| Project/Area Number |
22390252
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
KATAYOSE Yu 東北大学, 大学院・医学系研究科, 准教授 (20302151)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Kuniharu 東北大学, 大学院・医学系研究科, 非常勤講師 (00375073)
YOSHIDA Hiroshi 東北大学, 病院, 講師 (60436152)
NAKAGAWA Kei 東北大学, 大学院・医学系研究科, 助教 (20542294)
HAYASHI Hiroshi 東北大学, 病院, 助教 (30422124)
中山 啓子 東北大学, 大学院・医学系研究科, 教授 (60294972)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 胆道癌 / ユビキチンリガーゼ / Fbw7 / 胆管癌 / 遺伝子 |
|---|
| Research Abstract |
The gene variation of Fbw7 of a biliary tract cancer cell line was considered, three sorts of isoform(s) of alpha-beta-gamma existed, and especially the expression level of gamma traced that it was low in predominance by all the cell strains in order to solve the role of Fbw7 in a biliary tract cancer occurrence. Next, in order to solve protein control of a biliary tract cancer, the Mouse Embryonic Fibroblast (MEF) of Fbxw7 conditional KO (CKO) mouse, CDK inhibitor showed clearly to have received the complicated control by the proteolytic mechanism by Fbxw7.
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