Analysis of carcinogenic mechanism of biliary tract cancer from the protein control by ubiquitin ligase Fbw7
| Project/Area Number |
22390252
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
KATAYOSE Yu 東北大学, 大学院・医学系研究科, 准教授 (20302151)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Kuniharu 東北大学, 大学院・医学系研究科, 非常勤講師 (00375073)
YOSHIDA Hiroshi 東北大学, 病院, 講師 (60436152)
NAKAGAWA Kei 東北大学, 大学院・医学系研究科, 助教 (20542294)
HAYASHI Hiroshi 東北大学, 病院, 助教 (30422124)
中山 啓子 東北大学, 大学院・医学系研究科, 教授 (60294972)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 胆道癌 / ユビキチンリガーゼ / Fbw7 / 胆管癌 / 遺伝子 |
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| Research Abstract |
The gene variation of Fbw7 of a biliary tract cancer cell line was considered, three sorts of isoform(s) of alpha-beta-gamma existed, and especially the expression level of gamma traced that it was low in predominance by all the cell strains in order to solve the role of Fbw7 in a biliary tract cancer occurrence. Next, in order to solve protein control of a biliary tract cancer, the Mouse Embryonic Fibroblast (MEF) of Fbxw7 conditional KO (CKO) mouse, CDK inhibitor showed clearly to have received the complicated control by the proteolytic mechanism by Fbxw7.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] An analysis of asecond-line S-1 monotherapy for gemcitabine-refractory biliary tract cancer2012
Author(s)
Katayose Y, Ohtsuka H, Kitamura Y, Masuda K, Nakagawa K, Yamamoto K, Yoshida H, Onogawa T, Motoi F, Naitoh T, Rikiyama T, Egawa S, Unno M.
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Journal Title
Hepatogastroenterology
Volume: 59(115)
Pages: 691-695
Related Report
Peer Reviewed
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[Journal Article] Lymph nodes metastasis is a risk factor for bone metastasis from extrahepatic cholangiocarcinoma2012
Author(s)
Katayose Y, Nakagawa K, Yamamoto K, Yoshida H, Hayashi H, Mizuma M, Ohtsuka H, Fukase K, Onogawa T, Motoi F, Rikiyama T, Egawa S, Unno M
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Journal Title
Hepatogastroenterology
Volume: 59(118)
Pages: 1758-1760
Related Report
Peer Reviewed
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[Journal Article] Phase I trial of neoadjuvant chemoradiation with gemcitabine and surgical resection for cholangiocarcinoma patients (NACRAC study)2011
Author(s)
Katayose Y, Rikiyama T, Motoi F, Yamamoto K, Yoshida H, Morikawa T, Hayashi H, Kanno A, Hirota M, Satoh K, Ariga H, Suzuki M, Ohyauchi M, Kondo Y, Ikeya S, Ogawa Y, Shimosegawa T, Egawa S, Unno M.
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Journal Title
Hepatogastroenterology
Volume: 58(112)
Pages: 1866-1872
Related Report
Peer Reviewed
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