| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Research Abstract |
We found 5 kinds of compound (the compound A ~ E), which had inhibitory activity of cyclinA expression, from a compound's library including approximately 10,000 kinds of small molecular compound. Of these 5 compounds, the compound C most strongly inhibited the growth of several cancer cells and indicated synergistic effects to cisplatin and paclitaxel. This compound C inhibited the growth of xenograft of HEC1B cell in nude mice.These results suggested that this is a promising compound for novel cyclin A targeted anti-cancer therapy of endometrial carcinoma.
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