain diseases and genetics. In : Trends on the role of PET in drug development(Elsinga, P.H., van Waarde, A., Paans, A.M.J.and Dierckx, R.A., eds.)2012

    • Author(s)
      Toyohara J, et al
    • Publisher
      World Scientific Publishing Co, Singapore
    • Related Report
      2011 Annual Research Report
  • [Book] Springer Verlag, Tumors of the central nervous system

    • Author(s)
      Nariai, T., Inaji, M., Sakata, M. and Toyohara, J.
    • Publisher
      (in press)
    • Related Report
      2012 Final Research Report
  • [Book] Springer Verlag, PET and SPECT for neurobiological systems

    • Author(s)
      Toyohara, J., Sakata, M. and Ishiwata, K.
    • Publisher
      (in press)
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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