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Cardiac Regeneration using 3-Dimensional Cardiac Tissue

Research Project

Project/Area Number 22390267
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionSaga University

Principal Investigator

MORITA Shigeki  佐賀大学, 医学部, 教授 (70243938)

Co-Investigator(Kenkyū-buntansha) NODE Kouichi  佐賀大学, 医学部, 教授 (80359950)
NAKAYAMA Kouichi  佐賀大学, 工学系研究科, 教授 (50420609)
NOGUCHI Ryo  佐賀大学, 医学部, 助教 (70530187)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Keywords心臓大血管外科学 / 再生医療 / 心筋再生 / 組織工学 / 心臓外科 / 心不全治療 / 心筋細胞
Research Abstract

We fabricated scaffold-free 3-Dimensional functional cardiac tissue using spheroid based technology. Proper cardiac tissue spheroids are fabricated with cardiomyocytes, dermal fibroblasts, and vascular endothelial cells. We also fabricated 3-D cardiac tissue with the diameter 1cm, and these constructs were implanted to nude rat heart. Furthermore, implantation for acute myocardial infarction nude rat model indicates improvement of left ventricular ejection fraction.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (2 results) Presentation (11 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 再生医療による人工臓器研究の最近の進歩:Scaffold free の心臓・血管組織の構築2012

    • Author(s)
      森田茂樹、野口亮、野出孝一、中山功一
    • Journal Title

      人工器

      Volume: 41.3 Pages: 168-171

    • NAID

      10031136470

    • Related Report
      2012 Final Research Report
  • [Journal Article] 再生医療による人工臓器研究の最近の進歩:Scaffold free の心臓・血管組織の構築2012

    • Author(s)
      森田茂樹
    • Journal Title

      人工臓器

      Volume: 41.3 Pages: 168-171

    • NAID

      10031136470

    • Related Report
      2012 Annual Research Report
  • [Presentation] 規組織工学による心臓・血管再生医療2013

    • Author(s)
      野口亮
    • Organizer
      第9回CTRC(Cardiovascular Translational Research Conference)
    • Place of Presentation
      福岡グランドハイアット
    • Year and Date
      2013-01-12
    • Related Report
      2012 Final Research Report
  • [Presentation] ISHLT 2013 Development of 3-Dimensional Prevascularized Scaffold-free Contractile Cardiac Patch for Heart Regeneration2013

    • Author(s)
      野口亮
    • Place of Presentation
      カナダ モントリオール国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] Scaffold-freeな機能的心筋構造体および移植法の開発2013

    • Author(s)
      森田茂樹、野口亮
    • Organizer
      第12回日本再生医療学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 新しい組織工学を用いた自己細胞のみで形成される3次元組織構築法の開発2013

    • Author(s)
      野口亮
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Spheroid Based Cardiovascular Regeneration using Robotics Engineering2013

    • Author(s)
      Morita Shigeki,Ryo Noguchi
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Development of 3-Dimensional Prevascularized Scaffold-free Contractile Cardiac Patch for Heart Regeneration2013

    • Author(s)
      野口亮
    • Organizer
      ISHLT 2013
    • Place of Presentation
      カナダ モントリオール国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Spheroids Based Scaffold-free Tissue Engineering for Cardiovascular Regeneration2012

    • Author(s)
      野口亮
    • Organizer
      第29回国際心臓研究学会(ISHR)日本部会総会
    • Place of Presentation
      九州大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Spheroids Based Scaffold-free Tissue Engineering for Cardiovascular Regeneration2012

    • Author(s)
      野口亮
    • Organizer
      第29回国際心臓研究学会(ISHR)日本部会総会
    • Place of Presentation
      九州大学医学部百年講堂
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新しい心筋細胞立体構造体形成技術による心不全治療の可能性2011

    • Author(s)
      野口亮
    • Organizer
      第41回日本心臓血管外科学会総会
    • Place of Presentation
      千葉 東京ベイホテル
    • Year and Date
      2011-02-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fabrication of tissue engineered pulsatile 3-Dimensional scaffold-free cardiac tissue from embryonic stem cells2011

    • Author(s)
      野口亮, 森田茂樹、野出孝一、中山功一
    • Organizer
      ISHLT2011
    • Place of Presentation
      San Diego, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規組織工学による心臓・血管再生医療

    • Author(s)
      野口亮
    • Organizer
      第9回CTRC(Cardiovascular Translational Research Conference)
    • Place of Presentation
      福岡グランドハイアット
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 心臓又は血管組織型スフェロイド2013

    • Inventor(s)
      森田茂樹、野口亮
    • Industrial Property Rights Holder
      佐賀大学
    • Industrial Property Number
      2013-053037
    • Filing Date
      2013-03-15
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 心臓又は血管組織型スフェロイド2013

    • Inventor(s)
      森田茂樹
    • Industrial Property Rights Holder
      佐賀大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-053037
    • Filing Date
      2013-03-15
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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