Biomarker discovery for spinal cord injury using shotgun proteomics

• Project/Area Number: 22390292
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyushu University
• Principal Investigator: OKADA Seiji 九州大学, 医学研究院, 准教授 (30448435)
• Co-Investigator(Kenkyū-buntansha): OHKAWA Yasuyuki 九州大学, 医学研究院, 准教授 (80448430)
• Co-Investigator(Renkei-kenkyūsha): SHIBA Keiichiro 独立行政法人労働者健康福祉機構総合せき損センター, 研究部, 研究員 (90574137) ; UETA Takayoshi 独立行政法人労働者健康福祉機構総合せき損センター, 研究部, 研究員 (00574138)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
• Keywords: 脊髄損傷 / 網羅的解析 / バイオマーカー / 予後予測

Research Abstract

To identify the neurochemical biomarkers which can predict possibilities for neurological recovery in the acute phase of spinal cord injury, we produced three different severity of contusion mouse spinal cord injury and established technical basis with shotgun proteomics experiments, transcriptome analysis, bioimaging evaluation, and established monoclonal antibodies.

Research Products

• [Journal Article] Dedifferentiated chondrosarcoma of the cervical spine: a case report (2013)
  • Author(s): Matsumoto Y, Takahashi Y, Harimaya K, Nakagawa T, Kawaguchi K, Okada S, Hayashida M, Doi T, Sakamoto A, Matsunobu T, Oda Y, Iwamoto Y
  • Journal Title: World J Surg Oncol Volume: 2 Issue: 1 Pages: 32-32
  • DOI: 10.1186/1477-7819-11-32
  • Peer Reviewed
• [Journal Article] Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury. (2013)
  • Author(s): Saiwai H, Kumamaru H, Ohkawa Y, Kubota K, Kobayakawa K, Yamada H, Yokomizo T, Iwamoto Y, Okada S.
  • Journal Title: J Neurochem. Volume: 125 Issue: 1 Pages: 74-88
  • DOI: 10.1111/jnc.12135
  • Peer Reviewed
• [Journal Article] Disturbance of ribcage development causes progressive thoracic scoliosis: The creation of a nonsurgical structural scoliosis mode in mice (2013)
  • Author(s): Kubota K, Doi T, Murata M, Kobayakawa K, Matsumoto Y, Harimaya , Shiba K, Hashizume M, Iwamoto Y, Okada S
  • Journal Title: J Bone Joint Surg
  • Peer Reviewed
• [Journal Article] The therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord (2013)
  • Author(s): Kumamaru H, Kobayakawa K, Saiwai H, Kubota K, Yokota K, Ohkawa Y, Shiba K, Iwamoto Y, Okada S
  • Journal Title: Stem Cells Volume: 31(8) Issue: 8 Pages: 1535-47
  • DOI: 10.1002/stem.1404
  • Peer Reviewed
• [Journal Article] Hematoma of the ligamentum flavum in the thoracic spine: report of two cases and possible role of the transforming growth factor beta-vascular endothelial growth factor signaling axis in its pathogenesis (2013)
  • Author(s): Matsumoto Y, Fujiwara T, Imamura R, Okada Y, Harimaya K, Doi T, Kawaguchi K, Okada S, Yamada Y, Oda Y, Iwamoto Y
  • Journal Title: J Orthop Sci Volume: 18 Issue: 2 Pages: 347-54
  • DOI: 10.1007/s00776-011-0150-3
  • Peer Reviewed
• [Journal Article] Age-related differences in the cellular and molecular profiles of inflammatory responses after spinal cord injury (2012)
  • Author(s): Kumamaru H, Saiwai H, Ohkawa Y, Yamada H, Iwamoto Y, Okada S
  • Journal Title: Journal of Cellular Physiology Volume: 227 Issue: 4 Pages: 1335-46
  • DOI: 10.1002/jcp.22845
  • Peer Reviewed
• [Journal Article] Extradural nodular fasciitis arising in the spinal canal (2012)
  • Author(s): Kubota K, Okada S, Maeda T, Matsumoto Y, Sakamoto A, Doi T, Harimaya K, Saiwai H, Kumamaru H, Oda Y, Iwamoto Y
  • Journal Title: Spine Volume: 37 Issue: 2 Pages: E133-E137
  • DOI: 10.1097/brs.0b013e318224568a
  • Peer Reviewed
• [Journal Article] Spinous proves splitting open pedicle screw fusion reduces low back pain and discomfort compared to the conventional open technique over one year after lumbar surgery (2012)
  • Author(s): Mori E, Okada S, Ueta T, Yugue I, Maeda T, Kawano O, Shiba K.
  • Journal Title: Eur Spine J Volume: 21 Issue: 4 Pages: 745-53
  • DOI: 10.1007/s00586-011-2146-2
  • Peer Reviewed
• [Journal Article] Myeloperoxidase exacerbates secondary injury by generating highly reactive oxygen species and mediating neutrophils recruitment in experimental spinal cord injury (2012)
  • Author(s): Kubota K, Sawai H, kumamaru H, Maeda T, Ohkawa Y, Aratani Y, Nagano T, Urano Y, Iwamoto Y, Okada S
  • Journal Title: Spine Volume: 37 Issue: 16 Pages: 1363-9
  • DOI: 10.1097/brs.0b013e31824b9e77
  • Peer Reviewed
• [Journal Article] Neurological recovery in impaired by concurrent, but not by asymptomatic pre-existing spinal cord compression after traumatic spinal cord injury (2012)
  • Author(s): Kuboka K, Saiwai H, Kumamaru H, Kobayakawa K, Maeda T, Matsumoto Y, Harimaya K, Iwamoto Y, Okada S
  • Journal Title: Spine Volume: 37 Issue: 17 Pages: 1448-55
  • DOI: 10.1097/brs.0b013e31824ffda5
  • Peer Reviewed
• [Journal Article] Bioluminescent system for dynamic imaging of cell and animal behavior (2012)
  • Author(s): Hara-Miyauchi C, Tsuji O, Hanyu A, Okada S, Yasuda A, Fukano T, Akazawa C, Nakamura M, Imamura T, Matsuzaki Y, Okano HJ, Miyawaki A, Okano H
  • Journal Title: Biochem Biophys Res Commun Volume: 419(2) Issue: 2 Pages: 188-93
  • DOI: 10.1016/j.bbrc.2012.01.141
  • Peer Reviewed
• [Journal Article] Chd2 interacts with H3.3 to determine myogenic cell fate (2012)
  • Author(s): Harada A, Okada S, Konno D, Odawara J, Yoshimi T, Yoshimura S, Kumamaru H, Saiwai H, Tsubota T, Kurumizaka H, Akashi K, Tachibana T, Imbalzano AN, Ohkawa Y
  • Journal Title: EMBO J Volume: 31 Issue: 13 Pages: 2994-3007
  • DOI: 10.1038/emboj.2012.136
  • Peer Reviewed
• [Journal Article] Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures (2012)
  • Author(s): Kumamaru H, Saiwai H, Kobayakawa K, Kubota K, Rooijen NV, Inoue K, Iwamoto Y, Okada S
  • Journal Title: Journal of Neuroinflammation Volume: 9 Issue: 1 Pages: 116-116
  • DOI: 10.1186/1742-2094-9-116
  • Peer Reviewed
• [Journal Article] Soft tissue damage and segmental instability in adult patients with cervical spinal cord injury without major bone injury (2012)
  • Author(s): Maeda T, Ueta T, Mori E, Yugue I, Kawano O, Takao T, Sakai H, Okada S, Shiba K
  • Journal Title: Spine Volume: 37 Issue: 25 Pages: 1560-6
  • DOI: 10.1097/brs.0b013e318272f345
  • Peer Reviewed
• [Journal Article] Analysis of the risk factors for tracheostomy in traumatic cervical spinal cord injury (2012)
  • Author(s): Yugue I, Okada S, Ueta T, Maeda T, Mori E, Kawano O, Takao T, Sakai H, msuda M, Hayashi T, Morishita Y, Shiba K
  • Journal Title: Spine Volume: 37 Issue: 26 Pages: E1633-E1638
  • DOI: 10.1097/brs.0b013e31827417f1
  • Peer Reviewed
• [Journal Article] Direct isolation and RNA-Seq reveal environment-dependent properties of engrafted neural stem/progenitor cells (2012)
  • Author(s): Kumamaru H, Ohkawa Y, Saiwai H, Yamada H, Kubota K, Kobayakawa K, Akashi K, Okano H, Iwamoto Y, Okada S
  • Journal Title: Nat Commun Volume: 3 Issue: 1 Pages: 1140-1140
  • DOI: 10.1038/ncomms2132
  • Peer Reviewed
• [Journal Article] Flow cytometric sorting of neuronal and glial nuclei from central nervous system tissue (2011)
  • Author(s): Okada S, Saiwai H, Kumamaru H, Kubota K, Harada A, Yamaguchi M, Iwamoto Y, Ohkawa Y
  • Journal Title: Journal of Cellular Physiology Volume: 226 Issue: 2 Pages: 552-558
  • DOI: 10.1002/jcp.22365
  • Peer Reviewed
• [Journal Article] Macrophage Infiltration Predicts a Poor Prognosis for the Human Ewing Sarcoma (2011)
  • Author(s): Fujiwara T, Fukushi JI, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
  • Journal Title: American Journal of Pathology Volume: 179 Issue: 3 Pages: 1157-70
  • DOI: 10.1016/j.ajpath.2011.05.034
  • NAID: 120005107981
  • Peer Reviewed
• [Journal Article] Beneficial compaction of spinal cord lesion by migrating astrocytes through Glycogen Synthase Kinase-3 inhibition (2011)
  • Author(s): Renault-Mihara F, Katoh H, Ikegami T, Iwanami A, Mukaino M, Tada H, Yasuda A, Nori S, Shibata S, Saito K, Matsushita M, Kaibuchi K, Okada S, Toyama Y, Nakamura M, and Okano H
  • Journal Title: EMBO Mol Med Volume: 3 Issue: 11 Pages: 682-96
  • DOI: 10.1002/emmm.201100179
  • Peer Reviewed
• [Journal Article] Generation of a rat monoclonal antibody specific for HSP72 (2011)
  • Author(s): Tanaka K, Shiota M, Okada S, Harada A, Odawara J, Mun S, Iwao H, Ohkawa Y
  • Journal Title: Hybridoma Volume: 30 Issue: 4 Pages: 397-400
  • DOI: 10.1089/hyb.2011.0015
  • Peer Reviewed
• [Journal Article] The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on geneome-wide approach (2011)
  • Author(s): Odawara J, Harada A, Yoshimi T, Maehara K, Tachbana T, Okada S, Akashi K, Ohkawa Y
  • Journal Title: BMC Genomics Volume: 12 Issue: 1 Pages: 516-516
  • DOI: 10.1186/1471-2164-12-516
  • Peer Reviewed
• [Journal Article] Clinical characteristics and surgical outcome of the symptomatic ossification of ligamentum flavum at the thoracic level with combined lumbar spinal stenosis (2011)
  • Author(s): Matsumoto Y, Harimaya K, Doi T, Kawaguchi K, Okada S, Inoguchi A, Fujiwara M, Iwamoto Y
  • Journal Title: Arch Orthop Trauma Surg Volume: 132 Issue: 4 Pages: 465-70
  • DOI: 10.1007/s00402-011-1438-7
  • Peer Reviewed
• [Journal Article] 脊髄損傷後のアストロサイトの動態と役割 (2011)
  • Author(s): 岡田誠司, 他
  • Journal Title: Bone Joint Nerve Volume: 2 Pages: 425-432
  • Peer Reviewed
• [Journal Article] 非骨傷性頸髄損傷の治療-保存療法vs手術療法 (2011)
  • Author(s): 岡田誠司, 他
  • Journal Title: Bone Joint Nerve Volume: 2 Pages: 515-520
  • Peer Reviewed
• [Journal Article] 基礎研究による脊髄損傷の病態解明 (2011)
  • Author(s): 岡田誠司, 他
  • Journal Title: 整形外科 Volume: 62 Pages: 669-677
  • Peer Reviewed
• [Journal Article] Production of a rat monoclonal antibody specific for Myf5 (2010)
  • Author(s): Harada A, Okada S, Odawara J, Kumamaru H, Saiwai H, Aoki M, Nakamura M, Nishiyama Y, Ohkawa Y
  • Journal Title: Hybridoma Volume: 29 Issue: 1 Pages: 59-62
  • DOI: 10.1089/hyb.2009.0066
  • Peer Reviewed
• [Journal Article] Generation of a rat monoclonal antibody specific for CHD2 (2010)
  • Author(s): Harada A, Yoshimura S, Odawara J, Azuma M, Okada S, Nakamura M, Tachibana T, Ohkawa Y
  • Journal Title: Hybridoma Volume: 29 Issue: 2 Pages: 173-7
  • DOI: 10.1089/hyb.2009.0090
  • Peer Reviewed
• [Journal Article] Rat monoclonal antibody specific for the chromain remodeling factor, CHD1 (2010)
  • Author(s): Yoshimura S, Harada A, Odawara J, Azuma M, Okada S, Nakamura M, Ohkawa Y, Tachibana T
  • Journal Title: Hybridoma Volume: 29 Issue: 3 Pages: 237-40
  • DOI: 10.1089/hyb.2009.0106
  • Peer Reviewed
• [Journal Article] Rat monoclonal antibody specific for MyoD (2010)
  • Author(s): Harada A, Ohkawa Y, Ao S, Odawara J, Okada S, Azuma M, Nishiyama Y,Nakamura M, Tachibana T
  • Journal Title: Hybridoma Volume: 29 Issue: 3 Pages: 255-8
  • DOI: 10.1089/hyb.2009.0117
  • Peer Reviewed
• [Journal Article] Monoclonal antibody specific for Dhx9/NDHII/RHA (2010)
  • Author(s): Kotani M, Harada A, Odawara J, Azuma M, Okada S, Nishiyama Y, Nakamura M, Tachibana T, Ohkawa Y
  • Journal Title: Hybridoma Volume: 29 Issue: 3 Pages: 259-61
  • DOI: 10.1089/hyb.2009.0107
  • Peer Reviewed
• [Journal Article] The LTB4-BLT1 axis mediates neutrophils infiltration and secondary injury in experimental spinal cord injury (2010)
  • Author(s): Saiwai H, Ohkawa Y, Yamada H, Kumamaru H, Harada A, Okano H, Yokomizo T, Iwamoto Y, Okada S
  • Journal Title: American Journal of Pathology Volume: 176 Pages: 2352-2377
  • Peer Reviewed
• [Journal Article] Ossification of the longitudinal ligament of the lumbar spine (2010)
  • Author(s): Okada S, Maeda T, Saiwai H, Ohkawa Y, Shiba K, Iwamoto Y
  • Journal Title: Neurosurgery Volume: 67 Issue: 5 Pages: 1311-1318
  • DOI: 10.1227/neu.0b013e3181ef2806
  • Peer Reviewed
• [Journal Article] Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation (2010)
  • Author(s): Mukaino M, Nakamura M, Yamada O, Okada S, Morikawa S, Renault-Mihara F, Iwanami A, Ikegami T, Ohsugi Y, TsujiO, Katoh H, Matsuzaki Y, Toyama Y, Liu M, Okano H
  • Journal Title: Exp Neurol Volume: 224(2) Issue: 2 Pages: 403-14
  • DOI: 10.1016/j.expneurol.2010.04.020
  • Peer Reviewed
• [Journal Article] Production of a rat monoclonal antibody specific for Myf5. (2010)
  • Author(s): Harada A, Okada S, et al.
  • Journal Title: Hybridoma. Volume: 29 Pages: 59-62
  • Peer Reviewed
• [Journal Article] The LTB4-BLT1 axis mediates neutrophils infiltration and secondary injury in experimental spinal cord injury. (2010)
  • Author(s): Saiwai H, Ohkawa Y, Yamada H, et al., Okada S.
  • Journal Title: American Journal of Pathology. Volume: 176 Pages: 2352-2377
  • Peer Reviewed
• [Journal Article] Generation of a rat monoclonal antibody specific for CHD2. (2010)
  • Author(s): Harada A, Yoshimura S, Odawara J, Azuma M, Okada S, et al.
  • Journal Title: Hybridoma. Volume: 29 Pages: 173-177
  • Peer Reviewed
• [Journal Article] Ossification of the longitudinal ligament of the lumbar spine. (2010)
  • Author(s): Okada S, Maeda T, Saiwai H, Ohkawa Y, Shiba K, Iwamoto Y.
  • Journal Title: Neurosurgery. Volume: 67 Pages: 1311-1318
  • Peer Reviewed
• [Journal Article] Flow cytometric sorting of neuronal and glial nuclei from central nervous systemtissue. (2010)
  • Author(s): Okada S, Saiwai H, Kumamaru H, Kubota K, et al.
  • Journal Title: Journal of Cellular Physiology. Volume: 226 Pages: 552-558
  • Peer Reviewed
• [Journal Article] Anti-IL-6-receptor antibody promtes repair of spinal cord injury by inducing microglial-dominant inflammation. (2010)
  • Author(s): Mukaino M, Nakamura M, Yamada O, Okada S, et al.
  • Journal Title: Experimental Neurology. Volume: 224 Pages: 406-414
  • Peer Reviewed
• [Journal Article] Generation of a rat monoclonal antibody specific for heat schock cognate protein70. (2010)
  • Author(s): Shiota M, Saiwai H, Mun S, Harada A, Okada S, et al.
  • Journal Title: Hybridoma. Volume: 29 Pages: 453-456
  • Peer Reviewed
• [Journal Article] Rat monoclonal antibody specific for the chromain remodeling factor, CHD1. (2010)
  • Author(s): Yoshimura S, Harada A, Odawara J, Azuma M, Okada S, et al.
  • Journal Title: Hybridoma. Volume: 29 Pages: 237-240
  • Peer Reviewed
• [Journal Article] Monoclonal antibody specific for Dhx9/NDH II/RHA. (2010)
  • Author(s): Kotani M, Harada A, Odawara J, Azuma M, Okada S, et al.
  • Journal Title: Hybridoma. Volume: 29 Pages: 259-261
  • Peer Reviewed
• [Journal Article] Rat monoclonal antibody specific for MyoD. (2010)
  • Author(s): Harada A, Ohkawa Y, Ao S, Odawara J, Okada S, et al.
  • Journal Title: Hybridoma. Volume: 29 Pages: 255-258
  • Peer Reviewed
• [Journal Article] 脊髄損傷に対する細胞移植療法の現状と展望 (2010)
  • Author(s): 岡田誠司、芝啓一郎、岩本幸英
  • Journal Title: 福岡医学雑誌 Volume: 101 Pages: 75-82
  • NAID: 120002383158
  • Peer Reviewed
• [Presentation] セルソーターの脊髄再生研究への応用 (2013)
  • Author(s): 岡田誠司、熊丸浩仁、林田光正、松本嘉寛、播广谷勝三、岩本幸英
  • Organizer: 第42回日本脊椎脊髄病学会
  • Place of Presentation: 沖縄
• [Presentation] 脊髄損傷後の自己修復メカニズム (2012)
  • Author(s): 岡田誠司、熊丸浩仁、久保田健介、小早川和、中村雅也、Renault-Mihara Francois、岡野栄之、岩本幸英
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋
• [Presentation] 脊髄損傷研究に於けるMDSC(myeloid-derived suppressor cell)の生理的修復作用 (2012)
  • Author(s): 岡田誠司、幸博和、熊丸浩仁、久保田健介、小早川和、岩本幸英
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋
• [Presentation] 脊髄再生ー細胞移植研究の現状 (2012)
  • Author(s): 岡田誠司
  • Organizer: 第124回西日本整形災害外科学会
  • Place of Presentation: 大分県別府市
  • Invited
• [Presentation] 脊髄損傷後の自己修復メカニズム (2012)
  • Author(s): 岡田誠司
  • Organizer: 第27回日本整形外科基礎学術集会
  • Place of Presentation: 愛知県名古屋市
  • Invited
• [Presentation] 脊髄損傷研究に於けるMDSC(myeloid-derived suppressor cell)の生理的修復作用 (2012)
  • Author(s): 岡田誠司
  • Organizer: 第27回日本整形外科基礎学術集会
  • Place of Presentation: 愛知県名古屋市
• [Presentation] 高血糖はマイクログリアのNF-kb活性化を介して脊髄損傷後の二次損傷を増悪させ機能回復を悪化させる (2012)
  • Author(s): 岡田誠司
  • Organizer: 第31回日本運動器移植再生医学研究会
  • Place of Presentation: 青森県弘前市
• [Presentation] Myeloperoxidase(MPO)は反応性の高い活性酸素種を産生することに加え、好中球浸潤を促進することで脊髄損傷を二次的に拡大する (2012)
  • Author(s): 岡田誠司
  • Organizer: 第31回日本運動器移植再生医学研究会
  • Place of Presentation: 青森県弘前市
• [Presentation] 損傷脊髄部での移植神経幹細胞のin situ analysis (2011)
  • Author(s): 岡田誠司
  • Organizer: 第46回日本脊髄障害医学会
  • Place of Presentation: 大阪(シンポジスト)
  • Year and Date: 2011-11-19
• [Presentation] 脊髄圧迫病変が脊髄損傷の予後に与える影響 (2011)
  • Author(s): 岡田誠司
  • Organizer: 第46回日本脊髄障害医学会
  • Place of Presentation: 大阪(シンポジスト)
  • Year and Date: 2011-11-18
• [Presentation] Delivery of Ly6C(+) MDSCs promote functional recovery after spinal cord injury (2011)
  • Author(s): Saiwai H
  • Organizer: The 41^<th> Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-16
• [Presentation] Age-related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury (2011)
  • Author(s): Kumamaru H
  • Organizer: The 41^<th> Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-16
• [Presentation] 脊髄損傷研究に於ける網羅的遺伝子解析の応用 (2011)
  • Author(s): 岡田誠司
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋(シンポジスト)
  • Year and Date: 2011-10-21
• [Presentation] 細胞移植による脊髄再生研究の現状と課題 (2011)
  • Author(s): 岡田誠司
  • Organizer: 第30回日本運動器移植・再生医学研究会
  • Place of Presentation: 福岡(特別講演)
  • Year and Date: 2011-09-25
• [Presentation] 脊髄損傷は治るのか?-研究の現状と展望 (2011)
  • Author(s): 岡田誠司
  • Organizer: 第5回九州山口労災病院薬剤部会研修会
  • Place of Presentation: 飯塚(招待講演)
  • Year and Date: 2011-06-25
• [Presentation] 脊髄再生研究の臨床応用における課題とその最先端 (2011)
  • Author(s): 岡田誠司
  • Organizer: 第84回日本整形外科学術集会
  • Place of Presentation: 横浜(シンポジスト)
  • Year and Date: 2011-05-23
• [Presentation] 脊髄損傷に対する再生研究の現状と展望 (2011)
  • Author(s): 岡田誠司
  • Organizer: 第6回福岡県認知症・脳卒中広域ネットワーク研修会
  • Place of Presentation: 福岡
  • Year and Date: 2011-03-02
• [Presentation] 脊髄損傷研究に於ける網羅的遺伝子解析の応用 (2011)
  • Author(s): 岡田誠司、熊丸浩仁、久保田健介、小早川和、幸博和、岩本幸英
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋
• [Presentation] 脊髄圧迫病変が脊髄損傷の予後に与える影響 (2011)
  • Author(s): 岡田誠司
  • Organizer: 第46回日本脊髄障害医学会
  • Place of Presentation: 大阪
• [Presentation] 損傷脊髄部での移植神経幹細胞のin situ analysis (2011)
  • Author(s): 岡田誠司
  • Organizer: 第46回日本脊髄障害医学会
  • Place of Presentation: 大阪
• [Presentation] Age-related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury (2011)
  • Author(s): Kumamaru H, Saiwai H, Iwamoto Y, Okada S
  • Organizer: The 41th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] Delivery of Ly6C(+) myeloid-derived suppressor cells (MDSCs) promote tissue repair process and functional recovery after spinal cord injury (2011)
  • Author(s): Saiwai H, Kumamaru H, Kubota K, Kobayakawa K, Iwamoto Y, Okada S
  • Organizer: The 41th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] 損傷慢性期脊髄に移植された神経幹細胞の発現遺伝子プロファイル解析 (2010)
  • Author(s): 岡田誠司、熊丸浩仁、横田和也、小早川和、久保田健介、岩本幸英
  • Organizer: 第31回日本運動器移植再生医学研究会
  • Place of Presentation: 弘前
  • Year and Date: 2010-09-29
• [Presentation] 損傷脊髄に移植された神経幹細胞の網羅的発現遺伝子解析 (2010)
  • Author(s): 岡田誠司、熊丸浩仁、幸博和、久保田健介、岩本幸英
  • Organizer: 第29回日本運動器移植・再生医学研究会
  • Place of Presentation: 京都
  • Year and Date: 2010-09-25
• [Presentation] セルソーターによる脊髄損傷後の炎症反応の分析的解析 (2010)
  • Author(s): 岡田誠司、幸博和、熊丸浩仁、久保田健介、岩本幸英
  • Organizer: 第29回日本運動器移植・再生医学研究会
  • Place of Presentation: 京都
  • Year and Date: 2010-09-25
• [Presentation] 基礎研究による脊髄損傷の病態解明 (2010)
  • Author(s): 岡田誠司
  • Organizer: 第10回名古屋脊椎脊髄セミナー
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-10
• [Presentation] 脊髄損傷に対する基礎的研究と現状 (2010)
  • Author(s): 岡田誠司
  • Organizer: 第73回西日本脊椎研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-04
• [Presentation] セルソーターによる脊髄損傷後の炎症反応の分析的解析 (2010)
  • Author(s): 岡田誠司、幸博和、熊丸浩仁、久保田健介、岩本幸英
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都
• [Presentation] Direct isolation and mRNA sequencing of engrafted neural stem cells injured spinal cord (2010)
  • Author(s): Kumamaru H, Saiwai H, Iwamoto Y, Okada S
  • Organizer: The 40th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Procoagulant effect of infiltrating neutrophils after traumatic spinal cord injury (2010)
  • Author(s): Saiwai H, Kumamaru H, Iwamoto Y, Okada S
  • Organizer: The 40th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Remarks]
  • URL: http://hyoka.ofc.kyushu-u.ac.jp/search/details/K003217