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New application in treatment of head and neck cancer using genome and proteome analysis

Research Project

Project/Area Number 22390314
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionHokkaido University

Principal Investigator

FUKUDA Satoshi  北海道大学, 北海道大学病院, 教授 (20125347)

Co-Investigator(Kenkyū-buntansha) HOMMA Akihiro  北海道大学, 北海道大学病院, 講師 (30312359)
HATAKEYAMA Shigetugu  北海道大学, 大学院・医学研究科, 教授 (70294973)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywords頭頸部癌 / トランスクリプトーム / EGFR / NF-kB / プロテオーム / ユビキチン
Research Abstract

In this study, we could get the genome, proteome and microRNAs profile using the head and neck cancer samples from our institute. Furthermore, salivary grand samples could be added to this study and the molecular which showed difference depending on prognosis were confirmed their expression with the immunohistochemical methods. A lot of data were presented on meetings of American head and neck society, Asian society of head and neck, and other international meetings.We got the tremendous volume of data of head and neck cancer, so we need to continue the data-mining and the examination of protein-protein reaction to apply clinically.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (91 results)

All 2013 2012 2011 2010

All Journal Article (35 results) (of which Peer Reviewed: 35 results) Presentation (48 results) (of which Invited: 1 results) Book (8 results)

  • [Journal Article] Combined modality therapy for laryngeal cancer with superselective intra-arterial cisplatin infusion and concomitant radiotherapy2012

    • Author(s)
      Taki S, Homma A, Suzuki F, Oridate N, Hatakeyama H, Mizumachi T, Kano S, Furusawa J, Sakashita T, Inamura N, Yoshida D, Onimaru R, Shirato H, Fukuda S
    • Journal Title

      Int J Clin Oncol

      Volume: 17 Pages: 441-446

    • NAID

      10031144330

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer2012

    • Author(s)
      Sakashita T, Homma A, Oridate N, Suzuki S, Hatakeyama H, Kano S, Mizumachi T, Yoshida D, Fujima N, Fukuda S
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Issue: 10 Pages: 1121-1125

    • DOI

      10.3109/00016489.2012.680494

    • NAID

      10031131102

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of nodal response after intra-arterial chemoradiation for node-positive head and neck cancer2012

    • Author(s)
      Sakashita T, Homma A, Oridate N, Hatakeyama H, Kano S, Mizumachi T, Fukuda S
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 269 Issue: 6 Pages: 1671-1676

    • DOI

      10.1007/s00405-011-1814-5

    • NAID

      120005946626

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved survival of Japanese patients with human papillomavirus-positive oropharyngeal squamous cell carcinoma2012

    • Author(s)
      Mizumachi T, Kano S, Sakashita T, Hatakeyama H, Suzuki S, Homma A, Oridate N, Fukuda S
    • Journal Title

      Int J Clin Oncol

      Volume: online 31 Issue: 5 Pages: 0-0

    • DOI

      10.1007/s10147-012-0469-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Malignant melanoma of the head and neck : A multi-institutional retrospective analysis of cases in Northern Japan2012

    • Author(s)
      Shiga K, Ogawa T, Kobayashi T, Ueda S, Kondo A, Nanba A, Kuwashima S, Asada Y, Suzuki S, Nagahashi T, Takahashi M, Suzuki M, Ishida A, Watanabe K, Harabuchi Y, Himi T, Shinkawa H, Sato H, Saijyo S, Fukuda S, Tanaka K, Ishikawa K, Omori K, Aoyagi M, Hashimoto S
    • Journal Title

      Head Neck

      Volume: (in press) Issue: 11 Pages: 1537-1541

    • DOI

      10.1002/hed.21984

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and indices neuritogenesis2012

    • Author(s)
      Yaguchi, H., Okumura, F., Takahashi, H., Kano, T., Kameda, H., Uchigashima, M., Tanaka, S., Watanabe, M., Sasaki, H. and Hatakeyama, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Issue: 15 Pages: 12050-12059

    • DOI

      10.1074/jbc.m111.307678

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ymer acts as a multufunctional regulator in NF-kB and Fas signaling pathways2012

    • Author(s)
      Tsukiyama, T., et al
    • Journal Title

      Mol.Med.

      Volume: (in press) Issue: 4 Pages: 587-597

    • DOI

      10.2119/molmed.2011.00435

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM6 interacts with c-Myc and maintains pluripotency of mouse embryonal stem cells2012

    • Author(s)
      Sato T, Okumura F, Ariga T, Hatakeyama S
    • Journal Title

      J Cell Sci

      Volume: (in press) Pages: 1544-1555

    • DOI

      10.1242/jcs.095273

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM32 promotes retinoic acid receptor alpha-mediated differentiation in human promyelogenous leukemic cell line HL602012

    • Author(s)
      Sato T, Okumura F, Iguchi A, Ariga T, Hatakeyama S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417 Issue: 1 Pages: 594-600

    • DOI

      10.1016/j.bbrc.2011.12.012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonal stem cells2012

    • Author(s)
      Sato, T., Okumura, F., Ariga, T. and Hatakeyama, S.
    • Journal Title

      J. Cell Sci.

      Volume: 125 Issue: 20 Pages: 1544-1555

    • DOI

      10.1242/jcs.088799

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Superselective arterial cisplatin infusion with concomitant radiation therapy for advanced nasal cavity and paranasal sinus carcinoma2011

    • Author(s)
      Homma A
    • Journal Title

      Recent Adv Res Updat

      Volume: 12 Pages: 197-211

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concomitant weekly Cisplatin and radiotherapy for head and neck cancer2011

    • Author(s)
      Homma A, Inamura N, Oridate N, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Onimaru R, Yasuda K, Shirato H, Fukuda S
    • Journal Title

      Jpn J Clin Onco

      Volume: l41 Pages: 980-986

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Superselective arterial cisplatin infusion with concomitant radiation therapy for base of tongue cancer2011

    • Author(s)
      Kano S, Homma A, Oridate N, Suzuki F, Hatakeyama H, Mizumachi T, Furusawa J, Sakashita T, Yoshida D, Onimaru R, Shirato H, Fukuda S
    • Journal Title

      Oral Oncol

      Volume: 47 Pages: 665-670

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct epigenetic profiling in head and neck squamous cell carcinoma stem cells2011

    • Author(s)
      Furusawa J, Zhang H, Vural E, Stone A, Fukuda S, Oridate N, Fang H, Ye Y, Suen JY, Fan CY
    • Journal Title

      Otolaryngol Head Neck Surg

      Volume: 144 Pages: 900-909

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concomitant weekly Cisplatin and radiotherapy for head and neck cancer2011

    • Author(s)
      Homma A, Inamura N, Oridate N, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Onimaru R, Yasuda K, Shirato H, Fukuda S
    • Journal Title

      Jpn J Clin Oncol

      Volume: 41 Issue: 8 Pages: 980-986

    • DOI

      10.1093/jjco/hyr086

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiotherapy for Glottic T1NO Carcinoma with Slight Hypofractionation and Standard Overall Treatment Time : Importance of Overall Treatment Time2011

    • Author(s)
      Onimaru R, Hasegawa M, Yasuda K, Homma A, Oridate N, Fukuda S, Shirato H
    • Journal Title

      Jpn J Clin Oncol

      Volume: 41 Issue: 1 Pages: 103-109

    • DOI

      10.1093/jjco/hyq153

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter phase II study of an opioid-based pain control program for head and neck cancer patients receiving chemoradiotherapy2011

    • Author(s)
      Zenda S, Matsuura K, Tachibana H, Homma A, Kirita T, Monden N, Iwae S, Ota Y, Akimoto T, Otsuru H, Tahara M, Kato K, Asai M
    • Journal Title

      Radiother Oncol

      Volume: 101 Issue: 3 Pages: 410-414

    • DOI

      10.1016/j.radonc.2011.09.016

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM proteins and cancer2011

    • Author(s)
      Hatakeyama, S.
    • Journal Title

      Nature Rev. Cancer

      Volume: 11 Issue: 11 Pages: 792-804

    • DOI

      10.1038/nrc3139

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM8 regulates Nanog via Hsp90 beta-mediated nuclear translocation of STAT3 in embryonic stem cells2011

    • Author(s)
      Okumura, F., Okumura, A.J., Matsumoto, M., Nakayama, K.I. and Hatakeyama, S.
    • Journal Title

      BBA-Mol. Cell Res.

      Volume: 1813 Issue: 10 Pages: 1784-1792

    • DOI

      10.1016/j.bbamcr.2011.05.013

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRM40 promotes neddylation of IKK gamma and is downregulated in gastrointestinal cancers2011

    • Author(s)
      Noguchi, K., Okumura, F., Takahashi, N., Kataoka, A., Kamiyama, T., Todo, S. and Hatakeyama, S.
    • Journal Title

      Carcinogenesis

      Volume: 32 Issue: 7 Pages: 995-1004

    • DOI

      10.1093/carcin/bgr068

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM29 negativelyregulates p53 via inhibition of Tip602011

    • Author(s)
      Sho, T., Tsukiyama, T., Sato, T., Kondo, T., Cheng, J., Saku, T., Asaka, M. and Hatakeyama, S.
    • Journal Title

      BBA-Mol. Cell Res.

      Volume: 1813 Issue: 6 Pages: 1245-1253

    • DOI

      10.1016/j.bbamcr.2011.03.018

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p532011

    • Author(s)
      Wu H, Pomeroy SL, Ferreira M, Teider N, Mariani J, Nakayama KI, Hatakeyama S, Tron VA, Saltibus LF, Spyracopoulos L, Leng RP.
    • Journal Title

      Nature Med

      Volume: 17 Pages: 347-355

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin2011

    • Author(s)
      Bohgaki M, Matsumoto M, Atsumi T, Kondo T, Yasuda S, Horita T, Nakayama KI, Okumura F, Hatakeyama S, Koike T.
    • Journal Title

      J Cell Mol Med

      Volume: 15 Pages: 141-151

    • NAID

      120003660581

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNF43 interacts with NEDL1 and regulates p53-mediated transcription2011

    • Author(s)
      Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 404 Pages: 143-147

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MDA-9/syntenin interacts with ubiquitin via a novel ubiquitin-binding motif2011

    • Author(s)
      Okumura F, Yoshida K, Liang F, Hatakeyama S.
    • Journal Title

      Mol Cell Biochem

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of comorbidity in hypopharyngeal cancer2010

    • Author(s)
      Homma A, Sakashita T, Oridate N, Suzuki F, Suzuki S, Hatakeyama H, Mizumachi T, Taki S, Fukuda S
    • Journal Title

      Head Neck

      Volume: 32 Pages: 148-153

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase I/II Study of S-1 plus Cisplatin Combination Chemotherapy in Patients with Advanced/Recurrent Head and Neck Cancer2010

    • Author(s)
      Fujii M, Tomita K, Nishijima W, Tsukuda M, Hasegawa Y, Ishitoya J, Yamane H, Homma A, Tomita T.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 40 Pages: 214-221

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of comorbidity in hypouharyngeal cancer2010

    • Author(s)
      Homma A, Sakashita T, Oridate N, Suzuki F, Suzuki S, Hatakeyama H, Mizumachi T, Taki S, Fukuda S.
    • Journal Title

      Head Neck

      Volume: 32 Pages: 148-153

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cesium implant for tongue carcinoma with a thickness of 1.5cm ormore : cases successfully treated with a Modified Manchester System2010

    • Author(s)
      Nishioka T, Fujino M, Homma A, Yamashita T, Sato A, Ohmori K, Obinata K, Shirato H, Notani K, Nishio M.
    • Journal Title

      Yonsei Med J

      Volume: 51 Pages: 557-561

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening examination for superficial carcinoma of the head and neck following endoscopic resection for esophageal carcinoma2010

    • Author(s)
      Shimizu Y, Yoshida T, Kato M, Ono S, Homma A, Oridate N, Asaka M.
    • Journal Title

      Endoscopy

      Volume: 42 Pages: 686-687

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salvage surgery for local recurrence after chemoradiotherapy or radiotherapy in hypopharyngeal cancer patients2010

    • Author(s)
      Taki S, Homma A, Oridate N, Suzuki S, Suzuki F, Sakashita T, Fukuda S
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 267 Pages: 1765-1769

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway2010

    • Author(s)
      Sasai M, Tatematsu M, Oshiumi H, Funami K, Matsumoto M, Hatakeyama S, Seya T.
    • Journal Title

      Mol Immunol

      Volume: 47 Pages: 1283-1291

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis for the association of human E4B U-box ubiquitin ligase with E2 conjugating enzymes UbcH5c and Ubc42010

    • Author(s)
      Benirschke RC, Thompson JR, Nomine Y, Wasielewski E, Juranie N, Macura S, Hatakeyama S, Nakayama KI, Botuyan MV, Mer G.
    • Journal Title

      Structure

      Volume: 8 Pages: 955-965

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM8 modulates STAT3 activity through negative regulation of PIAS32010

    • Author(s)
      Okumura F, Matsunaga Y, Katayama Y, Nakayama KI, Hatakeyama S.
    • Journal Title

      J Cell Sci

      Volume: 123 Pages: 2238-2245

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of recombinant sea urchin cellulase SnEG54 using mammalian cell lines2010

    • Author(s)
      Okumura F, Kameda H, Ojima T, Hatakeyama S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 395 Pages: 352-355

    • NAID

      120002148680

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] <Symposium>head and neck cancer「 Superselective intra-arterial chemotherapy with concurrent radiotherapy for sinonasal malignant tumors」2012

    • Author(s)
      Homma A, Fukuda S, et al
    • Organizer
      The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kyoto Hotel Okura, Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] <Symposium>head and neck cancer「Superselective intra-arterial chemotherapy with concurrent radiotherapy for sinonasal malignant tumors」2012

    • Author(s)
      Homma A, Oridate N, Sakashita T, Yoshida D, Onimaru R, Tsuchiya K, Hatakeyama H, Mizumachi T, Kano S, Shirato H, Fukuda S,
    • Organizer
      The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kyoto Hotel Okura, Kyoto, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cyclin D1 is an immunohistochemical predicting indicator for local recurrence in head and neck squamous cell carcinomas2012

    • Author(s)
      Sakashita T, Oridate N, Homma A, Suzuki S, Hatakeyama H, Kano S, Mizumachi T, Fukuda S
    • Organizer
      The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kyoto Hotel Okura, Kyoto, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] <シンポジウム>オートファジー・プロテオステイシスとがん「TRIM proteins and cancer」2012

    • Author(s)
      Hatakeyama, S
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] <ランチタイム教育講演2>免疫と癌を制御するTRIM型ユビキチンリガーゼ2012

    • Author(s)
      畠山鎮次
    • Organizer
      第40回日本臨床免疫学会総会
    • Place of Presentation
      京王プラザホテル(北海道)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 癌化を制御するTRIMファミリーユビキチンリガーゼ2012

    • Author(s)
      畠山鎮次
    • Organizer
      第21回泌尿器科分子・細胞研究会
    • Place of Presentation
      北海道大学(札幌)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] TRIM proteins in inflammation and carsinogenosis2012

    • Author(s)
      Hatakeyama S
    • Organizer
      2nd International Symposium INFECTION-ASSOCIATED CANCERS
    • Place of Presentation
      Hokkaido University (Japan)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔癌に対してガンマプローブを利用したセンチネルリンパ節生検の臨床応用2011

    • Author(s)
      坂下智博, 本間明宏, 折舘伸彦, 鈴木清護, 畠山博充, 加納里志, 水町貴諭, 福田諭
    • Organizer
      第13回耳鼻咽喉科手術支援システム・ナビ研究会
    • Place of Presentation
      東京医科歯科大学(東京)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] <シンポジウム2>舌根部癌に対する喉頭機能温存治療「中咽頭前壁原発扁平上皮癌に対する超選択的動注化学療法と照射の同時併用療法」2011

    • Author(s)
      本間明宏, 坂下智博, 折舘伸彦, 鈴木清護, 畠山博充, 加納里志, 水町貴諭, 福田諭
    • Organizer
      第4回喉頭機能温存治療研究会
    • Place of Presentation
      東京コンフアレンスセンター(東京)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] < Symposium1 > Nasopharyngeal cancer and nasal cavity and paranasal sinus-Superselective Intra-arterial Infusion of Cisplatin and Concomitant Radiotehrapy for Paranasal Sinus Cancers2011

    • Author(s)
      Homma A, Oridate N, Sakashita T, Yoshida D, Onimaru R, Tsuchiya K, Yasuda K, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Shirato H, Fukuda S
    • Organizer
      ANA CROWNE PLAZA KOBE
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule : a report of two cases2011

    • Author(s)
      Homma A, Suzuki F, Hatakeyama H, Sakashita T, Oridate N, Yoshida D, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
    • Organizer
      The 2nd Asian Society of Head & Neck Oncology Meeting
    • Place of Presentation
      Grand Hyatt, Goa, India
    • Related Report
      2012 Final Research Report
  • [Presentation] < Symposium 9>Up to date therapy for sinonasal malignant tumors-Superselective intra-arterialchemotherapy with concurrent radiotherapy for sinonasal malignant tumors2011

    • Author(s)
      Homma A, Sakashita T, Oridate N, Mizumachi T, Kano S, Furusawa J, Inamura N, Taki S, Fukuda S
    • Organizer
      14th International Rhinologic Society, 30th International Symposium Infection and Allergy of the Nose
    • Place of Presentation
      ANA Intercontinental hotel Tokyo, Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] <Symposium 9>Up to date therapy for sinonasal malignant tumors-Superselective intra-arterial chemotherapy with concurrent radiotherapy for sinonasal malignant tumors2011

    • Author(s)
      Homma A, Sakashita T, Oridate N, Mizumachi T, Kano S, Furusawa J, Inamura N, Taki S, Fukuda S
    • Organizer
      14th International Rhinologic Society, 30th International Symposium Infection and Allergy of the Nose
    • Place of Presentation
      ANA InterContinental Tokyo (Japan)
    • Related Report
      2011 Annual Research Report
  • [Presentation] BIOCON Panel-Newer Targets and therapy2011

    • Author(s)
      Homma A
    • Organizer
      The 2nd Asian Society of Head & Neck Oncology Meeting
    • Place of Presentation
      Grand Hyatt, (India)
    • Related Report
      2011 Annual Research Report
  • [Presentation] <Symposiuml>Nasopharyngeal cancer and nasal cavity and paranasal sinus-Superselective Intra-arterial Infusion of Cisplatin and Concomitant Radiotehrapy for Paranasal Sinus Cancers2011

    • Author(s)
      Homma A, Oridate N, Sakashita T, Yoshida D, Onimaru R, Tsuchiya K, Yasuda K, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Shirato H, Fukuda S
    • Organizer
      The 11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      ANA CROWNE PLAZA KOBE (Japan)
    • Related Report
      2011 Annual Research Report
  • [Presentation] TRIM32 facilitates cell growth, migration and anti-apoptosis2011

    • Author(s)
      Kano S, Hatakeyama S, Fukuda S
    • Organizer
      Am Association for Cancer Research
    • Place of Presentation
      Orange County Convention Center (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule : a report of two cases2011

    • Author(s)
      Homma A, Suzuki F, Hatakeyama H, Sakashita T, Oridate N, Yoshida D, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
    • Organizer
      The 2nd Asian Society of Head & Neck Oncology Meeting
    • Place of Presentation
      Grand Hyatt (India)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Efficacy of weekly cisplatin and concurrent radiotherapy to control neck disease in advanced head and neck cancer2011

    • Author(s)
      Sakashita T, Homma A, Oridate N, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
    • Organizer
      11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Sugery
    • Place of Presentation
      ANA CROWNE PLAZA KOBE (Japan)
    • Related Report
      2011 Annual Research Report
  • [Presentation] <パネルディスカッション2>個別化を目指す薬物療法「HPV陽性中咽頭癌に対する個別化治療戦略」2011

    • Author(s)
      水町貴諭, 畠山博充, 加納里志, 坂下智博, 鈴木清護, 本間明宏, 折舘伸彦, 福田諭
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウインクあいち(愛知)
    • Related Report
      2011 Annual Research Report
  • [Presentation] <シンポジウム3>機能温存をめざした下咽頭癌の治療「下咽頭癌に対する超選択的動注化学療法と照射の同時併用療法の有用性」2011

    • Author(s)
      本間明宏, 加納里志, 水町貴諭, 福田諭
    • Organizer
      第24回日本口腔・咽頭科学会
    • Place of Presentation
      ANAクラウンプラザホテル広島(広島)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 頭頸部癌セツキシマブ耐性獲得におけるEGFRリガンドの発現とmicroRNA制御2011

    • Author(s)
      畠山博充, 本間明宏, 折舘伸彦, 福田論
    • Organizer
      第112回日本耳鼻咽喉科学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 唾液腺悪性腫瘍におけるEGFR, HER2, c-KITの発現解析2011

    • Author(s)
      加納里志, 鈴木清護, 折舘伸彦, 本間明宏, 畠山博充, 水町貴諭, 坂下智博, 福田諭
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウインクあいち(愛知)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 頭頸部進行癌に対する集学的治療"導入化学療法→化学放射線同時併用療法"2011

    • Author(s)
      本間明宏, 清水康, 折舘伸彦, 鬼丸力也, 鈴木清護, 畠山博充, 加納里志, 水町貴諭, 坂下智博, 安田耕一, 秋田弘俊, 白土博樹, 福田諭
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウインクあいち(愛知)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 頭頸部癌におけるNF-kBパスウエイの活性化とセツキシマブ耐性2011

    • Author(s)
      畠山博充, 鈴木清護, 坂下智博, 加納里志, 水町貴諭, 本間明宏, 折舘伸彦, 福田諭
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウインクあいち(愛知)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ymer functions as a multifunctional regulator in NF-kB and Fas signaling pathways2011

    • Author(s)
      Tsukiyama T, Tsukiyama M M, bohgaki M, Tanaka S, Hatakeyama S
    • Organizer
      the 41st meeting of the Australasian Society for immunology 2011
    • Place of Presentation
      Adelaide Convention Centre (Australia)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of apolipoprotein B100 and oxidized low-density lipoprotein in antibeta2 glycoprotein I induced tissue factor expression on monocytes2011

    • Author(s)
      Otomo K, Atsumi T, Fujieda Y, Nakagawa H, Amengual O, Kato M, Horita T, Tasuda S, Matsumoto M, Hatakeyama S, Koike T
    • Organizer
      The 75th annual meeting of the American College of Rheumatology
    • Place of Presentation
      Sheraton Chicago Hotel & Towers (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] TRIMファミリー分子によるPPARγシグナルの制御2011

    • Author(s)
      渡部昌、畠山鎮次
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌N+症例における放射線動注化学療法の頸部制御と頸部郭清~治療後早期の頸部郭清の必要性2011

    • Author(s)
      坂下智博, 本間明宏, 折舘伸彦, 畠山博充, 水町貴諭, 加納里志, 福田諭
    • Organizer
      第21回日本頭頸部外科学会
    • Place of Presentation
      宇都宮
    • Related Report
      2010 Annual Research Report
  • [Presentation] 〈パネルディスカッション〉北海道大学病院における鼻副鼻腔癌の治療成績~上顎洞原発扁平上皮癌を中心に~2010

    • Author(s)
      本間明宏, 折舘伸彦, 鈴木清護, 畠山博充, 加納里志, 古沢純, 水町貴諭, 坂下智博, 鈴木章之, 瀧重成, 稲村直哉, 福田諭
    • Organizer
      第16回北日本頭頸部癌治療検討会
    • Place of Presentation
      札幌 招待講演
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌化の関与するTRIMファミリーユビキチンリガーゼ2010

    • Author(s)
      畠山鎮次
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      大阪 招待講演
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 〈サテライトセミナー〉頭頸部癌に対する超選択的動注療法~北海道大学病院耳鼻咽喉科の現状~2010

    • Author(s)
      本間明宏
    • Organizer
      第64回日本口腔科学会サテライト「口腔癌の動注化学療法セミナー」
    • Place of Presentation
      札幌 招待講演
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] ユビキチンシステム関連酵素の多様性と機能2010

    • Author(s)
      畠山鎮次
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌 招待講演
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] The efficacy of superselective intra-arterial infusion for unresectable carcinoma of the paranasal sinuses2010

    • Author(s)
      Homma A, Oridate N, Suzuki F, Sakashita T, Furusawa J, Taki S, Inamura N, Mizumachi T, Kano S, Yoshida D, Onimaru R, Fukuda S
    • Organizer
      The American Head and Neck Society 2010Research Workshop
    • Place of Presentation
      Hyatt RegencyCrystal City, Arlington, VA, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] <Symposium>Recent Progress in Chemoradiotherapy in Head and Neck Cancer2010

    • Author(s)
      Fukuda S
    • Organizer
      4th World Congress of International Federation of Head and Neck Oncologic Societies(IFHNOS)
    • Place of Presentation
      Lotte Hotel Seoul , Seoul,Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] <宿題報告2>頭頸部癌治療における分子生物学的アプローチ2010

    • Author(s)
      福田諭
    • Organizer
      第111回日本耳鼻咽喉科学会
    • Place of Presentation
      仙台国際センター(仙台)
    • Related Report
      2012 Final Research Report
  • [Presentation] <Symposium> Recent Progress in Chemoradiotherapy in Head and Neck Cancer2010

    • Author(s)
      Fukuda S.
    • Organizer
      4th World Congress of International Federation of Head and Neck Oncologic Societies
    • Place of Presentation
      Seoul, Korea 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Superselective Intra-Arterial Cisplatin Infusion with Concomitant Radiotherapy for Laryngeal Cancer2010

    • Author(s)
      Homma A, Suzuki F, Oridate N, Mizumachi T, Kano S, Furusawa J, Inamura N, Taki S, Sakashita T, Fukuda S.
    • Organizer
      4th World Congress of International Federation of Head and Neck Oncologic Societies
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] Concurrent Chemoradiotherapy for Oropharyngeal Cancer : A Retrospective Comparison of Superselective High-Dose Cisplatin Infusion and Systemic Chemotherapy2010

    • Author(s)
      Kano S, Homma A, Oridate N, Suzuki S, Suzuki F, Hara T, Mizumachi T, Furusawa J, Inamura N, Fukuda S.
    • Organizer
      4th World Congress of International Federation of Head and Neck Oncologic Societies
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] Human papillomavirus frequency in oropharyngeal squamou cell carcinoma in Japan2010

    • Author(s)
      Mizumachi T, Kano S, Inamura N, Hara T, Suzuki F, Suzuki S, Homma A, Oridate N, Fukuda S.
    • Organizer
      The 7th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways
    • Place of Presentation
      Asahikawa, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Improved survival of patients with human papillomavirus-positiveoropharyngeal squamous cell carcinoma in Japan2010

    • Author(s)
      Mizumachi T, Kano S, Inamura N, Hara T, Suzuki F, Suzuki S, Homma A, Oridate N, Fukuda S.
    • Organizer
      AAO-HNS Annual Meeting & OTO EXPO
    • Place of Presentation
      Boston, Ma, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] <Invited special lecture-1> Skull base surgery-Hokkaido University Experience from 19892010

    • Author(s)
      Fukuda S.
    • Organizer
      4th Annual Meeting of Taiwan Skull Base Society
    • Place of Presentation
      Taipei, Taiwan 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Multicenter Phase II Study of an Opioid-based Pain Control Program for Head and Neck Cancer Patients Receiving Chemoradiotherapy2010

    • Author(s)
      Homma A, Zenda S, Tahara M, Matsuura K, Kato K, Tachibana H, Kirita T, Monden N, Asai M.
    • Organizer
      35th European Society for Medical Oncology Congress
    • Place of Presentation
      Milano, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] The efficacy of superselective intra-arterial infusion for unresectable carcinoma of the paranasal sinuses2010

    • Author(s)
      Homma A, Oridate N, Suzuki F, Sakashita T, Furusawa J, Taki S, Inamura N, Mizumachi T, Kano S, Yoshida D, Onimaru R, Fukuda S.
    • Organizer
      The American Head and Neck Society 2010 Research Workshop
    • Place of Presentation
      Arlington, VA, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 〈宿題報告2〉頭頸部癌治療における分子生物学的アプローチ2010

    • Author(s)
      福田諭
    • Organizer
      第111回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      仙台 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中咽頭扁平上皮癌における且PV感染と治療成績の検討2010

    • Author(s)
      水町貴諭, 加納里志, 原敏浩, 鈴木章之, 鈴木清護, 本間明宏, 折舘伸彦, 福田諭
    • Organizer
      第34回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 頭頸部癌に対するweekly cisplatinと放射線同時併用療法の検討2010

    • Author(s)
      稲村直哉, 本間明宏, 折舘伸彦, 鈴木清護, 鈴木章之, 原敏浩, 真栄田裕行, 加納里志, 水町貴諭, 福田諭, 他4名
    • Organizer
      第34回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 〈臨床教育講演〉新しいがん治療と機能温存「超選択的動注化学療法と放射線の同時併用療法」2010

    • Author(s)
      本間明宏, 福田諭
    • Organizer
      第72回耳鼻咽喉科臨床学会
    • Place of Presentation
      倉敷 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] 〈パネルディスカッション〉鼻副鼻腔腫瘍治療戦略の新しい可能性を探る「鼻副鼻腔悪性腫瘍に対する超選択的動注療法」2010

    • Author(s)
      本間明宏, 水町貴諭, 原敏浩, 福田諭
    • Organizer
      第49回日本鼻科学会
    • Place of Presentation
      札幌 招待講演
    • Related Report
      2010 Annual Research Report
  • [Book] がんを見逃さない-頭頸部癌診療の最前線2013

    • Author(s)
      本間明宏
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report
  • [Book] がんを見逃さない─頭頸部癌診療の最前線 (ENT臨床フロンティア)2013

    • Author(s)
      岸本誠司, 本間明宏他
    • Total Pages
      308
    • Publisher
      中山書店
    • Related Report
      2012 Annual Research Report
  • [Book] 北大病院の医療健康セミナー2012

    • Author(s)
      福田諭
    • Publisher
      北海道新聞社
    • Related Report
      2012 Final Research Report
  • [Book] 北大病院の医療健康セミナー2012

    • Author(s)
      佐藤 孝一, 福田 諭他
    • Total Pages
      224
    • Publisher
      北海道新聞社
    • Related Report
      2012 Annual Research Report
  • [Book] 感覚器(視覚と聴覚)と社会とのつながりー見るよろこび・聞くよろこびー2011

    • Author(s)
      福田諭
    • Publisher
      (財)日本学術協力財団
    • Related Report
      2012 Final Research Report
  • [Book] 今日の診断指針第6版2010

    • Author(s)
      福田諭, 他
    • Total Pages
      2091
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] 今日の治療指針20102010

    • Author(s)
      福田諭, 他
    • Total Pages
      1903
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] EBM耳鼻咽喉科・頭頸部外科の治療2010-20112010

    • Author(s)
      本間明宏, 他
    • Total Pages
      528
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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