Elucidation ofpathogenesis and establishment of objective assessment for intraocular pressure-dependent optic nerve damage

• Project/Area Number: 22390324
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kobe University
• Principal Investigator: NEGI Akira 神戸大学, 大学院・医学研究科, 教授 (00189359)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Makoto 神戸大学, 大学院・医学研究科, 講師 (80273788) ; YAMADA Yuko 神戸大学, 大学院・医学研究科, 助教 (00359861) ; 今井 尚徳 神戸大学, 医学研究科, 非常勤講師 (90569211)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: 緑内障 / 視神経症 / 眼圧 / 網膜神経節細胞 / 多局所視覚誘発電位 / 光干渉断層計 / 一次視覚野 / グリア細胞 / アクアポリン / アストロサイト / 網膜神経線維 / 視神経乳頭

Research Abstract

The degree of visual field defect in glaucomatous patients correlated with postural fluctuation of intraocular pressure. Optimal conditions for multi-channel, multifocal visual evoked potential (mfVEP) recordings were established. Visual dysfunction in glaucomatous damages was objectively detected by quantitative analysis of mfVEP global index we have developed. We found that astrocytes in the optic nerve and retinal ganglion cells express aquaporin 9 water channel and that glaucoma and optic nerve crush injuries decrease it.

Research Products

• [Journal Article] Spectral-domain optical coherence tomography detects optic atrophy due to optic tract syndrome (2013)
  • Author(s): Akiyasu Kanamori, Makoto Nakamura, Yuko Yamada, Akira Negi
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 251 Issue: 2 Pages: 591-595
  • DOI: 10.1007/s00417-012-2096-3
  • Peer Reviewed
• [Journal Article] 視神経疾患の新しい展開 (2013)
  • Author(s): 根木 昭
  • Journal Title: 日本眼科学会雑誌 Volume: 117 Pages: 186-211
  • NAID: 10031155924
  • Peer Reviewed
• [Journal Article] Better performance of RTVue than Cirrus spectral-domain optical coherence tomography in detecting band atrophy of the optic nerve. (2012)
  • Author(s): Makoto Nakamura, Kumiko Ishikawa-Tabuchi, Akiyasu Kanamori, Yuko Yamada, Akira Negi.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 250 Issue: 10 Pages: 1499-1507
  • DOI: 10.1007/s00417-012-2095-4
  • Peer Reviewed
• [Journal Article] Agreement among three types of spectral-domain optical coherent tomography instruments in measuring parapapillary retinal nerve fibre layer thickness. (2012)
  • Author(s): Akiyasu Kanamori, Makoto Nakamura, Mari Tomioka, Yuki Kawaka, Yuko Yamada, Akira Negi.
  • Journal Title: Br J Ophthalmol Volume: 96 Issue: 6 Pages: 832-837
  • DOI: 10.1136/bjophthalmol-2011-301084
  • Peer Reviewed
• [Journal Article] Longitudinal study of retinal nerve fiber layer thickness and ganglion cell complex in traumatic optic neuropathy. (2012)
  • Author(s): Akiyasu Kanamori, Makoto Nakamura, Yuko Yamada, Akira Negi.
  • Journal Title: Arch Ophthalmol. Volume: 130 Issue: 8 Pages: 1067-1069
  • DOI: 10.1001/archophthalmol.2012.470
  • Peer Reviewed
• [Journal Article] Postural changes in intraocular pressure are associated with asymmetrical retinal nerve fiber thinning in treated patients with primary open-angle glaucoma. (2011)
  • Author(s): Junji Mizokami, Yuko Yamada, Akira Negi, Makoto Nakamura.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 249 Issue: 6 Pages: 879-885
  • DOI: 10.1007/s00417-010-1565-9
  • Peer Reviewed
• [Journal Article] Optimal conditions for multifocal VEP recording for normal Japanese population established by receiver operating characteristic analysis. (2011)
  • Author(s): Kumiko Ishikawa, Takayuki Nagai, Yuko Yamada, Akira Negi, Makoto Nakamura.
  • Journal Title: Doc Ophthalmol Volume: 122 Issue: 1 Pages: 29-37
  • DOI: 10.1007/s10633-010-9252-z
  • Peer Reviewed
• [Journal Article] Receiver-operating characteristic analysis of multifocal VEPs to diagnose and quantify glaucomatous functional damage. (2011)
  • Author(s): Makoto Nakamura, Kumiko Ishikawa, Takayuki Nagai, Akira Negi.
  • Journal Title: Doc Ophthalmol Volume: 123 Issue: 2 Pages: 93-108
  • DOI: 10.1007/s10633-011-9285-y
  • Peer Reviewed
• [Journal Article] Diabetes induces expression of aquaporin-0 in the retinal nerve fibers of spontaneously diabetic Torii rats. (2011)
  • Author(s): Masahide Fukuda, Maiko Naka, Junji Mizokami, Akira Negi, Nakamura M.
  • Journal Title: Exp Eye Res Volume: 91 Pages: 195-201
  • Peer Reviewed
• [Journal Article] A preliminary study of reduced expression of aquaporin-9 in the optic nerve of primate and human eyes with glaucoma. (2011)
  • Author(s): Junji Mizokami, Akiyasu Kanamori, Akira Negi, Makoto Nakamura
  • Journal Title: Curr Eye Res Volume: 36 Issue: 11 Pages: 1064-1067
  • DOI: 10.3109/02713683.2011.611610
  • Peer Reviewed
• [Journal Article] Diabetes induces expression of aquaporin-O in the retinal nerve fibers of spontaneously diabetic Torii rats (2011)
  • Author(s): Masahide Fukuda, et al
  • Journal Title: Experimental Eye Research Volume: 91 Pages: 195-201
  • Peer Reviewed
• [Journal Article] Receiver-operating characteristic analysis of multifocal VEPs to diagnose and quantify glaucomatous functional damage (2011)
  • Author(s): Makoto Nakamura, et al
  • Journal Title: Documenta Ophthalmologica Volume: 123 Pages: 93-108
  • Peer Reviewed
• [Journal Article] Optimal conditions for multifocal VEP recording for normal Japanese population established by receiver operating characteristic analysis (2011)
  • Author(s): Kumiko Ishikawa
  • Journal Title: Documents Ophthalmologica Volume: 122 Pages: 29-37
  • Peer Reviewed
• [Journal Article] Reduced expression of aquaporin-9 in rat optic nerve head and retina following elevated intraocular pressure. (2010)
  • Author(s): Maiko Naka, Akiyasu Kanamori, Akira Negi, Makoto Nakamura.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 51 Issue: 9 Pages: 4618-4626
  • DOI: 10.1167/iovs.09-4712
  • Peer Reviewed
• [Journal Article] Reduced expression of aquaporin-9 in rat optic nerve head and retina following elevated intraocular pressure (2010)
  • Author(s): Maiko Naka
  • Journal Title: Investigative Ophthalmology and Visual Science Volume: 51 Pages: 4618-4626
  • Peer Reviewed
• [Journal Article] Postural changes in intraocular pressure are associated with asymmetrical retinal nerve fiber thinning in treated patients with primary open-angle glaucoma.
  • Author(s): Junji Mizokami
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology Volume: (印刷中)
  • Peer Reviewed
• [Presentation] 多局所視覚誘発電位の受信者操作特性曲線解析に及ぼす高度近視の影響 (2012)
  • Author(s): 加藤 慶、鎌田誠子、田渕久美子、中村 誠、根木 昭.
  • Organizer: 第60回日本臨床視覚電気生理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-10-05
• [Presentation] Objective Functional assessment in Glaucoma (2012)
  • Author(s): Makoto Nakamura
  • Organizer: 27th Asia-Pacific Academy of Ophthalmology Congress(招待講演)
  • Place of Presentation: 大韓民国(釜山)
  • Year and Date: 2012-04-13
• [Presentation] 緑内障における多局所視覚誘発電位と構造変化の一致性と相関 (2012)
  • Author(s): 中村 誠、田渕久美子、近藤誠子、長井隆行、根木 昭
  • Organizer: 第116回日眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-07
• [Presentation] 視神経疾患の新しい展開 (2012)
  • Author(s): 根木 昭
  • Organizer: 第116回日本眼科学会総会招待講演
  • Place of Presentation: 東京
  • Year and Date: 2012-04-07
• [Presentation] 緑内障における多局所視覚誘発電位と構造変化の一致性と相関 (2012)
  • Author(s): 中村 誠、田渕久美子、近藤誠子、長井隆行、根木 昭（代表者）
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] Objective Functional assessment in Glaucoma (2012)
  • Author(s): Makoto Nakamura
  • Organizer: 27th Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: 大韓民国
  • Invited
• [Presentation] 視神経疾患の新しい展開 (2012)
  • Author(s): 根木 昭
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 緑内障性視神経症への挑戦.その基礎と臨床における三つの仮説の提唱 (2011)
  • Author(s): 中村 誠
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-14
• [Presentation] 緑内障性視神経症への挑戦.その基礎と臨床における三つの仮説の提唱 (2011)
  • Author(s): 中村誠
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京)(招待講演)
  • Year and Date: 2011-05-14
• [Presentation] The role of aquaporin in glaucomatous optic neuropathy. (2010)
  • Author(s): Makoto Nakamura
  • Organizer: 第25回アジア太平洋眼科連合集会
  • Place of Presentation: 中華人民共和国(北京)
  • Year and Date: 2010-09-18
• [Presentation] The role of aquaporin in glaucomatous optic neuropathy (2010)
  • Author(s): Makoto Nakamura
  • Organizer: 25^<th> APAO Congress
  • Place of Presentation: (中華人民共和国)北京(招待講演)
  • Year and Date: 2010-09-18