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Development of new treatment for eye diseases by use of combination with gene therapy, cellular therapy and reproducing medicine.

Research Project

Project/Area Number 22390327
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionNational Research Institute for Child Health and Development

Principal Investigator

AZUMA Noriyuki  独立行政法人国立成育医療研究センター, その他部局等, その他 (10159395)

Co-Investigator(Kenkyū-buntansha) SEKO Yuko  国立障害者リハビリテーションセンター(研究所), 感覚機能系障害研究部 視覚機能障害研究室, 室長 (60301157)
UMEZAWA Akihiro  国立成育医療研究センター 再生医療センター, 副所長・再生医療センター長 (70213486)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords再生医学 / 遺伝学 / 遺伝子・細胞治療 / 角膜 / 網膜 / 遺伝子
Outline of Final Research Achievements

On aspect of gene therapy and cellular therapy: 1.Successful engraftment of GFP-positive cells in mouse retina in vivo, 2. Identification of candidate gene in a family of novel congenital anomaly of the optic disc and vitreous by exome analysis, 3. Identification of Pax6 mutations in 23 cases with congenital eye anomalies. On aspect of reproducing medicine: 1. Generation of iPS cells from infantile iris and retina tissue, 2. Generation of the self-induced eye primordium and retina tissue from human iPS cells, 3. Generation of photoreceptor-like cells of the retina from human skin by introduction of external genes, 4. Generation of self-induced retinal ganglion cells with functional axons from human iPS cells.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (74 results)

All 2015 2014 2013 2012 2011 2010

All Journal Article (37 results) (of which Peer Reviewed: 36 results,  Acknowledgement Compliant: 7 results,  Open Access: 4 results) Presentation (33 results) (of which Invited: 5 results) Book (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells.2015

    • Author(s)
      Tanaka T, Yokoi T, Tamalu F, Watanabe S, Nishina S, Azuma N
    • Journal Title

      Sci. Rep

      Volume: 10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Generation of pluripotent stem cells without the use of genetic material.2015

    • Author(s)
      Higuchi A, Ling QD, Kumar SS, Munusamy MA, Alarfaj AA, Chang Y, Kao SH, Lin KC, Wang HC, Umezawa A
    • Journal Title

      Lab Invest

      Volume: 95(1) Pages: 26-42

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A practical guide to induced pluripotent stem cell research using patient samples2015

    • Author(s)
      Santostefano KE, Hamazaki T, Biel NM, Jin S, Umezawa A, Terada N
    • Journal Title

      Lab Invest

      Volume: 95(1) Pages: 4-13

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Derivation of human differential photoreceptor cells from adult human dermal fibroblasts by defined combinations of CRX, RAX, OTX2 and NEUROD.2014

    • Author(s)
      Seko Y, Azuma N, Ishii T, Komuta Y, Miyamoto K, Miyagawa Y, Kaneda M, Umezawa A.
    • Journal Title

      Genes Cells

      Volume: 19 Pages: 198-208

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Three Cases of rhegmatogenous retinal detachment associated with regressed retinoblastoma after conservative tumor therapy.2014

    • Author(s)
      Tanaka M, Yokoi T, Kobayashi Y, Nishina S, Noda E, Ito M, Azuma N.
    • Journal Title

      Retin Cases Brief Rep

      Volume: 8 Pages: 223-226

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Surgical outcomes of progressive tractional retinal detachment associated with familial exudative vitreoretinopathy2014

    • Author(s)
      Yamane T, Yokoi T, Nakayama Y, Nishina S, Azuma N
    • Journal Title

      Am J Ophthalmol

      Volume: 158 Pages: 1049-1055

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability.2014

    • Author(s)
      Fukawatase Y, Toyoda M, Okamura K, Nakamura K, Nakabayashi K, Takada S, Yamazaki-Inoue M, Masuda A, Nasu M, Hata K, Hanaoka K, Higuchi A, Takubo K, Umezawa A
    • Journal Title

      Sci Rep

      Volume: 4 Pages: 5421-5421

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Three cases of rhegmatogenous retinal detachment associated with regressed retinoblastoma after conservative therapy.2014

    • Author(s)
      Tanaka M, Yokoi T, Ito M, Kobayashi Y, Noda E, Matsuoka K, Nishina S, Azuma N
    • Journal Title

      Retin Cases Brief Rep Epub

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Derivation of human differential photoreceptor cells from adult human dermal fibroblasts by defined combinations of CRX, RAX, OTX2 and NEUROD.2014

    • Author(s)
      Seko Y, Azuma N, Ishii T, Komuta Y, Miyamoto K, Miyagawa Y, Kaneda M, Umezawa A.
    • Journal Title

      Gene to Cells Epub

      Volume: 19(3) Pages: 198-208

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a premacular vitreous pocket2013

    • Author(s)
      Yokoi T, Toriyama N, Yamane T, Nakayama Y, Nishina S, Azuma N
    • Journal Title

      JAMA Ophthalmol

      Volume: 131(8) Pages: 1095-1096

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electroretinography combined with spectral domain optical coherence tomography to detect retinal damage in shaken baby syndrome..2013

    • Author(s)
      Nakayama Y, Yokoi T, Nishina S, Okuyama M, Azuma N
    • Journal Title

      J AAPOS

      Volume: 17(4) Pages: 411-413

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual outcomes after early vitreous surgery for aggressive posterior retinopathy of prematurity2013

    • Author(s)
      Azuma N, Ito M, Yokoi T, Nakayama Y, Nishina S.
    • Journal Title

      JAMA Ophthalmol

      Volume: 131(10) Pages: 1309-1313

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 巻頭言 未熟児網膜症治療の現状2013

    • Author(s)
      東 範行
    • Journal Title

      日眼会誌

      Volume: 117( 8) Pages: 605-607

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 太陽電池を用いた人工視覚2013

    • Author(s)
      東 範行
    • Journal Title

      日本の眼科

      Volume: 84 Pages: 1550-1553

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of functioning human corneal endothelial cell line with high growth potential.2012

    • Author(s)
      Yokoi T, Seko Y, Yokoi T, Makino H, Hatou S, Yamada M, Kiyono T, Umezawa A, Nishina H, Azuma N.
    • Journal Title

      PLoS One

      Volume: 7(1) Issue: 1 Pages: e29677-e29677

    • DOI

      10.1371/journal.pone.0029677

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Derivation of Human Differential Photoreceptor-like Cells from the Iris by Defined Combinations of CRX, RX and NEUROD.2012

    • Author(s)
      Seko Y, Azuma N, Kaneda M, Nakatani K, Miyagawa Y, Noshiro Y, Kurokawa R, Okano H, Umezawa A.
    • Journal Title

      PLoS One

      Volume: 7(4) Issue: 4 Pages: e35611-e35611

    • DOI

      10.1371/journal.pone.0035611

    • NAID

      120007137243

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Novel Mutations in the EYS Gene Are Possible Major Causes of Autosomal Recessive Retinitis Pigmentosa in the Japanese Population.2012

    • Author(s)
      Nakanishi H, Ueno S, Yokoi T, Hikoya A, Fujita T, Zhao Y, Nishina S, Shin JP, Kim IT, Yamamoto S, Azuma N, Terasaki H, Sato M, Kondo M, Minoshima M, Hotta Y.
    • Journal Title

      PLoS One

      Volume: 7(2) Issue: 2 Pages: e31036-e31036

    • DOI

      10.1371/journal.pone.0031036

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of congenital retinal folds.2012

    • Author(s)
      Nishina S、Suzuki Y, Yokoi T, Kobayashi Y, Noda E, Azuma N.
    • Journal Title

      Am J Ophthalmol

      Volume: 153(1) Issue: 1 Pages: 81-87

    • DOI

      10.1016/j.ajo.2011.06.002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survey of microphthalmia in Japan.2012

    • Author(s)
      Nishina S, Kurosaka D, Nishida Y, Kondo H, Kobayashi Y, Azuma N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 56 Issue: 3 Pages: 198-202

    • DOI

      10.1007/s10384-012-0126-7

    • NAID

      10030626740

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of functioning human corneal endothelial cell line with high growth potential2012

    • Author(s)
      Yokoi T, Seko Y, Yokoi T, Makino H, Hatou S, Yamada M, Kiyono T, Umezawa A, Nishina H, Azuma N
    • Journal Title

      PLoS One

      Volume: 7(1)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Derivation of Human Differential Photoreceptor-like Cells from the Iris by Defined Combinations of CRX, RX and NEUROD2012

    • Author(s)
      Seko Y, Azuma N, Kaneda M, Nakatani K, Miyagawa Y, Noshiro Y, Kurokawa R, Okano H, Umezawa A
    • Journal Title

      PLoS One

      Volume: 7(4)

    • NAID

      120007137243

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Novel Mutations in the EYS Gene Are Possible Major Causes of Autosomal Recessive Retinitis Pigmentosa in the Japanese Population2012

    • Author(s)
      Hosono K, Azuma N, et al
    • Journal Title

      PLoS One

      Volume: 7(2)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of congenital retinal folds2012

    • Author(s)
      Nishina S, Suzuki Y, Yokoi T, Kobayashi Y, Noda E, Azuma N
    • Journal Title

      Am J Ophthalmol

      Volume: 153(1) Pages: 81-87

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survey of microphthalmia in Japan2012

    • Author(s)
      Nishina S, Kurosaka D, Nishida Y, Kondo H, Kobayashi Y, Azuma N
    • Journal Title

      Jpn J Ophthalmol

      Volume: Feb 23(Equb ahead of print)

    • NAID

      10030626740

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ophthalmic features of CHARGE syndrome with CHD7 mutations2012

    • Author(s)
      Nishina S, Azuma N, et al
    • Journal Title

      Am J Med Genet A

      Volume: 158A(3) Pages: 514-518

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of anterior segment dysgenesis associated with congenital corneal opacities2012

    • Author(s)
      Shigeyasu C, Yamada M, Mizuno Y, Yokoi T, Nishina S, Azuma N
    • Journal Title

      Cornea

      Volume: 31 Pages: 293-298

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex2011

    • Author(s)
      Yamasaki T, Azuma N, et al
    • Journal Title

      J Neurosci

      Volume: 31(46) Pages: 16872-16883

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of aniridia with uniocular Peters anomaly2011

    • Author(s)
      Sawada M, Sato M, Hikoya A, Wang C-X, Minoshima S, Azuma N, Hotta Y
    • Journal Title

      J AAPOS

      Volume: 15 Pages: 104-106

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Fluorescein staining of the vitreous during vitrectomy for retinopathy of prematurity2011

    • Author(s)
      Kobayashi Y, Yokoi T, Yokoi T, Hiraoka H, Nishina S, Azuma N
    • Journal Title

      Retina

      Volume: 31 Pages: 1717-1719

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nishida's procedure combined with medial rectus recession for large-angle esotropia in Duane syndrome2011

    • Author(s)
      Tanaka M, Nishina S, Ogonuki S, Akaike S, Azuma N
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55(3) Pages: 264-267

    • NAID

      10029021414

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for recurrent fibrovascular proliferation in aggressive posterior retinopathy of prematurity after early vitreous surgery.2010

    • Author(s)
      Yokoi T, Yokoi T, Kobayashi Y, Nishina S, Azuma N.
    • Journal Title

      Am J.Ophthalmol

      Volume: 150 Pages: 10-15

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterozygous OTX2 mutations are associated with variable pituitary phenotype.2010

    • Author(s)
      Dateki S, Kosaka K, Hasegawa K, Tanaka H, Azuma N, Yokoya S, Muroya K, Adachi M, Tajima T, Motomura K, Kinoshita E, Moriuchi H, Fukami M, Ogata T
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 95 Pages: 756-764

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p38 mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating MEF2C-dependent BMP2 transcription.2010

    • Author(s)
      Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, Watanabe T, Azuma N, Katada T, Nishina H.
    • Journal Title

      Stem Cells Dev

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous Candida chorioretinitis in a healthy infant.2010

    • Author(s)
      Ito M, Yokoi T, Sugita S, Shinohara N, Nishina S, Azuma N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: In press

    • NAID

      10027666584

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neovascularization in child following laser pinter-induced macular injury.2010

    • Author(s)
      Fujinami K, Yokoi T, Hiraoka M, Nishina S, Azuma N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is a 6-week course of ganciclovir therapy effective for chorioretinitis in infants with congenital cytomegalovirus infection2010

    • Author(s)
      Shoji K, Ito N, Ito Y, Inoue N, Adachi S, Fujimaru T, Nakamura T, Nishina S, Azuma N, Saitoh A.
    • Journal Title

      J Pediatr

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescein staining of the vitreous during vitrectomy for retinopathy of prematurity.2010

    • Author(s)
      Kobayashi Y, Yokoi T, Yokoi T, Hiraoka H, Nishina S, Azuma N.
    • Journal Title

      Retina

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小児の眼底が教えてくれること -疾患の理解から未来の医療へ-2014

    • Author(s)
      東 範行
    • Organizer
      第68回日本臨床眼科学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 近視化の伴う眼軸延長のメカニズム-網膜と強膜における分子レベルのアプローチ-2014

    • Author(s)
      世古裕子
    • Organizer
      第11回 Medical Retina League テーマ:近視の基礎・臨床アップデート 特別講演
    • Place of Presentation
      東京
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト培養誘導網膜視細胞の光応答について2014

    • Author(s)
      世古裕子、東範行、石井俊行、小牟田縁、金田誠、梅澤明弘
    • Organizer
      第18回視覚科学フォーラム研究会
    • Place of Presentation
      群馬
    • Year and Date
      2014-08-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Direct reprogramming法を用いた視細胞の再生医学2014

    • Author(s)
      世古裕子
    • Organizer
      第245回生理学東京談話会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 網膜シグナル制御による眼軸延長抑制の可能性2014

    • Author(s)
      世古裕子
    • Organizer
      第118回日本眼科学会総会、 シンポジウム 【近視の近未来治療を科学する】
    • Place of Presentation
      東京
    • Year and Date
      2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of retinal structure and function in eyes with optic nerve hypoplasia. An International Perspective of Pediatric Ophthalmology & Strabismus2013

    • Author(s)
      Nishina S, Yokoi T, Nakayama Y, Ui M, Tanaka M, Azuma N
    • Organizer
      AAPOS&SNEC joint meeting
    • Place of Presentation
      Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of a premacular vitreous pocket2013

    • Author(s)
      Yokoi T, Toriyama N, Yamane T, Nakayama Y, Nishina S, Azuma N
    • Organizer
      ARVO
    • Place of Presentation
      Seattle
    • Related Report
      2013 Annual Research Report
  • [Presentation] Surgical outcomes of traction retinal detachment associated with familial exudative vitreoretinopathy2013

    • Author(s)
      Azuma N.
    • Organizer
      AAPOS&SNEC joint meeting,
    • Place of Presentation
      Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structure and function of the fovea region in eyes with peripapillary staphyloma.2013

    • Author(s)
      Nakayama Y, Tanaka M, Yokoi T, Nishina S, Azuma N
    • Organizer
      AAPOS&SNEC joint meeting,
    • Place of Presentation
      Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] SS-OCTによる小児の眼底疾患所見―Pit-macular症候群の発生機序―2013

    • Author(s)
      横井 匡,東 範行
    • Organizer
      Japan Macula Club
    • Place of Presentation
      蒲郡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structure and function of the fovea region in eyes with peripapillary staphyloma2013

    • Author(s)
      Nakayama Y, Tanaka M, Yokoi T, Nishina S. Azuma N
    • Organizer
      The 8th APVRS Congress
    • Place of Presentation
      Nagoya
    • Related Report
      2013 Annual Research Report
  • [Presentation] Detailed structure of optic disc pits examined by swept-source OCT.2013

    • Author(s)
      Yokoi T, Nakayama Y, Nishina S. Azuma N
    • Organizer
      The 8th APVRS Congress
    • Place of Presentation
      Nagoya
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児眼疾患の診かた考え方2013

    • Author(s)
      東 範行
    • Organizer
      さざなみ眼科研究会
    • Place of Presentation
      滋賀
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小児の内眼手術2013

    • Author(s)
      東 範行
    • Organizer
      大阪眼科手術シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 未熟児網膜症の診断と治療2013

    • Author(s)
      東 範行
    • Organizer
      千葉県眼科手術懇話会
    • Place of Presentation
      幕張
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小児の眼底疾患2013

    • Author(s)
      東 範行
    • Organizer
      東京都眼科医会卒後研修会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 眼の発生と進化 ーさまざまな動物の眼やヒトの進化からー2012

    • Author(s)
      東 範行
    • Organizer
      Retina-Glaucoma Meeting
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 視神経の構造と機能2012

    • Author(s)
      東 範行
    • Organizer
      Japan Macula Club
    • Place of Presentation
      蒲郡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Survey of mucrophthalmos in Japan2012

    • Author(s)
      Nishina S, Yokoi N,
    • Organizer
      American Academy of Ophthalmology
    • Place of Presentation
      シカゴ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Structure and function of optic nerve hypoplasia.2012

    • Author(s)
      Nishia S, Nakayama Y, Yokoi T, Yamane T, Azuma N.
    • Organizer
      第51回網膜硝子体学会
    • Place of Presentation
      甲府
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis of retinal structure and function in eyes with foveal hypoplasia2011

    • Author(s)
      Yokoi T, Ui R, Ito M, Nakayama Y, Nishina S, Azuma N
    • Organizer
      Distinguished investigators' forum第50日本網膜硝子体学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 眼の形態形成遺伝子と再生医療2011

    • Author(s)
      東範行
    • Organizer
      CIBAビジョンシンポジウム第114回日本眼科学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ocular manifestations and prognosis of shaken baby syndrome in two Japanese children's hospitals.2010

    • Author(s)
      Kobayashi Y, Yamada K, Ohba S, Nishina S, Okuyama M, Azuma N.
    • Organizer
      XXXIIth International Congress of Ophthalmology
    • Place of Presentation
      ベルリン
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endogenous Candida choriorednitis in a healthy infant.2010

    • Author(s)
      Ito M, Yokoi T, Sugita S, Shinohara N, Nishina S, Azuma N.
    • Organizer
      XXXIIth International congress of Ophthalmology
    • Place of Presentation
      ベルリン
    • Related Report
      2010 Annual Research Report
  • [Presentation] Risk factors for recurrent fibrovascular proliferation in aggressive posterior retinopathy of prematurity after early vitreous surgery2010

    • Author(s)
      Yokoi T, Yokoi T, Kobayashi Y, Nishina S, Azuma N.
    • Organizer
      XXXIIth International Congress of Ophthalmology
    • Place of Presentation
      ベルリン
    • Related Report
      2010 Annual Research Report
  • [Presentation] 未熟児網膜症の診断と治療2010

    • Author(s)
      東範行
    • Organizer
      日本医科大学眼科研究会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 眼を作るシステムと視覚の成立2010

    • Author(s)
      東範行
    • Organizer
      第66回日本弱視斜視学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 未熟児網膜症の網膜剥離に対する治療2010

    • Author(s)
      東範行
    • Organizer
      第13回静岡網膜硝子体研究会
    • Place of Presentation
      静岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 児の病理 眼の発生と形成異常2010

    • Author(s)
      東範行
    • Organizer
      第114回日本眼科学会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児眼底の広範な構造と機能の検査2010

    • Author(s)
      伊藤牧子, 田中三千子, 横井匡, 小林百合, 野田英一郎, 仁科幸子, 東範行
    • Organizer
      第35回日本小児眼科学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 検眼鏡的に異常がない視力不良例に対する網膜電図検査2010

    • Author(s)
      田中三千子, 伊藤牧子, 横井匡, 野田英一郎, 小林百合, 仁科幸子, 東範行
    • Organizer
      第35回日本小児眼科学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児眼底の広範な構造と機能の検査2010

    • Author(s)
      東範行
    • Organizer
      Japan Macula Club
    • Place of Presentation
      蒲郡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新生児におけるトスフロキサシン点眼液の有効性と安全性の検討2010

    • Author(s)
      宮永嘉隆, 東範行, 大野重昭
    • Organizer
      第64回日本臨床眼科学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Book] 細胞工学 別冊ハンドブック ダイレクトリプログラミング2015

    • Author(s)
      世古裕子、梅澤明弘(監修:鈴木淳史)
    • Total Pages
      119
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2014 Annual Research Report
  • [Book] 眼科診療クオリファイ28 サイエンティフィック・クエスチョン 実験近視研究の進歩について教えてください、近視の病態とマネジメント2015

    • Author(s)
      世古裕子(編集:大野京子)
    • Publisher
      中山書店
    • Related Report
      2014 Annual Research Report
  • [Book] 新体系看護学全書 小児看護学2 健康障害をもつ小児の看護. 眼疾患2013

    • Author(s)
      野田英一郎, 東 範行
    • Total Pages
      642
    • Publisher
      メヂルフレンド社
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 網膜神経節細胞の作製方法2014

    • Inventor(s)
      東範行
    • Industrial Property Rights Holder
      東範行
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-08-08
    • Related Report
      2014 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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