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The molecular targeted therapy for endometrial cancer; the basicanalysis of novel cyclinA inhibitor

Research Project

Project/Area Number 22390310
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionShinshu University

Principal Investigator

SHIOZAWA Tanri  信州大学, 医学部, 教授 (20235493)

Co-Investigator(Kenkyū-buntansha) HORIUCHI Akiko  信州大学, 医学部附属病院, 特任研究員 (80334895)
SUZUKI Akihisa  信州大学, 医学部, 助教 (10547095)
TAKATSU Akiko  信州大学, 医学部附属病院, 助教 (90447730)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords子宮内膜癌 / サイクリン / 抗癌剤感受性 / 分子標的 / MAPK / サイクリンA / 子官内膜癌
Research Abstract

We found 5 kinds of compound (the compound A ~ E), which had inhibitory activity of cyclinA expression, from a compound's library including approximately 10,000 kinds of small molecular compound. Of these 5 compounds, the compound C most strongly inhibited the growth of several cancer cells and indicated synergistic effects to cisplatin and paclitaxel. This compound C inhibited the growth of xenograft of HEC1B cell in nude mice.These results suggested that this is a promising compound for novel cyclin A targeted anti-cancer therapy of endometrial carcinoma.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (44 results)

All 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 12 results) Presentation (29 results) (of which Invited: 1 results)

  • [Journal Article] Immunohistochemical expression of core 2 β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factor.2013

    • Author(s)
      Miyamoto T
    • Journal Title

      Histopathology

      Volume: Feb 9 [Epub ahead of print] Issue: 7 Pages: 986-93

    • DOI

      10.1111/his.12107

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells.2012

    • Author(s)
      Mitsuhashi Y, Horiuchi A, Miyamoto T, Kashima H, Suzuki A, Shiozawa T
    • Journal Title

      Histopathology.

      Volume: 30 Issue: 5 Pages: 826-37

    • DOI

      10.1111/j.1365-2559.2011.04158.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of pelvic inflammation-related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis.2012

    • Author(s)
      Fuseya C, Horiuchi A, Hayashi A, Suzuki A, Miyamoto T, Hayashi T, Shiozawa T.
    • Journal Title

      Hum Pathol.

      Volume: 43 Issue: 11 Pages: 1964-72

    • DOI

      10.1016/j.humpath.2012.02.005

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] LEGH(lobular endocervical grandular hyperplasia)は悪性腺腫の前駆病変か?2012

    • Author(s)
      高津亜希子、塩沢丹里
    • Journal Title

      産婦人科の実際

      Volume: 61巻 Pages: 1539-1543

    • NAID

      40019469026

    • Related Report
      2012 Final Research Report
  • [Journal Article] 子宮体癌の増殖制御と性ステロイドホルモン (特集 子宮体癌の生物学的特性から診断・治療まで)2012

    • Author(s)
      塩沢丹里
    • Journal Title

      産科と婦人科

      Volume: 79巻 Pages: 209-217

    • NAID

      40019188023

    • Related Report
      2012 Final Research Report
  • [Journal Article] Laser-captured micro dissection-microarray analysis of the genes involved in endometrial carcinogenesis : stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance2011

    • Author(s)
      Miyamoto T, Kashima H, Suzuki A, Kikuchi N, Konishi I, Seki N, Shiozawa T.
    • Journal Title

      Hum Pathol

      Volume: 42(9) Issue: 9 Pages: 1265-74

    • DOI

      10.1016/j.humpath.2010.07.027

    • NAID

      120007107405

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular end cervical glandular hyperplasia of the uterine cervix : a multicenter study of clinico pathology and magnetic resonance imaging findings2011

    • Author(s)
      Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I.
    • Journal Title

      Int J Gynecol Cancer

      Volume: 21(7) Issue: 7 Pages: 1287-96

    • DOI

      10.1097/igc.0b013e31821f746c

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma.2011

    • Author(s)
      Miyamoto T, Asaka R, Suzuki A, Takatsu A, Kashima H, Shiozawa T.
    • Journal Title

      Exp Mol Pathol.

      Volume: 91 Issue: 2 Pages: 563-8

    • DOI

      10.1016/j.yexmp.2011.06.002

    • NAID

      120007107372

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical expression of keratan sulfate: a possible diagnostic marker for carcinomas of the female genital tract.2011

    • Author(s)
      Miyamoto T, Ishii K, Asaka R, Suzuki A, Takatsu A, Kashima H, Shiozawa T.
    • Journal Title

      J Clin Pathol.

      Volume: 64 Issue: 12 Pages: 1058-63

    • DOI

      10.1136/jclinpath-2011-200231

    • NAID

      120007107373

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peutz-Jeghers症候群と子宮頸部腫瘍 (特集 婦人科における遺伝性腫瘍の取扱いの実際)2011

    • Author(s)
      高津亜希子, 塩沢丹里
    • Journal Title

      産科と婦人科

      Volume: 78巻 Pages: 1096-1100

    • NAID

      40018951725

    • Related Report
      2012 Final Research Report
  • [Journal Article] Immunohistochemical detection of steroid receptor cofactors in ovarian endometriosis: involvement of down-regulated SRC-1 expression in the limited growth activity of the endometriotic epithelium.2010

    • Author(s)
      Suzuki A, Horiuchi A, Oka K, Miyamoto T, Kashima H, Shiozawa T.
    • Journal Title

      Virchows Arch.

      Volume: 456 Issue: 4 Pages: 433-41

    • DOI

      10.1007/s00428-010-0884-x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical detection of his tone deacetylases in endometrial carcinoma : involvement of his tone deacetylase 2 in the proliferation of endometrial carcinoma cells2010

    • Author(s)
      Fakhry H, Miyamoto T, Kashima H, Suzuki A, Ke H, Konishi I, Shiozawa T.
    • Journal Title

      Hum Pathol

      Volume: 41(6) Issue: 6 Pages: 848-58

    • DOI

      10.1016/j.humpath.2009.11.012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Type-specific roles of his tone deacetylase(HDAC) over expression in ovarian carcinoma : HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with down regulation of E-cadherin2010

    • Author(s)
      Hayashi A, Horiuchi A, Kikuchi N, Hayashi T, Fuseya C, Suzuki A, Konishi I, Shiozawa T.
    • Journal Title

      Int J Cancer

      Volume: 127(6) Issue: 6 Pages: 1332-46

    • DOI

      10.1002/ijc.25151

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shiozawa T. Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin2010

    • Author(s)
      Suzuki A, Horiuchi A, Ashida T, Miyamoto T, Kashima H, Nikaido T, Konishi I
    • Journal Title

      J Cell Mol Med

      Volume: 14(9) Issue: 9 Pages: 2305-17

    • DOI

      10.1111/j.1582-4934.2009.00839.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin.2010

    • Author(s)
      Suzuki A, et al.
    • Journal Title

      J Cell Mol Med.2010

      Volume: 14(9) Pages: 2305-17

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子宮頸部と嚢胞性病変の取り扱い、子宮内膜癌の発生とエストロゲン2012

    • Author(s)
      塩沢丹里
    • Organizer
      平成 24 年度山口県産婦人科医会研修 会
    • Place of Presentation
      特別講演 山口
    • Year and Date
      2012-11-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Preoperative Differential Diagnosis of Minimal Deviation Adenocarcinoma (MDA) and Lobular Endocervical Glandular Hyperplasia (LEGH) of the Uterine Cervix by Clininopathology and Magnetic Resonance Imaging (MRI) Findings2012

    • Author(s)
      Shiozawa T
    • Organizer
      Asian Society of Gynecologic Oncology 2nd International Workshop in Gynecologic Oncology(ASGO)
    • Place of Presentation
      招待講演 京都
    • Year and Date
      2012-09-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮内膜癌の発生とエストロゲン2012

    • Author(s)
      塩沢丹里
    • Organizer
      岩手産科婦人科学会集談会
    • Place of Presentation
      岩手
    • Year and Date
      2012-01-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Sirtuin1(SIRT1),a longevity gene,is over-expressed in endometrial carcinoma.2012

    • Author(s)
      Asaka R,Miymamoto T,Suzuki A,IshikawaK,Yamada Y,Kobara H,Shiozawa T
    • Organizer
      14th International Gynecologic Cancer Society(IGCS)
    • Place of Presentation
      Oral Vancouver Canada
    • Related Report
      2012 Final Research Report
  • [Presentation] The expression of lipocalin2 in ovarian carcinoma and endometriosis.2012

    • Author(s)
      Yamada Y,Miyamoto T,Asaka R,Ishikawak,Kobara H,Suzuki A,Shiozawa T
    • Organizer
      14th International Gynecologic Cancer Society(IGCS)
    • Place of Presentation
      Oral Vancouver Canada
    • Related Report
      2012 Final Research Report
  • [Presentation] おけるSirtuin1(SIRT1)の発現と機能の検討2012

    • Author(s)
      浅香亮一、宮本 強、石川香織、山田 靖、小原久典、鈴木昭久、塩沢丹里
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ポスター 札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮内膜癌におけるポリコーム遺伝子 mRNA 発現と臨床病理学的意義の検討.2012

    • Author(s)
      石川香織、宮本 強、 鈴木昭久、山田 靖、浅香亮一、塩沢丹里
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ポスター 札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 卵巣明細胞腺癌におけるレトロウイルス cDNA ライブラリーを用いた機能的スクリーニングの試み2012

    • Author(s)
      鈴木昭久、宮本 強、小原久典、山田 靖、石川香織、浅香亮一、塩沢丹里
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ポスター 札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 正常子宮内膜および子宮内膜癌における sirtuin1 発現の検討2012

    • Author(s)
      浅香亮一、宮本 強、 鈴木昭久、鹿島大靖、塩沢丹里
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      一般講演 神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 薬剤ライブラリーを用いたサイクリンAを標的とする新規抗腫瘍薬同定の試み2011

    • Author(s)
      鈴木昭久
    • Organizer
      第63回日本産科婦人科学会・総会・学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮体癌の発生とエストロゲン.2011

    • Author(s)
      塩沢丹里
    • Organizer
      第7回子宮体癌治療に関するシンポジウム
    • Place of Presentation
      要望講演 東京
    • Year and Date
      2011-06-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮内膜癌の発生とエストロゲン2011

    • Author(s)
      塩沢丹里
    • Organizer
      福井県産婦人科医会第71回冬期臨床研究会
    • Place of Presentation
      特別講演福井
    • Year and Date
      2011-02-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Immunohistochemical expression of Core2 β1-6 N-acetylglucosaminyl transferase 1 in the endometrial carcinoma;a novel potential prognostic factor.2011

    • Author(s)
      Asaka R,Miyamoto T,Suzuki A,Takatsu A, Kashima H,Nakayama J,Shiozawa T
    • Organizer
      Asian Society of Gynecologic Oncology
    • Place of Presentation
      Poster korea
    • Related Report
      2012 Final Research Report
  • [Presentation] Pre-operative diagnosis and the management of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix:a multi-center,retrospective study2011

    • Author(s)
      Takatsu A,Imanishi T,Tunoda H,Tanino S, Asaka R,Kashima H,Miyamoto T,Shiozawa T
    • Organizer
      Asian Society of Gynecologic Oncology
    • Place of Presentation
      Poster korea
    • Related Report
      2012 Final Research Report
  • [Presentation] Lasr captured microdissection-microarray analysis of the genes innolved in endometrial carcinogenesis:stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria,and its functional relevance2011

    • Author(s)
      Miyamoto T,Asaka R,Imanishi T,Kashima H,Shiozawa T
    • Organizer
      Asian Society of Gynecologic Oncology
    • Place of Presentation
      Oral korea
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮内膜癌の新規予後因子としての糖転移酵素 C2GnT1 発現2011

    • Author(s)
      浅香亮一、宮本 強、鈴木昭久、高津亜希子、鹿島大靖、中山 淳、塩沢丹里
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      ポスター 名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 薬剤ライブラリーを用いたサイクリン A を標的とする新規抗腫瘍薬同定の試み2011

    • Author(s)
      鈴木昭久、宮本 強、鹿島大靖、塩沢丹里
    • Organizer
      第63回日本産科婦人科学会・総会・学術講演会
    • Place of Presentation
      ポスター 大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮体癌の発生とエストロゲン2010

    • Author(s)
      塩沢丹里
    • Organizer
      第24回日本臨床細胞学会関東連合学術集会
    • Place of Presentation
      教育講演 軽井沢
    • Year and Date
      2010-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 卵巣子宮内膜症の癌化におけるミスマッチ修復機構異常の関与2010

    • Author(s)
      布施谷千穂、堀内晶子、林 晶子、高津亜希子、鈴木昭久、塩沢丹里
    • Organizer
      第9回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      一般講演 大阪
    • Year and Date
      2010-09-10
    • Related Report
      2012 Final Research Report
  • [Presentation] エストロゲンと子宮内膜癌update.2010

    • Author(s)
      塩沢丹里
    • Organizer
      第122回近畿産婦人科学会オープニングレクチャー
    • Place of Presentation
      オープニングレクチャー 京都
    • Year and Date
      2010-06-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 内膜癌におけるサイクリンAmRNAの3'非翻訳領域を介した調節2010

    • Author(s)
      鈴木昭久
    • Organizer
      日本産科婦人科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮内膜腺上皮におけるケラタン硫酸および C2GnT1 発現とその診断への応用.2010

    • Author(s)
      宮本 強、石井恵子、小原久典、浅香亮一、高津亜希子、鈴木昭久、鹿島大靖、中山 淳、塩沢丹里
    • Organizer
      第49回日本臨床細胞学会秋期大会
    • Place of Presentation
      ワークショップ 神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of mismatch repair(MMR)abnormality in the malignant transformation of ovarian endometriosis2010

    • Author(s)
      Fuseya C,Horiuchi A,Kikuchi N,Suzuki A, Takatsu A,Osada R,Shiozawa T
    • Organizer
      International Gynecologic Cancer Society(IGCS 2010)
    • Place of Presentation
      poster Praha Oeska republika
    • Related Report
      2012 Final Research Report
  • [Presentation] Pre-operative diagnosis and the management of minimal deviation adenocarcinoma(MDA)and lobular endocervical glandular hyperplasia(LEGH):a multi-center,retrospective study2010

    • Author(s)
      Takatsu A,Fuseya C,Miyamoto T,Horiuchi A, Shiozawa T
    • Organizer
      International Gynecologic Cancer Society(IGCS 2010)
    • Place of Presentation
      poster Praha Oeska republika
    • Related Report
      2012 Final Research Report
  • [Presentation] Microarray analysis of the genes involved in endometrial carcinogenesis:up-regulation of lipocalin2 in neoplastic endometria,and its functional relevance .2010

    • Author(s)
      Miyamoto T,Kashima H,Suzuki A,Kikuchi N,Takatsu A,Konishi I, Seki N,Shiozawa T
    • Organizer
      International Gynecologic Cancer Society(IGCS 2010)
    • Place of Presentation
      poster Praha Oeska republika
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮内膜癌発生における Notch シグナリングの関与の検討2010

    • Author(s)
      三橋祐布子、堀内晶子、宮本 強、鈴木昭久、塩沢丹里
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      一般講演 大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] 内膜癌におけるサイクリン AmRNA の 3'非翻訳領域を介した調節2010

    • Author(s)
      浅香亮一、鈴木昭久、塩沢丹里
    • Organizer
      第62回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      ポスター 東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮内膜癌における Notch シグナル関連タンパク発現の検討2010

    • Author(s)
      三橋祐布子、堀内晶子、鈴木昭久、塩沢丹里
    • Organizer
      第62回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      ポスター 東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Preoperative Differential Diagnosis of Minimal Deviation Adenocarcinoma (MDA) and Lobular

    • Author(s)
      Shiozawa T
    • Organizer
      Asian Society of Gynecologic Oncology 2nd International Workshop in Gynecologic Oncology(ASGO)
    • Place of Presentation
      kyoto
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2010-08-23   Modified: 2019-07-29  

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