D.I.Y. Medicine:Development of autologous tissue heart valves constructed in the body of the patient
Project/Area Number |
22390269
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Thoracic surgery
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
KANDA Keiichi 京都府立医科大学, 医学研究科, 講師 (60295649)
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Co-Investigator(Kenkyū-buntansha) |
TAKAMIZAWA Keiichi 国立循環器病センター研究所, 生体工学部, 室員 (10163312)
OHBA Keikichi 関西大学, 工学部, 教授 (30029186)
TAJIKAWA Tsutomu 関西大学, 工学部, 講師 (80351500)
UECHI Masami 日本大学, 生物資源科学部, 教授 (90296426)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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Keywords | 自家組織 / 心臓生体弁 / 再生医療 / 組織工学 / in vivo / D.I.Y. / 生体内組織形成技術 / 同種・異種移植 / 血管内治療 |
Research Abstract |
We have developed the autologous tissue heart valves (Biovalves) constructed by the simple, safe and economical in vivo tissue engineering without any use of specially clean facilities nor complicated procedures. A specially designed mold embedded in the subcutaneous space of rabbits, beagle dogs and goats were covered by autologous tissues for 4 weeks. After removal of the mold, tri-leaflet valvular shaped autologous tissues were formed. They were also built in the tube grafts for implantation to circulation systems. In the flow circuit, smooth valvular movements of the Biovalves (5 mm in diameter) constructed in the rabbits were observed. Their flow volume pattern was very close to that of native rabbit aortic valves. Biovalves (10-15 mm in diameter) were successfully implanted to the pulmonary valves in the allogeneic beagle model as a pilot experiment. Recently, they were composed to metallic stents for catheter intervention. In vivo tissue engineered “Biovalves” could be idealistic autologous heart valve prostheses with potentiality replacing the short-coming Homografts.
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Report
(4 results)
Research Products
(138 results)
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[Journal Article] Development of a completely autologous valved-conduit with the sinus of valsalva (BIOVALVE) using in-body tissue architecture technology : a pilot study in pulmonary valve replacement in a beagle model.2010
Author(s)
Yamanami M, Yahata Y, Uechi M, Fujiwara M, Ishibashi-Ueda H, Kanda K, Watanabe T, Tajikawa T, Ohba K, Yaku H, Nakayama Y
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Journal Title
Circulation
Volume: 122[suppl 1]
Related Report
Peer Reviewed
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[Presentation] reparation of a completely autologous valved conduit with the open form of trileaflets (Type VI Biovalve)2011
Author(s)
Yamanami M, Yahata Y, Uechi M, Takekawa Y, Shimakawa Y,Matsui T,Tajikawa T, Ohba K,Kanda K, Yaku H, Tatsumi E, Nakayama Y
Organizer
4th Joint ESAO-IFAO Congress 2011
Place of Presentation
Porto,Portugal
Related Report
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[Presentation] Development of Completely Autologous Tissue Valved-Conduits BIOVALVEs ; Mold design and Transplantation Study in Beagle Model2011
Author(s)
Yamanami M, Uechi M, Fujiwara M, Yahata Y, Ishibashi-Ueda H, Kanda K, Watanabe T, Oie T, Tajikawa T, Ohba K, Yaku H, Nakayama Y
Organizer
The Society for Heart Valve Disease 6th Biennial Meeting
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] Development of a completely autologous valved conduit with the sinus of valsalva using in-body tissue architecture technology2011
Author(s)
Yamanami M, Uechi M, Fujita M, Ishibashi-Ueda H, Kanda K, Watanabe T, Tajikawa T, Ohba K, Yaku H, Nakayama Y
Organizer
16th World Congress on Heart Disease Annual Schientific Sessions 2011
Place of Presentation
Vancouver, Canada
Related Report
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[Presentation] Feasibility study of in-body tissue-engineered, completely autologous valved conduits (BIOVALVEs type IV) as an aortic valve in a goat model2011
Author(s)
Yamanami M, Takewa Y, Kanda K, Matsui Y, Tajikawa T, Ohba K, Yaku H, Taenaka Y, Tatsumi E, Nakayama Y.
Organizer
ESC congress 2011. (European Society of Cardiology)
Place of Presentation
Paris France
Related Report
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[Presentation] Preparation of a completely autologous valved conduit with the open form of trileaflets (Type VI Biovalve)2011
Author(s)
Yamanami M, Yahata Y, Uechi M, Takekawa Y, Shimakawa Y, Matsui T, Tajikawa T, Ohba K, Kanda K, Yaku H, Tatsumi E, Nakayama Y.
Organizer
4th Joint ESAO-IFAO Congress 2011
Place of Presentation
Porto, Portugal
Related Report
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[Presentation] Architecture design of a novel separable mold to obtain autologous tissue heart valves "Biovalves" non-invasively2011
Author(s)
Nakayama Y, Matsui Y, Yamanami M, Takewa Y, Tatsumi E, Taenaka Y, Oie T, Tajikawa T, Ohba K, Kanda K, Yaku H
Organizer
4th Joint ESAO-IFAO Congress 2011
Place of Presentation
Porto, Portugal
Related Report
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[Presentation] Successful Aortic Valve Implantation Using an In-Body Tissue-Engineered, Completely Autologous Valve Conduit (BIOVALVE) in a Goat Model2011
Author(s)
Takewa Y, Nakayama Y, Yamanami M, Umeki A, Matsui Y, Kanda K, Yaku H, Tajikawa T, Ohba K, Taenaka Y, Tatsumi E
Organizer
American Heart Association Scientific Sessions 2011
Place of Presentation
Orlando, USA
Related Report
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[Presentation] Transcatheter Implantation of Autologous in vivo Tissue-Engineered, Valved Stents (BIOVALVED STENTs) in the Pulmonary Position in a Beagle Model2011
Author(s)
Uechi M, Funayama M, Matsui Y, Mizuno T, Fujiwara M, Tajikawa T, Ohba K, Yamanami M, Watanabe T, Kanda K, Yaku H, Nakayama Y.
Organizer
American Heart Association Scientific Sessions 2011
Place of Presentation
Orlando, USA
Related Report
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