Development of new HPV vaccine for prevention of cervical cancer

• Project/Area Number: 22390309
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Tsukuba
• Principal Investigator: YOSHIKAWA Hiroyuki 筑波大学, 医学医療系, 教授 (40158415)
• Co-Investigator(Renkei-kenkyūsha): MATSUMOTO Kouji 筑波大学, 医学医療系, 准教授 (30302714)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 子宮頸癌 / ワクチン / HPV / L2 / VLP

Research Abstract

Development of specific neutralizing antibodies following natural HPV 16 infection did not favor a better outcome of low-grade cervical lesions induced by HPV 16. There are at least two cross-neutralization epitopes in the region from aa56 to aa75 and an antigen capable of presenting the two cross-neutralization epitopes would be a good vaccine candidate for a broad-spectrum of high-risk HPVs.

Research Products

• [Journal Article] Human papillomavirus infection and risk for cervical cancer in Japan. (2013)
  • Author(s): Matsumoto K, Yoshikawa H
  • Journal Title: J Obstet Gynaecol Res Volume: 39(1) Issue: 1 Pages: 7-17
  • DOI: 10.1111/j.1447-0756.2012.01977.x
  • Peer Reviewed
• [Journal Article] Safety and efficacy of substituting nedaplatin after carboplatin hypersensitivity reactions in gynecologic malignancies. (2013)
  • Author(s): Michikami H, Minaguchi T, Ochi H, Onuki M, Okada S, Matsumoto K, Satoh T, Oki A, Yoshikawa H.
  • Journal Title: J Obstet Gynecol Res Volume: 39(1) Issue: 1 Pages: 330-335
  • DOI: 10.1111/j.1447-0756.2012.01893.x
  • Peer Reviewed
• [Journal Article] PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma (2013)
  • Author(s): Abe A, Minaguchi T, Ochi H, Onuki M, Okada S, Matsumoto K, Satoh T, Oki A, Yoshikawa H
  • Journal Title: Human Pathology Volume: 44(2) Issue: 2 Pages: 199-207
  • DOI: 10.1016/j.humpath.2012.05.005
  • Peer Reviewed
• [Journal Article] Efficacy of quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine (GARDASIL[〇!R]) in Japanese women aged 18 to 26 years. (2013)
  • Author(s): Yoshikawa H, Ebihara K, Tanaka Y, Noda K
  • Journal Title: Cancer Science Volume: 104(4) Issue: 4 Pages: 465-472
  • DOI: 10.1111/cas.12106
  • Peer Reviewed
• [Journal Article] Incidence of venous thromboembolism before treatment in cervical cancer and the impact of management on venous thromboembolism after commencement of treatment. (2013)
  • Author(s): Toyomi Satoh, Koji Matsumoto, Yumiko O Tanaka, Azusa Akiyama, Sari Nakao, Manabu Sakurai, Hiroyuki Ochi, Mamiko Onuki, Takeo Minaguchi, Hideyuki Sakurai, Hiroyuki Yoshikawa.
  • Journal Title: Thrombosis Research Volume: 131(4) Issue: 4 Pages: e127-e132
  • DOI: 10.1016/j.thromres.2013.01.027
  • Peer Reviewed
• [Journal Article] Clinical Management of Atypical Polypoid Adenomyoma of the Uterus. A Clinicopathological Review of 29 Cases (2013)
  • Author(s): Matsumoto T, Hiura M, Baba T, Ishiko O, Shiozawa T, Yaegashi N, Kobayashi H, Yoshikawa H, Kawamura N, Kaku T
  • Journal Title: Gynecol Oncol Volume: 129(1) Issue: 1 Pages: 54-57
  • DOI: 10.1016/j.ygyno.2012.12.040
  • Peer Reviewed
• [Journal Article] Diversity in size and signal intensity in multilocular cystic ovarian masses: New parameters for distinguishing metastatic from primary mucinous ovarian neoplasms. (2013)
  • Author(s): Tanaka YO, Okada S, Satoh T, Matsumoto K, Oki A, Saida T, Yoshikawa H, Minami M
  • Journal Title: J Magn Reson Imaging. Volume: (in press) Issue: 4 Pages: 794-801
  • DOI: 10.1002/jmri.24058
  • Peer Reviewed
• [Journal Article] HPVブロードペクトラム・ワクチンの開発 (2013)
  • Author(s): 近藤一成、吉川裕之
  • Journal Title: 産婦人科の実際金原出版 Volume: 62(3) Pages: 315-321
• [Journal Article] 病気がみえる (2013)
  • Author(s): 監修 井上裕美、峯岸 敬、大場 隆、松崎利也、鈴木(堀田)眞理、緒方 勤、竹下俊行、三鴨廣繁、北村邦夫、若槻明彦、吉川裕之、深谷孝夫、林 保良、新倉 仁、小林浩、松井英雄、中原健次、苛原 稔、杉浦真弓、福富隆志、松村讓兒
  • Journal Title: メディックメディア Volume: Vol.9
• [Journal Article] Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study. (2013)
  • Author(s): Fujii T
  • Journal Title: Int J Clin Oncol Volume: in press Issue: 6 Pages: 1091-101
  • DOI: 10.1007/s10147-012-0486-5
  • Peer Reviewed
• [Journal Article] HLA Class II DRB1*1302 1 allele protects against progression to cervical intraepithelial neoplasia grade 3:A multicenter, prospective, cohort study. (2012)
  • Author(s): Matsumoto K, Maeda H, Oki A, Takatsuka N, Yasugi T, Furuta R, Hirata R, Mitsuhashi A, Fujii T, Hirai Y, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Yoshikawa H
  • Journal Title: Int J Gynecol Cancer Volume: 22(3) Issue: 3 Pages: 471-478
  • DOI: 10.1097/igc.0b013e3182439500
  • Peer Reviewed
• [Journal Article] Do neutralizing antibody responses generated by human papillomavirus infections favor a better outcome of low-grade cervical lesions? (2012)
  • Author(s): Ochi H, Matsumoto K, Kondo K, Oki A, Furuta R, Hirai Y, Yasugi T, Takatsuka N, Maeda H, Mitsuhashi A, Fujii T, Kawana K, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Kanda T, Yoshikawa H
  • Journal Title: J Med Virol Volume: 84(7) Issue: 7 Pages: 1128-1134
  • DOI: 10.1002/jmv.23258
  • Peer Reviewed
• [Journal Article] A multi-institutional phase II trial of paclitaxel and carboplatin in the treatment of advanced or recurrent cervical cancer (2012)
  • Author(s): Kitagawa R, Katsumata N, Ando M, Shimizu C, Fujiwara Y, Yoshikawa H, Satoh T, Nakanishi T, Ushijima K, Kamura T
  • Journal Title: Gynecol Oncol Volume: 125(2) Issue: 2 Pages: 307-311
  • DOI: 10.1016/j.ygyno.2012.02.009
  • Peer Reviewed
• [Journal Article] Guidelines for office gynecology in Japan: Japan Society of Obstetrics and Gynecology and Japan Association of Obstetricians and Gynecologists 2011 edition. (2012)
  • Author(s): Takeda T, Wong TF, Adachi T, Ito K, Uehara S, Kanaoka Y, Kamada M, Kitagawa H, Koseki S, Gomibuchi H, Saito J, Shirasu K, Sueoka K, Sugimoto M, Suzuki M, Sumi T, Takeda S, Tasaka K, Noguchi Y, Fujii S, Fujii T, Fujiwara M, Maeda T, Matsumoto K, Momoeda M
  • Journal Title: J Obstet Gynaecol Res Volume: 38(4) Issue: 4 Pages: 615-631
  • DOI: 10.1111/j.1447-0756.2012.01858.x
  • Peer Reviewed
• [Journal Article] Subsequent risks for cervical precancer and cancer in women with low-grade squamous intraepithelial lesions unconfirmed by colposcopy-directed biopsy: results from a multicenter, prospective, cohort study (2012)
  • Author(s): Matsumoto K, Hirai Y, Furuta R, Takatsuka N, Oki A, Yasugi T, Maeda H, Mitsuhashi A, Fujii T, Kawana K, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Yoshikawa H
  • Journal Title: Int J Clin Oncol Volume: 17(3) Issue: 3 Pages: 233-239
  • DOI: 10.1007/s10147-011-0280-9
  • NAID: 10030951526
  • Peer Reviewed
• [Journal Article] Cigarette smoke stimulates VEGF-C expression in cervical intraepithelial neoplasia (CIN) 1 and 2 lesions. (2012)
  • Author(s): Inamine M, Nagai Y, Mitsuhashi A, Nagase S, Yaegashi N, Yoshikawa H, Aoki Y.
  • Journal Title: Int J Clin Oncol Volume: 17(5) Issue: 5 Pages: 498-504
  • DOI: 10.1007/s10147-011-0322-3
  • NAID: 10031144338
  • Peer Reviewed
• [Journal Article] Monoclonal antibodies recognizing cross-neutralization epitopes in human papillomavirus 16 minor capsid protein L2. (2012)
  • Author(s): Nakao S, Mori S, Kondo K, Matsumoto K, Yoshikawa H, Kanda T.
  • Journal Title: Virology Volume: 434(1) Issue: 1 Pages: 110-117
  • DOI: 10.1016/j.virol.2012.09.006
  • Peer Reviewed
• [Journal Article] Rapid genotyping of carcinogenic human papillomavirus by loop-mediated isothermal amplification using a new automated DNA test (ClinichipHPV). (2012)
  • Author(s): Satoh T, Matsumoto K, Fujii T, Sato O, Gemma N, Onuki M, Saito H, Aoki D, Hirai Y, Yoshikawa H
  • Journal Title: J Virol Methods Volume: 188(1-2) Issue: 1-2 Pages: 83-93
  • DOI: 10.1016/j.jviromet.2012.10.014
  • Peer Reviewed
• [Journal Article] HPV DNA テスト (2012)
  • Author(s): 吉川裕之
  • Journal Title: 産科と婦人科(増刊号)診断と治療社 Volume: 79 Pages: 121-125
• [Journal Article] 局所進行子宮頸癌のシスプラチン併用化学放射線療法に初めて優った臨床試験 (2012)
  • Author(s): 吉川裕之
  • Journal Title: CRITICAL EYES Volume: 42:2
• [Journal Article] 子宮頸がんの発生-我が国および世界の動向 (2012)
  • Author(s): 吉川裕之
  • Journal Title: 婦人科がん 日本臨牀社 Volume: 70(増刊号4) Pages: 73-76
• [Journal Article] HPV核酸検出検査試薬「インベーダー^<[〇!R]Cervista [〇!R]HPVHR>」の評価」 (2012)
  • Author(s): 松本光司、紀 美和、小泉基生、平井康夫、吉川裕之
  • Journal Title: 医療と検査機器・試薬 宇宙堂八木書店 Volume: 35(3) Pages: 387-394
• [Journal Article] 進みつつある子宮頸がんワクチンの普及と今後の展望 (2012)
  • Author(s): 吉川裕之
  • Journal Title: 婦人科産科 Volume: 66 Pages: 92-97
  • NAID: 40019187703
• [Journal Article] 婦人科学 (2012)
  • Author(s): 吉川裕之
  • Journal Title: 臨床医学の展望2012 Volume: 4580 Pages: 58-63
• [Journal Article] 子宮頸癌の発癌機序 (2012)
  • Author(s): 水口剛雄、吉川裕之
  • Journal Title: 産婦人科の実際 Volume: 61 Pages: 295-300
• [Journal Article] HPVワクチンの最新情報 (2012)
  • Author(s): 吉川裕之
  • Journal Title: 感染症 Volume: 42 Pages: 11-15
• [Journal Article] Do neutralizing antibody responses generated by human papillomavirus infections favor a better outcome of low-grade cervical lesions? (2012)
  • Author(s): Ochi H, Yoshikawa H, et al.
  • Journal Title: J Med Virol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Safety and efficacy of substituting nedaplatin after carboplatin hyper sensitivity reactions in gynecologic malignancies (2012)
  • Author(s): Michikami H, Yoshikawa H, et al.
  • Journal Title: J Obstet Gynecol Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] Impaired glucose tolerance during pregnancy : possible risk factor for vaginal/anorectal colonization by group B Streptococcus (2012)
  • Author(s): Obata-Yasuoka M, Yoshikawa H, et al.
  • Journal Title: J Obstet Gynecol Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] 総論HPVと悪性腫瘍 (2011)
  • Author(s): 吉川裕之
  • Journal Title: 細胞The CELL Volume: 43 Pages: 2-4
• [Journal Article] HPV (2011)
  • Author(s): 吉川裕之
  • Journal Title: ドクターサロンラジオNIKKEI Volume: 55 Pages: 35-39
• [Journal Article] 子宮頸癌自然史研究の最前線 (2011)
  • Author(s): 吉川裕之
  • Journal Title: 臨床検査 Volume: 55 Pages: 1399-1403
• [Journal Article] HPVワクチンの臨床試験成績update (2011)
  • Author(s): 吉川裕之
  • Journal Title: 臨床婦人科産科 Volume: 65 Pages: 1216-1219
• [Journal Article] ワクチンによる予防の進歩-HPVワクチン- (2011)
  • Author(s): 吉川裕之
  • Journal Title: 腫瘍内科 Volume: 8 Pages: 452-457
• [Journal Article] Prevalence and type distribution of human papillomavirus in healthy Japanese women aged 20 to 25 years old enrolled in a clinical study (2011)
  • Author(s): Konno R, Yoshikawa H, et al.
  • Journal Title: Cancer Sci Volume: 102 Issue: 4 Pages: 877-882
  • DOI: 10.1111/j.1349-7006.2011.01878.x
  • NAID: 10029292763
  • Peer Reviewed
• [Journal Article] Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno-associated virus vector (2011)
  • Author(s): Yagi H, Ogura T, Mizukami H, Urabe M, Hamada H, Yoshikawa H, Ozawa K and Kume A
  • Journal Title: J. Gene Med Volume: 13巻 Issue: 2 Pages: 114-122
  • DOI: 10.1002/jgm.1543
  • Peer Reviewed
• [Journal Article] Predicting the Progression of Cervical Precursor Lesions by Human Papillomavirus Genotyping : A Prospective Cohort Study (2011)
  • Author(s): Matsumoto K, Yoshikawa H, et al.
  • Journal Title: Int J Cancer Volume: 128 Issue: 12 Pages: 2898-2910
  • DOI: 10.1002/ijc.25630
  • Peer Reviewed
• [Journal Article] Ovarian serous surface papillary borderline tumors form sea anemone-like masses (2011)
  • Author(s): Tanaka YO, Yoshikawa H, et al.
  • Journal Title: J Magn Reson Imaging Volume: 33 Issue: 3 Pages: 633-640
  • DOI: 10.1002/jmri.22430
  • Peer Reviewed
• [Journal Article] Alveolar capillary dysplasia associated with duodenal atresia : Ultraso nographic findings of enlarged, highly echogenic lungs and gastric dilatation in a third-trimester fetus (2011)
  • Author(s): Obata-Yasuoka M, Yoshikawa H, et al.
  • Journal Title: J Obstet Gynecol Res Volume: 37 Issue: 7 Pages: 937-939
  • DOI: 10.1111/j.1447-0756.2010.01447.x
  • Peer Reviewed
• [Journal Article] Neoadjuvant chemotherapy for advanced ovarian cancer : overview of outcomes and unanswered auestions (2011)
  • Author(s): Onda T, Yoshikawa H
  • Journal Title: Expert Review of Anticancer Therapy Volume: 11 Issue: 7 Pages: 1053-1067
  • DOI: 10.1586/era.11.24
  • Peer Reviewed
• [Journal Article] Villinl, a diagnostic marker for endometrial adenocarcinoma with high grade nuclear atypia (2011)
  • Author(s): Nakamura E, Yoshikawa H, et al.
  • Journal Title: Cancer Biology & Therapy Volume: 12 Issue: 3 Pages: 181-190
  • DOI: 10.4161/cbt.12.3.15964
  • Peer Reviewed
• [Journal Article] Japan Society of Obstetrics and Gynecology ; Japan Association of Obstetricians and Gynecologists. Guidelines for obstetrical practice in Japan : Japan Society of Obstetrics and Gynecology(JSOG) and Japan Association of Obstetricians and Gynecologists(JAO (2011)
  • Author(s): Minakami H, Hiramatsu Y, Koresawa M, Fujii T, Hamada H, Iitsuka Y, Ikeda T, Ishikawa H, Ishimoto H, Itoh H, Kanayama N, Kasuga Y, Kawabata M, Konishi I, Matsubara S, Matsuda H, Murakoshi T, Ohkuchi A, Okai T, Saito S, Sakai M, Satoh S, Sekizawa A, Suzuki
  • Journal Title: J Obstet Gynaecol Res Volume: 37(9) Issue: 9 Pages: 1174-97
  • DOI: 10.1111/j.1447-0756.2011.01653.x
  • Peer Reviewed
• [Journal Article] The history of the Gynecologic Cancer Study Group(GCSG) of the Japan Clinical Oncology Group(JCOG) (2011)
  • Author(s): Onda T, Konishi I, Yoshikawa H, Kamura T.
  • Journal Title: Jpn J Clin Oncol Volume: 41(10) Issue: 10 Pages: 1156-61
  • DOI: 10.1093/jjco/hyr111
  • Peer Reviewed
• [Journal Article] Solid non-invasive ovarian masses on MR : Histopathology and a diagnostic approach (2011)
  • Author(s): Tanaka YO, Yoshikawa H, et al.
  • Journal Title: Eur J Radiol Volume: 80 Issue: 2 Pages: e91-e97
  • DOI: 10.1016/j.ejrad.2010.05.032
  • Peer Reviewed
• [Journal Article] The elongation of Fe-His Bond in α subunit induced by binding of the allosteric effector bezafibrate to hemoglobins (2011)
  • Author(s): Nagatomo S, Yoshikawa H, et al.
  • Journal Title: J Phys Chem B Volume: 115 Issue: 44 Pages: 12971-1297
  • DOI: 10.1021/jp205010m
  • Peer Reviewed
• [Journal Article] Solid non-invasive ovarian masses on MR : Histopathology and a diagnostic approach. (2011)
  • Author(s): Tanaka YO, Yoshikawa H, et al.
  • Journal Title: Eur J Radiol. Volume: in press(in press)
  • Peer Reviewed
• [Journal Article] Predicting the Progression of Cervical Precursor Lesions by Human Papillomavirus Genotyping : A Prospective Cohort Study. (2011)
  • Author(s): Matsumoto K, Yoshikawa H, et al.
  • Journal Title: Int J Cancer Volume: in press(in press)
  • Peer Reviewed
• [Journal Article] Alveolar capillary dysplasia associated with duodenal atresia : Ultrasonographic findings of enlarged, highly echogenic lungs and gastric dilatation in a third-trimester fetus. (2011)
  • Author(s): Obata-Yasuoka M, Yoshikawa H, etal.
  • Journal Title: J Obstet Gynecol Res Volume: in press(in press)
  • Peer Reviewed
• [Journal Article] A Randomized Phase II/III Trial of 3 Weekly Intraperitoneal versus Intravenous Carboplatin in Combination with Intravenous Weekly Dose-Dense Paclitaxel for Newly Diagnosed Ovarian, Fallopian Tube and Primary Peritoneal Cancer. (2011)
  • Author(s): Fujiwara K, Yoshikawa H, et al.
  • Journal Title: Jpn J Clin Oncol Volume: 41(2) Pages: 278-282
  • Peer Reviewed
• [Journal Article] Prevalence and type distribution of human papillomavirus in healthy Japanese women aged 20 to 25 years old enrolled in a clinical study (2011)
  • Author(s): Konno R, Yoshikawa H, et al.
  • Journal Title: Cancer Science Volume: in press(in press)
  • NAID: 10029292763
  • Peer Reviewed
• [Journal Article] Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno- associated virus vector. (2011)
  • Author(s): Yagi H, Yoshikawa H, et al.
  • Journal Title: Journal of Gene Medicine Volume: in press(in press)
  • Peer Reviewed
• [Journal Article] Guidelines for obstetrical practice in Japan : Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2011 edition. (2011)
  • Author(s): Minakami H, Yoshikawa H, et al.
  • Volume: (in press)
  • NAID: 120004608955
  • Peer Reviewed
• [Journal Article] Ovarian serous surface papillary borderline tumors form sea anemone-like masses. (2011)
  • Author(s): Tanaka YO, Yoshikawa H, et al.
  • Journal Title: J Magn Reson imaging. Volume: in press(in press)
  • Peer Reviewed
• [Journal Article] Neoadjuvant chemotherapy for advanced ovarian cancer : overview of outcomes and unanswered questions. (2011)
  • Author(s): Onda T, Yoshikawa H.
  • Journal Title: Expert Review of Anticancer Therapy Volume: in press(in press)
  • Peer Reviewed
• [Journal Article] The Optimal Debulking After Neoadjuvant Chemotherapy in Ovarian Cancer ; Proposal Based on Interval Look During Upfront Surgery Setting Treatment. (2010)
  • Author(s): Onda T, Yoshikawa H, et al.
  • Journal Title: Jpn J Clin Oncol Volume: 40(1) Pages: 36-41
  • Peer Reviewed
• [Journal Article] A Phase III Trial of Paclitaxel plus Carboplatin Versus Paclitaxel plus Cisplatin in Stage IVB, Persistent or Recurrent Cervical Cancer : Gynecologic Cancer Study Group/Japan Clinical Oncology Group Study (JCOG0505). (2010)
  • Author(s): Saito I, Yoshikawa H, et al.
  • Journal Title: Jpn J Clin Oncol Volume: 40(1) Pages: 90-93
  • Peer Reviewed
• [Journal Article] Outcomes of Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer : A Proposal for Patient Selection. (2010)
  • Author(s): Satoh T, Yoshikawa H, et al.
  • Journal Title: J Clin Oncol. Volume: 28(10) Pages: 1727-1732
  • Peer Reviewed
• [Journal Article] MRI of endometriotic cysts in association with ovarian carcinoma. (2010)
  • Author(s): Tanaka YO, Yoshikawa H, et al.
  • Journal Title: Am J Roentgenol Volume: 194(2) Pages: 355-361
  • Peer Reviewed
• [Journal Article] Hypoxia responsive mesenchymal stem cells derived from human umbilical cord blood are effective for bone repair. (2010)
  • Author(s): Nagano M, Yoshikawa H, et al.
  • Journal Title: Stem Cells Dev Volume: 19(8) Pages: 1195-1210
  • Peer Reviewed
• [Journal Article] Evidence-based guidelines for treatment of cervical cancer in Japan : Japan Society of Gynecologic Oncology (JSGO) 2007 edition. (2010)
  • Author(s): Nagase S, Yoshikawa H, et al.
  • Journal Title: Int J Clin Oncol Volume: 15(2) Pages: 117-124
  • NAID: 10027201880
  • Peer Reviewed
• [Journal Article] Efficacy of human papillomavirus 16/18 ASO4-adjuvanted vaccine in Japanese women aged 20 to 25 years : interim analysis of a phase 2 double-blind, randomized, controlled trial. (2010)
  • Author(s): Konno R, Yoshikawa H, et al.
  • Journal Title: Int J Gynecol Cancer Volume: 20(3) Pages: 404-410
  • Peer Reviewed
• [Journal Article] Interleukin-10-1082 gene polymorphism and susceptibility to Cervical Cancer among Japanese Women. (2010)
  • Author(s): Matsumoto K, Yoshikawa H, et al.
  • Journal Title: Jpn J Clin Oncol Volume: 40(11) Pages: 1113-1116
  • Peer Reviewed
• [Journal Article] Characterization of the acid-alkaline transition in the individual subunits of human adult and fetal methemoglobins. (2010)
  • Author(s): Shibata T, Yoshikawa H, et al.
  • Journal Title: Biochemistry Volume: 148(2) Pages: 217-229
  • Peer Reviewed
• [Journal Article] Efficacy of Human Papillomavirus Type 16/18 ASO4-Adjuvanted Vaccine in Japanese Women Aged 20 to 25 Years : Final Analysis of a Phase 2 Double-Blind, Randomized Controlled Trial. (2010)
  • Author(s): Konno R, Yoshikawa H, et al.
  • Journal Title: Int J Gynecol Cancer Volume: 20(5) Pages: 847-855
  • Peer Reviewed
• [Journal Article] High-dose unfractionated heparin therapy in a pregnant patient with an tiphospolipid syndrome : a case report. (2010)
  • Author(s): Ogishima H, Yoshikawa H, et al.
  • Journal Title: Int J Rheum Dis Volume: 13(3)
  • Peer Reviewed
• [Journal Article] Can MRI predict local control rate of uterine cervical cancer immediately after radiation therapy? (2010)
  • Author(s): Saida T, Yoshikawa H, et al.
  • Journal Title: Magn Reson Med Sci Volume: 9(3) Pages: 141-148
  • NAID: 10027851334
  • Peer Reviewed
• [Journal Article] Cervical Cancer Working Group report. (2010)
  • Author(s): Konno R, Yoshikawa H, et al.
  • Journal Title: Jpn J Clin Oncol Volume: 40 Suppl 1
  • Peer Reviewed
• [Journal Article] Tobacco Smoking and Regression of Low-Grade Cervical Abnormalities. (2010)
  • Author(s): Matsumoto K, Yoshikawa H, et al.
  • Journal Title: Cancer Sciences Volume: 101(9) Pages: 2065-2073
  • NAID: 10027831777
  • Peer Reviewed
• [Journal Article] Evidence-based guidelines for treatment of uterine body neoplasm in Japan: Japan Society of Gynecologic Oncology (JSGO) 2009 edition. (2010)
  • Author(s): Nagase S, Yoshikawa H, et al.
  • Journal Title: Int J Clin Oncol Volume: 15(6) Pages: 531-542
  • NAID: 10027665090
  • Peer Reviewed
• [Journal Article] Identification of human placenta-derived mesenchymal stem cells involved in re-endothelialization. (2010)
  • Author(s): Tran TC, Yoshikawa H, et al.
  • Journal Title: J Cell Physiol Volume: 226(1) Pages: 224-235
  • Peer Reviewed
• [Journal Article] HPVワクチンの現状 (2010)
  • Author(s): 吉川裕之
  • Journal Title: 臨床婦人科産科 Volume: 64(3) Pages: 252-255
• [Journal Article] HPVワクチンの最新臨床試験結果と接種の実際 (2010)
  • Author(s): 吉川裕之
  • Journal Title: 産婦人科の実際 Volume: 59(4) Pages: 623-628
• [Journal Article] 子宮頸癌予防ワクチンの世界における現状と日本の問題点 (2010)
  • Author(s): 吉川裕之
  • Journal Title: 癌と化学療法 Volume: 37(6) Pages: 971-975
• [Journal Article] 子宮頸がんの疫学 (2010)
  • Author(s): 吉川裕之
  • Journal Title: 最新医療情報誌 アニムス Volume: 63 Pages: 13-16
• [Journal Article] ヒトパピローマウイルスワクチンによる子宮頸がん征圧研究の最近の進歩 (2010)
  • Author(s): 吉川裕之
  • Journal Title: 血液・腫瘍科 Volume: 61(1) Pages: 82-93
  • NAID: 40019064309
• [Journal Article] HPV (2010)
  • Author(s): 吉川裕之
  • Journal Title: 臨床検査(増刊号) Volume: 54(11) Pages: 1371-1375
• [Journal Article] 子宮頸がんとHPVワクチン (2010)
  • Author(s): 吉川裕之
  • Journal Title: 臨床とウイルス Volume: 38(4) Pages: 312-317
  • NAID: 10027748206
• [Journal Article] 1BおよびII期子宮頸がんにはどのような治療が推奨されるか (2010)
  • Author(s): 吉川裕之
  • Journal Title: EBMがん化学療法・分子標的治療法 Pages: 404-406
• [Journal Article] 局所進行(IIIA-IVA期)子宮頸がんにはどのような治療が推奨されるか (2010)
  • Author(s): 吉川裕之
  • Journal Title: EBMがん化学療法・分子標的治療法 Pages: 407-409
• [Journal Article] ヒトパピローマウイルスワクチン (2010)
  • Author(s): 吉川裕之
  • Journal Title: 小児内科 Volume: 42(12) Pages: 1967-1970
• [Journal Article] 広汎子宮全摘出(小林術式) (2010)
  • Author(s): 吉川裕之
  • Journal Title: OGS Now(産婦人科手術シリーズ) Volume: 5 Pages: 46-55
• [Journal Article] HPVワクチンの最新情報 (2010)
  • Author(s): 吉川裕之
  • Journal Title: 化学療法の領域 Volume: 27(2) Pages: 91-96
• [Journal Article] HPVワクチン (2010)
  • Author(s): 吉川裕之
  • Journal Title: 医薬ジャーナル Volume: 47(2) Pages: 115-120
• [Journal Article] Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study.
  • Author(s): Fujii T, Takatsuka N, Nagata C, Matsumoto K, Oki A, Furuta R, Maeda H, Yasugi T, Kawana K, Mitsuhashi A, Hirai Y, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, and Yoshikawa H.
  • Journal Title: Int J Clin Oncol Volume: (in press)
  • Peer Reviewed
• [Presentation] HPVワクチンとHPV検査による子宮頸癌予防 (2012)
  • Author(s): 吉川裕之
  • Organizer: 第51回日本臨床細胞学会秋期大会
  • Place of Presentation: 新潟
  • Year and Date: 2012-11-10
• [Presentation] 子宮頸部最小偏倚型粘液性腺癌(MDA)と鑑別を要した分葉状頸管腺過形成(LEGH)の一例 (2012)
  • Author(s): 小宮春奈、小貫麻美子、加藤 敬、田中勝洋、吉川智之、櫻井 学、八木洋也、越智寛幸、水口剛雄、松本光司、佐藤豊実、吉川裕之
  • Organizer: 第124回関東連合産科婦人科学会総会・学術集会
  • Place of Presentation: 山梨
  • Year and Date: 2012-10-28
• [Presentation] シンポジウム「子宮頸がん治療の近未来展望 化学療法への期待と縮小手術」 (2012)
  • Author(s): 吉川裕之
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-10-25
• [Presentation] 発表・座長「子宮頸部発癌における喫煙の関与とそのしくみ-子宮頸部前癌病変の消失・進展と喫煙との関連に関する総合解析-」 (2012)
  • Author(s): 吉川裕之
  • Organizer: 平成23年度助成研究発表会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-18
• [Presentation] Does paclitaxel plus carboplatin (TC) substitute for paclitaxel plus cisplatin (TP) in cervical cancer without prior platinum treatment (2012)
  • Author(s): Tanabe H,Kitagawa R,Shibata T,Saito M,Okamoto A,Takakura S,Sasaki H,Ochiai K,Yoshikawa H,Kamura T
  • Organizer: The 37th ESMO
  • Place of Presentation: Vienna,Austria
• [Presentation] IVb 期・再発子宮頸癌に対するPaclitaxel/Cisplatin 併用療法とPaclitaxel/Carboplatin併用療法のランダム化比較試験(JCOG0505) (2012)
  • Author(s): 喜多川 亮、勝俣 範之、柴田 大朗、中西透、西村 貞子、西尾 真、高野 政志、佐藤 豊実、横田 治重、落合 和徳、紀川 純三、小林 裕明、金戸 啓介、吉川裕之、嘉村 敏治
  • Organizer: 第10回日本臨床腫瘍学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 当院における子宮頸癌4期の治療成績 (2012)
  • Author(s): 志鎌あゆみ、佐藤豊実、新 夏樹、加藤 敬、道上大雄、吉川智之、越智寛幸、小貫麻美子、水口剛雄、松本光司、櫻井英幸、吉川裕之
  • Organizer: 第52回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 東京
• [Presentation] コルポスコピー下生検の見逃しを減らすための前方視的研究 (2012)
  • Author(s): 中村優子、松本光司、島袋剛二、西出 健、永井公洋、佐藤豊実、沖 明典、吉川裕之
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] CICIN2-3治療後のフォローアップにおけるHPV DNA検査の有用性:メタアナリシス解析による検討 (2012)
  • Author(s): 小貫麻美子、松本光司、越智寛幸、岡田智志、水口剛雄、佐藤豊実、沖 明典、吉川裕之
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] ヒトパピローマウイルス(HPV)16 型副キャプシド蛋白質L2の交差性中和エピトープの解析:型共通HPVワクチンの開発を目指して (2012)
  • Author(s): 中尾砂里、松本光司、近藤一成、吉川裕之
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] LSIL・HSILトリアージのためのHPVタイピング検査の有用性 (2012)
  • Author(s): 松本光司、中村優子、島袋剛二、西出 健、永井公洋、佐藤豊実、沖 明典、吉川裕之
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] LSIL･HSILトリアージのためのHPVタイピング検査の有用性 (2012)
  • Author(s): 松本光司
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] ヒトパピローマウイルス(HPV)16型副キャプシド蛋白質Ｌ2の交差性中和エピトープの解析:型共通HPVワクチンの開発を目指して (2012)
  • Author(s): 中尾砂里
  • Organizer: 第64回日本産科婦人科学会学術講演
  • Place of Presentation: 神戸
• [Presentation] CICIN2-3治療後のフォローアップにおけるHPV DNA検査の有用性：メタアナリシス解析による検討 (2012)
  • Author(s): 小貫麻美子
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] サーバリックス 海外、国内における最新の臨床試験結果 (2012)
  • Author(s): 吉川裕之
  • Organizer: 第1回ワクチンフォーラム
  • Place of Presentation: 東京
  • Invited
• [Presentation] 子宮頸がんとHPV -ワクチンとHPVテスト- (2012)
  • Author(s): 吉川裕之
  • Organizer: HPVワクチンフォーラム
  • Place of Presentation: 四日市
  • Invited
• [Presentation] 子宮頸部発癌における喫煙の関与とそのしくみ-子宮頸部前癌病変の消失・進展と喫煙との関連に関する総合解析- (2012)
  • Author(s): 吉川裕之
  • Organizer: 平成23年度助成研究発表会
  • Place of Presentation: 東京
• [Presentation] IVb期・再発子宮頸癌に対するPaclitaxel/Cisplatin併用療法とPaclitaxel/Carboplatin併用療法のランダム化比較試験(JCOG0505) (2012)
  • Author(s): 喜多川 亮
  • Organizer: 第10回日本臨床腫瘍学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Does paclitaxel plus carboplatin (TC) substitute for paclitaxel plus cisplatin (TP) in cervical cancer without prior platinum treatment? (subset analysis of Japan Clinical Oncology Group trial (JCOG 0505). (2012)
  • Author(s): Tanabe H
  • Organizer: The 37th The European Society for Medical Oncology (ESMO)
  • Place of Presentation: Vienna，Austria
• [Presentation] 子宮頸がん治療の近未来展望 化学療法への期待と縮小手術 (2012)
  • Author(s): 吉川裕之
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 子宮頸部最小偏倚型粘液性腺癌(MDA)と鑑別を要した分葉状頸管腺過形成(LEGH)の一例 (2012)
  • Author(s): 小宮春奈
  • Organizer: 第124回関東連合産科婦人科学会総会･学術集会
  • Place of Presentation: 山梨
• [Presentation] HPVﾜｸﾁﾝとHPV検査による子宮頸癌予防 (2012)
  • Author(s): 吉川裕之
  • Organizer: 第51回日本臨床細胞学会秋期大会
  • Place of Presentation: 新潟
• [Presentation] HPVワクチンの最新情報-特に小児科医のために- (2011)
  • Author(s): 吉川裕之
  • Organizer: 第36回東日本小児科学会
  • Place of Presentation: つくば(招待講演)
  • Year and Date: 2011-11-23
• [Presentation] HPVワクチンの最新情報と将来の展望 (2011)
  • Author(s): 吉川裕之
  • Organizer: 第131回日本産科婦人科学会東北連合地方部会総会・学術講演会
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2011-06-05
• [Presentation] 子宮頸がん予防のためのHPVワクチン;最新情報を含めて (2011)
  • Author(s): 吉川裕之
  • Organizer: 第59回日本化学療法学会総会
  • Place of Presentation: 札幌(招待講演)
• [Presentation] 子宮頸部異形性上皮における喫煙がVEGF-C発現・病変の存続に及ぶ影響 (2011)
  • Author(s): 稻嶺盛彦、吉川裕之, 他
  • Organizer: 第63回日本産科婦人科学会・総会・学術講演会
  • Place of Presentation: 大阪
• [Presentation] ヒトパピローマウイルスのタイプとCIN3への進展リスク (2011)
  • Author(s): 松本光司、吉川裕之, 他
  • Organizer: 第63回日本産科婦人科学会・総会・学術講演会
  • Place of Presentation: 大阪
• [Presentation] 子宮頸部発癌の宿主要因としてのHLA遺伝子多型の解析-第一報 (2011)
  • Author(s): 沖明典、吉川裕之, 他
  • Organizer: 第63回日本産科婦人科学会・総会・学術講演会
  • Place of Presentation: 大阪
• [Presentation] Smoking And Alcohol Drinking Affects Outcome Of Low-Grade CIN (2011)
  • Author(s): Fujii T, Yoshikawa H, et al.
  • Organizer: The 27th International Papillomavirus Conference and Clinical Workshop
  • Place of Presentation: Berlin, Germany
• [Presentation] Monoclonal Antibodies Recognizing Crioss-neutralization Epitopes In HPV16 L2 AA56-75 Region (2011)
  • Author(s): Mori S, Yoshikawa Y, et al.
  • Organizer: The 27th International Papillomavirus Conference and Clinical Workshop
  • Place of Presentation: Berlin, Germany
• [Presentation] 低悪性度子宮頸部上皮内病変における抗酸化微量栄養素、喫煙、アルコール摂取に関するコホート研究の解析結果 (2011)
  • Author(s): 藤井多久磨、吉川裕之, 他
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] HPV16副キャプシドタンパク質L2の交差性中和エピトープを認識するモノクローナル抗体の分離と解析 (2011)
  • Author(s): 中尾砂里、吉川裕之, 他
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 疫学研究とHPVワクチン (2010)
  • Author(s): 吉川裕之
  • Organizer: 東京慈恵会医科大学産婦人科学教室同窓会
  • Place of Presentation: 東京慈恵大学(東京)
  • Year and Date: 2010-11-20
• [Presentation] HPVワクチン:子宮頸がんと尖圭コンジローマの予防 (2010)
  • Author(s): 吉川裕之
  • Organizer: みちのくSTDセミナーin仙台2010
  • Place of Presentation: 仙台市医師会館(宮城)
  • Year and Date: 2010-11-13
• [Presentation] HPV関連疾患・疫学-4価HPVワクチン臨床効果 (2010)
  • Author(s): 吉川裕之
  • Organizer: HPV Consultant Meeting
  • Place of Presentation: ザ・リッツカールトン大阪(大阪)
  • Year and Date: 2010-09-04
• [Presentation] 子宮頸がん予防の為のHPVワクチン (2010)
  • Author(s): 吉川裕之
  • Organizer: 第1回つくばセントラル病院 臨床懇話会
  • Place of Presentation: つくばセントラル病院(茨城)
  • Year and Date: 2010-09-01
• [Presentation] 子宮頸がんは予防できます°予防ワクチンの意義・検診の重要性について (2010)
  • Author(s): 吉川裕之
  • Organizer: 子宮頸がんからすべての女性を守りたい
  • Place of Presentation: 常総市生涯学習センター(茨城)
  • Year and Date: 2010-08-20
• [Presentation] HPVワクチン-産婦人科医の立場から (2010)
  • Author(s): 吉川裕之
  • Organizer: 第33回日本産婦人科医会性教育指導セミナー全国大会
  • Place of Presentation: ホテレグリーンハトンク津(三重)
  • Year and Date: 2010-08-01
• [Presentation] 子宮頸癌の発生と予防 (2010)
  • Author(s): 吉川裕之
  • Organizer: 第20回がん臨床研究フォーラム
  • Place of Presentation: 国立がん研究センター(東京)
  • Year and Date: 2010-06-04
• [Presentation] 産婦人科治療とガイドラインについて (2010)
  • Author(s): 吉川裕之
  • Organizer: 平成22年度日産婦学会鳥取地方部会総会
  • Place of Presentation: 鳥取県医師会館(鳥取)
  • Year and Date: 2010-05-16
• [Presentation] ワクチンによる子宮頸癌の予防戦略 (2010)
  • Author(s): 吉川裕之
  • Organizer: 第3回彩の国 婦人科化学療法講演会
  • Place of Presentation: パステルホテル大宮(埼玉)
  • Year and Date: 2010-04-09
• [Presentation] HPVワクチン (2010)
  • Author(s): 今野良、吉川裕之
  • Organizer: 第62回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] HPVワクチンのすすめ;思春期女性に対して (2010)
  • Author(s): 吉川裕之
  • Organizer: 第29回日本思春期学会総会・学術集会
  • Place of Presentation: グランドハトンク小樽(北海道)
• [Presentation] 子宮頸がんとHPV;疫学研究とワクチンによる予防 (2010)
  • Author(s): 吉川裕之
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] 子宮がん・卵巣がん (2010)
  • Author(s): 吉川裕之
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都国際会館(京都)
• [Presentation] 子宮頸がんと HPV -ワクチンとHPVテスト-
  • Author(s): 吉川裕之
  • Organizer: HPVワクチンフォーラム
  • Place of Presentation: 四日市(三重)
• [Presentation] サーバリックス 海外、国内における最新の臨床試験結果
  • Author(s): 吉川裕之
  • Organizer: 第1回ワクチンフォーラム
  • Place of Presentation: 東京
• [Book] 産婦人科の実際 (2013)
  • Author(s): 近藤一成
  • Publisher: ＨＰＶブロードペクトラム・ワクチンの開発
• [Book] 病気がみえる Vol.9 (2013)
  • Author(s): 監修 井上裕美
  • Publisher: 婦人科・乳腺外科
• [Book] 産科と婦人科(増刊号) (2012)
  • Author(s): 吉川裕之
  • Publisher: HPV DNA テスト
• [Book] CRITICAL EYES (2012)
  • Author(s): 吉川裕之
  • Total Pages: 2
  • Publisher: 局所進行子宮頸癌のシスプラチン併用化学放射線療法に初めて優った臨床試験
• [Book] 婦人科がん (2012)
  • Author(s): 吉川裕之
  • Publisher: 子宮頸がんの発生-我が国および世界の動向-
• [Book] 医療と検査機器･試薬 (2012)
  • Author(s): 松本光司
  • Publisher: インベーダー:Cervista :HPVHRの評価