Functional analysis of microRNA in the regulation of brain tumor stem cell
| Project/Area Number |
22390280
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Koji 九州大学, 大学病院, 講師 (70444784)
AMANO Toshiyuki 九州大学, 大学病院, 助教 (70448413)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 脳腫瘍幹細胞 / microRNA / 神経膠腫 / 悪性神経膠腫 |
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| Research Abstract |
We established brain tumor stem cells and mouse xenographt models. Global microRNA expression analysis revealed that miR-196, which is associated with malignant transformation of glioma, is also overexpressed in brain tumor stem cells. Functional assays showed that miR-196 could increase proliferation and inhibit apoptosis in glioma cell lines. In addition, comparison between gene expression and microRNA expression indicated that miR-128a and miR-504 are associated with mesenchymal gene expression.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance2010
Author(s)
Guan Y, Mizoguchi M, Yoshimoto K, Hata N, Shono T, Suzuki SO, Araki Y, Kuga D, Nakamizo A, Amano T, Ma X, Hayashi K, Sasaki T
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Journal Title
ClinCancer Res
Volume: 16(16)
Issue: 16
Pages: 4289-4297
DOI
Related Report
Peer Reviewed
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