| Project/Area Number |
22390266
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURATANI Toru 大阪大学, 大学院・医学系研究科, 寄附講座教授 (90448035)
UENO Takayoshi 大阪大学, 大学院・医学系研究科, 寄附講座准教授 (60437316)
SAKAGUCHI Taichi 大阪大学, 大学院・医学系研究科, 寄附講座准教授 (10467574)
YOSHIKAWA Yasushi 大阪大学, 大学院・医学系研究科, 助教 (40570594)
YAMAUCHI Takashi 大阪大学, 大学院・医学系研究科, 助教 (20527999)
SHIRAKAWA Yukitoshi 大阪大学, 大学院・医学系研究科, 寄附講座准教授 (20457013)
SAWA Yoshiki 大阪大学, 大学院・医学系研究科, 教授 (00243220)
SHIMAMURA Kazuo 大阪大学, 医学部附属病院, 医員 (10507205)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 人工心臓 / 再生医療 / 心不全 / 幹細胞 / 左室形成デバイス / 心不全薬 / 移植・再生医療 / 再生医学 / 細胞・組織 / トランスレーショナルリサーチ |
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| Research Abstract |
In this project we evaluated histologies of heart tissue at LVAD implantation and heart transplantation. We performed myoblast sheet implantation to cardiomyopathy patients as clinical trial. We implanted myoblast sheet to 4 dilated cardiomyopathy (DCM) patients who received LVAD, 7 DCM patients without LVAD, and 8 ICM patients without LVAD. 2 of 4 DCM patients who received LVAD showed bridge to recovery from LVAD. In one DCM patient who could not show functional recovery after myoblast sheet implantation, we could not detect implanted myoblasts in heart sample obtained at heart transplantation in spite of histological angiogenesis and enhanced expression of cytoskeletal protains in myocytes. We could detect hypertrophy in smooth muscle layer in microvasculature in continuous flow LVAD compared with pulsatile flow LVAD, suggesting that poor functional recovery after LVAD implantation because of decrease of blood perfusion in continuous flow LVAD.
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