Biological role of chemokines in pancreatic cancer angiogenesis
| Project/Area Number |
22390261
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
MATSUO Yoichi 名古屋市立大学, 大学院・医学研究科, 講師 (40381800)
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| Co-Investigator(Kenkyū-buntansha) |
FUNAHASI Hitoshi 名古屋市立大学, 大学院・医学研究科, 講師 (10347411)
OKADA Yuji 名古屋市立大学, 大学院・医学研究科, 准教授 (10305550)
TAKEYAMA Hiromitsu 名古屋市立大学, 大学院・医学研究科, 教授 (00216946)
KOIDE Syuji 名古屋市立大学, 大学院・医学研究科, 臨床研究医 (90569261)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 膵臓外科学 / 膵癌 / 血管新生 / CXC-Chemokine / ケモカイン / 浸潤 |
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| Research Abstract |
The prognosis of pancreatic cancer (PaCa) is extremely poor, so new and more effective therapies are clearly needed. The growth of PaCa is dependent on the development of new blood vessels that provide oxygen and nutrients to the tumor cells. We investigatedparacrine effects of CXC-chemokines on vascular endothelial cells. CXC-chemokinessignificantly enhanced proliferation, invasion, and tube formation of vascular endothelial cells. Our results show thatCXC-chemokines promote PaCa tumor-associated angiogenesis through CXCR2, suggesting that CXCR2 is an anti-angiogenic target in PaCa.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.2010
Author(s)
Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B, Kelland L, Jamieson S, Sutherland R, Raynham T, Charles M, Bagherzadeh A, Foxton C, Boakes A, Farooq M, Maru D, Diagaradjane P, Matsuo Y, Sinnett-Smith J, Gelovani J, Krishnan S, Aggarwa
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Journal Title
Mol Cancer Ther
Volume: 9(peer reviewed)
Pages: 1136-1146
Related Report
Peer Reviewed
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