| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Research Abstract |
PTHrP signal through both G alpha s and G alpha q play important roles in regulation of chondrocyte differentiation, although a precise mechanism is not clear. In this study, we have tried to establish mouse model of both overexpression of either G alpha s or G alpha q in chondrocyte and also establish conditional knock-out mice of either G alpha s or G alpha q in chondrocytes to explore the specific roles of G alpha s and G alpha q in chondrocytes. Moreover, we have explored to find any proteins that interact directly with PTHrP receptor or downstream of its signal and examined any involvement in chondrocyte differentiation.
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