Development of an acellular cartilage tissue engineering technique using an ultra-purified in-situ forming gel
| Project/Area Number |
22390285
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KASAHARA Yasuhiko 北海道大学, 病院・整形外科, 助教 (00581927)
HUNAKOSHI Tadanao 北海道大学, 病院・整形外科, 講師 (10528334)
金城 政孝 北海道大学, 先端生命科学研究科(研究院), 教授 (70177971)
藤崎 和弘 独立行政法人理化学研究所, その他部局等, 研究員 (90435678)
三浪 明男 北海道大学, 大学院・医学研究科, 教授 (20133738)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Keywords | 軟骨再生 / SDF-1 / 無細胞治療 / ウサギ / 骨髄間葉幹細胞 / 骨髄間葉系細胞 |
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| Research Abstract |
We succeeded in achieving hyaline-like cartilage repair by local administration of SDF-1 using an ultra-purified in-situ forming (UPIF) gel without cells. The obtained results indicate that UPIF gel enhances chondrogenesis of bone marrow stromal cells recruited by the chemotactic effect of SDF-1, leading to a novel cell-free approach for cartilage tissue engineering.
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Report
(4 results)
Research Products
(32 results)
