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Relationship between periodontal disease and systemic diseases: molecular mechanisms and novel therapy discovery

Research Project

Project/Area Number 22390350
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionKyushu University

Principal Investigator

YAMAMOTO Kenji  九州大学, 薬学研究院, 特命教授 (40091326)

Co-Investigator(Kenkyū-buntansha) KAWAKUBO Tomoyo  九州大学, 大学院・薬学研究院, 特任助教 (70507813)
YAMAATAAKE Kumiko  九州大学, 大学院・薬学研究院, 学術研究員 (50622114)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords感染症 / 酵素 / 細菌 / 歯学 / 薬学
Research Abstract

To establish the molecular basis of the possible linkage between periodontal diseases and a variety of systemic diseases such as atherosclerosis, obesity, diabetes, and preterm birth and fetal death, we used various animal models and different cell types and manipulated the endolysosomal aspartic proteinase cathepsin E (CatE) as a host-derived protease and gingipains (GP) as a periodontopathogen-derived protease. In this study, we first found that CatE plays a crucial role in host defense against infection with Porphyromonas gingivalis, a major etiological bacterium of adult periodontal disease through proper trafficking and cell surface expressionof Toll-like receptors such as TLR4 in macrophages. Second, GP mediates atherosclerosis progression accelerated by P. gingivalisinfection through selective proteolysis of apolipoprotein B-100 in LDL cholesterol. Third,GP acts as a strong virulence factor to induce preterm birth and low birth weight through the enhancement of immune responses to pregnant mice infected with P. gingivalis. Fourth, CatE plays a crucial role in normal development of adipose tissues through biochemical analysis of CatE-/-mice that were fed a high-fat diet as an obesity mouse model. Forth, using techniques of cDNA display, selection-by-function, γ-ligation-based block shuffling and others, we generated peptide inhibitors for CatE and GP. The newly developed inhibitors for each enzyme showed an IC50 of nM order and high selectivity. This method is thus expected to be widely applicable for the development of peptide inhibitors of various proteases.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (60 results)

All 2012 2011 2010

All Journal Article (25 results) (of which Peer Reviewed: 24 results) Presentation (34 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Cathepsin E is critical for the proper trafficking of both intracellular membrane and cell surface proteins2012

    • Author(s)
      Tsukuba T, Okamoto K, Yamamoto K
    • Journal Title

      J. Oral Biosci

      Volume: 54 (1) Pages: 48-53

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene2012

    • Author(s)
      Okamoto K, Okamoto Y, Kawakubo T, Iwata J, Yasuda Y, Tsukuba T, Yamamoto K
    • Journal Title

      J Biochem

      Volume: 151(3) Pages: 263-272

    • NAID

      10031166065

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a Japanese energy healing method known as Johrei on viability and proliferation of cultured cancer cells in vitro2012

    • Author(s)
      Abe K, Ichinomiya R, Kanai T, Yamamoto K
    • Journal Title

      J Alternat. Comlement. Med

      Volume: 18(3) Pages: 221-228

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Emerging roles of cathepsin E in host defense mechanisms2012

    • Author(s)
      Yamamoto K, Kawakubo T, Yasukochi A, Tsukuba T
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1824 Pages: 105-112

    • NAID

      120005324431

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin E is critical for the proper trafficking of both intracellular membrane and cell surface proteins2012

    • Author(s)
      Tsukuba T, Okamoto K, Yamamoto K.
    • Journal Title

      J. Oral Biosci.

      Volume: 54 Pages: 48-53

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene2012

    • Author(s)
      Okamoto K
    • Journal Title

      J.Biochem.

      Volume: 151 Issue: 3 Pages: 263-272

    • DOI

      10.1093/jb/mvr135

    • NAID

      10031166065

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emerging roles of cathepsin E in host defense mechanisms2012

    • Author(s)
      Yamamoto, K., et al
    • Journal Title

      Biochim.Biophys.Acta.

      Volume: 1824 Issue: 1 Pages: 105-112

    • DOI

      10.1016/j.bbapap.2011.05.022

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene2012

    • Author(s)
      Okamoto K, Okamoto Y, Kawakubo T, Iwata J, Yasuda Y, Tsukuba T, Yamamoto K
    • Journal Title

      J Biochem.

      Volume: 151 Pages: 263-272

    • NAID

      10031166065

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin E is critical for the proper trafficking of both intracellular membrane and cell surface proteins2012

    • Author(s)
      Tsukuba T, Okamoto K, Yamamoto K
    • Journal Title

      J.Oral Biosci.

      Volume: 54 Pages: 48-53

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of cathepsin E in terminal differentiation of keratinocytes2011

    • Author(s)
      Kawakubo T, Yasukochi A, Okamoto K, Okamoto Y, Nakamura S, Yamamoto K
    • Journal Title

      Biol. Chem

      Volume: 392 Pages: 571-583

    • NAID

      120005007885

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin E as a potent anticancer protease2011

    • Author(s)
      Kawakubo T, Yasukochi A, Nakamura S, Yamamoto K
    • Journal Title

      J. Oral Biosci

      Volume: 53 (2) Pages: 126-136

    • NAID

      10028222723

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptide aptamer-based ELISA-like system for detection of cathepsin E in tissues and plasma2011

    • Author(s)
      Kitamura, K., et al
    • Journal Title

      Mol.Biomark.Diagn.

      Volume: 2 Issue: 01 Pages: 104-104

    • DOI

      10.4172/2155-9929.1000104

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro selection of cathepsin E-activity-enhancing peptide aptamers at neutral pH2011

    • Author(s)
      Biyani M, Futakami M, Kitamura K, Kawakubo T, Suzuki M, Yamamoto K, Nishigaki K
    • Journal Title

      Int. J. Pep

      Volume: 2011 Pages: 1-8

    • DOI

      10.1155/2011/834525

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptide aptamer-based ELISA-like system for detection of cathepsin E in tissues and plasma2011

    • Author(s)
      Kitamura K, Biyani M, Futakami M, Ueno-Tsuji S, Suzuki M, Kawakubo T, Yamamoto K, Nishigaki K
    • Journal Title

      J.Mol.Biomark.Diagn.

      Volume: 2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin E as a potent anticancer protease2011

    • Author(s)
      Kawakubo T, Yasukochi A, Nakamura S, Yamamoto K
    • Journal Title

      J.Oral Biosci.

      Volume: 53 Pages: 126-136

    • NAID

      10028222723

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of cathepsin E in terminal differentiation of keratinocytes2011

    • Author(s)
      Kawakubo T
    • Journal Title

      Biol.Chem.

      Volume: 392 Issue: 6 Pages: 571-585

    • DOI

      10.1515/bc.2011.060

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone in vasion by oral squamous cell carcinoma cells2011

    • Author(s)
      Shin M, et al
    • Journal Title

      Carcinogenesis

      Volume: 32 Issue: 11 Pages: 1634-1640

    • DOI

      10.1093/carcin/bgr198

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a Japanese energy healing method known as Johrei on viability and proliferation of cultured cancer cells in vitro2011

    • Author(s)
      Abe K, Ichinomiya R, Kanai T, Yamamoto K
    • Journal Title

      J Alternat.Comlement.Med.

      Volume: 18 Issue: 3 Pages: 221-228

    • DOI

      10.1089/acm.2011.0467

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro selection of cathepsin E-activity-enhancing peptide aptamers at neutral pH2011

    • Author(s)
      Biyani M, Futakami M, Kitamura K, Kawakubo T, et al
    • Journal Title

      Int.J.Pep.

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptide aptamer-based ELISA-like system for detection of cathepsin E in tissuesand plasma2011

    • Author(s)
      Kitamura K, Biyani M, Futakami M, et al.
    • Journal Title

      J.Mol.Biomark.Diagn.

      Volume: 2(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin E as a potent anticancer protease.2011

    • Author(s)
      Kawakubo T, Yasukochi A, Nakamura S, Yamamoto K.
    • Journal Title

      J.Oral Biosci.

      Volume: 53(印刷中)

    • NAID

      10028222723

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emerging roles of cathepsin E in host defense mechanisms2011

    • Author(s)
      Yamamoto K, Kawakubo T, Yasukochi A, Tsukuba T.
    • Journal Title

      Biochim.Biophys.Acta

      Volume: (印刷中)

    • NAID

      120005324431

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis2010

    • Author(s)
      Yasukouchi A, Kawakubo T, Nakamura S, Yamamoto K
    • Journal Title

      Biol. Chem

      Volume: 391 Pages: 947-958

    • NAID

      120006900038

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大学改革後の歩みと国際競争力2010

    • Author(s)
      山本健二
    • Journal Title

      生化学

      Volume: 81 Pages: 363-363

    • NAID

      10026425747

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Cathepsin E enhances anticancer activity of doxorubicin on human prostatecancer cells showing resistance to TRAIL-mediated apoptosis2010

    • Author(s)
      Yasukochi A, Kawakubo T, Nakamura S, Yamamoto K
    • Journal Title

      Biol.Chem.

      Volume: 391 Pages: 947-958

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] p53 はカテプシン E 遺伝子の発現を制御する2012

    • Author(s)
      岡元邦彰、岩田淳一、坂井詠子、西下一久、山本健二、筑波隆幸
    • Organizer
      第85回日本生化学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] p53はカテプシンE遺伝子の発現を制御する2012

    • Author(s)
      岡元邦彰、岩田淳一、坂井詠子、西下一久、山本健二、筑波隆幸
    • Organizer
      第85回日本生化学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cathepsin E : related signaling systems, functions and implication in diseases2012

    • Author(s)
      Yamamoto K., Kawakubo T., Yasukochi A., Okamoto K., Tsukuba T
    • Organizer
      13th International Symposium on Proteinase Inhibitors and Biological Control
    • Place of Presentation
      スロベニア
    • Year and Date
      2012-09-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] Selection-by-Function 法によるプロテアーゼアクチベーターの開発2012

    • Author(s)
      小松将之、北村幸一郎、Sunita Gautam, Madhu Biyani, 山本健二、西垣功一
    • Organizer
      第17回日本病態プロテアーゼ学会
    • Place of Presentation
      浜松
    • Year and Date
      2012-08-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 反復流産病態における妊娠初期脱落膜中マクロファージの cathepsin E の役割2012

    • Author(s)
      後藤志信、尾崎康彦、都筑佳苗、安河内篤、川久保友世、国松己歳、山本健二、杉浦真弓
    • Organizer
      第17回日本病態プロテアーゼ学会
    • Place of Presentation
      浜松
    • Year and Date
      2012-08-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Selection-by-Function法によるプロテアーゼアクチベーターの開発2012

    • Author(s)
      小松将之、北村幸一郎、Sunita Gautam, Madhu Biyani, 山本健二、西垣功一
    • Organizer
      第17回日本病態プロテアーゼ学会
    • Place of Presentation
      浜松
    • Year and Date
      2012-08-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] 反復流産病態における妊娠初期脱落膜中マクロファージのcathepsin Eの役割2012

    • Author(s)
      後藤志信、尾崎康彦、都筑佳苗、安河内篤、川久保友世、国松己歳、山本健二、杉浦真弓
    • Organizer
      第17回日本病態プロテアーゼ学会
    • Place of Presentation
      浜松
    • Year and Date
      2012-08-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] Accumulation of NADPH oxidase (NOX2) and increased oxidative stress in cathepsin E-deficient macrophages2012

    • Author(s)
      Tsukuba T, Kadowaki T, Okamoto K, Yamamoto K
    • Organizer
      The 85^<th>Annual Meeting of Pharmacological Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Idetification of two transcripts and in vivo promoter analysis for cathepsin E2012

    • Author(s)
      Okamoto K, Sakai E, Nishishita K, Yamamoto K, Tsukuba T
    • Organizer
      The 85^<th>Annual Meeting of Pharmacological Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Accumulation of NADPH oxidase (N0X2) and increased oxidative stress in cathepsin E-deficient macrophages2012

    • Author(s)
      Tsukuba T., Kadowaki T., Okamoto K., Yamamoto K.
    • Organizer
      The 85^<th> Annual Meeting of Pharmacological Society
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] Idetification of two transcripts and in vivo promoter analysis for cathepsin E2012

    • Author(s)
      Okamoto K, Sakai E, Nishishita K, Yamamoto K, Tsukuba T.
    • Organizer
      The 85^<th> Annual Meeting of Pharmacological Society
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] カテプシンEによるガン細胞の増殖抑制とアポトーシス誘導および関連シグナリング2012

    • Author(s)
      山本健二、川久保友世、安河内篤、筑波隆幸
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] カテプシンE遺伝子の発現機構の解析2012

    • Author(s)
      岡元邦彰、岡本美子、坂井詠子、西下一久、山本健二、筑波隆幸
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] カテプシンE欠損マクロファージにおけるNADPH oxidase (NOX2)の蓄積と酸化ストレスの増加2012

    • Author(s)
      筑波隆幸、門脇知子、岡元邦彰、山本健二
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cathepsin E-induced growth arrest and apoptosis of cancer cells and the related signaling2012

    • Author(s)
      Yamamoto K, Kawakubo T, Yasukochi A, Tsukuba T.
    • Organizer
      The 85^<th> Annual Meeting of Pharmacological Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-03-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Cathepsin E-induced growth arrest and apoptosis of cancer cells and the related signaling2012

    • Author(s)
      Yamamoto K., Kawakubo T., Yasukochi A. Tsukuba T
    • Organizer
      The 85^<th> Annual Meeting of Pharmacological Society
    • Place of Presentation
      京都
    • Year and Date
      2012-03-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cathepsin E: related signaling systems, functions and implication in diseases2012

    • Author(s)
      Yamamoto K, Kawakubo T, Yasukochi A, Okamoto K, Tsukuba T
    • Organizer
      13th International Symposium on Proteinase Inhibitors and Biological Control
    • Place of Presentation
      Portoroz, Slovenia
    • Related Report
      2012 Final Research Report
  • [Presentation] カテプシンE結合ペプチド群を例としたP2p (Protei-topeptide)研究展開-「副作用のない創薬」を目指して-2011

    • Author(s)
      北村幸一郎、Biyani Madhu、二上雅恵、相田拓洋、後藤仁志、小松将之、川久保友世、鈴木美穂、山本健二、西垣功一
    • Organizer
      第16回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 反復流産病態における妊娠初期頸管粘液中Cathepsin Eの役割2011

    • Author(s)
      後藤志信、尾崎康彦、大林勇輝、北折珠央、平光由衣乃、安河内篤、川久保友世、山本健二、杉浦真弓
    • Organizer
      第16回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス皮膚表皮細胞における内在性カテプシンEの役割2011

    • Author(s)
      安河内篤、川久保友世、中村誠司、山本健二
    • Organizer
      第16回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] DMBA/TPA二段階乳頭腫形成モデルにおける表皮カテプシンEの役割2011

    • Author(s)
      安河内篤、川久保友世、中村誠司、山本健二
    • Organizer
      第65回日本口腔科学会学術集会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-04-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] DMBA/TPA二段階乳頭腫形成モデルにおける表皮カテプシンEの役割2011

    • Author(s)
      安河内篤、川久保友世、中村誠司、山本健二
    • Organizer
      第65回日本口腔科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of cathepsin E in deciduas of patients with recurrent miscarriage2011

    • Author(s)
      Goto S, Ozaki Y, Kitaori T, Yasukochi A, Kawakubo T, Sugiura M, Yamamoto K
    • Organizer
      7^<th> General Meeting of the International Proteolysis Society
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] カテプシンE欠損におけるは骨細胞分化への影響2010

    • Author(s)
      岡元邦彰、坂井詠子, 他7名
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel functions of cathepsin E in epidermal differentiation and aging2010

    • Author(s)
      Kawakubo T, Yasukochi A, Yamamoto K
    • Organizer
      12^<th> Symposium on Proteases, Inhibitors and Biological Control
    • Place of Presentation
      Portoroz (Slovenia)
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cathepsin E is essential for proper mammogenesis2010

    • Author(s)
      Kawakubo T, Yasukochi A, Yamamoto K
    • Organizer
      12th Symposium on Proteases, Inhibitors and Biological Control
    • Place of Presentation
      Portoroz (Slovenia)
    • Year and Date
      2010-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of cathepsin E function in epidermal differentiation using a model of DMBA/TPA- induced skin papillomas2010

    • Author(s)
      Yasukochi A, Kawakubo T, Yamamoto K
    • Organizer
      12th Symposium on Proteases, Inhibitors and Biological Control
    • Place of Presentation
      Portoroz (Slovenia)
    • Year and Date
      2010-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Cathepsin E is essential for proper mammogenesis2010

    • Author(s)
      Kawakubo T, Yasukochi A, Yamamoto K
    • Organizer
      12^<th> Symposium on Proteases, Inhibitors and Biological Control
    • Place of Presentation
      Portoroz (Slovenia)
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of cathepsin E function in epidermal differentiation using a model of DMBA/TPA-induced skin papillomas2010

    • Author(s)
      Yasukochi A, Kawakubo T, Yamamoto K.
    • Organizer
      12^<th> Symposium on Proteases, Inhibitors and Biological Control
    • Place of Presentation
      Portoroz (Slovenia)
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cathepsin E: related signaling systems, functions and implication in diseases2010

    • Author(s)
      Yamamoto K, Kawakubo T, Yasukochi A, Okamoto K, Tsukuba T
    • Organizer
      13th International Symposium on Proteinase Inhibitors and Biological Control
    • Place of Presentation
      Portoroz, Slovenis
    • Year and Date
      2010-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] プロテアーゼを活性化するペプチの取得とその戦略2010

    • Author(s)
      Biyani M, 二上雅恵, 他5名
    • Organizer
      第15回日本病態プロテアーゼ学会
    • Place of Presentation
      千里ライフサイエンスホール(大阪)
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト卵胞液中のcathepsin Eの存在と意義2010

    • Author(s)
      後藤志信、尾崎康彦, 他8名
    • Organizer
      第15回日本病態プロテアーゼ学会
    • Place of Presentation
      千里ライフサイエンスホール(大阪)
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transcription factor Spl regulates the expression of the murine cathepsin E in gastric adenosarcoma cells2010

    • Author(s)
      Okamoto K, Okamoto Y, Kawakubo T, Yamamoto K, Tsukuba T
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-03-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel functions of cathepsin E in epidermal differentiation and aging2010

    • Author(s)
      Yamamoto K
    • Organizer
      12th International Symposium on Proteinase Inhibitors and Biological Control
    • Place of Presentation
      Portoroz, Slovenis
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] カテプシン E の腫瘍マーカーとしての用途およびカテプシン E ならびにカテプシン D の腫瘍血管新生阻害療法としての用途2010

    • Inventor(s)
      山本健二、岩田淳一
    • Industrial Property Rights Holder
      山本健二、岩田淳一
    • Acquisition Date
      2010-02-12
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2023-03-16  

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