Aberrant pre-mRNA splicinginvolved in increased fluxof glycolysis in non-small lung cancer
| Project/Area Number |
22390272
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
SATO Masami 鹿児島大学, 大学院・医歯学総合研究科, 教授 (30250830)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Yoshihiro 鹿児島大学, 医学部・歯学部附属病院, 講師 (60381159)
SAKASEGAWA Koichi 鹿児島大学, 医学部・歯学部附属病院, 特任助教 (80601393)
OTSUKA Tsunayuki 鹿児島大学, 医学部・歯学部附属病院, 助教 (40464466)
NAGATA Toshiyuki 鹿児島大学, 大学院・医歯学総合研究科, 特任助教 (70611763)
AOKI Masaya 鹿児島大学, 大学院・医歯学総合研究科, 特任助教 (50624996)
SHIMA Hiroshi 宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 (10196462)
TANUMA Nobuhiro 宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
佐藤 郁郎 宮城県立がんセンター(研究所), 病理学部, 部長 (50225918)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 呼吸器外科学 / 肺がん / 非小細胞肺がん / 解糖系 / ワールブルグ効果 / FDG-PET / スプライシング / 肺癌 / モノクロナル抗体 / 解糖系酵素 |
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| Research Abstract |
Increased flux of glycolysis is known as Warburg effect, and now recognized as a core hallmark of cancer. In this study, we explored roles and mechanisms for isozyme-conversion of pyruvate kinase M (PKM), termed PKM-switch, which mediates Warburg effect in lung cancer. PKM-switch was correlated with FDG-PET signal intensity. In addition, a mouse model incapable of switching PKM isoforms was developed.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas2012
Author(s)
Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, Katakura R, Yamashita Y, Sato M, Tanuma N, Shima H
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Journal Title
Oncol Rep
Volume: 28(3)
Pages: 931-6
DOI
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Peer Reviewed
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[Journal Article] EGFR mutations and human papillomavirus in lung cancer2012
Author(s)
Kato T, Koriyama C, Khan N, Samukawa T, Yanagi M, Hamada T, Yokomakura N, Otsuka T, Inoue H, Sato M, Natsugoe S, Akiba S
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Journal Title
EGFR mutations and human papillomavirus in lung cancer
Volume: 78
Issue: 2
Pages: 144-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Cytological Characteristics of Pulmonary Pleomorphic and Giant Cell Carcinomas.2011
Author(s)
Hiroshima K, Akita H, Usuda K, Ogura S, Kusunoki Y, Kodama T, Saito Y, Sato M, Tagawa Y, Baba M, Hirano T, Horai T, MatsunoY
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Journal Title
Acta Cytologica
Volume: 55
Issue: 2
Pages: 173-179
DOI
Related Report
Peer Reviewed
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[Journal Article] DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011
Author(s)
Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, Katakura R, Shiiba K, Nomura E, Sato M, Tanuma N, Shima H
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Journal Title
Mol Cell Biochem
Volume: 352(1-2)
Issue: 1-2
Pages: 155-62
DOI
Related Report
Peer Reviewed
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[Journal Article] Early Hilar Type Lung Cancer in Japan: A Survey from January 2006 to December 20072011
Author(s)
佐藤雅美, 斎藤泰紀,渋谷潔,中山富雄,平野隆,近藤丘,馬場雅行,池田徳彦,佐川元保,伊豫田明,宝来威,中嶋隆太郎,平田哲士,三宅真司,楠洋子,多田 弘人,古川欣也,渡辺洋一
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Journal Title
Haigan
Volume: 51
Issue: 7
Pages: 777-786
DOI
NAID
ISSN
0386-9628, 1348-9992
Related Report
Peer Reviewed
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[Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm2010
Author(s)
Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H
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Journal Title
Biochem Biophys Res Commun
Volume: 393(2)
Issue: 2
Pages: 201-6
DOI
Related Report
Peer Reviewed
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[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples2010
Author(s)
Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
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Journal Title
J Neuroncol
Volume: 100
Issue: 1
Pages: 43-4
DOI
Related Report
Peer Reviewed
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[Presentation] 第2次肺癌検診喀痰細胞診合同委員会活動状況報告2012
Author(s)
佐藤雅美、斎藤泰紀,佐藤之俊,柴光年,渋谷潔,土田敬明,中山富雄,池田徳彦,三浦弘之,田中良太,河原栄,中嶋隆太郎,神尾淳子,島垣二佳子,田口明美,長尾緑,岡上愼一,三宅真司,矢羽田一信
Organizer
第51回日本臨床細胞学会秋期大会
Place of Presentation
新潟
Year and Date
2012-11-10
Related Report
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[Presentation] 肺癌進行に対する BMP-7 の臨床病理学的重要性2012
Author(s)
青木雅也, 梅原正,鈴木聡一,原田亜矢,渡辺有為,永田俊行,大塚綱志,狩集弘太,酒瀬川浩一,中村好宏,脇田和博,横枕直哉,柳正和,佐藤雅美
Organizer
第53回日本肺癌学会
Place of Presentation
岡山
Year and Date
2012-11-09
Related Report
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[Presentation] 近赤外光カメラとインドシアニングリーンによる胸膜直下のリンパ流の検討2012
Author(s)
原田亜矢, 中村好宏,鈴木聡一,梅原正,脇田和博,渡辺有為,青木雅也,永田俊行,大塚綱志,酒瀬川浩一,佐藤雅美
Organizer
第65回日本胸部外科学会
Place of Presentation
福岡
Year and Date
2012-10-19
Related Report
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