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Development of license-free platform for image analysis of joint diseases to standardize medical diagnosis technologies

Research Project

Project/Area Number 22390290
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionOsaka University

Principal Investigator

NISHII Takashi  大阪大学, 医学系研究科, 寄附講座准教授 (70304061)

Co-Investigator(Kenkyū-buntansha) NAKATA Ken  大阪大学, 医学系研究科, 講師 (00283747)
TANAKA Hisashi  大阪大学, 医学部附属病院, 准教授 (40294087)
MURSE Kenya  大阪大学, 医学系研究科, 教授 (50157773)
KURODA Kagayaki  東海大学, 情報理工学部, 教授 (70205243)
SUGANO Nobuhiko  大阪大学, 医学系研究科, 寄附講座教授 (70273620)
YAMAZAKI Youichi  大阪大学, 医学系研究科, 助教 (70379270)
Co-Investigator(Renkei-kenkyūsha) SAKAI Takashi  大阪大学, 医学部附属病院, 助教 (00444539)
TAKAO Masaki  大阪大学, 医学系研究科, 助教 (30528253)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywords変形性関節症 / MRI / 関節病学 / 関節病
Research Abstract

In this project, we aimed to develop sensitive and reproducible technologies for assessment of two - or three - dimensional joint imaging, and to provide those technologies in public in order to establish the standard analyzing tool among the majority of medical physicians. Various analyzing softwares for plain radiographs, static and loading MRI, and CT arthrography of hip and knee joints were developed, and the accuracy and clinical usefulness of the softwares were investigated among normal volunteers and patients with knee or hip osteoarthritis. Those softwares were provided as the free - license tools via the home pages for widespread use among many associated physicians.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (64 results)

All 2013 2012 2011 2010 Other

All Journal Article (20 results) (of which Peer Reviewed: 13 results) Presentation (37 results) (of which Invited: 4 results) Remarks (7 results)

  • [Journal Article] Three-dimensional topographical variation of femoral cartilage T2 in healthy volunteer knees2013

    • Author(s)
      Shiomi T, Nishii T, Nakata K,Tamura S, Tanaka H,Yamazaki Y, Murase K,Yoshikawa H, Sugano N
    • Journal Title

      Skeletal Radiol

      Volume: 42巻 Issue: 3 Pages: 363-370

    • DOI

      10.1007/s00256-012-1522-2

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computational measurement of joint space width and structural parameters in normal hips2012

    • Author(s)
      Nishii T, Shiomi T, Sakai T, Takao M, Yoshikawa H, Sugano N
    • Journal Title

      Arch Orthop Trauma Surg

      Volume: 132巻 Issue: 5 Pages: 591-598

    • DOI

      10.1007/s00402-012-1463-1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of medial meniscectomy on stress distribution of the femoral cartilage in porcine knees: a 3D reconstructed T2 mapping study2012

    • Author(s)
      Shiomi T, Nishii T, Tamura S, Tanaka H, Murase K, Yoshikawa H, Sugano N
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 20巻 Issue: 11 Pages: 1383-1390

    • DOI

      10.1016/j.joca.2012.07.015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional patterns of early acetabular cartilage damage in hip dysplasia; a high-resolutional CT arthrography study2012

    • Author(s)
      Tamura S, Nishii T, Shiomi T, Yamazaki Y, Murase K, Yoshikawa H, Sugano N
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 20巻 Issue: 7 Pages: 646-652

    • DOI

      10.1016/j.joca.2012.03.015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasound Screening of Periarticular Soft Tissue Abnormality Around Metal-on-Metal Bearings2012

    • Author(s)
      Nishii T, Sakai T,Takao M, Yoshikawa H, Sugano N
    • Journal Title

      J Arthroplasty

      Volume: 27巻 Pages: 895-900

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 股関節X線像の自動解析評価-解析のデジタル化へ2012

    • Author(s)
      西井孝、吉川秀樹、菅野伸彦
    • Journal Title

      別冊整形外「運動器疾患の画像診断」

      Volume: 62巻 Pages: 18-22

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MRI T2マッピングによる関節軟骨変性の三次元定量的評価2012

    • Author(s)
      塩見俊行、西井孝、田村理、中田研、前達雄、吉川秀樹
    • Journal Title

      別冊整形外「運動器疾患の画像診断」

      Volume: 62巻 Pages: 74-80

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasound screening of periarticular soft tissue abnormality around metal-on-metal bearings.2012

    • Author(s)
      Nishii T
    • Journal Title

      J Arthroplasty

      Volume: 27 Issue: 6 Pages: 895-900

    • DOI

      10.1016/j.arth.2011.09.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 股関節X線像の自動解析評価 -解析のデジタル化へ2012

    • Author(s)
      西井 孝
    • Journal Title

      別冊整形外 「運動器疾患の画像診断」

      Volume: 62 Pages: 18-22

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRI T2マッピングによる関節軟骨変性の三次元定量的評価2012

    • Author(s)
      塩見 俊行
    • Journal Title

      別冊整形外 「運動器疾患の画像診断」

      Volume: 62 Pages: 74-80

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 変形性股関節症のMRI所見2011

    • Author(s)
      西井孝、塩見俊行、吉川秀樹、菅野伸彦
    • Journal Title

      Monthly Book Orthopaedics

      Volume: 24巻 Pages: 45-52

    • Related Report
      2012 Final Research Report
  • [Journal Article] 荷重下MRIを用いた関節軟骨の差分T2マッピング-臼蓋形成不全例への応用2011

    • Author(s)
      西井孝
    • Journal Title

      臨床雑誌整形外科

      Pages: 244-244

    • Related Report
      2012 Final Research Report
  • [Journal Article] 変形性股関節症のMRI所見2011

    • Author(s)
      西井 孝
    • Journal Title

      Monthly Book Orthopaedics

      Volume: 24 Pages: 45-52

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 荷重下MRIを用いた関節軟骨の差分T2マッピング -臼蓋形成不全例への応用2011

    • Author(s)
      西井 孝
    • Journal Title

      臨床雑誌 整形外科

      Volume: 62 Pages: 244-244

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Loaded cartilage T2 mapping in patients with hip dysplasia2010

    • Author(s)
      Nishii T, Shiomi T, Tanaka H, Yamazaki Y, Murase K, Sugano N
    • Journal Title

      Radiology

      Volume: 256巻 Issue: 3 Pages: 955-965

    • DOI

      10.1148/radiol.10091928

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loading and knee alignment have significant influence on cartilage MRI T2 in porcine knee joints2010

    • Author(s)
      Shiomi T, Nishii T, Tanaka H, Yamazaki Y, Murase K, Myoui A, Yoshikawa H, Sugano N
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 18巻 Issue: 7 Pages: 902-908

    • DOI

      10.1016/j.joca.2010.05.002

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of kneepositions on T2, T*2, and dGEMRIC mapping in porcine knee cartilage2010

    • Author(s)
      Shiomi T, Nishii T, Myoui A, Yoshikawa H, Sugano N
    • Journal Title

      Magn Reson Med

      Volume: 64巻 Issue: 3 Pages: 707-714

    • DOI

      10.1002/mrm.22469

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 股関節の画像診断の進め方2010

    • Author(s)
      西井孝
    • Journal Title

      整形外科臨床パサージュ3運動器画像診断マスターガイド

      Pages: 170-184

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] Influence of knee positions on T2, T^*2, and dGEMRIC mapping in porcine knee cartilage2010

    • Author(s)
      Shiomi T, Nishii T, Myoui A, Yoshikawa H, Sugano N
    • Journal Title

      Magn Reson Med

      Volume: 64 Pages: 707-714

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 人工股関節関連のX線計測法2010

    • Author(s)
      西井孝
    • Journal Title

      変形性股関節症基本とUP TO DATE

      Pages: 230-237

    • Related Report
      2010 Annual Research Report
  • [Presentation] Difference in pathological modes of labral tears between dysplastic hips and FAI hips -3D assessment by high resolution CT arthrography2013

    • Author(s)
      Tamura S., Nishii T.,Takao M., Sakai T.,Sugano N
    • Organizer
      Annual Meeting of Orthopadic Research Society
    • Place of Presentation
      San Antonio, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Influence of Loading on Cartilage T1rho and T2 Value in the Porcine Knee Joint2013

    • Author(s)
      Hamada H., Nishii T.,Tamura S., Wakayama T., Tanaka H.Murase K.,Yoshikawa H.,Sugano N
    • Organizer
      Annual Meeting of Orthopadic Research Society
    • Place of Presentation
      San Antonio, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Difference in pathological modes of labral tears between dysplastic hips and FAI hips - 3D assessment by high resolution CT arthrography –2013

    • Author(s)
      Tamura S
    • Organizer
      Annual Meeting of Orthopadic Research Society
    • Place of Presentation
      San Antonio
    • Related Report
      2012 Annual Research Report
  • [Presentation] Influence of Loading on Cartilage T1rho and T2 Value in the Porcine Knee Joint2013

    • Author(s)
      Hamada H
    • Organizer
      Annual Meeting of Orthopadic Research Society
    • Place of Presentation
      San Antonio
    • Related Report
      2012 Annual Research Report
  • [Presentation] MRIで関節軟骨変化はどこまで描出できるか2012

    • Author(s)
      西井孝
    • Organizer
      第24回中之島リウマチセミナー
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Biomechanical MRI2012

    • Author(s)
      Nishii T
    • Organizer
      ICRS Focus Meeting -Cartilage Imaging
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] 軟骨変性の可視化と痛みの関連性2012

    • Author(s)
      西井孝、田村理、濱田英敏、中田研、前達雄、吉川秀樹、田中壽
    • Organizer
      第5回日本運動器疼痛学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 関節軟骨MRイメージングの力学環境評価への応用2012

    • Author(s)
      西井孝、田村理、菅野伸彦、中田研、前達雄、北圭介、吉川秀樹、田中壽
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 整形外科分野におけるT2・T1rho mapping の臨床応用2012

    • Author(s)
      西井孝
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical efficacy of alendronate treatment in patients with hip osteoarthritis: A 2-year randomized controlled trial2012

    • Author(s)
      Nishii T,Tamura S, Shiomi T, Takao M, Yoshikawa H, Sugano N
    • Organizer
      2012 World Congress on Osteoarthritis
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Final Research Report
  • [Presentation] Associations of Hip Dysplasia and FAI on Modes of Acetabular Labral Tears2012

    • Author(s)
      Tamura S., Nishii T.,Takao M., Sakai T.,Sugano N
    • Organizer
      2012 World Congress on Osteoarthritis
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Final Research Report
  • [Presentation] Femoroacetabular impingement指標と関節唇障害との関連性2012

    • Author(s)
      西井孝、坂井孝司、高尾正樹、田村理、阿部裕仁、菅野伸彦
    • Organizer
      第118回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] 変形性股関節症に対するビスフォスフォネート製剤の効果2012

    • Author(s)
      西井孝、田村理、塩見俊行、坂井孝司、高尾正樹、吉川秀樹、菅野伸彦
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Early Cartilage Degeneration in Patients with ACL Rupture by assessment of 3D reconstructed T2 mapping2012

    • Author(s)
      Tamura S., Nishii T., Nakata.K., Shiomi T., Yamazaki Y., Murase K., Tanaka H., Kita K., Mae T., Yoshikawa H., Sugano N
    • Organizer
      Annual Meeting of Orthopadic Research Society
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Femoroacetabular impingement指標と関節唇障害との関連性2012

    • Author(s)
      西井 孝
    • Organizer
      第118回 中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Clinical efficacy of alendronate treatment in patients with hip osteoarthritis: A 2-year randomized controlled trial2012

    • Author(s)
      Nishii T
    • Organizer
      2012 World Congress on Osteoarthritis
    • Place of Presentation
      Barcelona
    • Related Report
      2012 Annual Research Report
  • [Presentation] Associations of Hip Dysplasia and FAI on Modes of Acetabular Labral Tears2012

    • Author(s)
      Tamura S
    • Organizer
      2012 World Congress on Osteoarthritis
    • Place of Presentation
      Barcelona
    • Related Report
      2012 Annual Research Report
  • [Presentation] 整形外科分野におけるT2・T1rho mapping の臨床応用2012

    • Author(s)
      西井 孝
    • Organizer
      第40回 日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 軟骨変性の可視化と痛みの関連性2012

    • Author(s)
      西井 孝
    • Organizer
      第5回 日本運動器疼痛学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Biomechanical MRI2012

    • Author(s)
      Nishii T
    • Organizer
      ICRS Focus Meeting –Cartilage Imaging
    • Place of Presentation
      Vienna
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Early Cartilage Degeneration in Patients with ACL Rupture by assessment of 3D reconstructed T2 mapping2012

    • Author(s)
      Tamura S
    • Organizer
      Annual Meeting of Orthopadic Research Society
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Annual Research Report
  • [Presentation] Significant influence on load response of knee cartilage T2 by meniscus disorder -a loading MRI study2011

    • Author(s)
      Nishii T., Tamura S., Shiomi T., Yamazaki Y., Murase K., Tanaka H.,Yoshikawa H., Sugano N
    • Organizer
      5th Osteoarthritis Imaging Workshop
    • Place of Presentation
      Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] Non-invasiveAssessment of 3D Load Distribution over the Femoral Articular Cartilage after Medial Menisectomy2011

    • Author(s)
      Shiomi T., Nishii T., Tamura S., Tanaka H., Yamazaki Y., Murase K., Yoshikawa H., Sugano N
    • Organizer
      5th Osteoarthritis Imaging Workshop
    • Place of Presentation
      Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] 3D patterns of acetabular cartilage damage in hip dysplasia at pre-and early arthritic stages; a high-resolutional CT arthrography study2011

    • Author(s)
      Tamura S., Nishii T., Shiomi T. Yamazaki Y., Murase K., Yoshikawa H., Sugano N
    • Organizer
      5th Osteoarthritis Imaging Workshop
    • Place of Presentation
      Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] 荷重下MRIを用いた半月板損傷膝の荷重伝達障害評価の試み2011

    • Author(s)
      西井孝、田村理、菅野伸彦、中田研、前達雄、北圭介、吉川秀樹
    • Organizer
      第3回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 膝関節鏡手術後の関節軟骨細胞外基質変化-T2 mappingによる1年追跡調査2011

    • Author(s)
      西井孝、田村理、菅野伸彦、中田研、前達雄、北圭介、吉川秀樹、田中壽、山嵜洋一、村瀬研也
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      小倉
    • Related Report
      2012 Final Research Report
  • [Presentation] T2mapping3次元再構築画像を用いた前十字靭帯損傷膝における早期軟骨障害評価2011

    • Author(s)
      田村理、西井孝、菅野伸彦、中田研、前達雄、北圭介、吉川秀樹、田中壽、山嵜洋一、村瀬研也
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      小倉
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 膝・股関節のMRI画像診断の進歩2011

    • Author(s)
      西井孝、田村理、塩見俊行、菅野伸彦、吉川秀樹、田中壽、山嵜洋一、村瀬研也、中田研
    • Organizer
      第39回日本関節病学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Significant influence on load response of knee cartilage T2 by meniscus disorder –a loading MRI study2011

    • Author(s)
      Nishii T
    • Organizer
      5th Osteoarthritis Imaging Workshop
    • Place of Presentation
      Salzburg, Austria
    • Related Report
      2011 Annual Research Report
  • [Presentation] Non-invasive Assessment of 3D Load Distribution over the Femoral Articular Cartilage after Medial Menisectomy2011

    • Author(s)
      Shiomi T
    • Organizer
      5th Osteoarthritis Imaging Workshop
    • Place of Presentation
      Salzburg, Austria
    • Related Report
      2011 Annual Research Report
  • [Presentation] 3D patterns of acetabular cartilage damage in hip dysplasia at pre- and early arthritic stages; a high-resolutional CT arthrography study2011

    • Author(s)
      Tamura S
    • Organizer
      5th Osteoarthritis Imaging Workshop
    • Place of Presentation
      Salzburg, Austria
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膝関節鏡手術後の関節軟骨細胞外基質変化―T2 mappingによる1年追跡調査2011

    • Author(s)
      西井 孝
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      小倉
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関節軟骨T2マッピング-3D・荷重下撮影への拡張-2010

    • Author(s)
      西井孝, ら
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば(招待講演)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Load response of knee cartilage T2 in patients with meniscus disorder : evaluation using loading in situ MRI2010

    • Author(s)
      Nishii T
    • Organizer
      2010 World Congress on Osteoarthritis
    • Place of Presentation
      Brussels (Belgium)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自動解析ツールを用いた変形性股関節症の単純X線主要指標評価と臨床症状との関連性2010

    • Author(s)
      西井孝, ら
    • Organizer
      第83回日本整形外科学学術総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evaluation of Cartilage T2 Using Loading in situ MRI in patients with knee injuries2010

    • Author(s)
      Nishii T, et al
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB
    • Place of Presentation
      Stockholm (Sweden)
    • Year and Date
      2010-05-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] MRI image analysis to detect cartilage degeneration in OA2010

    • Author(s)
      Nishii T
    • Organizer
      第54回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://baummri.sakura.ne.jp/Baum/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.novel-image.org/research.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 大阪大学 運動器疾患 イメージング/センシンググループ

    • URL

      http://www.novel-image.org/research.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] T2(T1rho)/T1/ADC値解析ソフト Baum 2D/3D

    • URL

      http://baummri.sakura.ne.jp/Baum/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] 大阪大学 運動疾患イメージング/センシンググループ

    • URL

      http://www.novel-image.org/research.html

    • Related Report
      2011 Annual Research Report
  • [Remarks] T2(T1rho)/T1/ADC値解析ソフト Baum 2D/3D

    • URL

      http://baummri.sakura.ne.jp/Baum/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.novel-image.org/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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