Development of treatment for injury of central and peripheral nervous system

• Project/Area Number: 22390333
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Tazuke Kofukai Medical Research Institute
• Principal Investigator: SUZUKI Yoshihisa 公益財団法人田附興風会, 医学研究所 第5研究部, 研究主幹 (30243025)
• Co-Investigator(Renkei-kenkyūsha): NAKATANI Toshio 関西医科大学, 医学部, 教授 (70188978) ; TANIHARA Masao 奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (50294286)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: 細胞培養 / 移植学 / 脊髄の再生医療 / 中枢神経 / 末梢神経 / 再生 / 骨髄細胞 / 再生医療

Research Abstract

Intrathecal transplantation of autologous bone marrow-derived mononuclear cells for treatment of the patients with spinal cord injury was conducted to assess the safety and feasibility. Ten patients were included. No adverse associated with the treatment responses were observed.

Research Products

• [Journal Article] Autotransplanting of Bone Marrow-Derived Mononuclear Cells for Complete Cases of Canine Paraplegia and Loss of Pain Perception, Secondary to Intervertebral Disc Herniation (2012)
  • Author(s): Tamura ,K,. Harada, Y,. Nagashima ,N,. Kunimi, M,. Itoi, T,. Ishino, H., Yogo, T., Nezu, Y., Hara, Y., Suzuki, Y., Ide, C., Tagawa, M
  • Journal Title: Experimental and Clinical Transplantation Volume: 3 Pages: 263-272
• [Journal Article] Administration of cultured autologous bone marrow stromal cells into cerebrospinal fluid in spinal injury patient: a pilot study (2012)
  • Author(s): Saito, F., Nakatani, T., Iwase, M., Maeda, Y., Murao, Y., Suzuki, Y., Fukushima, M., Ide, C
  • Journal Title: Restrative Neurology and Neuroscience Volume: 30 Pages: 127-136
• [Journal Article] Methods for cell harvesting and the biological properties of canine bone marrow stromal cells at successive passages (2012)
  • Author(s): Nishida H, Shoji Y, Nakamura M, Hatoya S, Sugiura K, Yamate J, Kuwamura M, Kotani T, Nakayama M, Suzuki Y, Ide C, Inaba T
  • Journal Title: Am. J. Vet. Res Volume: (印刷中) Issue: 8 Pages: 1118-1123
  • DOI: 10.2460/ajvr.72.8.1118
  • Peer Reviewed
• [Journal Article] Administration of cultured autologous bone marrow stromal cells into cerebrospinal fluid in spinal injury patient : a pilot study (2012)
  • Author(s): Fukuki Saito, Toshio Nakatani, Masaaki Iwase, Yuji Maeda, Yoshinori Murao, Yoshihisa Suzuki, Masanori Fukushima, Chizuka Ide
  • Journal Title: Restrative Neurology and Neuroscience Volume: 30 Issue: 2 Pages: 127-136
  • DOI: 10.3233/rnn-2011-0629
  • Peer Reviewed
• [Journal Article] Biomechanics of the volar plate of the proximal interphalangeal joint : A dynamic ultrasonographic study (2011)
  • Author(s): Saito S, Suzuki Y
  • Journal Title: J Hand Surg Volume: 36 Issue: 2 Pages: 265-271
  • DOI: 10.1016/j.jhsa.2010.10.034
  • Peer Reviewed
• [Journal Article] Bone Marrow Stromal Cell Transplantation for Treatment of Sub-acute Spinal Cord Injury in the Rat (2010)
  • Author(s): Ide, C., Nakai, Y., Nakano, N., Seo, TB., Yamada, Y., Endo, K., Noda, T., Saito, F., Suzuki, Y., Fukushima, M,. Nakatani, T
  • Journal Title: Brain Res Volume: 1332 Pages: 32-47
• [Journal Article] 急性期脊髄損傷に対する培養自家骨髄間質細胞移植 (2010)
  • Author(s): 齋藤福樹、岩瀬正顕、中谷壽男、前田祐仁、鈴木義久、井出千束
  • Journal Title: 脊椎脊髄ジャーナル Volume: 23(9) Pages: 829-834
  • NAID: 110006450535
• [Journal Article] Transplantation of cultured choroid plexus epithelial cells via cerebrospinal fluid shows prominent neuroprotective effects against acute ischemic brain injury in the rat. (2010)
  • Author(s): Matsumoto N., Taguchi A., Kitayama H., Dezawa M.Suzuki Y., et al.
  • Journal Title: Neuroscience Lette r Volume: 469 Pages: 283-288
  • Peer Reviewed
• [Journal Article] Characterization of conditioned medium of cultured bone marrowstromal cells. (2010)
  • Author(s): Nakano N, Nakai Y, Seo TB, Nagai Y, Fukushima M, Suzuki Y, et al.
  • Journal Title: Neurosci Lett Volume: 483 Pages: 57-61
  • Peer Reviewed
• [Presentation] bFGF徐放化のあるヘパリン/アルギン酸ゲルを用いたラット急性期脊髄損傷に対する神経再生の評価 (2013)
  • Author(s): 平井達也、鈴木義久、石川奈美子、太田正佳、西田英高、田村勝利、井出千束、谷原正夫、鈴木康夫
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 自家骨髄単核球を用いた脊髄損傷の治療法の開発（第１－２相試験） (2013)
  • Author(s): 石川奈美子
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: 神奈川県横浜市西区パシフィコ横浜
• [Presentation] ｂFGF徐放化のあるヘパリン/アルギン酸ゲルを用いたラット急性期脊髄損傷に対する神経再生の評価 (2013)
  • Author(s): 平井達也
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: 神奈川県横浜市西区 パシフィコ横浜
• [Presentation] 自己骨髄間質細胞投与による重度脊髄損傷犬の慢性期における効果 (2013)
  • Author(s): 西田英高
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: 神奈川県横浜市西区 パシフィコ横浜
• [Presentation] 脊髄損傷の治療法の開発 (2012)
  • Author(s): 鈴木義久、石川奈美子、平井達也、月野暁彦、西林涼子、太田正佳
  • Organizer: 第21回日本形成外科学会基礎学術集会
  • Place of Presentation: ホテルリステル猪苗代
• [Presentation] 脊髄損傷の治療法の開発 (2012)
  • Author(s): 鈴木義久
  • Organizer: 第21回日本形成外科学会基礎学術集会
  • Place of Presentation: 福島県耶麻郡 ホテルリステル猪苗代
• [Presentation] ｂFGF徐放ヘパリン/アルギン酸ゲルを用いたラット急性期脊髄損傷治療の評価 (2012)
  • Author(s): 平井達也
  • Organizer: 第21回日本形成外科学会基礎学術集会
  • Place of Presentation: 福島県耶麻郡 ホテルリステル猪苗代
• [Presentation] AMERICAN ASSOCIATION FOR THE SURGERY OF TRAUMA (2010)
  • Author(s): T,Nakatani,.M,Iwase,.F,Saito,. Y,Maeda,.H,Tsuchiya,.T,Ikeda,.T,Omura,.O,Iiji,.K,Matumoto,.A,Hirakawa,.Y,Urao,.Y,Suzuki,. M,Fukushima,. C,Ide
  • Organizer: ADMINISTRATION OF AUTOLOGOUS INCUBA TED BONE MARROW STROMALCELLS INTO CEREBROSPINASL FLUID IN SPINAL INJURY PATIENTS:A PILOT STUDY
  • Place of Presentation: BOSTON MARRIOTT COPLEY PLACE BOSTON,MA, U.S.A.
• [Presentation] bFGF徐放化アルギン酸ゲルを用いたラット脊髄の再生 (2010)
  • Author(s): 鈴木義久
  • Organizer: 第19回日本形成外科学会基礎学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Remarks]
  • URL: http://svso01.kitano-hp.or.jp/bportal/portal?PSML=PPage&Action=SBLogin
• [Remarks] これまでの研究の概要「中枢神経、脊髄の再生」
  • URL: http://www.kitano-hp.or.jp/etcproject/keisei/kenkyu_keisei/index.html