Central Nociceptive Pathway in Joint contracture associated ChronicPainful Model Animal.

• Project/Area Number: 22390294
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Aichi Medical University
• Principal Investigator: USHIDA Takahiro 愛知医科大学, 医学部, 教授 (60304680)
• Co-Investigator(Kenkyū-buntansha): OHSAKO Yhoji 高知大学, 医歯学系, 准教授 (40335922) ; NISHIGAMI Tomohiko 甲南女子大学, 看護リハビリテーション学部, 准教授 (60515691) ; OHMICHI Yusuke 愛知医科大学, 医学部, 助教 (50506673) ; OHMICHI Mika 愛知医科大学, 医学部, 助教 (30581079)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: 神経科学 / 疼痛 / 痛みモデル / 関節拘縮 / CRPS / ギプス固定 / 慢性痛モデル / 神経ペプチド / CRP

Research Abstract

Animal models of joint contracture after immobilization (casting) are known to develop long lasting painful behavior after cast removal. In this study, we obtainedup-regulations of brain and spinal microglia, astrocyte, C-Fos activities in this model animal. Present results suggest that functional changes of pain pathway occurredin brain and spinal cord level. Also we conducted treadmill exercise and passive stretching for therapeutic approach. Animals showed the improvement of painful behavior after both approaches.

Research Products

• [Journal Article] Development of heat hyperalgesia and changes of TRPV1 and NGF expression in rat dorsal root ganglion following joint immobilization. (2013)
  • Author(s): Nishigami T, Osako Y, Ikeuchi M, Yuri K, Ushida T.
  • Journal Title: Physiol Res Volume: 62(2) Pages: 215-9
• [Journal Article] Treadmill running andstatic stretching improve long-lasting hyperalgesia, joint limitation, and muscle atrophy induced by cast immobilization in rats. (2013)
  • Author(s): Morimoto A, Winaga H, Sakurai H, Ohmichi M, Yoshimoto T, Ohmichi Y, Ushida T et al.
  • Journal Title: Neurosci Lett. Volume: 534 Pages: 295-300
• [Journal Article] Health survey of numbness/pain and its associated factors in kotohira (2013)
  • Author(s): Inoue S, Ikeuchi M, Okumura K, Nakamura M, Kawakami C, Ushida T, et al.
  • Journal Title: Japan. PLoS One. Volume: 8(4)
• [Journal Article] Treadmill running and static stretching improve long-lasting hyperalgesia, joint limitation, and muscle atrophy induced by cast immobilization in rats. (2013)
  • Author(s): Morimoto A
  • Journal Title: Neurosci Lett Volume: 534 Pages: 295-300
  • DOI: 10.1016/j.neulet.2012.11.009
  • Peer Reviewed
• [Journal Article] Development of heat hyperalgesia and changes of TRPV1 and NGF expression in rat dorsal root ganglion following joint immobilization. (2013)
  • Author(s): Nishigami T
  • Journal Title: Physiol Res Volume: 62 Pages: 215-219
  • Peer Reviewed
• [Journal Article] 筋機能(特集慢性疼痛への包括的アプローチ). (2012)
  • Author(s): 櫻井博紀,牛田享宏.慢性疼痛への理学療法
  • Journal Title: 理学療法ジャーナル Volume: 46(2) Pages: 117-22
• [Journal Article] 緩和医療神経障害性疼痛の保存的治療 (2012)
  • Author(s): 林和寛, 牛田享宏
  • Journal Title: 難病と在宅ケア Volume: 18(6) Pages: 49-52
  • NAID: 40019421560
• [Journal Article] 日本における慢性疼痛保有者の実態調査: Pain in Japan 2010 より (2012)
  • Author(s): 矢吹省司, 牛田享宏, 竹下克志
  • Journal Title: 臨床整形外科 Volume: 47(2) Pages: 127-34
  • NAID: 40019203566
• [Journal Article] 運動器の慢性疼痛に関する疫学調査 (2012)
  • Author(s): 中村雅也,西脇祐司,牛田享宏
  • Journal Title: Journal of musculoskeletal pain research:日本運動器疼痛学会誌 Volume: 4(1) Pages: 46-50
  • NAID: 40019402481
• [Journal Article] 慢性疼痛への包括的アプローチ (2012)
  • Author(s): 大道裕介,牛田享宏
  • Journal Title: 理学療法ジャーナル Volume: 46(2) Pages: 101-9
• [Journal Article] 椎間関節由来の慢性腰痛に対するMRガイド下集束超音波治療の治療経験 (2012)
  • Author(s): 川崎元敬,牛田享宏,南場寛文,加藤友也,谷俊一.
  • Journal Title: 中部日本整形外科災害外科学会雑誌中部日本整形外科災害外科学会抄録 Volume: 55(1) Pages: 121-2
  • NAID: 10030185972
• [Journal Article] 整形外科疼痛の脊髄・脳機能イメージング法による評価(シンポジウム疼痛評価の進歩 (2012)
  • Author(s): 牛田享宏,下和弘,池本竜則
  • Journal Title: 日本整形外科学会雑誌 Volume: 86(11) Pages: 1009-14
  • NAID: 40019510579
• [Journal Article] 運動器慢性痛の病態と学際的治療(特集痛みの神経学:末梢神経から脳まで) (2012)
  • Author(s): 井上真輔,牛田享宏,井上雅之
  • Journal Title: Brainandnerve:神経研究の進歩 Volume: 64(11) Pages: 1287-97
  • NAID: 40019487389
• [Journal Article] Effect of muscle load tasks with maximal isometric contractions on oxygenation of the trapezius muscle and sympathetic nervous activity in females with chronic neck and shoulder pain (2012)
  • Author(s): Shiro Y, Arai YC, Matsubara T, Isogai S, Ushida T
  • Journal Title: BMC Musculoskelet Disord Volume: 13 Pages: 146-146
• [Journal Article] Two-week cast immobilization induced chronic widespread hyperalgesia in rats (2012)
  • Author(s): Ohmichi Y, Sato J, Ohmichi M, Sakurai H, Yoshimoto T, Morimoto A, Ushida T et al
  • Journal Title: Eur J Pain. [Research Support, Non-U.S.Gov't] Volume: 16(3) Pages: 338-48
• [Journal Article] A pilot feasibility study for immediate relief of referred knee pain by hip traction in hip osteoarthritis. (2012)
  • Author(s): Nishigami T, Ikeuchi M, Okanoue Y, Wakamatsu S, Matsuya A, Ishida K,Ushida T et al.
  • Journal Title: J Orthop Sci. Volume: 17(3) Pages: 328-30
• [Journal Article] Clinical characteristics and multidisciplinary management of chronic musculoskeletal pain (2012)
  • Author(s): Inoue S,Ushida T,Inoue M.
  • Journal Title: Brain Nerve.[Review] Volume: 64(11) Pages: 1287-97
  • NAID: 40019487389
• [Journal Article] A pilot feasibility study for immediate relief of referred knee pain by hip traction in hip osteoarthritis (2012)
  • Author(s): Nishigami T, et al
  • Journal Title: J Orthop Sci Pages: 328-330
  • Peer Reviewed
• [Journal Article] 寒さを感じなくなった慢性痛患者に対する環境温曝露試験.Pain research:the journal of the Japanese Society for the Study of Pain= (2011)
  • Author(s): 櫻井博紀,佐藤純,吉本隆彦,大道裕介森本温子,新井健一,牛田享宏etal.
  • Journal Title: 日本疼痛学会誌. Volume: 26(1) Pages: 11-8
• [Journal Article] 慢性の痛みとその課題(特集医師から学ぶ慢性の痛み) (2011)
  • Author(s): 西原真理,牛田享宏
  • Journal Title: 調剤と情報 Volume: 17(2) Pages: 153-5
  • NAID: 40018702124
• [Journal Article] 運動器慢性痛と学際的アプローチ(物理療法研究部会) (2011)
  • Author(s): 牛田享宏
  • Journal Title: 理学療法学 Volume: 38(8) Pages: 649-52
• [Journal Article] Frequency components of systolic blood pressure variability reflect vasomotor and cardiac sympathetic functions in conscious rats (2011)
  • Author(s): Yoshimoto T, Eguchi K, Sakurai H,Ohmichi Y, Hashimoto T, Ohmichi M,Ushida T et al.
  • Journal Title: J Physiol Sci Volume: 61(5) Pages: 373-83
  • NAID: 10029575648
• [Journal Article] Visualization of painful experiences believed to trigger the activation of affective and emotional brain regions in subjects with low back pain (2011)
  • Author(s): Shimo K, Ueno T, Younger J, Nishihara M, Inoue S, Ikemoto T, Ushida T et al
  • Journal Title: PLoS One.[Research Support, Non-U.S. Gov't]. Volume: 6(11)
• [Journal Article] Prevalence and characteristics of chronic musculoskeletal pain in Japan. (2011)
  • Author(s): Nakamura M, Nishiwaki Y, Ushida T, Toyama Y.
  • Journal Title: JOrthop Sci. Volume: 16(4) Pages: 424-32
  • NAID: 10029573986
• [Journal Article] Comparative effects of acupressure at local and distal acupuncture points on pain conditions and autonomic function in females with chronic neck pain. (2011)
  • Author(s): Matsubara T, Arai YC, Shiro Y, Shimo K, Nishihara M, Sato J, Ushida T et al.
  • Journal Title: Evid Based Complement Alternat Med. Volume: 2011
• [Journal Article] Percutaneous radiofrequency treatment for refractory anteromedial pain of osteoarthritic knees. Pain Med. (2011)
  • Author(s): Ikeuchi M, Ushida T, Izumi M, Tani T.
  • Journal Title: Clinical Trial Volume: 12(4) Pages: 546-51
• [Journal Article] 【運動器の痛み その診断と治療】手術後の痛み瘢痕性の痛み (2011)
  • Author(s): 西上智彦、牛田享宏
  • Journal Title: Orthopaedics Volume: 5 Pages: 168-72
• [Journal Article] 脳波・筋電図の臨床脊髄・一次求心性線維の機能変化と痛み (2010)
  • Author(s): 櫻井博紀,牛田享宏
  • Journal Title: 臨床脳波 Volume: 52(7) Pages: 385-91
  • NAID: 40017210924
• [Journal Article] 脳波・筋電図の臨床脊髄での機能的MRI画像の試み (2010)
  • Author(s): 池本竜則,牛田享宏,谷俊一
  • Journal Title: 臨床脳波 Volume: 52(4) Pages: 207-12
  • NAID: 40017066122
• [Journal Article] 痛み刺激による前頭前野の即時的な脳血流量変化.Pain research: the journal of the Japanese Society for the Study of Pain= (2010)
  • Author(s): 西上智彦,池本竜則,牛田享宏.
  • Journal Title: 日本疼痛学会誌 Volume: 25(3) Pages: 127-34
• [Journal Article] 頚椎手術後の頚部軸性疼痛--軸性疼痛のメカニズムと対処法(特集項頚部痛の病態と治療--最近の知見) (2010)
  • Author(s): 神谷光広,牛田享宏
  • Journal Title: 整形・災害外科 Volume: 53(1) Pages: 31-7
  • NAID: 40016955813
• [Journal Article] 神経障害性疼痛の痛覚認知機構(神経因性疼痛) (2010)
  • Author(s): 牛田享宏,池本竜則,下和弘
  • Journal Title: 臨床脳波 Volume: 52(10) Pages: 556-63
  • NAID: 40017328821
• [Journal Article] 運動器の痛みのメカニズムと課題 (2010)
  • Author(s): 牛田享宏
  • Journal Title: 現代医学 Volume: 58(2) Pages: 213-9
  • NAID: 40018779801
• [Journal Article] Alterations of contralateral thalamic perfusion in neuropathic pain. (2010)
  • Author(s): Ushida T, Fukumoto M, Binti C, Ikemoto T, Taniguchi S, Ikeuchi M, et al.
  • Journal Title: Open Neuroimag J. Volume: 4 Pages: 182-6
• [Journal Article] Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine. (2010)
  • Author(s): Arai YC, Matsubara T, Shimo K, Suetomi K, Nishihara M, Ushida T, et al.
  • Journal Title: J Anesth. Volume: 24(3) Pages: 407-10
  • NAID: 10026545553
• [Journal Article] 運動器の痛みの慢性化とその問題点 (2010)
  • Author(s): 牛田享宏
  • Journal Title: 日本ペインクリニック学会誌 Volume: 別冊 Pages: 176-177
  • Peer Reviewed
• [Journal Article] 運動器の慢性痛と適切な対応の必要性 (2010)
  • Author(s): 牛田享宏
  • Journal Title: 整形・災害外科 Volume: 53 Pages: 11-11
  • Peer Reviewed
• [Presentation] ラット後肢のギプス固定により出現する長期の機械的痛覚過敏に対して2週間のトレッドミル運動が及ぼす影響 (2011)
  • Author(s): 森本温子、大道裕介、牛田享宏, 他
  • Organizer: 日本理学療法学術集会
  • Place of Presentation: 宮崎市
  • Year and Date: 2011-06-28
• [Presentation] MECHANISMS OF IMMOBILIZATION INDUCED MUSCULOSKELETAL PAIN AND ROLE OF EXERCISE FOR PAIN PREVENTION
  • Author(s): Ushida, T
  • Organizer: 14th World congress on Pain
  • Place of Presentation: Milano
• [Presentation] INHIBITORY EFFECTS OF MINOCYCLINE, AN INHIBITOR OF SPINAL MICROGLIAL ACTIVATION, ON WIDESPREAD MECHANICAL HYPERALGESIA IN A RAT MODEL OF CAST IMMOBILIZATION
  • Author(s): Ohmichi, M
  • Organizer: 14th World congress on Pain
  • Place of Presentation: Milano
• [Presentation] COMPARISON STUDY BETWEEN ACTIVE AND PASSIVE EXERCISE EFFECT IN CHRONIC PAIN ON JOINT CONTRACTURE IN RATS
  • Author(s): Winaga, H
  • Organizer: 14th World congress on Pain
  • Place of Presentation: Milano
• [Presentation] INHIBITORY EFFECTS OF TEMPOL, A FREE RADICAL SCAVENGER, ON LONG-LASTING WIDESPREAD MECHANICAL HYPERALGESIA IN A RAT MODEL OF CAST IMMOBILIZATION
  • Author(s): Ohmichi, Y
  • Organizer: 14th World congress on Pain
  • Place of Presentation: Milano