| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
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| Research Abstract |
We fabricated scaffold-free 3-Dimensional functional cardiac tissue using spheroid based technology. Proper cardiac tissue spheroids are fabricated with cardiomyocytes, dermal fibroblasts, and vascular endothelial cells. We also fabricated 3-D cardiac tissue with the diameter 1cm, and these constructs were implanted to nude rat heart. Furthermore, implantation for acute myocardial infarction nude rat model indicates improvement of left ventricular ejection fraction.
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