Study of the molecular mechanism of neural tumor formation mediatedby NF1 gene deficiency

• Project/Area Number: 22390281
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kumamoto University
• Principal Investigator: ARAKI Norie 熊本大学, 大学院・生命科学研究部, 准教授 (80253722)
• Co-Investigator(Kenkyū-buntansha): KURATSU Juniti 熊本大学, 大学院・命科学研究部, 教授 (20145296) ; IRIE Atsushi 熊本大学, 大学院・命科学研究部, 講師 (30250343)
• Co-Investigator(Renkei-kenkyūsha): SAYA Hideyuki 慶應義塾大学, 医学部, 教授 (80264282)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: 神経線維腫症 / NF1 / プロテオミクス / 腫瘍抑制シグナル / Neurofibromin / NF2 / Merlin / siRNA

Research Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder that predisposesindividuals to developing benign neurofibromas and malignant peripheral nerve sheathtumors (MPNSTs). The molecular mechanism of NF1-associated tumor pathogenesis has beenlargely unknown, and the strategy of medical treatments for NF1 tumors has not beenestablished. To identify the molecular marker/target in malignant tumors mediated by NF1gene deficiency, we established the NF1 gene knockdown (KD) system in neural cells asa NF1 disease model, and analyzed the expression profiles of genes/proteins by anintegrated proteomics. Of 4000 non-redundant proteins semi-quantitatively identified,we extracted 38 molecular signals which were abnormally upregulated in NF1 KD cellscompared with control cells. These proteins were mostly related to cell motility,apoptosis, and cell differentiation, and including several novel protein networks inneuronal cells, such as TCTP(Translationally Controlled Tumor Protein)-mTOR signal andDynein-GR-COX1 signal. We confirmed that these signals were significantly up-regulatedin NF1-deficient neural cells via the activation of MAPK/PI3K-AKT signaling in responseto growth factors. The knockdown or inhibitor treatments of these signals suppressed theviability and differentiation of NF1 disease model/tumor cells. These results suggestthat these novel NF1-related signals are functionally implicated in the tumorigenesisand it’s progression, and serves as a diagnostic biomarker/therapeutic target for NF1tumors.

Research Products

• [Journal Article] Integrated proteomics identified anovel activation signaling of dyneinIC2-GR-COX-1 in NF1 disease model cells (2013)
  • Author(s): Hirayama M, Kobayashi D, Mizuguchi S,Morikawa T, Nagayama M, Wilson MM,Nambu NA, Y oshizawa A, Kawano S, andAraki N*
  • Journal Title: Mol. Cell. Proteomics Volume: 12(5) Pages: 1377-1394
  • Peer Reviewed
• [Journal Article] Gliomainitiating cells form a differentiation nichevia the induction of extracellular matrices andintegrin alpha V (2013)
  • Author(s): Nambu, NA., Midorikawa U, Mizuguchi S,Hide T, Nagai M, Komohara Y, Nagayama1M, Hirayama M, Kobayashi D, Tsubota N,Takezaki T, Makino K, Nakamura H, TakeyaM, Kuratsu J and Araki N*.
  • Journal Title: PLOS ONE Volume: 8(5)
  • Peer Reviewed
• [Journal Article] Epiplakin modifies the motilityof the HeLa cells and accumulates at theouter surfaces of three-dimensional cellclusters (2013)
  • Author(s): Shimada H, Nambu-Niibori A, WilsonMorifuji M, Mizuguchi S, Araki N*, MezakiY , Senoo H, Ishikawa K, Okamoto O,Fujiwara S
  • Journal Title: J. Dermatol Volume: 40(4) Pages: 249-588
  • Peer Reviewed
• [Journal Article] Enhancement ofhuman cancer cell motility and invasivenessby anaphylatoxin C5a via aberrantlyexpressed C5a-receptor (CD88). (2013)
  • Author(s): Nitta H, Wada Y, Kawano Y, Murakami Y,Irie A, Taniguchi K, Kikuchi K, Yamada G,Suzuki K, Honda J, Wilson MM, Araki N,Eto M, Baba H. Imamura T
  • Journal Title: ClinicalCancer Res Volume: 19(8) Pages: 1-10
  • Peer Reviewed
• [Journal Article] Integrated view of the human chromosome X-centric proteome project. (2013)
  • Author(s): Yamamoto T, Nakayama K, Hirano H, Tomonaga T, Ishihama Y, Yamada T, Kondo T,Kodera Y, Sato Y, Araki N, Mamitsuka H, Goshima N.
  • Journal Title: J Proteome Res. Volume: 12 Issue: 1 Pages: 58-61
  • DOI: 10.1021/pr300844p
  • Peer Reviewed
• [Journal Article] Integrated proteomics identified a novel activation signaling of dynein IC2-GR-COX-1 in NF1 disease model cells. (2013)
  • Author(s): Hirayama M, Kobayashi D, Mizuguchi S, Morikawa T, Nagayama M, Wilson MM, Nambu NA, Yoshizawa A, Kawano S, and Araki N*
  • Journal Title: Molecular & Cellular Proteomics Volume: 12(5) Pages: 1377-1394
  • Peer Reviewed
• [Journal Article] Glioma initiating cells form a differentiation niche via the induction of extracellular matrices and integrin alpha V. (2013)
  • Author(s): Nambu, NA., Midorikawa U, Mizuguchi S, Hide T, Nagai M, Komohara Y, Nagayama1 M, Hirayama M, Kobayashi D, Tsubota N, Takezaki T, Makino K, Nakamura H, Takeya M, Kuratsu J and Araki N*
  • Journal Title: PLOS ONE Volume: -
  • Peer Reviewed
• [Journal Article] Enhancement of human cancer cell motility and invasiveness by anaphylatoxin C5a via aberrantly expressed C5a-receptor (CD88). (2013)
  • Author(s): Nitta H, Wada Y, Kawano Y, Murakami Y, Irie A, Taniguchi K, Kikuchi K, Yamada G, Suzuki K, Honda J, Wilson MM, Araki N, Eto M, Baba H and Imamura T.
  • Journal Title: Clinical Cancer Research Volume: 19(8) Pages: 1-10
  • Peer Reviewed
• [Journal Article] TGF-β Mediates Homing of Bone Marrow-Derived Human Mesenchymal Stem Cells to Glioma Stem Cells. (2013)
  • Author(s): Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini FC, Andreeff M, Kuratsu J, Lang FF.
  • Journal Title: Cancer Res Volume: 73(7) Pages: 2333-44
  • Peer Reviewed
• [Journal Article] Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma . (2013)
  • Author(s): Shibui S, Narita Y, Mizusawa J, Beppu T, Ogasawara K, Sawamura Y, Kobayashi H, Nishikawa R, Mishima K, Muragaki Y, Maruyama T, Kuratsu J, Nomura K etl .
  • Journal Title: Cancer Chemother Pharmacol. Volume: 71(2) Issue: 2 Pages: 511-21
  • DOI: 10.1007/s00280-012-2041-5
  • Peer Reviewed
• [Journal Article] Phosphorylation by PKD2 at Ser171 of SETreduced its inhibitory effect on PP2Aphosphatase in T cells (2012)
  • Author(s): Irie A, Harada K, Araki N, Nishimura Y
  • Journal Title: PLOS ONE Volume: 7(12)
  • Peer Reviewed
• [Journal Article] Possibleinvolvement of cyclophilin a processing infumagillin-induced suppression ofcholangiocarcinoma cell proliferation. (2012)
  • Author(s): Sawanyawisuth K, Wongkham C, Riggins GJ,Wongkham S, Araki N*
  • Journal Title: AsianPac J Cancer Prev Volume: 13 Suppl Pages: 137-41
  • Peer Reviewed
• [Journal Article] Serial Analysis of Gene Expression RevealsPromising Therapeutic Targets for LiverFluke-associated Cholangiocarcinoma (2012)
  • Author(s): Sawanyawisuth K, Wongkham C, Araki N,Zhao Q, Riggins GJ, Wongkham S*
  • Journal Title: AsianPac J Cancer Prev Volume: 13 Suppl Pages: 89-93
  • Peer Reviewed
• [Journal Article] Contribution ofRIZ1 to regulation of proliferation andmigration of a liver fluke-relatedcholangiocarcinoma cell (2012)
  • Author(s): Khaenam P , Niibori A, Okada S, JearanaikoonP , Araki N*, Limpaiboon T*
  • Journal Title: Asian Pac J CancerPrev Volume: 13(8) Pages: 4007-11
  • Peer Reviewed
• [Journal Article] Epiplakin modifies the motility of the HeLa cells and accumulates at the outer surfaces of three-dimensional cell clusters. (2012)
  • Author(s): Shimada H, Nambu-Niibori A, Wilson-Morifuji M, Mizuguchi S, Araki N*, Mezaki Y, Senoo H, Ishikawa K, Okamoto O, Fujiwara S.
  • Journal Title: J. Dermatol Volume: 40(4) Pages: 249-58
  • Peer Reviewed
• [Journal Article] Phosphorylation by PKD2 at Ser171 of SET reduced its inhibitory effect on PP2A phosphatase in T cells. (2012)
  • Author(s): Irie A, Harada K, Araki N, Nishimura Y.
  • Journal Title: PLOS ONE Volume: 7(12) Issue: 12 Pages: e51242-e51242
  • DOI: 10.1371/journal.pone.0051242
  • Peer Reviewed
• [Journal Article] Possible involvement of cyclophilin a processing in fumagillin- induced suppression of cholangiocarcinoma cell proliferation. (2012)
  • Author(s): Sawanyawisuth K, Wongkham C, Riggins GJ, Wongkham S, Araki N*
  • Journal Title: Asian Pac J Cancer Prev Volume: 13 Suppl Pages: 137-41
• [Journal Article] Limpaiboon T*. Contribution of RIZ1 to regulation of proliferation and migration of a liver fluke-related cholangiocarcinoma cell. (2012)
  • Author(s): Khaenam P, Niibori A, Okada S, Jearanaikoon P, Araki N*
  • Journal Title: Asian Pac J Cancer Prev Volume: 13(8) Pages: 4007-11
  • Peer Reviewed
• [Journal Article] Serial Analysis of Gene Expression Reveals Promising Therapeutic Targets for Liver Fluke-associated Cholangiocarcinoma. (2012)
  • Author(s): Sawanyawisuth K, Wongkham C, Araki N, Zhao Q, Riggins GJ, Wongkham S*.
  • Journal Title: Asian Pac J Cancer Prev Volume: 13 Suppl Pages: 89-93
  • Peer Reviewed
• [Journal Article] Giant tumefactive perivascular spaces that expanded and became symptomatic 14 years after initial surgery. (2012)
  • Author(s): Fujimoto K, Kuroda J, Hide T, Hasegawa Y, Yano S, Kuratsu J.
  • Journal Title: Surg Neurol Int. Volume: 3 Issue: 1 Pages: 127-127
  • DOI: 10.4103/2152-7806.102942
  • Peer Reviewed
• [Journal Article] Prolonged and regionally progressive symptomatic cerebral hyperperfusion syndrome after superficial temporal artery-middle cerebral artery anastomosis in a patient with moyamoya disease. (2012)
  • Author(s): Takemoto Y, Morioka M, Nakagawa T, Hasegawa Y, Ohmori Y, Kawano T, Kai Y, Kuratsu J.
  • Journal Title: Surg Neurol Int. Volume: 3 Issue: 1 Pages: 106-106
  • DOI: 10.4103/2152-7806.100867
  • Peer Reviewed
• [Journal Article] Higher incidence of epilepsy in meningiomas located on the premotor cortex: a voxel-wise statistical analysis. (2012)
  • Author(s): Hamasaki T, Yamada K, Yano S, Nakamura H, Makino K, Hide T, Hasegawa Y, Kuroda J, Hirai T, Kuratsu J.
  • Journal Title: Acta Neurochir (Wien) Volume: 154(12) Issue: 1 Pages: 1-7
  • DOI: 10.1007/s00701-012-1514-y
  • Peer Reviewed
• [Journal Article] Usefulness of immunohistochemical expression analysis of metabolic-related molecules to differentiate between intracranial neoplastic and non-neoplastic lesions. (2012)
  • Author(s): Makino K, Nakamura H, Hide TI, Yano S, Kuroda JI, Takahashi Y, Iyama KI, Kuratsu JI.
  • Journal Title: Brain Tumor Pathol Volume: 12
  • Peer Reviewed
• [Journal Article] Induction of autophagic cell death of glioma-initiating cells by cell-penetrating D-isomer peptides consisting of Pas and the p53 C-terminus. (2012)
  • Author(s): Ueda Y, Wei FY, Hide T, Michiue H, Takayama K, Kaitsuka T, Nakamura H, Makino K, Kuratsu J, Futaki S, Tomizawa K.
  • Journal Title: Biomaterials. Volume: 33(35) Pages: 9061-9
  • Peer Reviewed
• [Journal Article] Importance of direct macrophage-tumor cell interaction on progression of human glioma. (2012)
  • Author(s): Komohara Y, Horlad H, Ohnishi K, Fujiwara Y, Bai B, Nakagawa T, Suzu S, Nakamura H, Kuratsu J, Takeya M.
  • Journal Title: Cancer Sci Volume: 103(12) Issue: 12 Pages: 2165-72
  • DOI: 10.1111/cas.12015
  • Peer Reviewed
• [Journal Article] Outer-diameter narrowing of the internal carotid and middle cerebral arteries in moyamoya disease detected on 3D constructive interference in steady-state MR image (2012)
  • Author(s): Kaku Y, Morioka M, Ohmori Y, Kawano T, Kai Y, Fukuoka H, Hirai T, Yamashita Y, Kuratsu J.
  • Journal Title: Acta Neurochir (Wien). Volume: 154(12) Issue: 12 Pages: 2151-7
  • DOI: 10.1007/s00701-012-1472-4
  • Peer Reviewed
• [Journal Article] Pituitary apoplexy associated with endocrine stimulation test: endocrine stimulation test, treatment, and outcome. (2012)
  • Author(s): Yamamoto T, Yano S, Kuroda J, Hasegawa Y, Hide T, Kuratsu J.
  • Journal Title: Case Rep Endocrinol. Volume: - Pages: 826901-826901
  • DOI: 10.1155/2012/826901
  • Peer Reviewed
• [Journal Article] Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma. (2012)
  • Author(s): Nagane M, Nishikawa R, Narita Y, Kobayashi H, Takano S, Shinoura N, Aoki T, Sugiyama K, Kuratsu J, Muragaki Y, Sawamura Y, Matsutani M.
  • Journal Title: Jpn J Clin Oncol Volume: 42(10) Pages: 887-95
  • Peer Reviewed
• [Journal Article] A 6-Fr guiding catheter (Slim Guide(®)) for use with multiple microdevices. (2012)
  • Author(s): Kai Y, Ohmori Y, Watanabe M, Kaku Y, Morioka M, Hirano T, Yano S, Kawano T, Hamada J, Kuratsu J.
  • Journal Title: Surg Neurol Int Volume: 3 Issue: 1 Pages: 59-59
  • DOI: 10.4103/2152-7806.97003
  • Peer Reviewed
• [Journal Article] Fatty acid synthase is a predictive marker for aggressiveness in meningiomas. (2012)
  • Author(s): Makino K, Nakamura H, Hide T, Yano S, Kuroda J, Iyama K, Kuratsu J.
  • Journal Title: J Neurooncol Volume: 109(2) Issue: 2 Pages: 399-404
  • DOI: 10.1007/s11060-012-0907-3
  • Peer Reviewed
• [Journal Article] Arterial graft to treat ruptured distal middle cerebral artery aneurysms in a patient with mucosa-associated lymphoid tissue lymphoma. Case report. (2012)
  • Author(s): Hasegawa Y, Morioka M, Makino K, Kai Y, Hamada J, Kuratsu J.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 52(6)
  • Peer Reviewed
• [Journal Article] Long Disease Duration Interferes With Therapeutic Effect of Globus Pallidus Internus Pallidal Stimulation in Primary Cervical Dystonia. (2012)
  • Author(s): Yamada K, Hamasaki T, Hasegawa Y, Kuratsu JI.
  • Journal Title: Neuromodulation Volume: - Issue: 3 Pages: 1-1
  • DOI: 10.1111/j.1525-1403.2012.00464.x
  • Peer Reviewed
• [Journal Article] Historical considerations of the predominance of lumboperitoneal shunt for treatment of adult communicating hydrocephalus in Kumamoto, Japan. (2012)
  • Author(s): Yamashiro S, Hitoshi Y, Yoshida A, Kuratsu J.
  • Journal Title: Clin Neurol Neurosurg Volume: 114(7) Issue: 7 Pages: 1115-6
  • DOI: 10.1016/j.clineuro.2012.02.018
  • Peer Reviewed
• [Journal Article] Accurate estimation of motor symptoms by diffusion tensor imaging in a patient with advanced Moyamoya disease. (2012)
  • Author(s): Hamasaki T, Imamura J, Kai Y, Ohmori Y, Kuratsu J.
  • Journal Title: Clin Neurol Neurosurg Volume: 114(7) Issue: 7 Pages: 1042-5
  • DOI: 10.1016/j.clineuro.2012.01.042
  • Peer Reviewed
• [Journal Article] Dissecting aneurysms of the vertebral artery--angiographic patterns at the dissecting site on balloon test occlusion. (2012)
  • Author(s): Kai Y, Hamada J, Morioka M, Ohmori Y, Watanabe M, Hirano T, Kawano T, Yano S, Kuratsu J.
  • Journal Title: Neuroradiology Volume: 54(8) Issue: 8 Pages: 857-62
  • DOI: 10.1007/s00234-011-0993-5
  • Peer Reviewed
• [Journal Article] Integrated proteomics for studying cellular mechanism of neural tumor formation (2012)
  • Author(s): Araki, N
  • Journal Title: Connective Tissue Research Volume: (in press)
  • Peer Reviewed
• [Journal Article] Endoscopic surgical treatment for pituitary apoplexy in three elderly patients over the age of 80 (2012)
  • Author(s): Makino K, Nakamura H, Hide T, Kuratsu J
  • Journal Title: J Neurooncol Volume: 106(1) Pages: 155-60
  • Peer Reviewed
• [Journal Article] A novel serumcarbohydrate marker on MUC5AC: valuesfor diagnostic and prognostic indicators forcholangiocarcinoma (2011)
  • Author(s): Silsirivanit A, Araki N*, Pairojkul C,Wongkham C, Narimatsu H, Kuwahara K,Wongkham S, Sakaguchi N
  • Journal Title: Cancer Volume: 117(15) Pages: 3393-403
  • Peer Reviewed
• [Journal Article] Expression and purification of humanFROUNT, a common cytosolic regulator ofCCR2 and CCR5 (2011)
  • Author(s): Esaki K, Terashima Y , Toda E, Y oshinaga S,Araki N, Matsushima K, Terasawa H
  • Journal Title: Protein Expression andPurification Volume: 77(1) Pages: 86-91
  • Peer Reviewed
• [Journal Article] A novel serum carbohydrate marker on MUC5AC : values for diagnostic and prognostic indicators for cholangiocarcinoma (2011)
  • Author(s): Silsirivanit A, Araki N, Pairojkul C, Wongkham C, Narimatsu H, Kuwahara K, Wongkham S, Sakaguchi N
  • Journal Title: Cancer Volume: 117(15) Pages: 3393-403
  • Peer Reviewed
• [Journal Article] Expression and purification of human FROUNT, a common cytosolic regulator of CCR2 and CCR5 (2011)
  • Author(s): Esaki K, Terashima Y, Toda E, Yoshinaga S, Araki N, Matsushima K, Terasawa H
  • Journal Title: Protein Expression and Purification Volume: 77(1) Pages: 86-91
  • Peer Reviewed
• [Journal Article] M2 macrophage/microglial cells induce activation of stat3 in primary central nervous system lymphoma (2011)
  • Author(s): Komohara Y, Horlad H, Ohnishi K, Ohta K, Makino K, Hondo H,Yamanaka R, Kajiwara K, Saito T, Kuratsu J, Takeya M
  • Journal Title: J Clin Exp Hematop Volume: 51(2) Pages: 93-9
  • Peer Reviewed
• [Journal Article] Ruptured cerebral aneurysm associated with a persistent primitive trigeminal artery variant (2011)
  • Author(s): Yamamoto T, Hasegawa Y, Ohmori Y, Kawano T, Kai Y, Morioka M, Kuratsu J
  • Journal Title: Surg Neurol Int Volume: 2 Pages: 126-126
  • Peer Reviewed
• [Journal Article] Endoscopic surgical treatment for pituitary apoplexy in three elderly patients over the age of 80 (2011)
  • Author(s): Hasegawa Y, Yano S, Sakurama T, Ohmori Y, Kawano T, Morioka M, Chen H, Zhang JH, Kuratsu J
  • Journal Title: Acta Neurochir Suppl Volume: 111 Pages: 429-33
  • Peer Reviewed
• [Journal Article] Molecular and clinical analysis of glioblastoma with an oligodendroglial component (GBMO) (2011)
  • Author(s): Nakamura H, Makino K, Kuratsu J
  • Journal Title: Brain Iumor Pathol Volume: 28(3) Pages: 185-90
  • Peer Reviewed
• [Journal Article] Strategy for treating unruptured vertebral artery dissecting aneurysms. Neurosurgery (2011)
  • Author(s): Kai Y, Nishi T, Watanabe M, Morioka M, Hirano T, Yano S, Ohmori Y, Kawano T, Hamada J, Kuratsu J
  • Journal Title: Brain Tumor Pathol Volume: 69(5) Pages: 1085-91
  • Peer Reviewed
• [Journal Article] Coil embolization of an aneurysm located at the trunk of the persistent primitive trigeminal artery (2011)
  • Author(s): Kai Y, Ohmori Y, Watanabe M, Morioka M, Hirano T, Kawano T, Sakurama T, Miura A, Kuratsu J
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 51(5) Pages: 361-4
  • Peer Reviewed
• [Journal Article] Development of a kit to treat subarachnoid hemorrhage by intrathecal simple urokinase infusion (ITSUKI) therapy : preliminary results in patients with World Federation of Neurological Surgery (WFNS) grade V subara chnoid hemorrhage (2011)
  • Author(s): Kai Y, Ito K, Watanabe M, Morioka M, Yano S, Ohmori Y, Kawano T, Hamada J, Kuratsu J
  • Journal Title: World Neurosurg Volume: 75(3-4) Pages: 485-90
  • Peer Reviewed
• [Journal Article] Therapy-associated secondary tumors in patients with non-germinomatous malignant germ cell tumors (2011)
  • Author(s): Nakamura H, Makino K, Ushio Y, Arima R, Kuratsu J
  • Journal Title: J Neurooncol Volume: 105(2) Pages: 359-64
  • Peer Reviewed
• [Journal Article] Evaluation of neoadjuvant therapy in patients with nongerminomatous malignatit germ cell tumors (2011)
  • Author(s): Nakamura H, Makino K, Kochi M, Ushio Y, Kuratsu J
  • Journal Title: J Neurosurg Pediatr Volume: 7(4)
  • Peer Reviewed
• [Journal Article] Gpi pallidal stimulation for Lance-Adams syndrome (2011)
  • Author(s): Yamada K, Sakurama T, Soyama N, Kuratsu J
  • Journal Title: Neurology Volume: 76(14) Pages: 1270-2
• [Journal Article] Does adding FDG-PET to MRI improve the differentiation between primary cerebral lymphoma and glioblastoma? Observer performance study (2011)
  • Author(s): Makino K, Hirai T, Nakamura H, Murakami R, Kitajima M, Shigematsu Y, Nakashima R, Shiraishi S, Uetani H, Iwashita K, Akter M, Yamashita Y, Kuratsu J
  • Journal Title: Ann Nucl Med Volume: 25(6) Pages: 432-8
  • Peer Reviewed
• [Journal Article] Cilostazol improves symptomatic intracranial artery stenosis-Evaluation of cerebral blood flow with single photon emission computed tomography (2011)
  • Author(s): Kai Y, Watanabe M, Morioka M, Hirano T, Yano S, Ohmori Y, Kawano T, Hamada J, Kuratsu J
  • Journal Title: Surg Neurol Int Volume: 24 Pages: 2-8
  • Peer Reviewed
• [Journal Article] Granulocyte colony-stimulating factor enhances the angiogenetic effect of indirect bypass surgery for chronic cerebral hypoperfusion in a rat model (2011)
  • Author(s): Ohmori Y, Morioka M, Kaku Y, Kawano T, Kuratsu J
  • Journal Title: Neurosurgery Volume: 68(5) Pages: 1372-9
  • Peer Reviewed
• [Journal Article] Epidemiological study of primary intracranial tumors : a regional survey in Kumamoto prefecture in southern Japan-20-year study (2011)
  • Author(s): Nakamura H, Makino K, Yano S, Kuratsu J; Kumamoto Brain Tumor Research Group
  • Journal Title: Int J Clin Oncol Volume: 16(4) Pages: 314-21
  • Peer Reviewed
• [Journal Article] Ruptured aneurysm at an anastomotic artery extending from the vertebral artery to the posterior inferior cerebellar artery : a case report (2011)
  • Author(s): Matsumoto J, Uemura S, Hayasaki A, Kimura H, Morioka M, Kuratsu J
  • Journal Title: Acta Neurochir (Wien) Volume: 153(4) Pages: 931-5
  • Peer Reviewed
• [Journal Article] Risk of primary childhood brain tumors related to season of birth in Kumamoto Prefecture, Japan (2011)
  • Author(s): Makino K, Nakamura H, Hide T, Kuratsu J; Kumamoto Brain Tumor Group
  • Journal Title: Childs Nerv Syst Volume: 27(1) Pages: 75-8
  • NAID: 120003913473
  • Peer Reviewed
• [Journal Article] Inhibition of eIF4E phosphorylation reduces cell growth and proliferation in primary central nervous system lymphoma cells (2011)
  • Author(s): Muta D, Makino K, Nakamura H, Yano S, Kudo M, Kuratsu J
  • Journal Title: J Neurooncol Volume: 101(1) Pages: 33-9
  • Peer Reviewed
• [Journal Article] Dispersion stability and exothermic properties of DNA-functionalized single-walled carbon nanotubes (2011)
  • Author(s): Kawaguchi M, Ohno J, Irie A, Fukushima T, Yamazaki J, Nakashima N
  • Journal Title: Int J Nanomedicine Volume: 6 Pages: 729-36
  • Peer Reviewed
• [Journal Article] Generation of dendritic cells and macrophages from human induced pluripotent stem cells aiming at cell therapy (2011)
  • Author(s): Senju S, Haruta M, Matsumura K, Matsunaga Y, Fukushima S, Ikeda T, Takamatsu K, Irie A, Nishimura Y
  • Journal Title: Gene Ther Volume: 18(9) Pages: 874-83
  • Peer Reviewed
• [Journal Article] Identification of HLA-A2-restricted CTL epitopes of a novel tumour-associated antigen, KIF20A, overexpressed in pancreatic cancer (2011)
  • Author(s): Imai K, Hirata S, Irie A, Senju S, Ikuta Y, Yokomine K, Harao M, Inoue M, Tomita Y, Tsunoda T, Nakagawa H, Nakamura Y, Baba H, Nishimura Y
  • Journal Title: Br J Cancer Volume: 104(2) Pages: 300-7
  • Peer Reviewed
• [Journal Article] A novel tumor-associated antigen, cell division cycle 45-like can induce cytotoxic T-lymphocytes reactive to tumor cells (2011)
  • Author(s): Tomita Y, Imai K, Senju S, Irie A, Inoue M, Hayashida Y, Shiraishi K, Mori T, Daigo Y, Tsunoda T, Ito T, Nomori H, Nakamura Y, Kohrogi H, Nishimura Y
  • Journal Title: Cancer Sci Volume: 102(4) Pages: 697-705
  • NAID: 10029291877
  • Peer Reviewed
• [Journal Article] IPeptides derived from human insulin-like growth factor-II mRNA binding protein 3 can induce human leukocyte antigen-A2-restricted cytotoxic T lymphocytes reactive to cancer cells (2011)
  • Author(s): Tomita Y, Harao M, Senju S, Imai K, Hirata S, Me A, Inoue M, Hayashida Y, Yoshimoto K, Shiraishi K, Mori T, Nomori H, Kohrogi H, Nishimura Y
  • Journal Title: Cancer Sci Volume: 102(1) Pages: 71-8
  • Peer Reviewed
• [Journal Article] Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus (2011)
  • Author(s): Ohbayashi T, Irie A, Murakami Y, Nowak M, Potempa J, Nishimura Y, Shinohara M, Imamura T
  • Journal Title: Microbiology Volume: 157(Pt3) Pages: 786-92
  • Peer Reviewed
• [Journal Article] TheContribution of BCR-ABL-inde pendentActivation of ERK1/2 to Acquired ImatinibResistance in K562 Chronic MyeloidLeukemia Cells (2010)
  • Author(s): Nambu T, Araki N*, Nakagawa A, KuniyasuA, Kawaguchi T, Hamada A, Saito H
  • Journal Title: Cancer Science Volume: 101(1) Pages: 137-42
  • Peer Reviewed
• [Journal Article] The Contribution of BCR-ABL-independent Activation of ERK1/2 to Acquired Imatinib Resistance in K562 Chronic Myeloid Leukemia Cells (2010)
  • Author(s): Nambu T, Araki N, Nakagawa A, Kuniyasu A, Kawaguchi T, Hamada A, Saito H
  • Journal Title: Cancer Science Volume: 101(1) Pages: 137-42
  • NAID: 10027199844
  • Peer Reviewed
• [Journal Article] Cardiac ^<123>I-MIBG scintigraphy as an outcome-predicting tool for subthalamic nucleus stimulation in Parkinson's disease (2010)
  • Author(s): Yamada K, Shiraishi SY, Hamasaki T, Kuratsu J
  • Journal Title: Acta Neurochir (Wien) Volume: 152(12) Pages: 2063-8
  • Peer Reviewed
• [Journal Article] Wnt3 a promotes hippocampal neurogenesis by shortening cell cycle duration of neural progenitor cells (2010)
  • Author(s): Yoshinaga Y, Kagawa T, Shimizu T, Inoue T, Takada S, Kuratsu J, Taga T
  • Journal Title: Cell Mol Neurobiol Volume: 30(7) Pages: 1049-58
  • Peer Reviewed
• [Journal Article] Radiation-induced glioblastoma occurring 35 years after radiation therapy for medulloblastoma : case report (2010)
  • Author(s): Hamasaki K, Nakamura H, Ueda Y, Makino K, Kuratsu J
  • Journal Title: Brain Tumor Pathol Volume: 27(1) Pages: 39-43
  • Peer Reviewed
• [Journal Article] Population-based epidemiological study of primary intracranial tumors in childhood (2010)
  • Author(s): Makino K, Nakamura H, Yano S, Kuratsu J; Kumamoto Brain Tumor Group
  • Journal Title: Childs Nerv Syst Volume: 26(8) Pages: 1029-34
  • Peer Reviewed
• [Journal Article] Ectopic adrenal cortical adenoma in the spinal region : case report and review of the literature (2010)
  • Author(s): Makino K, Kojima R, Nakamura H, Morioka M, Iyama K, Shigematsu K, Kuratsu J
  • Journal Title: Brain Tumor Pathol Volume: 27(2) Pages: 121-5
  • Peer Reviewed
• [Journal Article] Physiological importance of cytochrome c peroxidase in ethanologenic thermotolerant Zymomonas mobilis (2010)
  • Author(s): Charoensuk K, Irie A, Lertwattanasakul N, Sootsuwan K, Thanonkeo P, Yamada M
  • Journal Title: J Mol Microbiol Biotechnol Volume: 20(2) Pages: 70-82
  • Peer Reviewed
• [Journal Article] Integrin family (2010)
  • Author(s): Irie A
  • Journal Title: Nippon Rinsho Volume: 68 Suppl 7 Pages: 163-6
  • NAID: 40017200711
• [Presentation] 融合プロテオミクスによる癌特異的分子の統合的解析 (2013)
  • Author(s): 荒木 令江
  • Organizer: 産業総合技術研究所セミナー
  • Place of Presentation: 茨城県つくば市・産総研中央第２ OSL
  • Invited
• [Presentation] 融合プロテオミクスによる新規神経線維腫症 1 型(NF1)関連因子 TCTP の同定と、その NF1 腫瘍における機能解析 (2012)
  • Author(s): 小林大樹、平山未央、菰原義弘、水口惣平、ウィルソン森藤政代、尹浩信、竹屋元裕、倉持朗、荒木令江
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 福岡/国際会議場マリンメッセ福岡
• [Presentation] An integrated proteomics by iPEACH, anew application, identified novel activatedsignal cascades in chemotherapy resistantmalignant gliomas (2012)
  • Author(s): Araki N, Mizugushi S,Morikawa T , kawano S, Y amaguchi A,Kobayashi D, Hirayama M, Midorikawa U,Nakamura H, Kuratsu J
  • Organizer: HUPO 11th AnnualWorld Congress
  • Place of Presentation: Hynes Convention Center,Boston,US
• [Presentation] Integrated Proteomics Identified Translationally Controlled Tumor Protein as aBiological Target for Neurofibroma andMalignant Peripheral Nerve Sheath Tumors (2012)
  • Author(s): Kobayashi D, Hirayama M, Komohara Y ,Mizuguchi S, Wilson-morifuji M, Ihn h,Takeya M, Kuramochi A, Araki N.
  • Organizer: HUPO 11th Annual World Congress
  • Place of Presentation: HynesConvention Center, Boston,US
• [Presentation] Analysis of abnormal cellular signals viasilencing of NF1 tumor suppressor proteinin neuronal cells by integrated proteomics (2012)
  • Author(s): Hirayama M, Kobayashi D, Morikawa T,Nagayama M, Mizuguchi S, Araki N.
  • Organizer: HUPO 11th Annual World Congress
  • Place of Presentation: HynesConvention Center, Boston,US
• [Presentation] 融合プロテオミクスによる新規神経線維腫瘍症 I 型(NF1)関連因子 TCTP の同定と、治療標的としての機能解析 (2012)
  • Author(s): 小林大樹、平山未央、菰原義弘、水口惣平、 ウィルソン-森藤政代、 尹浩信、 竹屋元裕、倉持朗、荒木令江
  • Organizer: 日本プロテーム学会 2012 年大会日本プロテオーム機構
  • Place of Presentation: 東京/日本科学未来館
• [Presentation] 融合プロテオミクスによるがん幹細胞の分化誘導メカニズムの解析 (2012)
  • Author(s): 荒木令江、南部（新堀）晶子、緑川宇一、水口惣平、小林大樹、平山未央、菰原義弘、秀拓一郎、竹屋元裕、倉津純一
  • Organizer: 日本プロテオーム学会2012年大会日本ヒトプロテオーム機構
  • Place of Presentation: 東京・日本科学未来館
• [Presentation] 融合プロテオミクスによる新規神経線維腫瘍症I型（NF1）関連因子TCTPの同定と、治療標的としての機能解析 (2012)
  • Author(s): 小林大樹、平山未央、菰原義弘、水口惣平、ウィルソン-森藤政代、尹浩信、竹屋元裕、倉持朗、荒木令江
  • Organizer: 日本プロテオーム学会2012年大会日本ヒトプロテオーム機構
  • Place of Presentation: 東京・日本科学未来館
• [Presentation] An integrated proteomics by iPEACH, a new application, identified novel activated signal cascades in chemotherapy resistant malignant gliomas (2012)
  • Author(s): Araki N, Mizugushi S, Morikawa T, kawano S, Yamaguchi A, Kobayashi D, Hirayama M, Midorikawa U, Nakamura H, Kuratsu J.
  • Organizer: HUPO 11th Annual World Congress
  • Place of Presentation: Hynes Convention Center,Boston,US
• [Presentation] Integrated Proteomics Identified Translationally Controlled Tumor Protein as a Biological Target for Neurofibroma and Malignant Peripheral Nerve Sheath Tumors (2012)
  • Author(s): Kobayashi D, Hirayama M, Komohara Y, Mizuguchi S, Wilson-morifuji M, Ihn h, Takeya M, Kuramochi A, Araki N.
  • Organizer: HUPO 11th Annual World Congress
  • Place of Presentation: Hynes Convention Center,Boston,US
• [Presentation] Analysis of abnormal cellular signals via silencing of NF1 tumor suppressor protein in neuronal cells by integrated proteomics (2012)
  • Author(s): Hirayama M, Kobayashi D, Morikawa T, Nagayama M, Mizuguchi S, Araki N.
  • Organizer: HUPO 11th Annual World Congress
  • Place of Presentation: Hynes Convention Center,Boston,US
• [Presentation] 融合プロテオミクスによるグリオーマの化学治療予後予測分子ネットワークの解析 (2012)
  • Author(s): 荒木令江、水口惣平、森川崇、坪田誠之、小林大樹、平山未央、緑川宇一、中村英夫、倉津純一
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 札幌・ホテルロイトン札幌
• [Presentation] ヒト舌癌におけるHIF-1αを介した高転移性がん細胞の増殖機構の解析 (2012)
  • Author(s): 森藤政代、新堀晶子、水口惣平、小林大樹、荒木令江
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 札幌・ホテルロイトン札幌
• [Presentation] 薬学における融合オミクス解析 融合プロテオミクスによる癌の病態システムズバイオロジー (2012)
  • Author(s): 荒木 令江
  • Organizer: 生命医薬情報学連合大会2012（2012日本バイオインフォマティクス学会年会情報計算化学生物学会CBI学会）
  • Place of Presentation: 東京・タワーホール船堀
  • Invited
• [Presentation] プロテオミクスを基盤としたシステムズバイオロジー (2012)
  • Author(s): 荒木令江
  • Organizer: 和歌山県立医科大学特別公演
  • Place of Presentation: 和歌山・和歌山県立医科大学研究棟3階セミナー室
  • Invited
• [Presentation] 翻訳後の分子間相互作用をとらえる新しいタンパク質解析技術～融合プロテオミクスによる病態シグナルの検出と創薬への挑戦 (2012)
  • Author(s): 荒木 令江
  • Organizer: 新薬理セミナー2012
  • Place of Presentation: 熊本・熊本大学薬学部宮本記念館
  • Invited
• [Presentation] 融合プロテオミクスによるグリオーマ幹細胞の分化誘導ニッチの解析 (2012)
  • Author(s): 荒木令江、南部（新堀）晶子、、緑川宇一、永井美奈子、小林大樹、水口惣平、秀拓一郎、中村英夫、菰原義弘、竹屋元裕、倉津純一
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 福岡・福岡国際会議場/マリンメッセ福岡
• [Presentation] 融合プロテオミクスによる新規神経線維腫症1型（NF1）関連因子TCTPの同定と、そのNF1腫瘍における機能解析 (2012)
  • Author(s): 小林大樹、平山未央、菰原義弘、水口惣平、ウィルソン森藤政代、尹浩信、竹屋元裕、倉持朗、荒木令江
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 福岡・福岡国際会議場/マリンメッセ福岡
• [Presentation] 全自動2次元電気泳道装置を用いた腫瘍マーカータンパク質の解析 (2012)
  • Author(s): 西村宗徳、緑川宇一、長山慈、小林大樹、平山未央、廣田由夏、村上洋嗣、和田孝浩、今村隆寿、直江秀昭、佐々木裕、鵜沼豊、荒木令江
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 福岡・福岡国際会議場/マリンメッセ福岡
• [Presentation] 腫瘍細胞内ビメンチンの翻訳後就職およびフラグメント化とその機能解析 (2012)
  • Author(s): 山口浩、小林大樹、荒木令江
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 福岡・福岡国際会議場/マリンメッセ福岡
• [Presentation] バイオ分野で京を使うために (2011)
  • Author(s): 荒木令江
  • Organizer: 世界最速コンピューター「京」と生命科学
  • Place of Presentation: 九州大学医学部 百年講堂(招待講演)
  • Year and Date: 2011-10-06
• [Presentation] 融合プロテオミクスによるグリオーマの化学治療予後予測分子ネットワークの解析 (2011)
  • Author(s): 荒木令江、水口惣平、森川崇、坪田誠之、小林大樹、平山未央、緑川宇一、中村英夫、倉津純一
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(招待講演)
  • Year and Date: 2011-10-05
• [Presentation] Glycans on MUC5AC mucin as diagnostic/prognostic and early markers for cholangiocarcinoma (2011)
  • Author(s): Wongkham S, Silsirvivanit A, Wongkham C, Pairojkul C, Narimatsu Y, Narimatsu H, kuwahara K, Araki n, Sakaguchi N
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-05
• [Presentation] ヒト舌癌におけるHIF-1αを介した高転移性がん細胞の増殖機構の解析 (2011)
  • Author(s): 森藤政代、新堀晶子、水口惣平、小林大樹、荒木令江
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] Significance of fucosyltransferase III in cholangiocarcinoma progression (2011)
  • Author(s): Silsirivant A, Araki N, Wongkham C, Kuwahara N, Sakaguchi N, Narimatsu Y, Narimatsu H, Wongkham S
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] 融合プロテオミクスによる悪性脳腫瘍化学治療耐性に関わる分子ネットワークの解析 (2011)
  • Author(s): 荒木令江、水口惣平、森川崇、坪田誠之、小林大樹、平山未央、緑川宇一、南部晶子、中村英夫、倉津純一
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-09-24
• [Presentation] 融合プロテオミクスによるNF1腫瘍抑制遺伝子Neurofibrominの機能欠損による神経系細胞内異常シグナルの解析 (2011)
  • Author(s): 平山未央、小林大樹、森川崇、長山慈、緑川宇一、水口惣平、荒木令江
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-09-23
• [Presentation] 融合プロテオミクスによる幹細胞様グリオーマの分化制御機構の解析 (2011)
  • Author(s): 南部晶子、緑川宇一、水口惣平、長山慈、永井美奈子、平野久、荒木令江
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-09-22
• [Presentation] 融合プロテオミクスによる腫瘍特異的分子ネットワークの解析と病態マーカー/治療ターゲット開発への応用 (2011)
  • Author(s): 荒木令江
  • Organizer: ライフサイエンス統合データベースセンター講演会
  • Place of Presentation: 東京大学工学部12号館(招待講演)
  • Year and Date: 2011-09-07
• [Presentation] iPEACHを用いた統合プロテオミクスデータファイルの作成と応用 (2011)
  • Author(s): 水口惣平、荒木令江
  • Organizer: ライフサイエンス統合データベースセンター講演会
  • Place of Presentation: 東京大学工学部12号館(招待講演)
  • Year and Date: 2011-09-07
• [Presentation] 病態マーカーと治療ターゲット開発のための融合プロテオミクス (2011)
  • Author(s): 荒木令江、水口惣平、森川崇、緑川宇一、ウィルソン森藤政代、南部-新堀晶子、小林大樹、坪田誠之、中村英夫、倉津純一
  • Organizer: 日本プロテオーム学会2011年大会日本ヒトプロテオーム機構第9回大会
  • Place of Presentation: 新潟市朱鷲メッセ(招待講演)
  • Year and Date: 2011-07-29
• [Presentation] 2D-PAGE/2D-DIGEの基本・新技術と応用 (2011)
  • Author(s): 荒木令江
  • Organizer: 日本プロテオーム学会2011年大会日本ヒトプロテオーム機構第9回大会
  • Place of Presentation: 新潟市朱鷲メッセ(招待講演)
  • Year and Date: 2011-07-29
• [Presentation] 融合プロテオミクスによるNF1腫瘍抑制タンパク質の神経系細胞内発現抑制を介した異常シグナル分子群の解析 (2011)
  • Author(s): 平山未央、小林大樹、森川崇、長山慈、緑川宇一、水口惣平、荒木令江
  • Organizer: 日本プロテオーム学会2011年大会日本ヒトプロテオーム機構第9回大会
  • Place of Presentation: 新潟市朱鷲メッセ
  • Year and Date: 2011-07-29
• [Presentation] 融合プロテオミクスによる病態解析と創薬へのアプローチ (2011)
  • Author(s): 荒木令江
  • Organizer: 熊本大学拠点形成研究B主催薬学部附属創薬研究センター共催医薬品スクリーニング学特別講演
  • Place of Presentation: 熊本大学薬学部宮本記念館(招待講演)
  • Year and Date: 2011-07-19
• [Presentation] 融合プロテオミクスによる神経系腫瘍の発症メカニズムの解析 (2011)
  • Author(s): 荒木令江
  • Organizer: 第43回日本結合組織学会学術大会第58回マトリックス研究会大会合同学術集会
  • Place of Presentation: 別府ビーコンプラザ(招待講演)
  • Year and Date: 2011-06-10
• [Presentation] iPEACHを用いた融合プロテオミクスによる病態関連分子群の統合解析とその検証法 (2011)
  • Author(s): 荒木令江
  • Organizer: 東京医科歯科大講演
  • Place of Presentation: 東京医科歯科大学(招待講演)
  • Year and Date: 2011-06-01
• [Presentation] 融合プロテオミクスによる病態関連分子群の統合解析と検証 (2011)
  • Author(s): 荒木令江
  • Organizer: 第61回日本電気泳動学会シンポジウム第7回日本臨床ヒトプロテオーム研究会2011
  • Place of Presentation: 山口大学(招待講演)
  • Year and Date: 2011-05-09
• [Presentation] 融合プロテオミクスによる NF1 腫瘍抑制遺伝子 Neurofibromin の機能欠損による神経系細胞内異常シグナルの解析 (2011)
  • Author(s): 平山未央、小林大樹、森川崇、長山慈、緑川宇一、水口惣平、荒木令江
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都/国際会議場
• [Presentation] 融合プロテオミクスによる NF1 腫瘍抑制タンパク質の神経系細胞内発現抑制を介した異常シグナル分子群の解析 (2011)
  • Author(s): 平山未央、小林大樹、森川崇、長山慈、緑川宇一、水口惣平、荒木令江
  • Organizer: 日本プロテオーム学会 2011 年大会日本ヒトプロテオーム機構第9回大会
  • Place of Presentation: 新潟/朱鷺メッセ
• [Presentation] 融合プロテオミクスによる神経系腫瘍の発症メカニズムの解析 (2011)
  • Author(s): 荒木令江
  • Organizer: 第43回日本結合組織学会学術大会第58回マトリックス研究会大会合同学術集会教育講演
  • Place of Presentation: 別府/ビーコンプラザ
• [Presentation] 融合プロテオミクス解析による疾患原因タンパク質群の同定方法及び、薬剤効果検出方法 (2010)
  • Author(s): 荒木令江
  • Organizer: 平成22年度JST九州横断新技術講演会
  • Place of Presentation: キャンパス・イノベーションセンター東京(招待講演)
  • Year and Date: 2010-12-14
• [Presentation] 腫瘍医学教育における最先端基礎研究概念の導入の必要性と展望 (2010)
  • Author(s): 荒木令江
  • Organizer: 第42回日本医学教育学会大会
  • Place of Presentation: 都市センターホテル東京(招待講演)
  • Year and Date: 2010-07-31
• [Presentation] 融合プロテオミクスによる NF1 腫瘍抑制タンパク質の神経系細胞内発現抑制による異常シグナルの解析 (2010)
  • Author(s): 平山未央、小林大樹、森川崇、長山慈、緑川宇一、水口惣平、荒木令江
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同大会
  • Place of Presentation: 神戸/ポートアイランド
• [Presentation] Integrated proteomics of brain tumor cellsignals related to chemotherapy sensitivity (2010)
  • Author(s): Souhei Mizuguti 、 Takashi Morikawa 、Nobuyuki Tsubota 、 Uichi Midorikawa 、Akiko Niibori、 Daiki Kobayashi、 HideoNakamura、 Junichi Kuratsu、 Norie Araki
  • Organizer: HUPO2010 HumanProteomeWorldCongressSydney2010
  • Place of Presentation: Sydney、 Australia
• [Presentation] A proteomic integrated approach for targetingand elucidating the functions of novelproteins involved in neuronal differentiationand disorders (2010)
  • Author(s): Daiki Kobayashi 、 JiroKumagai 、 Takashi Morikawa 、 MioHirayama 、 Anthony Wilson 、 MasayoWilson、 Norie Araki
  • Organizer: HUPO2010 (HumanProteome World Congress Sydney 2010)
  • Place of Presentation: Sydney、 Australia
• [Presentation] 融合プロテオミクスによる神経系腫瘍の発症メカニズムの解析 (2010)
  • Author(s): 荒木令江
  • Organizer: 日本生理学会
  • Place of Presentation: 盛岡市民文化ホール(招待講演)
• [Presentation] Analysis of cellular signals activated in the tumor tissue related to chemotherapy snsitivity by Integrated Proteomics (2010)
  • Author(s): Araki N, Mizuguchi S, Morikawa T, Kobayashi D, Tsubota M, Midorikawa U, Niibori A, Wilson A, Nakamura H, Kuratsu J
  • Organizer: 日本ヒトプロテオーム機構第8回大会JHUPO
  • Place of Presentation: 東京ベイホテル東急(招待講演)
• [Presentation] 統合プロテオミクスによる新規な神経系疾患関連分子群の同定と機能解析 (2010)
  • Author(s): 小林大樹、平山未央、森川崇、水口惣平、長山慈、ウィルソン森藤政代、荒木令江
  • Organizer: 日本ヒトプロテオーム機構第8回大会JHUPO
  • Place of Presentation: 東京ベイホテル東急
• [Presentation] バイオインフォマティクスと統合プロテオミクスの手法を用いた病態組織細胞内の活性化分子ネットワークの解析 (2010)
  • Author(s): 水口惣平、森川崇、坪田誠之、緑川宇一、小林大樹、中村英夫、倉津純一、荒木令江
  • Organizer: 日本ヒトプロテオーム機構第8回大会JHUPO
  • Place of Presentation: 東京ベイホテル東急
• [Presentation] A quick cancer proteome validation system by a fully automated 2DE-westem blotting device (2010)
  • Author(s): Norie Araki
  • Organizer: HUPO2010 (Human Proteome World Congress Sydney 2010)
  • Place of Presentation: Sydney, Australia
• [Presentation] Integrated proteomics of brain tumor cell signals related to chemotherapy sensitivity (2010)
  • Author(s): Mizuguchi S, Morikawa T, Tsubota M, Midorikawa U, Niibori A, Kobasashi D, Nakamura H, Kuratsu J, Araki N
  • Organizer: HUPO2010 (Human Proteome World Congress Sydney 2010)
  • Place of Presentation: Sydney, Australia
• [Presentation] A proteomic integrated approach for targeting and elucidating the functions of novel proteins involved in neuronal differentiation and disorders (2010)
  • Author(s): Kobasashi D, Kumagai J, Morikawa T, Hirayama M, Wilson A, Wilson M, Araki N
  • Organizer: HUPO2010 (Human Proteome World Congress Sydney 2010)
  • Place of Presentation: Sydney, Australia
• [Presentation] ヘテロな細胞集団におけるHIFシグナル伝達を介した転移性癌細胞の発育機構の解明 (2010)
  • Author(s): 森藤政代、水口惣平、新堀晶子、小林大樹、森川崇、荒木令江
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 統合プロテオミクスによる腫瘍細胞内活性化シグナル分子群の解析と創薬への応用 (2010)
  • Author(s): 荒木令江
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(招待講演)
• [Presentation] 融合プロテオミクスによるNF1腫瘍抑制タンパク質の神経系細胞内発現抑制による異常シグナルの解析 (2010)
  • Author(s): 平山未央、小林大樹、森川崇、長山慈、緑川宇一、水口惣平、荒木令江
  • Organizer: 第33回日本分子生物学会大会・第83回日本生化学大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] プロテオミクスによるグリオーマ幹細胞分化に関する特異的分子群のプロファイリング解析 (2010)
  • Author(s): 緑川宇一、新堀晶子、水口惣平、新森加納子、丸尾祐二、鵜沼豊、中村眞、荒木令江
  • Organizer: 第33回日本分子生物学会大会・第83回日本生化学大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Integrated proteomics of cancer celluar activation signals related to chemotherapy sensitivity (2010)
  • Author(s): Mizuguchi S, Morikawa T, Tsubota M, Midorikawa U, Niibori A, Kobasashi D, Nakamura H, Kuratsu J, Araki N
  • Organizer: 第33回日本分子生物学会大会・第83回日本生化学大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Development of a fully automated 2DE-western blotting system for quick validation and profiling cancer specific proteome (2010)
  • Author(s): Araki N, Midorikawa U, Mizuguti S, Kinoshita H, Tsubota N, Morikawa T, Kobayash D, Maruo Y, Nakamura M
  • Organizer: 第33回日本分子生物学会大会・第83回日本生化学大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Book] 神経線維腫症2型,皮膚科臨床アセット15, 金田眞理編集 (2013)
  • Author(s): 荒木令江
  • Publisher: 中山書店
• [Book] 神経線維腫症2型『診療最前線の母斑と母斑症』，皮膚科臨床アセット15 (2013)
  • Author(s): 荒木令江
  • Publisher: 中山書店
• [Book] 融合プロテオミクスによる病態メカニズムの解析『創薬のためのタンパク質 ・ プロテオミクス解析』 小田吉哉・長野光司編集 (2010)
  • Author(s): 荒木令江
  • Publisher: 羊土社
• [Book] 融合プロテオミクスによる病態メカニズムの解析『創薬のためのタンパク質・プロテオミクス解析 (2010)
  • Author(s): Araki N
  • Total Pages: 8
  • Publisher: 羊土社
• [Remarks] 熊本大学大学院生命科学研究部腫瘍医学
  • URL: http://arv02.medic.kumamoto-u.ac.jp/dept/tumor/index.html
• [Remarks] 熊本大学大学院生命科学研究部腫瘍医学分野
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/tumor/index.html
• [Remarks]
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/tumor/index.html
• [Remarks]
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/tumor/index.html
• [Patent(Industrial Property Rights)] 統合プロテオーム解析用データ群の生成方法ならびに同生成方法にて生成した統合プロテオーム解析用データ群を用いる統合プロテオーム解析方法、およびそれを用いた原因物質同定方法 (2013)
  • Inventor(s): 荒木令江,水口惣平, 森川 崇, 坪田 誠之,倉津純一, 小林大樹, ウイルソン政代
  • Industrial Property Rights Holder: 国立大学法人熊本大学
  • Acquisition Date: 2013-01-24
  • Overseas
• [Patent(Industrial Property Rights)] 統合プロテオーム解析用データ群の生成方法ならびに同生成方法にて生成した統合プロテオーム解析用データ群を用いる統合プロテオーム解析方法、およびそれを用いた原因物質同定方法 (2013)
  • Inventor(s): 荒木令江 他4名
  • Industrial Property Rights Holder: 国立大学法人熊本大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-01-24
  • Overseas
• [Patent(Industrial Property Rights)] 融合プロテオミクスによるNF1特異的タンパク質の同定方法、NF1特異的タンパク質発現抑制方法、NF1特異的タンパク質の腫瘍マーカー及び治療ターゲットとしての使用方法 (2012)
  • Inventor(s): 荒木令江 他3名
  • Industrial Property Rights Holder: 荒木令江 他3名
  • Industrial Property Rights Type: 特許
  • Patent Publication Number: 2012-213391
  • Filing Date: 2012-11-08
• [Patent(Industrial Property Rights)] 融合プロテオミクスによるNF1特異的タンパク質の同定方法、NF1特異的タンパク質発現抑制方法、NF1特異的タンパク質の腫瘍マーカー及び治療ターゲットとしての使用方法 (2012)
  • Inventor(s): 荒木令江, 他3名
  • Industrial Property Rights Holder: 国立大学法人熊本大学
  • Industrial Property Number: 2012-075242
  • Filing Date: 2012-03-28
• [Patent(Industrial Property Rights)] 融合プロテオミクスによる NF1 特異的タンパク質の同定方法、NF1 特異的タンパク質発現抑制方法、NF1 特異的タンパク質の腫瘍マーカー及び治療ターゲットとしての使用方法 (2011)
  • Inventor(s): 荒木令江、小林大樹、水口惣平、平山未央
  • Industrial Property Rights Holder: 国立大学法人熊本大学
  • Industrial Property Number: 2012-075242
  • Filing Date: 2011-03-28
• [Patent(Industrial Property Rights)] 統合プロテオーム解析用データ群の生成方法ならびに同生成方法にて生成した統合プロテオーム解析用データ群を用いる統合プロテオーム解析方法、およびそれを用いた原因物質同定方法 (2011)
  • Inventor(s): Araki N, 他5名(1番目)
  • Industrial Property Rights Holder: 国立大学法人熊本大学
  • Filing Date: 2011-03-31
  • Overseas
• [Patent(Industrial Property Rights)] 融合プロテオミクスによるNF1特異的タンパク質の同定方法、NF1特異的タンパク質発現抑制方法、およびNF1特異的タンパク質の腫瘍マーカーとしての使用方法 (2011)
  • Inventor(s): Araki N, 他4名(1番目)
  • Industrial Property Rights Holder: 国立大学法人熊本大学
  • Industrial Property Number: 2011-007110
  • Filing Date: 2011-03-28