| Project/Area Number |
22390259
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
HIRATA Koichi 札幌医科大学, 医学部, 教授 (50136959)
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| Co-Investigator(Kenkyū-buntansha) |
MITAKA Toshihiro 札幌医科大学, 医学部, 教授 (50231618)
MIZUGUCHI Toru 札幌医科大学, 医学部, 准教授 (30347174)
NAKAMURA Yukio 札幌医科大学, 医学部, 研究員 (50516648)
MEGURO Makoto 札幌医科大学, 医学部, 助教 (50448601)
KAWAMOTO Masaki 札幌医科大学, 医学部, 助教 (70404605)
IMAMURA Masafumi 札幌医科大学, 医学部, 助教 (00404608)
YAMAGUCHI Hiroshi 札幌医科大学, 医学部, 研究員 (80457704)
YAMA Naoya 札幌医科大学, 医学部, 助教 (20404709)
TATSUMI Hiroomi 札幌医科大学, 医学部, 助教 (70404613)
OTA Shigenori 札幌医科大学, 医学部, 研究員 (90457705)
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Takashi 札幌医科大学, 医学部, 教授 (30260764)
SAWADA Norimasa 札幌医科大学, 医学部, 教授 (30154149)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Keywords | 肝臓外科学 / 肝再生 / 組織肝細胞 / 細胞移植 / 肝予備機能 / 組織幹細胞 / 肝予備能 / 肝機能 |
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| Research Abstract |
We have achieved the results by the clinical and basic studies.【Study 1】We developed a rat model of acute liver failure after 2/3 partial hepatectomy (PH) for non-alcoholic steatohepatitis (NASH)-related cirrhosis. The mechanism by which HT improved the survival of the model rats was examined in short- and long-term investigations. Overall survival was significantly longer in the HT group than the non-HT group (7-day survival rates: 46.7% and 7.7%, respectively). Preoperative HT might improve the survival of rats with NASH-related cirrhosis after PH by preventing the host hepatocytes from accelerating their growth and falling into apoptosis. 【Study 2】We developed software to calculate the pixels of interest in the area between the hepatic and heart curves (ABC) of 99mTc-galactocyl human serum albumin (GSA) scintigraphy. The area under the receiver operating characteristic curve (AUC) was calculated for evaluation of Child-Pugh score grade B (Child B), pathological chronic hepatitis (CH), and liver cirrhosis (LC). We developed a novel liver functional indicator, the ABC, to count radioactivity in sequence.
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