| Project/Area Number |
22390269
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KANDA Keiichi 京都府立医科大学, 医学研究科, 講師 (60295649)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMIZAWA Keiichi 国立循環器病センター研究所, 生体工学部, 室員 (10163312)
OHBA Keikichi 関西大学, 工学部, 教授 (30029186)
TAJIKAWA Tsutomu 関西大学, 工学部, 講師 (80351500)
UECHI Masami 日本大学, 生物資源科学部, 教授 (90296426)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 自家組織 / 心臓生体弁 / 再生医療 / 組織工学 / in vivo / Ｄ．I．Y． / 生体内組織形成技術 / 同種・異種移植 / 血管内治療 |
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| Research Abstract |
We have developed the autologous tissue heart valves (Biovalves) constructed by the simple, safe and economical in vivo tissue engineering without any use of specially clean facilities nor complicated procedures. A specially designed mold embedded in the subcutaneous space of rabbits, beagle dogs and goats were covered by autologous tissues for 4 weeks. After removal of the mold, tri-leaflet valvular shaped autologous tissues were formed. They were also built in the tube grafts for implantation to circulation systems. In the flow circuit, smooth valvular movements of the Biovalves (5 mm in diameter) constructed in the rabbits were observed. Their flow volume pattern was very close to that of native rabbit aortic valves. Biovalves (10-15 mm in diameter) were successfully implanted to the pulmonary valves in the allogeneic beagle model as a pilot experiment. Recently, they were composed to metallic stents for catheter intervention. In vivo tissue engineered “Biovalves” could be idealistic autologous heart valve prostheses with potentiality replacing the short-coming Homografts.
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