| Project/Area Number |
22390334
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MIZUTANI Taro 筑波大学, 医学医療系, 教授 (80181890)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOJO Nobutake 筑波大学, 医学医療系, 講師 (20462210)
SAKAI Satoshi 筑波大学, 医学医療系, 講師 (30282362)
KAWANO Satoru 筑波大学, 医学医療系, 講師 (90323295)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Naoto 茨城県立医療大学, 保健医療学部, 教授 (40239900)
JESMIN Subrina 筑波大学, 医学医療系, 助教 (60374261)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 集中治療学 / 敗血症ショック / β1選択的遮断薬 / 急性循環不全 / バイオマーカー / 血管内皮機能 / 敗血症モデルラット / ランジオロール |
|---|
| Research Abstract |
Septic shock is mortal status for infectious patients. Circulatory, inflammatory and coagulant regulations on the acute phase critically affect their prognosis. However, the effect of potentially underlying endothelial dysfunction has not been revealed. The purpose of this study is to elucidate whether underlying endothelial dysfunction affects the prognosis of the patients after septic shock status or not, and the mechanism of the pathway. Next we aim to establish the new biomarker to the prognosis the patients and discover the new target of therapeutic molecule for the patients.
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