Attempt to induce tolerance of kidneys by pharmacologic rejuvenation of thymus in miniature swine
| Project/Area Number |
22390249
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NOBORI Shuji 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30433288)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Kazuhiko 鹿児島大学, 医用ミニブタ先端医療開発研究センター, 教授 (40241103)
SAHARA Hisashi 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 特任准教授 (90452333)
YOSHIMURA Norio 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00191643)
SHIMIZU Akira 日本医科大学, 医学部, 准教授 (00256942)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 移植・再生医療 / トランスレーショナルリサーチ / 胸腺 / ミニブタ / 免疫寛容 / 若年化再生 / テストステロン / 制御性 T 細胞 / 制御性T細胞 / 腎移植 / 移植免疫寛容 |
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| Research Abstract |
We have previously demonstrated that (1) thymus plays an important role in induction of transplant tolerance, and (2) extrinsic factors predominantly promote thymic rejuvenation in preclinical MHC inbred swine. Since considerable data in the swine model have indicated that the reason for this age dependence lies in the importance of a non-involuted, functional thymus during the induction period, the proposed study aimed to examine whether pharmacologically rejuvenated thymus induced by LH-RH agonist restored ability of inducing tolerance of allogeneic renal grafts in MHC inbred miniature swine.
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Report
(4 results)
Research Products
(7 results)
