| Project/Area Number |
22390313
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Keio University |
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Principal Investigator |
AOKI Daisuke 慶應義塾大学, 医学部, 教授 (30167788)
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| Co-Investigator(Kenkyū-buntansha) |
BANNO Kouji 慶應義塾大学, 医学部, 講師 (70265875)
HIRASAWA Akira 慶應義塾大学, 医学部, 助教 (90296658)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NOMURA Hiroyukiu 慶應義塾大学, 医学部, 助教 (50327590)
|
|---|
| Research Collaborator |
INAZAWA Johji 東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
KOZAKI Ken-ichi 東京医科歯科大学, 難治疾患研究所, 准教授 (50270715)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
|
|---|
| Keywords | 子宮体癌 / マイクロRNA / エピゲノム異常 / DNAメチル化 / 癌抑制型マイクロRNA / 癌 / ゲノム / 核酸 / microRNA / 抗癌剤感受性 / micro RNA / 癌抑制遺伝子 / がん抑制遺伝子 |
|---|
| Research Abstract |
The aim of this study is to identify a tumor-suppressor microRNA (miRNA) silenced by aberrant DNA methylation in endometrial cancer. By investigating escalation of expression level of microRNAs after exposure of 5-Aza-CdR in endometrial cancer cells, miR-
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