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Regulatory mechanisms of apoptosis and inflammation by ASK family proteins in oral carcinogenesis

Research Project

Project/Area Number 22390347
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionNagasaki University (2012)
The University of Tokyo (2010-2011)

Principal Investigator

TAKEDA Kohsuke  長崎大学, 大学院・医歯薬学総合研究科, 教授 (10313230)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords発癌 / アポトーシス / 炎症 / MAPキナーゼ / ストレス応答 / 発がん
Research Abstract

In this research project, we investigated the roles of ASK1 family proteins including the stress-activated kinases ASK1 and ASK2 in carcinogenesis. As a result, we found that ASK2 functions both as a tumor suppressor and a tumor promoter in a context-dependent manner, such as tissues and tumor-promoting stimuli, and that ASK1 is involved in the promotion of metastasis. Furthermore, we established two genetically modified mouse strains, ASK1ASKAmice and ASK1flox/floxmice, in which endogenous ASK1 activity can be specifically inhibited by an ATP analog compound, and ASK1 can be depleted in a tissue- or cell type-specific manner, respectively.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (74 results)

All 2013 2012 2011 2010 Other

All Journal Article (40 results) (of which Peer Reviewed: 40 results) Presentation (29 results) (of which Invited: 1 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Atypical protein phosphatases:emerging players in cellular signaling.2013

    • Author(s)
      Sadatomi, D., Tanimura, S., Ozaki, K. and Takeda, K.
    • Journal Title

      Int. J. Mol. Sci

      Volume: 14 Pages: 4596-612

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atypical protein phosphatases: emerging players in cellular signaling.2013

    • Author(s)
      Sadatomi, D. et al.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 14 Issue: 3 Pages: 4596-4612

    • DOI

      10.3390/ijms14034596

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster2012

    • Author(s)
      Ishida, Y., Sekine, Y., Oguchi, H., Chihara, T., Miura, M., Ichijo, H. and Takeda, K
    • Journal Title

      PLoS ONE

      Volume: 7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants2012

    • Author(s)
      Fujisawa, T., Homma, K., Yamaguchi, N., Kadowaki, H., Tsuburaya, N., Naguro, I., Matsuzawa, A., Takeda, K., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H. and Ichijo, H.
    • Journal Title

      Ann. Neurol.

      Volume: 72 Pages: 739-49

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.2012

    • Author(s)
      Sekine, S., Kanamaru, Y., Koike, M., Nishihara, A., Okada, M., Kinoshita, H., Kamiyama, M., Maruyama, J., Uchiyama, Y., Ishihara, N., Takeda, K. and Ichijo, H.
    • Journal Title

      J. Biol. Chem

      Volume: 287 Pages: 34635-45

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis signal-regulating kinase -1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer2012

    • Author(s)
      Hayakawa, Y., Hirata, Y., Sakitani, K., Nakagawa, H., Nakata, W., Kinoshita, H., Takahashi, R., Takeda, K., Ichijo, H., Maeda, S. and Koike, K.
    • Journal Title

      Cancer Sci.

      Volume: 103 Pages: 2181-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP52012

    • Author(s)
      Sekine, Y., Hatanaka, R., Watanabe, T., Sono, N., Iemura, S., Natsume, T., Kuranaga, E., Miura, M., Takeda, K. and Ichijo, H
    • Journal Title

      Mol. Cell

      Volume: 48 Pages: 692-704

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney2012

    • Author(s)
      Naguro, I., Umeda, T., Kobayashi, Y., Maruyama, J., Hattori, K., Shimizu, Y., Kataoka, K., Kim-Mitsuyama, S., Uchida, S., Vandewalle, A., Noguchi, T., Nishitoh, H., Matsuzawa, A., Takeda, K. and Ichijo, H
    • Journal Title

      Nat. Commun.

      Volume: 3 Pages: 1285-1285

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The phosphorylation-dependent regulation of mitochondrial proteins in stress responses2012

    • Author(s)
      Kanamaru, Y., Sekine, S., Ichijo, H. and Takeda, K
    • Journal Title

      J. Signal Transduct

      Volume: 2012 Pages: 931215-931215

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic targets in the ASK1-dependent stress signalling pathways.2012

    • Author(s)
      Hayakawa, R., Hayakawa, T., Takeda, K. and Ichijo, H.
    • Journal Title

      Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.

      Volume: 88 Pages: 434-53

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.2012

    • Author(s)
      Fujisawa, T., Homma, K., et al.
    • Journal Title

      Ann Neurol

      Volume: 72 Issue: 5 Pages: 739-749

    • DOI

      10.1002/ana.23668

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM52012

    • Author(s)
      Sekine, S., et al.
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Issue: 41 Pages: 34635-34645

    • DOI

      10.1074/jbc.m112.357509

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer.2012

    • Author(s)
      Hayakawa, Y., Hirata, Y., Sakitani, K., Nakagawa, H., Nakata, W., Kinoshita, H., Takahashi, R., Takeda, K., Ichijo, H., Maeda1, S. and Koike, K.
    • Journal Title

      Cancer Sci.

      Volume: 103 Issue: 12 Pages: 2181-2185

    • DOI

      10.1111/cas.12024

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP52012

    • Author(s)
      Yusuke Sekine, Ryo Hatanaka, Takeshi Watanabe. Naoki Sono, Shun-ichiro Iemura, Tohru Natsume, Erina Kuranaga, Masayuki Miura, Kohsuke Takeda, and Hidenori Ichijo
    • Journal Title

      Molecular Cell

      Volume: 48 Issue: 5 Pages: 1-13

    • DOI

      10.1016/j.molcel.2012.09.018

    • NAID

      120007150217

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.2012

    • Author(s)
      Naguro I., et al.
    • Journal Title

      Nature Communications

      Volume: 3 Issue: 1 Pages: 1285-1285

    • DOI

      10.1038/ncomms2283

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses2012

    • Author(s)
      Kanamaru, Y., Sekine S., Ichijo, H. and Takeda, K.
    • Journal Title

      J. Signal Transduc.

      Volume: 2012 Pages: 12-12

    • DOI

      10.1155/2012/931215

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic targets in the ASK1-dependent stress signaling pathways2012

    • Author(s)
      Hayakawa, R., Hayakawa, T., Takeda, K. and Ichijo, H.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 88 Issue: 8 Pages: 434-453

    • DOI

      10.2183/pjab.88.434

    • NAID

      130001924759

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster2012

    • Author(s)
      Ishida, Y., et al.
    • Journal Title

      PloS ONE

      Volume: 7 Issue: 2 Pages: 3006-3016

    • DOI

      10.1371/journal.pone.0030265

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel ASK1 inhibitors using virtual screening.2011

    • Author(s)
      Okamoto, M., Saito, N., Kojima, H., Okabe, T., Takeda, K., Ichijo, H., Furuya, T. and Nagano, T.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 19 Pages: 486-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.2011

    • Author(s)
      Hayakawa, Y., Hirata, Y., Nakagawa, H., Sakamoto, K., Hikiba, Y., Kinoshita, H., Nakata, W., Takahashi, R., Tateishi, K., Tada, M., Akanuma, M., Yoshida, H., Takeda, K., Ichijo, H., Omata, M., Maeda, S. and Koike, K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 108 Pages: 780-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins2011

    • Author(s)
      Hayakawa, T., Kato, K., Hayakawa, R., Hisamoto, N., Matsumoto, K., Takeda, K.and Ichijo, H.
    • Journal Title

      Genetics

      Volume: 187 Pages: 785-92

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK2011

    • Author(s)
      Nakagawa, H., Hirata, Y., Takeda, K., Hayakawa, Y., Sato, T., Kinoshita, H., Sakamoto, K., Nakata, W., Hikiba, Y., Omata, M., Yoshida, H., Koike, K. Ichijo, H. and Maeda, S.
    • Journal Title

      Hepatology

      Volume: 54 Pages: 185-95

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.2011

    • Author(s)
      Sekine, Y., Takagahara, S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K. and Ichijo, H
    • Journal Title

      J. Cell Sci.

      Volume: 124 Pages: 3006-16

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis signaling kinases: from stress response to health outcomes.2011

    • Author(s)
      Takeda, K., Naguro, I., Nishitoh, H., Matsuzawa, A. and Ichijo, H.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 15 Pages: 719-61

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] PGAM5: a novel type of protein serine/threonine phosphatase that exists in the mitochondria2011

    • Author(s)
      Takeda, K
    • Journal Title

      J. Oral Biosci

      Volume: 53 Pages: 122-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors2011

    • Author(s)
      Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K., and Ichijo, H.
    • Journal Title

      J. Cell Sci.

      Volume: 124 Issue: 17 Pages: 3006-3016

    • DOI

      10.1242/jcs.085902

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK.2011

    • Author(s)
      Nakagawa, H., et al.
    • Journal Title

      Hepatology

      Volume: (In press掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel ASK1 inhibitors using virtual screening.2011

    • Author(s)
      Okamoto, M., et al.
    • Journal Title

      Bioorg.Med.Chem.

      Volume: 19 Pages: 486-489

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins2011

    • Author(s)
      Hayakawa, T., et al.
    • Journal Title

      Genetics

      Volume: 187 Pages: 785-792

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.2011

    • Author(s)
      Hayakawa, Y., et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA.

      Volume: 108 Pages: 780-785

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis signaling kinases : from stress response to health outcomes.2011

    • Author(s)
      Takeda, K., et al.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: (In press掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice.2010

    • Author(s)
      Kumakura, K., Nomura, H., Toyoda, T., Hashikawa, K., Noguchi, T., Takeda, K., Ichijo, H., Tsunoda, M., Funatsu, T., Ikegami, D., Narita, M., Suzuki, T. and Matsuki, N
    • Journal Title

      Neurosci. Res

      Volume: 66 Pages: 313-20

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.2010

    • Author(s)
      Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H. and Ichijo, H
    • Journal Title

      EMBO J

      Volume: 29 Pages: 2501-14

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.2010

    • Author(s)
      Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B. and Takahashi, R.
    • Journal Title

      PLoS Genet

      Volume: 6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ASK1: Molecule Pages2010

    • Author(s)
      Matsuzawa, A., Takeda, K. and Ichijo, H.
    • Journal Title

      UCSD-Nature Signaling Gateway

    • DOI

      10.1038/mp.a002816.01

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila.2010

    • Author(s)
      Imai, Y., et al.
    • Journal Title

      PLoS Genet

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASK1 : Molecule Pages2010

    • Author(s)
      Matsuzawa, A., et al.
    • Journal Title

      UCSD-Nature Signaling Gateway

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.2010

    • Author(s)
      Maruyama, T., et al.
    • Journal Title

      EMBO J.

      Volume: 4 Pages: 2501-2514

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice.2010

    • Author(s)
      Kumakura, K., et al.
    • Journal Title

      Neurosci.Res.

      Volume: 66 Pages: 313-320

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic β cell exhaustion

    • Author(s)
      Yamaguchi, K., Takeda, K., Kadowaki, H., Ueda, I., Namba, Y., Ouchi, Y., Nishitoh, H. and Ichijo, H.
    • Journal Title

      Biochim. Biophys. Acta

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] ミトコンドリア機能低下の感知システムとしてのプロテインホスファターゼPGAM5の膜内切断2013

    • Author(s)
      武田弘資
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] ミトコンドリアのストレス受容・応答機構と炎症制御2013

    • Author(s)
      武田弘資
    • Organizer
      創薬シンポジウム:アカデミア創薬と探索医療
    • Place of Presentation
      長崎
    • Year and Date
      2013-03-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of mitochondrial phosphatase PGAM5 in inflammation.2013

    • Author(s)
      Takeda, K
    • Organizer
      JST-CREST International Symposium, Frontiers in Immunology and Inflammation: From Molecules to Disease
    • Place of Presentation
      東京
    • Year and Date
      2013-02-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of mitochondrial protein phosphatase PGAM5 in inflammation.2013

    • Author(s)
      貞富大地、武田弘資
    • Organizer
      10th International Conference on Protein Phosphatase
    • Place of Presentation
      東京
    • Year and Date
      2013-02-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of cellular stress response by mitochondrial protein phosphatase PGAM52013

    • Author(s)
      Takeda, K
    • Organizer
      1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
    • Place of Presentation
      東京
    • Year and Date
      2013-02-01
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Role of mitochondrial protein phosphatase PGAM5 in inflammation2013

    • Author(s)
      Sadatomi, D., Takeda, K.
    • Organizer
      10th International Conference on Protein Phosphatase
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of mitochondrial phosphatase PGAM5 in inflammation2013

    • Author(s)
      Takeda, K.
    • Organizer
      JST-CREST International Symposium, Frontiers in Immunology and Inflammation: From Molecules to Disease
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミトコンドリアのストレス受容・応答機構と炎症制御2013

    • Author(s)
      武田 弘資
    • Organizer
      創薬シンポジウム:アカデミア創薬と探索医療
    • Place of Presentation
      長崎
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミトコンドリア機能低下の感知システムとしてのプロテインホスファターゼ PGAM5の膜内切断2013

    • Author(s)
      武田 弘資
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミトコンドリア局在プロテインホスファターゼPGAM5によるストレス応答制御2012

    • Author(s)
      武田弘資
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of mitochondrial phosphatase PGAM5 in inflammation.2012

    • Author(s)
      Takeda, K.
    • Organizer
      The 12th Biennial International Endotoxicin & Innate Immunity Society Meeting (IEIIS2012)
    • Place of Presentation
      東京
    • Year and Date
      2012-10-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of ASK1 in contact hypersensitivity using a chemical genetic approach.2012

    • Author(s)
      Takeda , K., Mizukami, J., Tsuboi, R., Ichijo H.
    • Organizer
      The 4th Global COE Retreat in Oiso
    • Place of Presentation
      大磯
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of mitochondrial phosphatase PGAM5 in inflammation2012

    • Author(s)
      Takeda, K.
    • Organizer
      The 12th Biennial International Endotoxin & Innate Immunity Society Meeting (IEIIS2012)
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Analysis of ASK1 in contact hypersensitivity using a chemical genetic approach2012

    • Author(s)
      Takeda, K., et al.
    • Organizer
      The 4th Global COE Retreat in Oiso
    • Place of Presentation
      大磯
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of cellular stress response by an atypical protein phosphatase PGAM5.2011

    • Author(s)
      Takeda, K.
    • Organizer
      The First Japan-Taiwan Bilateral Conference on Protein Phosphatases.
    • Place of Presentation
      岡崎
    • Year and Date
      2011-12-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of cellular stress response by an atypical protein ghosphatase PGAM52011

    • Author(s)
      Takeda, K.
    • Organizer
      The First Japan-Taiwan Bilateral Conference on Protein Phosphatases
    • Place of Presentation
      岡崎
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of cellular stress response by mitochondrial protein phosphatase PGAM52011

    • Author(s)
      Takeda, K.
    • Organizer
      9th International Conference on Protein Phosphatase.
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] アティピカル・プロテインホスファターゼPGAM5によるストレス応答制御.2011

    • Author(s)
      武田弘資
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] KLHDC10によるPP5の活性制御と酸化ストレス応答2011

    • Author(s)
      武田弘資、関根悠介、一條秀憲
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] アティピカル・プロテインホスファターゼPGAM5によるストレス応答制御2011

    • Author(s)
      武田弘資
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] KLHDC10によるPP5の活性制御と酸化ストレス応答2011

    • Author(s)
      武田弘資, 他
    • Organizer
      第5回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of cellular stress response by mitochondrial protein phosphatase PGAM52011

    • Author(s)
      Kohsuke Takeda
    • Organizer
      9^<th> International Conference on Protein Phosphatase
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] ASKファミリー分子によるストレス応答の制御と疾患2010

    • Author(s)
      武田弘資
    • Organizer
      第149回日本獣医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] ミトコンドリア局在プロテインホスファターゼPGAM5によるストレス応答制御2010

    • Author(s)
      武田弘資、一條秀憲
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 細胞のストレス応答を制御するシグナル伝達機構の解明2010

    • Author(s)
      武田弘資
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] ASK2はマウス食道における4-NQO誘導性発がんを促進する.2010

    • Author(s)
      武田弘資、永田剛裕、一條秀憲
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] ミトコンドリア局在プロテインホスファターゼPGAM5 によるストレス応答制御2010

    • Author(s)
      武田弘資、一條秀憲
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] ASK2はマウス食道における4-NQO誘導性発がんを促進する2010

    • Author(s)
      武田弘資、永田剛裕、一條秀憲
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミトコンドリア局在プロテインホスファターゼPGAM5によるストレス応答制御2010

    • Author(s)
      武田弘資, 一條秀憲
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Book] Roles for the stress-responsive kinases ASK1 and ASK2 in tumorigenesis2012

    • Author(s)
      Kamiyama, M., Sato, T., Takeda, K. and Ichijo, H.
    • Publisher
      Chembiomolecular Science: At the Frontier ofChemistry and Biology, eds Shibasaki, M., Iino, M. and Osada, H. (Springer Japan)
    • Related Report
      2012 Final Research Report
  • [Book] Roles for the stress-responsive kinases ASK1 and ASK2 in tumorigenesis. Chembiomolecular Science: At the Frontier of Chemistry and Biology, eds Shibasaki, M., Iino, M. and Osada, H.2012

    • Author(s)
      Kamiyama, M. et al.
    • Total Pages
      325
    • Publisher
      Springer Japan
    • Related Report
      2012 Annual Research Report
  • [Book] がんと炎症.「がん増殖と悪性化の分子機構」2012

    • Author(s)
      武田 弘資
    • Total Pages
      280
    • Publisher
      化学同人
    • Related Report
      2012 Annual Research Report
  • [Book] ストレス応答シグナルと創薬. 「創薬科学の魅力 --東京大学大学院薬学系研究科からの発信--」2010

    • Author(s)
      武田弘資,一條秀憲
    • Publisher
      廣川書店
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.ph.nagasaki-u.ac.jp/lab/cell/index-j.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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