CXCL14/BRAK is a multifunctional tumor suppressor
| Project/Area Number |
22390353
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAEHATA Youjirou 神奈川歯科大学, 歯学部, 講師 (80410009)
IZUKURI Kazuhito 神奈川歯科大学, 歯学部, 講師 (90257296)
KATO Yasumasa 奥羽大学, 歯学部, 教授 (50214408)
KURATA Shunichi 東京医科歯科大学, 難治疾患研究所, 准教授 (60140901)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Keywords | 癌抑制因子 / ケモカイン / 転移抑制 / 副作用のない癌抑制法 / 腫瘍抑制 / CXCL14/BRAK / BRAK / CXCL14 / ドーマントセラピー / 血管新生阻害 / NK細胞 |
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| Research Abstract |
Objectives: The aim of this study was to determine whether or not chemokine BRAK/ CXCL14 transgenic (Tg) mice would show resistance to carcinogenesis, tumor growth and tumor metastasis. Methods: Wild type C57BL/6 (Wt) or Tg mice were injected intraperitoneally with 12 mg/kg body weight azoxymethane followed by intermittent addition of 3 % dextran sodium sulfate in the drinking water. We also injected tumor cells subcutaneously or via a tail vein of the mice. Results: No difference of body weight was observed between Wt and Tg mice but the rate of colorectal cancer was nearly ten times higher (P<0.001) in Wt mice than in Tg ones. Size of transplanted tumors and the number of metastatic foci on the lung of the animals were always significantly lower in the Tg that those in the Wt. Survival rates of the melanoma cell injected Tg mice were significantly higher than those of Wt. Conclusion: The Tg mice showed resistance to carcinogenesis, tumor growth and tumor cell metastasis, indicating BRAK/ CXCL14 has multifunctional effects on tumor suppression.
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Report
(4 results)
Research Products
(84 results)
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[Presentation] 選択的ROCK阻害剤による抗腫瘍性ケモカインBRAK/CXCL14を介した腫瘍進展抑制の検討2010
Author(s)
宮本千央, 前畑洋次郎, 小澤重幸, 生駒田丈晴, 居作和人, 小林杏, 高橋聡子, 高橋俊介, 吉野文彦, 杉山秀太, 吉田彩佳, 畑隆一郎, 李昌一
Organizer
第45回神奈川歯科大学学会総会
Place of Presentation
横須賀(最優秀演題賞受賞)
Year and Date
2010-12-04
Related Report
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