Understanding of non-canonical Wnt signaling network in bone and cartilage formation
| Project/Area Number |
22390348
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIMURA Riko 大阪大学, 大学院・歯学研究科, 教授 (60294112)
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| Co-Investigator(Renkei-kenkyūsha) |
HATA Kenji 大阪大学, 大学院・歯学研究科, 准教授 (80444496)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Keywords | Wnt / 骨芽細胞 / 軟骨細胞 / 転写因子 / Wnt5a / 骨 / 軟骨 / シグナル伝達 |
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| Research Abstract |
To understand the role of non-canonical Wnt including Wnt5a, weinvestigated the phenotype of Wnt5a null mice. The Wnt5a null mice showed severe impairment of skeletal development, especially in cartilage formation. We have attempted to identify the target of Wnt5a, and found that homeobox gene would be involved in Wnt5a-regulated endochondral ossification.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Osterix Regulates Calcification and Degradation of Chondrogenic Matrices Through Matrix Metalloproteinase (MMP13) Expression in Association with Transcription Factor Runx2 During Endochondral Ossification.2012
Author(s)
Nishimura R, Wakabayashi M, Hata K, Matsubara T, Honma S, Wakisaka S, Kiyonari H, ShioiG, YamaguchiA, Tsumaki N, Akiyama H, Yoneda T
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Journal Title
J Biol Chem
Volume: 287巻
Pages: 33179-33190
Related Report
Peer Reviewed
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[Journal Article] Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription2011
Author(s)
Amano K, Hata K, MuramatsuS, Wakabayashi M, Takigawa Y, Ono K, Nakanishi M, Takashima R, Kogo M, Matsuda A, NishimuraR, Yoneda T
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Journal Title
Mol Biol Cell
Volume: 22巻
Pages: 1300-1311
Related Report
Peer Reviewed
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[Presentation] 軟骨細胞分化のエピゲノム2012
Author(s)
波多 賢二、高島 利加子、西村 理行、米田 俊之
Organizer
第30回日本骨代謝学会
Place of Presentation
京王プラザホテル
Year and Date
2012-07-19
Related Report
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[Presentation] The transcription factor Arid5b modulates endochondral bone formation in cooperation withSox92011
Author(s)
Takashima R, Hata K, Wakabayashi M, Nakanishi M, Ono K, Amano K, Whitson R, Maeda Y, Nishimura R, Yoneda T
Organizer
Joint 2nd Asia-Pacific Osteoporosis and Bone Meeting & ANZBMS Annual Meeting
Place of Presentation
Australia, Gold Coast Convention center
Year and Date
2011-09-05
Related Report
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