The molecular targeted therapy for endometrial cancer; the basicanalysis of novel cyclinA inhibitor
| Project/Area Number |
22390310
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HORIUCHI Akiko 信州大学, 医学部附属病院, 特任研究員 (80334895)
SUZUKI Akihisa 信州大学, 医学部, 助教 (10547095)
TAKATSU Akiko 信州大学, 医学部附属病院, 助教 (90447730)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 子宮内膜癌 / サイクリン / 抗癌剤感受性 / 分子標的 / MAPK / サイクリンA / 子官内膜癌 |
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| Research Abstract |
We found 5 kinds of compound (the compound A ~ E), which had inhibitory activity of cyclinA expression, from a compound's library including approximately 10,000 kinds of small molecular compound. Of these 5 compounds, the compound C most strongly inhibited the growth of several cancer cells and indicated synergistic effects to cisplatin and paclitaxel. This compound C inhibited the growth of xenograft of HEC1B cell in nude mice.These results suggested that this is a promising compound for novel cyclin A targeted anti-cancer therapy of endometrial carcinoma.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular end cervical glandular hyperplasia of the uterine cervix : a multicenter study of clinico pathology and magnetic resonance imaging findings2011
Author(s)
Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I.
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Journal Title
Int J Gynecol Cancer
Volume: 21(7)
Pages: 1287-96
DOI
Related Report
Peer Reviewed
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