Central Nociceptive Pathway in Joint contracture associated ChronicPainful Model Animal.
| Project/Area Number |
22390294
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHSAKO Yhoji 高知大学, 医歯学系, 准教授 (40335922)
NISHIGAMI Tomohiko 甲南女子大学, 看護リハビリテーション学部, 准教授 (60515691)
OHMICHI Yusuke 愛知医科大学, 医学部, 助教 (50506673)
OHMICHI Mika 愛知医科大学, 医学部, 助教 (30581079)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 神経科学 / 疼痛 / 痛みモデル / 関節拘縮 / CRPS / ギプス固定 / 慢性痛モデル / 神経ペプチド / CRP |
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| Research Abstract |
Animal models of joint contracture after immobilization (casting) are known to develop long lasting painful behavior after cast removal. In this study, we obtainedup-regulations of brain and spinal microglia, astrocyte, C-Fos activities in this model animal. Present results suggest that functional changes of pain pathway occurredin brain and spinal cord level. Also we conducted treadmill exercise and passive stretching for therapeutic approach. Animals showed the improvement of painful behavior after both approaches.
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Report
(4 results)
Research Products
(42 results)
