New application in treatment of head and neck cancer using genome and proteome analysis
Project/Area Number |
22390314
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Otorhinolaryngology
|
Research Institution | Hokkaido University |
Principal Investigator |
FUKUDA Satoshi 北海道大学, 北海道大学病院, 教授 (20125347)
|
Co-Investigator(Kenkyū-buntansha) |
HOMMA Akihiro 北海道大学, 北海道大学病院, 講師 (30312359)
HATAKEYAMA Shigetugu 北海道大学, 大学院・医学研究科, 教授 (70294973)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
|
Keywords | 頭頸部癌 / トランスクリプトーム / EGFR / NF-kB / プロテオーム / ユビキチン |
Research Abstract |
In this study, we could get the genome, proteome and microRNAs profile using the head and neck cancer samples from our institute. Furthermore, salivary grand samples could be added to this study and the molecular which showed difference depending on prognosis were confirmed their expression with the immunohistochemical methods. A lot of data were presented on meetings of American head and neck society, Asian society of head and neck, and other international meetings.We got the tremendous volume of data of head and neck cancer, so we need to continue the data-mining and the examination of protein-protein reaction to apply clinically.
|
Report
(4 results)
Research Products
(91 results)
-
[Journal Article] Combined modality therapy for laryngeal cancer with superselective intra-arterial cisplatin infusion and concomitant radiotherapy2012
Author(s)
Taki S, Homma A, Suzuki F, Oridate N, Hatakeyama H, Mizumachi T, Kano S, Furusawa J, Sakashita T, Inamura N, Yoshida D, Onimaru R, Shirato H, Fukuda S
-
Journal Title
Int J Clin Oncol
Volume: 17
Pages: 441-446
NAID
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Malignant melanoma of the head and neck : A multi-institutional retrospective analysis of cases in Northern Japan2012
Author(s)
Shiga K, Ogawa T, Kobayashi T, Ueda S, Kondo A, Nanba A, Kuwashima S, Asada Y, Suzuki S, Nagahashi T, Takahashi M, Suzuki M, Ishida A, Watanabe K, Harabuchi Y, Himi T, Shinkawa H, Sato H, Saijyo S, Fukuda S, Tanaka K, Ishikawa K, Omori K, Aoyagi M, Hashimoto S
-
Journal Title
Head Neck
Volume: (in press)
Issue: 11
Pages: 1537-1541
DOI
Related Report
Peer Reviewed
-
[Journal Article] TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and indices neuritogenesis2012
Author(s)
Yaguchi, H., Okumura, F., Takahashi, H., Kano, T., Kameda, H., Uchigashima, M., Tanaka, S., Watanabe, M., Sasaki, H. and Hatakeyama, S.
-
Journal Title
J. Biol. Chem.
Volume: 287
Issue: 15
Pages: 12050-12059
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Concomitant weekly Cisplatin and radiotherapy for head and neck cancer2011
Author(s)
Homma A, Inamura N, Oridate N, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Onimaru R, Yasuda K, Shirato H, Fukuda S
-
Journal Title
Jpn J Clin Onco
Volume: l41
Pages: 980-986
Related Report
Peer Reviewed
-
[Journal Article] Superselective arterial cisplatin infusion with concomitant radiation therapy for base of tongue cancer2011
Author(s)
Kano S, Homma A, Oridate N, Suzuki F, Hatakeyama H, Mizumachi T, Furusawa J, Sakashita T, Yoshida D, Onimaru R, Shirato H, Fukuda S
-
Journal Title
Oral Oncol
Volume: 47
Pages: 665-670
Related Report
Peer Reviewed
-
-
[Journal Article] Concomitant weekly Cisplatin and radiotherapy for head and neck cancer2011
Author(s)
Homma A, Inamura N, Oridate N, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Onimaru R, Yasuda K, Shirato H, Fukuda S
-
Journal Title
Jpn J Clin Oncol
Volume: 41
Issue: 8
Pages: 980-986
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Multicenter phase II study of an opioid-based pain control program for head and neck cancer patients receiving chemoradiotherapy2011
Author(s)
Zenda S, Matsuura K, Tachibana H, Homma A, Kirita T, Monden N, Iwae S, Ota Y, Akimoto T, Otsuru H, Tahara M, Kato K, Asai M
-
Journal Title
Radiother Oncol
Volume: 101
Issue: 3
Pages: 410-414
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] TRM40 promotes neddylation of IKK gamma and is downregulated in gastrointestinal cancers2011
Author(s)
Noguchi, K., Okumura, F., Takahashi, N., Kataoka, A., Kamiyama, T., Todo, S. and Hatakeyama, S.
-
Journal Title
Carcinogenesis
Volume: 32
Issue: 7
Pages: 995-1004
DOI
Related Report
Peer Reviewed
-
[Journal Article] TRIM29 negativelyregulates p53 via inhibition of Tip602011
Author(s)
Sho, T., Tsukiyama, T., Sato, T., Kondo, T., Cheng, J., Saku, T., Asaka, M. and Hatakeyama, S.
-
Journal Title
BBA-Mol. Cell Res.
Volume: 1813
Issue: 6
Pages: 1245-1253
DOI
Related Report
Peer Reviewed
-
[Journal Article] UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p532011
Author(s)
Wu H, Pomeroy SL, Ferreira M, Teider N, Mariani J, Nakayama KI, Hatakeyama S, Tron VA, Saltibus LF, Spyracopoulos L, Leng RP.
-
Journal Title
Nature Med
Volume: 17
Pages: 347-355
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] <Symposium>head and neck cancer「Superselective intra-arterial chemotherapy with concurrent radiotherapy for sinonasal malignant tumors」2012
Author(s)
Homma A, Oridate N, Sakashita T, Yoshida D, Onimaru R, Tsuchiya K, Hatakeyama H, Mizumachi T, Kano S, Shirato H, Fukuda S,
Organizer
The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
Place of Presentation
Kyoto Hotel Okura, Kyoto, Japan
Related Report
-
-
-
-
-
-
-
-
[Presentation] < Symposium1 > Nasopharyngeal cancer and nasal cavity and paranasal sinus-Superselective Intra-arterial Infusion of Cisplatin and Concomitant Radiotehrapy for Paranasal Sinus Cancers2011
Author(s)
Homma A, Oridate N, Sakashita T, Yoshida D, Onimaru R, Tsuchiya K, Yasuda K, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Shirato H, Fukuda S
Organizer
ANA CROWNE PLAZA KOBE
Place of Presentation
Kobe, Japan
Related Report
-
[Presentation] Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule : a report of two cases2011
Author(s)
Homma A, Suzuki F, Hatakeyama H, Sakashita T, Oridate N, Yoshida D, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
Organizer
The 2nd Asian Society of Head & Neck Oncology Meeting
Place of Presentation
Grand Hyatt, Goa, India
Related Report
-
[Presentation] < Symposium 9>Up to date therapy for sinonasal malignant tumors-Superselective intra-arterialchemotherapy with concurrent radiotherapy for sinonasal malignant tumors2011
Author(s)
Homma A, Sakashita T, Oridate N, Mizumachi T, Kano S, Furusawa J, Inamura N, Taki S, Fukuda S
Organizer
14th International Rhinologic Society, 30th International Symposium Infection and Allergy of the Nose
Place of Presentation
ANA Intercontinental hotel Tokyo, Tokyo, Japan
Related Report
-
-
-
[Presentation] <Symposiuml>Nasopharyngeal cancer and nasal cavity and paranasal sinus-Superselective Intra-arterial Infusion of Cisplatin and Concomitant Radiotehrapy for Paranasal Sinus Cancers2011
Author(s)
Homma A, Oridate N, Sakashita T, Yoshida D, Onimaru R, Tsuchiya K, Yasuda K, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Shirato H, Fukuda S
Organizer
The 11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
Place of Presentation
ANA CROWNE PLAZA KOBE (Japan)
Related Report
-
-
[Presentation] Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule : a report of two cases2011
Author(s)
Homma A, Suzuki F, Hatakeyama H, Sakashita T, Oridate N, Yoshida D, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
Organizer
The 2nd Asian Society of Head & Neck Oncology Meeting
Place of Presentation
Grand Hyatt (India)
Related Report
-
[Presentation] Efficacy of weekly cisplatin and concurrent radiotherapy to control neck disease in advanced head and neck cancer2011
Author(s)
Sakashita T, Homma A, Oridate N, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
Organizer
11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Sugery
Place of Presentation
ANA CROWNE PLAZA KOBE (Japan)
Related Report
-
-
-
-
-
[Presentation] 頭頸部進行癌に対する集学的治療"導入化学療法→化学放射線同時併用療法"2011
Author(s)
本間明宏, 清水康, 折舘伸彦, 鬼丸力也, 鈴木清護, 畠山博充, 加納里志, 水町貴諭, 坂下智博, 安田耕一, 秋田弘俊, 白土博樹, 福田諭
Organizer
第35回日本頭頸部癌学会
Place of Presentation
ウインクあいち(愛知)
Related Report
-
-
-
[Presentation] Role of apolipoprotein B100 and oxidized low-density lipoprotein in antibeta2 glycoprotein I induced tissue factor expression on monocytes2011
Author(s)
Otomo K, Atsumi T, Fujieda Y, Nakagawa H, Amengual O, Kato M, Horita T, Tasuda S, Matsumoto M, Hatakeyama S, Koike T
Organizer
The 75th annual meeting of the American College of Rheumatology
Place of Presentation
Sheraton Chicago Hotel & Towers (USA)
Related Report
-
-
-
[Presentation] 〈パネルディスカッション〉北海道大学病院における鼻副鼻腔癌の治療成績~上顎洞原発扁平上皮癌を中心に~2010
Author(s)
本間明宏, 折舘伸彦, 鈴木清護, 畠山博充, 加納里志, 古沢純, 水町貴諭, 坂下智博, 鈴木章之, 瀧重成, 稲村直哉, 福田諭
Organizer
第16回北日本頭頸部癌治療検討会
Place of Presentation
札幌 招待講演
Year and Date
2010-10-02
Related Report
-
-
-
-
[Presentation] The efficacy of superselective intra-arterial infusion for unresectable carcinoma of the paranasal sinuses2010
Author(s)
Homma A, Oridate N, Suzuki F, Sakashita T, Furusawa J, Taki S, Inamura N, Mizumachi T, Kano S, Yoshida D, Onimaru R, Fukuda S
Organizer
The American Head and Neck Society 2010Research Workshop
Place of Presentation
Hyatt RegencyCrystal City, Arlington, VA, USA
Related Report
-
-
-
-
[Presentation] Superselective Intra-Arterial Cisplatin Infusion with Concomitant Radiotherapy for Laryngeal Cancer2010
Author(s)
Homma A, Suzuki F, Oridate N, Mizumachi T, Kano S, Furusawa J, Inamura N, Taki S, Sakashita T, Fukuda S.
Organizer
4th World Congress of International Federation of Head and Neck Oncologic Societies
Place of Presentation
Seoul, Korea
Related Report
-
[Presentation] Concurrent Chemoradiotherapy for Oropharyngeal Cancer : A Retrospective Comparison of Superselective High-Dose Cisplatin Infusion and Systemic Chemotherapy2010
Author(s)
Kano S, Homma A, Oridate N, Suzuki S, Suzuki F, Hara T, Mizumachi T, Furusawa J, Inamura N, Fukuda S.
Organizer
4th World Congress of International Federation of Head and Neck Oncologic Societies
Place of Presentation
Seoul, Korea
Related Report
-
-
[Presentation] Improved survival of patients with human papillomavirus-positiveoropharyngeal squamous cell carcinoma in Japan2010
Author(s)
Mizumachi T, Kano S, Inamura N, Hara T, Suzuki F, Suzuki S, Homma A, Oridate N, Fukuda S.
Organizer
AAO-HNS Annual Meeting & OTO EXPO
Place of Presentation
Boston, Ma, USA
Related Report
-
-
-
[Presentation] The efficacy of superselective intra-arterial infusion for unresectable carcinoma of the paranasal sinuses2010
Author(s)
Homma A, Oridate N, Suzuki F, Sakashita T, Furusawa J, Taki S, Inamura N, Mizumachi T, Kano S, Yoshida D, Onimaru R, Fukuda S.
Organizer
The American Head and Neck Society 2010 Research Workshop
Place of Presentation
Arlington, VA, USA
Related Report
-
-
-
[Presentation] 頭頸部癌に対するweekly cisplatinと放射線同時併用療法の検討2010
Author(s)
稲村直哉, 本間明宏, 折舘伸彦, 鈴木清護, 鈴木章之, 原敏浩, 真栄田裕行, 加納里志, 水町貴諭, 福田諭, 他4名
Organizer
第34回日本頭頸部癌学会
Place of Presentation
東京
Related Report
-
-
-
-
-
-
-
-
-
-