The molecular pathogenesis for age-related macular degeneration and establishment of novel treatment
Project/Area Number |
22390322
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
OHNO-MATSUI Kyoko 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (30262174)
|
Co-Investigator(Kenkyū-buntansha) |
MORITA Ikuo 東京医科歯科大学, 医歯学総合研究科, 教授 (60100129)
MOCHIZUKI Manabu 東京医科歯科大学, 医学部, 教授 (10010464)
|
Project Period (FY) |
2010-04-01 – 2013-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 加齢黄斑変性 / ドルーゼン / 網膜色素上皮 / 脈絡膜新生血管 / Amyloid beta / neprilysin / Bruch膜 / neovascularization / アミロイドβ / 弾性繊維 / beta-secretase / アミロイドbeta / 遺伝子導入 / 弾性線維 |
Research Abstract |
We previously demonstrated that Alzheimer's amyloid beta was an important causative factor for developing the age-related macular degeneration (AMD) by using neprilysin-deficient mice. Although this mouse developed the features of early AMD, such as the degeneration of retinal pigment epithelium (RPE) and drusen deposition, they did not develop the choroidal neovascularization, which was an important feature for late stage AMD. Thus, in the present study, we focused on the integrity of Bruch's membrane as well as a role of endothelial progenitor cells. As a key factor for disrupted integrity of Bruch's membrane, we examined the role of cathepsin L and HTRA-1 in the development of late stage AMD.
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Report
(4 results)
Research Products
(88 results)
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[Journal Article] Evaluation of Pigment Epithelium-derived Factor and Complement Factor I Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes2013
Author(s)
Miyake M, Yamashiro K, Nakanishi H, Nakata I, Akagi-Kurashige Y, Kumagai K, Oishi M, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yoshimura N
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 54(6)
Pages: 4208-4212
Related Report
Peer Reviewed
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[Journal Article] Evaluation of Pigment Epithelium-derived Factor and Complement Factor I Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes.2013
Author(s)
Miyake M, Yamashiro K, Nakanishi H, Nakata I, Akagi-Kurashige Y, Kumagai K, Oishi M, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yoshimura N
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Journal Title
Investigative Ophthalmology & Visual Science
Volume: 54
Pages: 4208-4212
Related Report
Peer Reviewed
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