| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Research Abstract |
We established brain tumor stem cells and mouse xenographt models. Global microRNA expression analysis revealed that miR-196, which is associated with malignant transformation of glioma, is also overexpressed in brain tumor stem cells. Functional assays showed that miR-196 could increase proliferation and inhibit apoptosis in glioma cell lines. In addition, comparison between gene expression and microRNA expression indicated that miR-128a and miR-504 are associated with mesenchymal gene expression.
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