| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
Chromatin structure is a critical determinant to regulate gene expression and it alters during fate decision or/and cell differentiation. Patterns of post-translational modification at histone tails as well as methylation patterns of cytosine residues at DNA affect chromatin structure. In this study, we examined histone modification during skeletal cell differentiation. We observed dynamic changes of expression of H3K9methyltransferases at H3K9 and localization of three H3K9 methylation patterns, me1, me2, and me3 , during skeletal development. It also suggests that nhibition of H3K9 me2 affects gene expression and subsequent cell differentiation.
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