Pioneering Research to Elucidate the Pathogenic Mechanism and Genetic Susceptibility of Stevens Johnson Syndrome/Toxic Epidermal Necrolysis

• Project/Area Number: 22390325
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: SOTOZONO Chie 京都府立医科大学, 医学(系)研究科(研究院), 講師 (30216585)
• Co-Investigator(Kenkyū-buntansha): TASHIRO Kei 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10263097) ; KINOSHITA Shigeru 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30116024) ; UETA Mayumi 同志社大学, 生命医科学部, 准教授 (60398386)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: Stevens-Johnson 症候群 / 眼合併症 / 遺伝子多型 / 遺伝子間相互作用 / 自然免疫異常 / Stevens-Johnson症候群 / 中毒性表皮壊死融解症 / 全ゲノム解析 / PTGER3遺伝子 / prostaglandin E receptor 3 (EP3) / 眼表面炎症 / 非ステロイド系解熱鎮痛薬(NSAID) / 重症薬疹 / ゲノム解析 / プロテオミクス / 自然免疫 / サイトカイン

Research Abstract

The purpose of this present study was to perform a Genome-Wide Association Study (GWAS) in order to elucidate in greater detail the pathophysiology of Stevens Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) with severe ocular surface complications. Our GWAS findings revealed 6 single-nucleotide polymorphisms (SNPs) (rs17131450, rs5702, rs1325949, rs7543182, rs7555874, and rs4147114) in prostaglandin E receptor 3 (EP3) that are significantly associated with SJS/TEN. When we looked for the expression of EP3 in the conjunctival epithelium of SJS/TEN patients with severe ocular surface complications, we did not find EP3 protein. On the other hand, the EP3 protein was present in the conjunctival epithelium of the control patients with conjunctivochalasis or pterygium. Moreover, we found a variable with SJS genetic susceptibility effects involved in the locus-pairs of genes PTGER3-TLR3 and HLA-A*0206-TLR3.

Research Products

• [Journal Article] A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.Pharmacogenomics J (2013)
  • Author(s): Tohkin M, Kaniwa N, Saito Y, Sugiyama E, Kurose K, Nishikawa J, Hasegawa R, Aihara M, Matsunaga K, Abe M, Furuya H, Takahashi Y, Ikeda H, Muramatsu M, Ueta M, Sotozono C, Kinoshita S, Ikezawa Z
  • Journal Title: Peer-Reviewed papers Volume: 13(1) Issue: 1 Pages: 60-69
  • DOI: 10.1038/tpj.2011.41
  • Peer Reviewed
• [Journal Article] Vancomycin Ophthalmic Ointment 1% for methicillin-resistant Staphylococcus aureus or methicillin-resistant Staphylococcus epidermidis infections: a case series.BMJ Open (2013)
  • Author(s): Sotozono C, Fukuda M, Ohishi M, Yano K, Origasa H, Saiki Y, Shimomura Y, Kinoshita S
  • Journal Title: Peer-Reviewed papers Volume: 3(1) Issue: 1 Pages: e001206-e001206
  • DOI: 10.1136/bmjopen-2012-001206
  • Peer Reviewed
• [Journal Article] Visual Improvement after Cultivated Oral Mucosal Epithelial Transplantatio (2013)
  • Author(s): Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Miyakoda K, Kaneda H, Fukushima M, Kinoshita S
  • Journal Title: Ophthalmol, Peer-Reviewed papers Volume: 120(1) Issue: 1 Pages: 193-200
  • DOI: 10.1016/j.ophtha.2012.07.053
  • Peer Reviewed
• [Journal Article] Identification of a novel gene by whole human genome tiling array. (2013)
  • Author(s): Ishida H, Yagi T, Tanaka M, Tokuda Y, Kamoi K, Hongo F, Kawauchi A, Nakano M, Miki T, Tashiro K
  • Journal Title: Gene, Peer-Reviewed papers Volume: 516(1) Issue: 1 Pages: 33-38
  • DOI: 10.1016/j.gene.2012.11.076
  • Peer Reviewed
• [Journal Article] 眼合併症を伴う日本人Stevens-Johnson 症候群の HLA classI 解析 (2012)
  • Author(s): 中路進之助、上田真由美、外園千恵、稲富勉、木下茂
  • Journal Title: 日本眼科学会雑誌 Volume: 116(6) Pages: 581-287
  • NAID: 10030627350
  • Peer Reviewed
• [Journal Article] 羊膜移植の適応と効果 (2012)
  • Author(s): 日野智之、 外園千恵、 稲富勉、 福岡秀記、中村隆宏、 永田真帆、 小泉範子、 森和彦、横井則彦、木下茂
  • Journal Title: 日本眼科学会雑誌 Volume: 116(4) Pages: 374-378
  • NAID: 10030548521
  • Peer Reviewed
• [Journal Article] HLA-A*0206 with TLR3 Polymorphisms Exerts More than Additive Effects in Stevens-Johnson Syndrome with Severe Ocular Surface Complications (2012)
  • Author(s): Ueta M, Tokunaga K, Sotozono C, Sawai H, Tamiya G, Inatomi T, Kinoshita S
  • Journal Title: PLoS One, Peer-Reviewed papers Volume: 7(8) Issue: 8 Pages: e43650-e43650
  • DOI: 10.1371/journal.pone.0043650
  • Peer Reviewed
• [Journal Article] Expression of prostaglandin E receptor subtype EP4 in conjunctival epithelium of patients with ocular surface disorders: case-control study (2012)
  • Author(s): Ueta M, Sotozono C, Yamada K, Yokoi N, Inatomi T, Kinoshita S
  • Journal Title: BMJ Open, Peer-Reviewed papers Volume: 2(5) Issue: 5 Pages: e001330-e001330
  • DOI: 10.1136/bmjopen-2012-001330
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 Suppresses Poly I: C-Stimulated Cytokine Production Via EP2 and EP3 in Immortalized Human Corneal Epithelial Cells (2012)
  • Author(s): Ueta M, Matsuoka T, Sotozono C, Kinoshita S
  • Journal Title: Cornea. Peer-Reviewed papers Volume: 31(11) Issue: 11 Pages: 1294-1298
  • DOI: 10.1097/ico.0b013e318242fd7c
  • Peer Reviewed
• [Journal Article] Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes (2012)
  • Author(s): Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, Kinoshita S
  • Journal Title: J Allergy Clin Immunol Peer-Reviewed papers Volume: 129(5) Issue: 5 Pages: 1413-1416
  • DOI: 10.1016/j.jaci.2012.01.069
  • Peer Reviewed
• [Journal Article] Downregulation of monocyte chemoattractant protein 1 expression by prostaglandin e2 in human ocular surface epithelium (2012)
  • Author(s): Ueta M, Sotozono C, Yokoi N, Kinoshita S
  • Journal Title: ArchOphthalmol,Peer-Reviewed papers Volume: 130(2) Issue: 2 Pages: 249-251
  • DOI: 10.1001/archopthalmol.2011.1472
  • Peer Reviewed
• [Journal Article] The relation between visual performance and clinical ocular manifestations in stevens-johnson syndrome.Am J Ophthalmol (2012)
  • Author(s): Kaido M, Yamada M, Sotozono C,Kinoshita S, 他
  • Journal Title: Peer-Reviewed papers Volume: 154(3) Issue: 3 Pages: 499-511
  • DOI: 10.1016/j.ajo.2012.03.044
  • Peer Reviewed
• [Journal Article] Cerebrospinal fluid proteomic patterns discriminate Parkinson's disease and multiple system atrophy (2012)
  • Author(s): Ishigami N, Tokuda T, Ikegawa M, Tashiro K, Nakagawa M, 他
  • Journal Title: Mov Disord.Peer-Reviewed papers Volume: 27(7) Issue: 7 Pages: 851-857
  • DOI: 10.1002/mds.24994
  • Peer Reviewed
• [Journal Article] Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese (2012)
  • Author(s): Nakano M, Ikeda Y, Mori K, Kinoshita S, Tashiro K, 他
  • Journal Title: PLoS One Peer-Reviewed papers Volume: 7(3) Issue: 3 Pages: e33389-e33389
  • DOI: 10.1371/journal.pone.0033389
  • Peer Reviewed
• [Journal Article] An approach to predict the risk of glaucoma development by integrating different attribute data. SpringerPlus (2012)
  • Author(s): Tokuda Y, Kinoshita S, Tashiro K, 他
  • Journal Title: Peer-Reviewed papers Volume: 1 Issue: 1 Pages: 41-41
  • DOI: 10.1186/2193-1801-1-41
  • Peer Reviewed
• [Journal Article] Proteomic pattern analysis discriminates among multiple sclerosis-related disorders. Ann. Neurol (2012)
  • Author(s): Komori M, Tashiro K, 他
  • Journal Title: Peer-Reviewed papers Volume: 71 Issue: 5 Pages: 614-623
  • DOI: 10.1002/ana.22633
  • Peer Reviewed
• [Journal Article] Epistatic interactions associatedwith stevens-johnson syndrome (2012)
  • Author(s): Ueta M
  • Journal Title: Cornea,Peer-Reviewed papers Volume: 31 Issue: Supplement 1 Pages: 57-62
  • DOI: 10.1097/ico.0b013e31826a7f41
  • Peer Reviewed
• [Journal Article] Ocular surface inflammation is regulated by innate immunity (2012)
  • Author(s): Ueta M, Kinoshita S
  • Journal Title: Prog Retin Eye Res.Peer-Reviewed papers Volume: 31(6) Issue: 6 Pages: 551-575
  • DOI: 10.1016/j.preteyeres.2012.05.003
  • Peer Reviewed
• [Journal Article] 眼合併症を伴う日本人Stevens-Johnson症候群のHLA classI解析 (2012)
  • Author(s): 中路進之助, 上田真由美, 外園千恵, 稲富勉, 木下茂
  • Journal Title: 日本眼科学会雑誌 Volume: 116(6) Pages: 581-587
  • NAID: 10030627350
  • Peer Reviewed
• [Journal Article] 眼合併症を伴う日本人Stevens-Johnson症候群のHLA classI解析 (2012)
  • Author(s): 中路進之助、上田真由美、外園千恵、稲富勉、木下茂
  • Journal Title: 日本眼科学会雑誌 Volume: 6 Pages: 581-587
  • NAID: 10030627350
  • Peer Reviewed
• [Journal Article] Long-term results of autologous cultivated oral mucosal epithelial transplantation in the scar phase of severe ocular surface disorders (2011)
  • Author(s): Nakamura T, Takeda K, Inatomi T, Sotozono C, Kinoshita S
  • Journal Title: Br J Ophthalmol Volume: 95(7) Issue: 7 Pages: 9426-9426
  • DOI: 10.1136/bjo.2010.195859
  • Peer Reviewed
• [Journal Article] Expression of interleukin-4 receptor α in human corneal epithelial cells (2011)
  • Author(s): Ueta M, Sotozono C, Kinoshita S
  • Journal Title: Jpn J Ophthalmol. Volume: 55(4) Issue: 4 Pages: 405-410
  • DOI: 10.1007/s10384-011-0030-6
  • NAID: 10029528270
  • Peer Reviewed
• [Journal Article] Prostaglandin E Receptor Subtype EP3 Expression in Human Conjunctival Epithelium and Its Changes in Various Ocular Surface Disorders (2011)
  • Author(s): Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S
  • Journal Title: PLoS One Volume: 6(9) Issue: 9 Pages: e25209-e25209
  • DOI: 10.1371/journal.pone.0025209
  • Peer Reviewed
• [Journal Article] Cytokine storm arising on the ocular surface in a patient with Stevens-Johnson syndrome (2011)
  • Author(s): Yagi T, Sotozono C, Tanaka M, Fuwa M, Sekiyama E, Ueta M, Tashiro K, Kinoshita S
  • Journal Title: Br J Ophthalmol Volume: 95(7) Issue: 7 Pages: 1030-1031
  • DOI: 10.1136/bjo.2010.196295
  • Peer Reviewed
• [Journal Article] Infectious keratitis caused by fluoroquinolone-resistant Corynebacterium (2011)
  • Author(s): Fukumoto A, Sotozono C, Hieda O, Kinoshita S
  • Journal Title: Jpn J Ophthalmol Volume: 55(5) Issue: 5 Pages: 579-80
  • DOI: 10.1007/s10384-011-0052-0
  • NAID: 10029689276
  • Peer Reviewed
• [Journal Article] Amino Acid profiles in human tear fluids analyzed by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry (2011)
  • Author(s): Nakatsukasa M, Sotozono C, Shimbo K, Ono N, Miyano H, Okano A, Hamuro J, Kinoshita S
  • Journal Title: Am J Ophthalmol Volume: 151(5) Issue: 5 Pages: 799-808
  • DOI: 10.1016/j.ajo.2010.11.003
  • Peer Reviewed
• [Journal Article] Ocular surface reconstruction using the combination of autologous cultivated oral mucosal epithelial transplantation and eyelid surgery for severe ocular surface disease (2011)
  • Author(s): Takeda K, Nakamura T, Inatomi T, Sotozono C, Watanabe A, Kinoshita S
  • Journal Title: Am J Ophthalmol Volume: 152(2) Issue: 2 Pages: 195-201
  • DOI: 10.1016/j.ajo.2011.01.046
  • Peer Reviewed
• [Journal Article] Critical factors differentiating erythema multiforme majus from Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) (2011)
  • Author(s): Watanabe R, Watanabe H, Sotozono C, Kokaze A, Iijima M
  • Journal Title: Eur J Dermatol Volume: 21(6) Issue: 6 Pages: 889-894
  • DOI: 10.1684/ejd.2011.1510
  • Peer Reviewed
• [Journal Article] Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by genome-wide association study. (2011)
  • Author(s): Ueta M, Sotozono C, Nakano M, Taniguchi T, et al
  • Journal Title: Journal of Allergy and Clinical Immunology. Volume: 126 Pages: 1218-1225
  • Peer Reviewed
• [Journal Article] Systemic and Local Management at the Onset of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis with Ocular Complications (2010)
  • Author(s): Sotozono C, Ueta M, Kinoshita S
  • Journal Title: Am J Ophthalmol Volume: 149(2) Issue: 2 Pages: 354-354
  • DOI: 10.1016/j.ajo.2009.09.017
  • Peer Reviewed
• [Journal Article] for the JSAR research group. HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxicepidermal necrolysis in Japanese patients (2010)
  • Author(s): Kaniwa N, Saito Y, Aihara M, Matsunaga K, Tohkin M, Kurose K, Furuya H,Takahashi Y, Muramatsu M, Kinoshita S, Abe M, Ikeda H, Kashiwagi M, Song Y, Ueta M, Sotozono C, Ikezawa Z, Hasegawa R
  • Journal Title: Epilepsia Volume: 51(12) Issue: 12 Pages: 2461-2465
  • DOI: 10.1111/j.1528-1167.2010.02766.x
  • Peer Reviewed
• [Journal Article] Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study (2010)
  • Author(s): Ueta M, Sotozono C, Nakano M, Taniguchi T, Yagi T, Tokuda Y, Fuwa M, Inatomi T, Yokoi N, Tashiro K, Kinoshita S
  • Journal Title: J Allergy Clin Immunol Volume: 126(6) Issue: 6 Pages: 1218-1225
  • DOI: 10.1016/j.jaci.2010.08.007
  • Peer Reviewed
• [Journal Article] Prostaglandin E receptor 4 expression in human conjunctival epithelium and its downregulation in devastating ocular surface inflammatory disorders (2010)
  • Author(s): Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S
  • Journal Title: Arch Ophthalmol Volume: 128(10) Issue: 10 Pages: 1369-1371
  • DOI: 10.1001/archophthalmol.2010.232
  • Peer Reviewed
• [Journal Article] HLA-B^*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. (2010)
  • Author(s): Kaniwa N, Saito Y, Kinoshita S, Sotozono C, et al
  • Journal Title: Epilepsia Volume: 51 Pages: 2461-2465
  • Peer Reviewed
• [Journal Article] Systemic and Local Management at the Onset of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis with Ocular Complications. (2010)
  • Author(s): Sotozono C, Ueta M, Kinoshita S
  • Journal Title: American Journal of Ophthalmology Volume: 149 Pages: 354-354
  • Peer Reviewed
• [Journal Article] Prostaglandin E Receptor Subtype EP4 expression in human conjunctival epithelium and its downregulation in devastating ocular surface inflammatory disorders. (2010)
  • Author(s): Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S.
  • Journal Title: Archives of Ophthalmology. Volume: 128 Pages: 1369-1371
  • Peer Reviewed
• [Presentation] HECTドメインを有する新規遺伝子の研究 (2012)
  • Author(s): 徳田雄市、 田中雅深、 石田博、 八木知人、三木恒治、 田代啓
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] EP3 negatively regulates TLR3-dependent cytokine expression in conjunctival epithelium (2012)
  • Author(s): Ueta M, Narumiya S, Akira S, Kinoshita S
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-06
• [Presentation] Etiologic Features of Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) with Ocular Involvement (2012)
  • Author(s): Sotozono C, Ueta M, Kinoshita S, Kitami A, Iijima M, Aihara M, Ikezawa Z, Kano Y, Shiohara T, Shirakata Y, Sakabayashi S, Matsubara Y, Hashimoto K
  • Organizer: Annual Meeting of the American Academy of Ophthalmology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2012-11-11
• [Presentation] 重症薬疹研究班: 眼障害を伴うStevens-Johnson 症候群および中毒性表皮壊死症の疫学調査 (2012)
  • Author(s): 外園千恵、 上田真由美、 木下茂、 北見周、飯島正文、相原道子、池澤善郎、狩野葉子、塩原哲夫、白方裕司、橋本公二
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-25
• [Presentation] 眼合併症を伴う Stevens-Johnson 症候群発症における HLA-A0206-TLR3 遺伝子多型間の相互作用 (2012)
  • Author(s): 上田真由美、徳永勝士、外園千恵、澤井裕美、田宮元、稲富勉、木下茂
  • Organizer: 第21回日本組織適合性学会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-15
• [Presentation] 眼発症を伴う Stevens-Johnson 症候群発症における TLR3-EP3 遺伝子間相互作用の関与 (2012)
  • Author(s): 上田真由美、田宮元、徳永勝士、外園千恵、植木優夫、澤井裕美、稲富勉、木下茂
  • Organizer: 第46回日本眼炎症学会
  • Place of Presentation: 横浜
  • Year and Date: 2012-07-15
• [Presentation] PGE2 受容体サブタイプ EP3 と TLR3 の遺伝子間相互作用 (2012)
  • Author(s): 上田真由美、成宮周、審良静男、木下茂
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-05
• [Presentation] EP3 Negatively Regulates TLR3 dependent eosinophilic infiltration of allergic conjunctivitis (2012)
  • Author(s): Ueta M, Matsuoka T, Narumiya S, Akira S, Kinoshita S
  • Organizer: European Academy of Allergy and Clinical Immunology Congress 2012
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2012-06-17
• [Presentation] HLA-A*0206 and TLR3 SNPs are jointly predisposed with more than an additive effect to stevens-johnson syndrome with severe ocular complications (2012)
  • Author(s): Ueta M, Tokunaga K, Sotozono C, Sawai H, Tamiya G, Inatomi T, Kinoshita S
  • Organizer: 16th International HLA and Immunogenetics Workshop
  • Place of Presentation: Liverpool, U.K
  • Year and Date: 2012-06-01
• [Presentation] 網膜における血管新生に関連する遺伝子の網羅的発現解析. (2012)
  • Author(s): 足立博子、丸山悠子、米田一仁、丸山和一、木下茂、中野正和、田代啓
  • Organizer: 第59回 日本生化学会近畿支部例会
  • Place of Presentation: 京都
  • Year and Date: 2012-05-19
• [Presentation] Toll-like receptor subtype Tlr5 expression in human conjunctival epithelium in various cicatricial corneal conjunctival disorders (2012)
  • Author(s): Yamada K, Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S
  • Organizer: 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale
  • Place of Presentation: Florida, USA
  • Year and Date: 2012-05-08
• [Presentation] Epistatic interaction between TLR3 and ptger3 genes in experimental allergic conjunctivitis (2012)
  • Author(s): Ueta M, Matsuoka T, Narumiya S, Akira S, Kinoshita S
  • Organizer: 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2012-05-08
• [Presentation] Genetic Predisposition of Stevens-Johnson Syndrome with Ocular Complications (2012)
  • Author(s): Ueta M
  • Organizer: APAO/SOE Busan 2012
  • Place of Presentation: Busan, Korea
  • Year and Date: 2012-04-16
• [Presentation] Earlier is Better for the Treatment of Stevens-Johnson Syndrom (2012)
  • Author(s): Ueta M
  • Organizer: APAO/SOE Busan 2012
  • Place of Presentation: Busan, Korea
  • Year and Date: 2012-04-13
• [Presentation] アレルギー性結膜炎における TLR3 と PGE2 受容体サブタイプ EP3の遺伝子間相互作用 (2012)
  • Author(s): 上田真由美、松岡俊行、成宮周、審良静男、木下茂
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-06
• [Presentation] 瘢痕性角結膜疾患における TLR5 の発現 (2012)
  • Author(s): 山田桂子、上田真由美、外園千恵、稲富勉、横井則彦、木下茂
  • Organizer: 第36回日本角膜学会総会、第28回日本角膜移植学会
  • Place of Presentation: 東京
  • Year and Date: 2012-02-24
• [Presentation] 瘢痕性角結膜疾患におけるTLR5の発現 (2012)
  • Author(s): 山田桂子、上田真由美、外園千恵、稲富勉、横井則彦、木下茂
  • Organizer: 第36回日本角膜学会総会、第28回日本角膜移植学会
  • Place of Presentation: 東京
  • Year and Date: 2012-02-24
• [Presentation] Stevens-Johnson 症候群に対する眼瞼手術の検討 (2012)
  • Author(s): 渡辺彰英、外園千恵、上田真由美、木村直子、木下茂
  • Organizer: 第35回日本眼科手術学会総会
  • Place of Presentation: 愛知
  • Year and Date: 2012-01-28
• [Presentation] Stevens-Johnson症候群に対する眼瞼手術の検討 (2012)
  • Author(s): 渡辺彰英、外園千恵、上田真由美、木村直子、木下茂
  • Organizer: 第35回日本眼科手術学会総会
  • Place of Presentation: 愛知
  • Year and Date: 2012-01-28
• [Presentation] 原発開放隅角緑内障患者における血液生化学データの解析 (2012)
  • Author(s): 吉井健吾、 池田陽子、 森和彦、 上野盛夫、丸山悠子、吉川晴菜、中野正和、大見奈津江、 徳田雄市、 田代啓、 木下茂
  • Organizer: 第23回日本緑内障学会
  • Place of Presentation: 金沢
• [Presentation] 眼発症を伴うStevens-Johnson症候群発症におけるTLR3-EP3遺伝子間相互作用の関与 (2012)
  • Author(s): 上田真由美, 田宮元, 徳永勝士, 外園千恵, 植木優夫, 澤井裕美, 稲富勉, 木下茂
  • Organizer: 第46回日本眼炎症学会
  • Place of Presentation: 横浜
• [Presentation] 眼合併症を伴うStevens-Johnson症候群発症におけるHLA-A0206-TLR3遺伝子多型間の相互作用 (2012)
  • Author(s): 上田真由美, 徳永勝士, 外園千恵, 澤井裕美, 田宮元, 稲富勉, 木下茂
  • Organizer: 第21回日本組織適合性学会
  • Place of Presentation: 東京
• [Presentation] 重症薬疹研究班: 眼障害を伴うStevens-Johnson症候群および中毒性表皮壊死症の疫学調査 (2012)
  • Author(s): 外園千恵, 上田真由美, 木下茂, 北見周, 飯島正文, 相原道子, 池澤善郎, 狩野葉子, 塩原哲夫, 白方裕司, 橋本公二
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
• [Presentation] Toll-like receptor subtype Tlr5 expression in human conjunctival epithelium in various cicatricial corneal conjunctival disorders. (2012)
  • Author(s): Yamada K, Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S
  • Organizer: 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Fort Lauderdale, Florida, USA,
• [Presentation] HLA-A*0206 and TLR3 SNPs are jointly predisposed with more than an additive effect to stevens-johnson syndrome with severe ocular complications. (2012)
  • Author(s): Ueta M, Tokunaga K, Sotozono C, Sawai H, Tamiya G, Inatomi T, Kinoshita S
  • Organizer: 16th International HLA and Immunogenetics Workshop2012.6.1.
  • Place of Presentation: Liverpool, U.K
• [Presentation] Etiologic Features of Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) with Ocular Involvement. (2012)
  • Author(s): Sotozono C, Ueta M, Kinoshita S, Kitami A, Iijima M, Aihara M, Ikezawa Z, Kano Y, Shiohara T, Shirakata Y, Sakabayashi S, Matsubara Y, Hashimoto K
  • Organizer: Annual Meeting of the American Academy of Ophthalmology
  • Place of Presentation: Chicago, USA
• [Presentation] Genetic Predisposition of Stevens-Johnson Syndrome with Ocular Complications. (2012)
  • Author(s): Ueta M
  • Organizer: APAO/SOE Busan 2012
  • Place of Presentation: Busan, Korea
  • Invited
• [Presentation] Earlier is Better for the Treatment of Stevens-Johnson Syndrom. (2012)
  • Author(s): Ueta M
  • Organizer: APAO/SOE Busan 2012
  • Place of Presentation: Busan, Korea
  • Invited
• [Presentation] EP3 Negatively Regulates TLR3 dependent eosinophilic infiltration of allergic conjunctivitis. (2012)
  • Author(s): Ueta M, Matsuoka T, Narumiya S, Akira S, Kinoshita S
  • Organizer: European Academy of Allergy and Clinical Immunology Congress 2012
  • Place of Presentation: Geneva, Switzerland,
• [Presentation] Epistatic interaction between TLR3 and ptger3 genes in experimental allergic conjunctivitis. (2012)
  • Author(s): Ueta M, Matsuoka T, Narumiya S, Akira S, Kinoshita S
  • Organizer: 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
• [Presentation] EP3 negatively regulates TLR3-dependent cytokine expression in conjunctival epithelium. (2012)
  • Author(s): Ueta M, Narumiya S, Akira S, Kinoshita S
  • Organizer: 第４１回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] PGE2受容体サブタイプEP3とTLR3の遺伝子間相互作用 (2012)
  • Author(s): 上田真由美, 成宮周, 審良静男, 木下茂
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: 福岡
• [Presentation] アレルギー性結膜炎におけるTLR3とPGE2受容体サブタイプEP3の遺伝子間相互作用 (2012)
  • Author(s): 上田真由美, 松岡俊行, 成宮周, 審良静男, 木下茂
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] 網膜における血管新生に関連する遺伝子の網羅的発現解析 (2012)
  • Author(s): 足立博子、丸山悠子、米田一仁、丸山和一、木下茂、中野正和、田代啓
  • Organizer: 第59回 日本生化学会近畿支部例会
  • Place of Presentation: 京都
• [Presentation] Cultivated Oral Mucosal Epithelial Transplantation for Ocular Surface Reconstruction in Stevens-Johnson Syndrome (2011)
  • Author(s): Sotozono C, Inatomi T, Nakamura T, Ueta M, Yokoi N, Miyakoda K, Kinoshita S
  • Organizer: Annual Meeting of the American Academy of Ophthalmology
  • Place of Presentation: Florida, USA
  • Year and Date: 2011-10-25
• [Presentation] 難治性角結膜疾患に対する自家培養口腔粘膜上皮シート移植のレトロスペクティブ調査 (2011)
  • Author(s): 外園千恵、 稲富勉、 中村隆宏、 小泉範子、横井則彦、 都田桂子、 松山琴音、 木下茂
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-08
• [Presentation] 自家培養口腔粘膜上皮シート移植による結膜嚢再建効果の検討 (2011)
  • Author(s): 稲富勉、 外園千恵、 中村隆宏、 小泉範子、都田桂子、松山琴音、木下茂
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-08
• [Presentation] 重篤な眼合併症を伴う日本人 Stevens-Johnson 症候群とHLA class I (2011)
  • Author(s): 中路進之介、上田真由美、外園千恵、稲富勉、松下正毅、木下茂
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-12
• [Presentation] 重篤な眼合併症を伴う日本人Stevens-Johnson症候群とHLA classI (2011)
  • Author(s): 中路進之介、上田真由美、外園千恵、稲富勉、松下正毅、木下茂
  • Organizer: 第115回日本眼科学会総会、東京
  • Place of Presentation: 東京
  • Year and Date: 2011-05-12
• [Presentation] Prostaglandin E Receptor Subtype Ep4 Expression In Human Conjunctival Epithelium And Its Changes In Various Ocular Surface Disorders (2011)
  • Author(s): Yamada K, Ueta M, Sotozono C, Yokoi N, Inatomi T, Koizumi N, Kinoshita S
  • Organizer: Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Florida, USA
  • Year and Date: 2011-05-04
• [Presentation] 眼表面疾患患者のMRSA保菌に関する検討 (2011)
  • Author(s): 田中寛、外園千恵, 他
  • Organizer: 第34回角膜カンファランス
  • Place of Presentation: 仙台、宮城県
  • Year and Date: 2011-02-11
• [Presentation] Therapeutic Modalities of Conjunctival Intraepithelial Neoplasia (2010)
  • Author(s): Sotozono C
  • Organizer: The 2nd Asia Cornea Society Biannual Scientific Meeting
  • Place of Presentation: Kyoto, JAPAN
  • Year and Date: 2010-12-02
• [Presentation] 眼発症を伴うSteven-Johnson 症候群発症に関わる遺伝子素因についての検討 (2010)
  • Author(s): 上田真由美、外園千恵、稲富勉、中路進之介、木下茂
  • Organizer: 眼発症を伴うSteven-Johnson 症候群発症に関わる遺伝子素因についての検討眼発症を伴うSteven-Johnson 症候群発症に関わる遺伝子素因についての検討眼発症を伴うSteven-Johnson 症候群発症に関わる遺伝子素因についての検討眼発症を伴うSteven-Johnson 症候群発症に関わる遺伝子素因についての検討眼発症を伴うSteven-Johnson 症候群発症に関わる遺伝子素因についての検討眼発症を伴うSteven-Johnson 症候群発症に関わる遺伝子素因についての検討眼発症
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-12
• [Presentation] 眼発症を伴うStevens-Johnson症候群発症に関わる遺伝子素因についての検討(SJSの遺伝子素因) (2010)
  • Author(s): 上田真由美、外園千恵, 他
  • Organizer: 第64回日本臨床眼科学会、DNAチップ研究会
  • Place of Presentation: 神戸、兵庫
  • Year and Date: 2010-11-11
• [Presentation] Stevens-Johnson 症候群に対する全遺伝子アプローチによる遺伝子多型解析 (2010)
  • Author(s): 木下茂、 上田真由美、 外園千恵、 稲富勉、横井則彦、中野正和、谷口孝純、八木知人、徳田雄市、不破正博、田代啓
  • Organizer: Stevens-Johnson 症候群に対する全遺伝子アプローチによる遺伝子多型解析
  • Place of Presentation: 東京
  • Year and Date: 2010-08-05
• [Presentation] Stevens-Johnson症候群に対する全遺伝子アプローチによる遺伝子多型解析 (2010)
  • Author(s): 木下茂、上田真由美、外園千恵, 他
  • Organizer: 第31回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-05
• [Presentation] Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome with ocular involvement identified by genome-wide association study in a Japanese population (2010)
  • Author(s): Mayumi Ueta, Chie Sotozono, Masakazu Nakano, et al
  • Organizer: Keystone Symposia, Bioactive Lipids : Biochemistry and Diseases (D2)
  • Place of Presentation: Kyoto, JAPAN
  • Year and Date: 2010-06-10
• [Presentation] Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome with ocular involvement identified by genome-wide association study in a Japanese population (2010)
  • Author(s): Ueta M, Sotozono C, Nakano M, Taniguchi T, Yagi T, Tokuda Y, Fuwa M, Inatomi T, Yokoi N, Tashiro K, Kinoshita S
  • Organizer: Keystone Symposia. Bioactive Lipids: Biochemistry and Diseases
  • Place of Presentation: Kyoto, JAPAN
  • Year and Date: 2010-06-09
• [Presentation] Chronic Ocular Complications in Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (2010)
  • Author(s): Sotozono C, Ueta M, Inatomi T, Kinoshita S
  • Organizer: 4th International Drug Hypersensitivity Meeting
  • Place of Presentation: Roma, Italy
  • Year and Date: 2010-04-22
• [Presentation] Genetic Factors of Stevens-Johnson Syndrome with ocular complications in Japanese (2010)
  • Author(s): Ueta M, Sotozono C, Inatomi T, Kinoshita S
  • Organizer: 4th International Drug Hypersensitivity Meeting
  • Place of Presentation: Roma, Italy
  • Year and Date: 2010-04-22
• [Presentation] Chronic Ocular Complications in Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (2010)
  • Author(s): Chie Sotozono, Mayumi Ueta, Tsutomu Inatomi, et al
  • Organizer: DHM 4Th International Drug Hypersensitivity Meeting.
  • Place of Presentation: Roma, Italy
  • Year and Date: 2010-04-22
• [Presentation] Genetic Factors of Stevens-Johnson Syndrome with ocular complications in Japanese (2010)
  • Author(s): Mayumi Ueta, Chie Sotozono, Tsutomu Inatomi, et al
  • Organizer: DHM 4Th International Drug Hypersensitivity Meeting.
  • Place of Presentation: Roma, Italy
  • Year and Date: 2010-04-22
• [Presentation] 眼表面疾患患者のMRSA 保菌に関する検討 (2010)
  • Author(s): 田中寛、 外園千恵、 上田真由美、 稲富勉、中村隆宏、木下茂
  • Organizer: 第34回角膜カンファランス、 第26回日本角膜移植学会
  • Place of Presentation: 仙台
• [Book] 薬疹 3 重症薬疹では眼病変に注意 (2010)
  • Author(s): 上田真由美、外園千恵
  • Publisher: メディカルレビュー社
• [Book] 重症薬疹では眼病変に注意、WHAT'S NEW IN皮膚科学 (2010)
  • Author(s): 上田真由美、外園千恵
  • Publisher: メディカルレビュー社