Development of tailor made peptide vaccines for renal cell carcinoma

• Project/Area Number: 22390305
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kinki University
• Principal Investigator: UEMURA Hirotsugu 近畿大学, 医学部, 教授 (90213397)
• Co-Investigator(Kenkyū-buntansha): MINAMI Takafumi 近畿大学, 医学部, 助教 (70340809) ; DE VELASCO Marco 近畿大学, 医学部, 助教 (20449838) ; HARADA Mamoru 島根大学, 医学部, 教授 (50260716) ; YOSHIMURA Kazuhiro 近畿大学, 医学部, 准教授 (20283757)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000); Fiscal Year 2010: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
• Keywords: 腎細胞癌 / 癌ワクチン / ペプチドワクチン / 免疫療法 / 腎細胞がん / 癌ワクチン療法 / CA9 / VEGFR / EPOR / HIF-1 / PDL-1 / ペプチド / ワクチン療法

Research Abstract

e have been working on the development of new MHC-class-I restricted peptide vaccines for five independent therapeutic targets and have identified a significant candidate EPORxx. We are preparing the application of a patent for this particular peptide vaccine. We also carried out phase-I/II clinical study with VEGFR1 peptide vaccines for 18 patients with disseminated renal cell carcinoma, and showed the safty and efficacy of the vaccination treatment.

Research Products

• [Journal Article] Phase I clinical trial of human vascular endothelial growth factor receptor 1 peptide vaccines for patients with metastatic renal cell carcinoma (2013)
  • Author(s): Yoshimura K, Minami T, Nozawa M, Uemura H
  • Journal Title: Br J Cancer Volume: 108(6) Pages: 1260-6
  • Peer Reviewed
• [Journal Article] STAT3 polymorphism can predict the response to interferon-α therapy in patients with metastatic renal cell carcinoma (2013)
  • Author(s): Eto M, Kamba T, Miyake H, Fujisawa M, Kamai T, Uemura H, Tsukamoto T, Azuma H, Matsubara A, Nishimura K, Nakamura T, Ogawa O, Naito S
  • Journal Title: Japan Immunotherapy SNPs-Study Group for Kidney Cancer Volume: Eur Urol Pages: 745-52
  • Peer Reviewed
• [Journal Article] Role of vaccine therapy for renal cell carcinoma in the era of targeted therapy. (2013)
  • Author(s): Yoshimura K, Uemura H. Yoshimura K, Uemura H.
  • Journal Title: Int J Urol. Volume: - Issue: 8 Pages: 1-10
  • DOI: 10.1111/iju.12147
  • NAID: 10031190532
  • Peer Reviewed
• [Journal Article] Phase I clinical trial of human vascular endothelial growth factor receptor 1 peptide vaccines for patients with metastatic renal cell carcinoma. (2013)
  • Author(s): Yoshimura K, Minami T, Nozawa M, Uemura H.
  • Journal Title: Br J Cancer. Volume: 108 Issue: 6 Pages: 1260-1266
  • DOI: 10.1038/bjc.2013.90
  • Peer Reviewed
• [Journal Article] STAT3 polymorphism can predict the response to interferon-α therapy in patients with metastatic renal cell carcinoma. (2013)
  • Author(s): Eto M, Kamba T, Miyake H, Fujisawa M, Kamai T, Uemura H, Tsukamoto T, Azuma H, Matsubara A, Nishimura K, Nakamura T, Ogawa O, Naito S; Japan Immunotherapy SNPs-Study Group for Kidney Cancer.
  • Journal Title: Eur Urol. Volume: 63 Issue: 4 Pages: 745-752
  • DOI: 10.1016/j.eururo.2012.09.052
  • Peer Reviewed
• [Journal Article] Sorafenib rechallenge in patients with metastatic renal cell carcinoma (2012)
  • Author(s): M Nozawa
  • Journal Title: BJU INTERNATIONAL
  • Peer Reviewed
• [Journal Article] Antitumor activity of BIBF 1120, a triple angiokinase inhibitor, and use of VEGFR2+pTyr+ peripheral blood leukocytes as a pharmacodynamic biomarker in vivo (2011)
  • Author(s): Kudo K, Arao T, De Velasco MA, Hirotsugu Uemura et al
  • Journal Title: Clin Cancer Res Volume: 15;17(6) Pages: 1373-81
  • Peer Reviewed
• [Journal Article] A new molecular targeted therapeutic approach for renal cell carcinoma with a p16 functional peptide using a novel transporter system (2011)
  • Author(s): Zennami K, Yoshikawa K, Kondo E, Nakamura K, Upsilonamada Y, De Velasco MA, Tanaka M, Uemura H, Shimazui T, Akaza H, Saga S, Ueda R, Honda N
  • Journal Title: Oncol Rep. Volume: 26 Pages: 327-333
  • Peer Reviewed
• [Journal Article] Basic research in kidney cancer (2011)
  • Author(s): Oosterwijk E, Rathmell WK, Junker K, Brannon AR, Pouliot F, Finley DS, Mulders PF, Kirkali Z, Uemura H
  • Journal Title: Belldegrun A Volume: Eur Urol Pages: 622-33
  • Peer Reviewed
• [Journal Article] Phase III trial of everolimus in metastatic renal cell carcinoma: subgroup analysis of Japanese patients from RECORD-1 (2011)
  • Author(s): Tsukamoto T, Shinohara N, Tsuchiya N, Hamamoto Y, Maruoka M, Fujimoto H, Niwakawa M, Uemura H, Usami M, Terai A, Kanayama HO, Sumiyoshi Y, Eto M, Akaza H
  • Journal Title: Jpn J Clin Oncol Volume: 41(1) Pages: 17-24
  • Peer Reviewed
• [Journal Article] Basic Research in Kidney Cancer (2011)
  • Author(s): E Oosterwijk
  • Journal Title: EUROPEAN UROLOGY Volume: 60 Pages: 622-633
  • Peer Reviewed
• [Journal Article] A new molecular targeted therapeutic approach for renal cell carcinoma with a p16 functional peptide using a novel transporter system (2011)
  • Author(s): K Zennami
  • Journal Title: Oncol Rep Volume: 26 Pages: 327-333
  • Peer Reviewed
• [Journal Article] Kidney Cancer Working Group report. (2011)
  • Author(s): Naito S., Uemura H., et al.
  • Journal Title: Jpn J Clin Oncol. Volume: Suppl1
  • Peer Reviewed
• [Journal Article] Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination (2010)
  • Author(s): Noguchi M, Mine T, Komatsu N, Suekane S, Moriya F, Matsuoka K, Yutani S, Shichijo S, Yamada A, Toh U, Kawano K, Azuma K, Uemura H, Okuno K, Matsumoto K, Yanagimoto H, Yamanaka R, Oka M, Todo S, Sasada T, Itoh K
  • Journal Title: Cancer Biol Ther Volume: 10(12) Pages: 1266-79
  • Peer Reviewed
• [Journal Article] Kidney Cancer Working Group report (2010)
  • Author(s): Naito S, Tomita Y, Rha SY, Uemura H, Oya M, Song HZ, Zhong LH, Wahid MI
  • Journal Title: Jpn J Clin Oncol Volume: 40 Suppl 1
  • Peer Reviewed
• [Journal Article] Assessment of immunological biomarkers in patients with advanced capcer treated by personalized peptide vaccination. (2010)
  • Author(s): Noguchi M., Uemura H., et al.
  • Journal Title: Cancer Biol Ther. Volume: 10 Pages: 1266-1279
  • Peer Reviewed
• [Journal Article] Molecular genetic events associated with renal cell carninoma and its implication to treatment by molecular target therapy. (2010)
  • Author(s): Kishida T., Uemura H.
  • Journal Title: Int J Urol. Volume: 17 Pages: 198-205
  • NAID: 10027257218
  • Peer Reviewed
• [Presentation] Clinical role of MHC-class I peptide vaccines for metastatic renal cell carcinoma (2013)
  • Author(s): T Minami, T Minami, N Shimizu, Y Yamamoto, M De Velasco, T Hayashi, M Nozawa, K Yoshimura, T Ishii, H Uemura
  • Organizer: 28th Annual EAU Congress
  • Place of Presentation: Milan
  • Year and Date: 2013-03-18
• [Presentation] HLA-A24 陽性腎細胞癌患者におけるcancer-reactive CTLs を誘導し得るEpoR 抗原由来ペプチドの同定 (2012)
  • Author(s): 南 高文、南 知子、大関孝之、デベラスコマルコ、清水信貴、山本 豊、辻 秀憲、野澤昌弘、吉村一宏、植村天受
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌市
  • Year and Date: 2012-09-19
• [Presentation] 転移性腎がんに対するMHC クラスI ペプチドワクチン療法の役割 (2012)
  • Author(s): 植村天受、吉村一宏、南 高文、デベラスコ マルコ
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌市
  • Year and Date: 2012-09-19
• [Presentation] The Clinical role of peptide vaccines for castration-resistant prostate cancer (2012)
  • Author(s): Takafumi Minami, Takahiro Kimura, Masahiro Nozawa, Kazuhiro Yoshimura, Toru Nakagawa, Akira Yamada, Kyogo Ito, Hiroyuki Fujimoto, Shi Egawa, Hirotsugu Uemura
  • Organizer: The 10th Annual Meeting of Japanese Society of Medical Oncology
  • Place of Presentation: Osaka
  • Year and Date: 2012-07-18
• [Presentation] A phase I trial of VEGFR1 peptide vaccines for patients with metastatic renal cell carcinoma (2011)
  • Organizer: AUA Annual Meeting
  • Place of Presentation: Washington DC
  • Year and Date: 2011-05-17
• [Presentation] A phase I trial of VEGFR1 peptide vaccines for patients with metastatic renal cell carcinoma (2011)
  • Author(s): 植村天受
  • Organizer: Annual Meeting of American Urological Association
  • Place of Presentation: ワシントン
  • Year and Date: 2011-05-17
• [Presentation] 転移性腎癌に対するMHCクラスIペプチドワクチン療法の役割
  • Author(s): 植村天受、吉村一宏ほか
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（札幌市）
• [Presentation] HLA-A24陽性腎細胞癌患者におけるcancer-rective CTLsを誘導し得るEpoR抗原由来ペプチドの同定
  • Author(s): 南 高文、植村天受ほか
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（札幌市）