Metabolic status of sentinel lymph node from gastrointestinal cancer

• Project/Area Number: 22390263
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Keio University
• Principal Investigator: KITAGAWA Yuko 慶應義塾大学, 医学部, 教授 (20204878)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Hiroya 慶應義塾大学, 医学部, 講師 (20265838) ; SAIKAWA Yoshihiro 慶應義塾大学, 医学部, 講師 (00225682) ; HAYASHIDA Tetsu (KAWACHI Shigeyuki) 慶應義塾大学, 医学部, 助教 (80234079) ; 林田 哲 慶應義塾大学, 医学部, 助教 (80327543)
• Co-Investigator(Renkei-kenkyūsha): WAKUI Masatoshi 慶應義塾大学, 医学部, 専任講師 (90240465) ; KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: MALDI-IMS / センチネルリンパ節 / 消化器癌 / 乳癌 / メタボローム解析

Research Abstract

Metabolic status of each intrinsic subtypes was analyzed by MALDI-IMS and CE-MS. It was revealed that triple negative breast cancer has the specific metabolic status which is related to the mechanisms of cell proliferation and the sensitivity against chem

Research Products

• [Journal Article] Suppression of heat shock protein 27 expression promotes 5-fluorouracil sensitivity in colon cancer cells in a xenograft model (2012)
  • Author(s): Hayashi R, Ishii Y, Ochiai H, Matsunaga A, Endo T, Hasegawa H, Kitagawa Y.
  • Journal Title: Oncol Rep. Volume: 28 Issue: 4 Pages: 1269
  • DOI: 10.3892/or.2012.1935
  • Peer Reviewed
• [Journal Article] Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer. (2012)
  • Author(s): Okabayashi K, Fujita T, Miyazaki J, Okada T, Iwata T, Hirao N, Noji S, Tsukamoto N, Goshima N, Hasegawa H, Takeuchi H, Ueda M, Kitagawa Y, Kawakami Y.
  • Journal Title: Cancer Sci Volume: 103(9) Issue: 9 Pages: 1617-24
  • DOI: 10.1111/j.1349-7006.2012.02355.x
  • Peer Reviewed
• [Journal Article] Antitumor effect of cetuximab in combination with S-1 in EGFR-amplified gastric cancer cells. (2012)
  • Author(s): Fukuda K, Saikawa Y, Takahashi M, Takahashi T, Wada N, Kawakubo H, Takeuchi H, Kitagawa Y.
  • Journal Title: Int J Oncol Volume: 40(4) Issue: 4 Pages: 975-82
  • DOI: 10.3892/ijo.2011.1279
  • Peer Reviewed
• [Journal Article] HOXB9 expression promoting tumor cell proliferation and angiogenesis is associated with clinical outcomes in breast cancer patients (2012)
  • Author(s): Seki H, Hayashida T, Jinno H, Hirose S, Sakata M, Takahashi M, Maheswaran S, Mukai M, Kitagawa Y.
  • Journal Title: Ann Surg Oncol Volume: 19 Issue: 6 Pages: 1831
  • DOI: 10.1245/s10434-012-2295-5
  • Peer Reviewed
• [Journal Article] Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling (2012)
  • Author(s): Ono Y, Hayashida T, Konagai A, Okazaki H, Miyao K, Kawachi S, Tanabe M, Shinoda M, Jinno H, Hasegawa H, Kitajima M, Kitagawa Y.
  • Journal Title: Cancer Sci. Volume: 103 Issue: 2 Pages: 317
  • DOI: 10.1111/j.1349-7006.2011.02133.x
  • Peer Reviewed