Spreading Nanotechnology to Conservative Dentistry

• Project/Area Number: 22390355
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Hokkaido University
• Principal Investigator: SANO Hidehiko 北海道大学, 大学院・歯学研究科, 教授 (90205998)
• Co-Investigator(Kenkyū-buntansha): INOUE Satoshi 北海道大学, 大学病院, 講師 (80184745) ; NODA Mamoru 岩手医科大学, 歯学部, 教授 (10301889)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: ナノテクノロジー / 歯質接着 / 生態適合性 / 耐久性 / 歯科保存 / ナノコロイド / 生体適合性

Research Abstract

Using Colloidal Platinum Nano-particles (CPN) as a adhesion promoter of dental adhesives increased its bond ability to tooth surface. When observing resin dentin bonds under the transmission electron microscope, improved bond performance was found by the condition that exposure of collagen fibrils were observed at the adhesive interface. CPN is well known as the strong scavenger for oxidation stress, but under the some conditions the scavenging effect was not detected. When CPN was applied to osteoclast cell lines, suppression of the activity of the cells was found.

Research Products

• [Journal Article] mproved long-term bonding performance of an experimen tal all-in-one adhesive (2013)
  • Author(s): Kakuda S, Fu J, Nakaoki Y, IKEDA T, Tnaka T, Sano H
  • Journal Title: DENTAL MATERIALS JOURNAL Volume: (in press)
  • Peer Reviewed
• [Journal Article] Bonding performance of a newly developed step-less all-in-one system on dentin (2013)
  • Author(s): Fu J, Kakuda S, Pan F, Hoshika S, Ting S, Fukuoka A, Bao Y, Ikeda T, Nakaoki Y, Selimovic D, S a no H , K Sidhu S
  • Journal Title: DENTAL MATERIALS JOURNAL Volume: 32 Pages: 203-11
  • Peer Reviewed
• [Journal Article] The effect of air-blowing duration on all-in-one systems (2012)
  • Author(s): Fu J, Pan F, Kakuda S, K Sidhu S, IkedaT, Nakaoki Y, Selimovic D, Sa n o H
  • Journal Title: DENTAL MATERIALS JOURNAL Volume: 31 Pages: 1075-81
  • Peer Reviewed
• [Journal Article] Colloidal platinum nanoparticles increase mitochondrial stress induced by resin composite components (2011)
  • Author(s): Kachi H, Noda M, Wataha JC, Nakaoki Y, Sano H
  • Journal Title: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS Volume: 95B Pages: 193-198
  • Peer Reviewed
• [Journal Article] Sa no HExpansion of3.20-25nanotechnology for dentistry: effect of colloidal platinum nanoparticles on dentin adhesion mediated by4-META/MMA-TBB (2011)
  • Author(s): Hoshika S, Nagano F, Tanaka T, WadaT, Asakura K, Koshiro K, SelimovicD,Miyamoto Y, SidhuSK
  • Journal Title: JOURNAL OF ADHESIVE DENTISTRY Volume: 13 Pages: 411-416
  • Peer Reviewed
• [Journal Article] Fluorine analysis of human dentin surrounding resin composite after fluoride application by mu-PIGE/PIXE analysis (2011)
  • Author(s): Okuyama K, Komatsu H, Yamamoto H, Pereira PNR, Bedran-Russo, Nomachi M, Sato, T, S an o H
  • Journal Title: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS Volume: 269 Pages: 2269-2273
  • Peer Reviewed
• [Journal Article] Hydrolytic Stability of One-step Self-etching Adhesives Bonded to Dentin (2011)
  • Author(s): Fukuoka A, Koshiro K, Inoue S, Yoshida Y, Tanaka T, Ikeda T, Suzuki K, Sano H, Van Meerbeek B
  • Journal Title: JOURNAL OF ADHESIVE DENTISTRY Volume: 13 Pages: 243-248
  • Peer Reviewed
• [Journal Article] Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells (2011)
  • Author(s): Nomura M, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Koshiro K, Sano H, Suzuki K, Inoue N
  • Journal Title: JOURNAL OF PHARMACOLOGICAL SCIENCES Volume: 117 Pages: 243-252
  • NAID: 10030453660
  • Peer Reviewed
• [Journal Article] Effect of application time of colloidal platinum nanoparticles on the microtensile bond strength to dentin (2010)
  • Author(s): Hoshika S, Nagano F, Tanaka T, Ikeda T, Wada T, Asakura K Koshiro K, Selimovic D, Miyamoto Y, Sidhu S, Sano H
  • Journal Title: DENTAL MATERIALS JOURNAL Volume: 29 Pages: 682-689
  • NAID: 10026962622
  • Peer Reviewed
• [Journal Article] Molecular force probe measurement of antigen I/II-matrix protein interactions (2010)
  • Author(s): Soell M, Hemmerle J, Hannig M, Haikel Y, S a no H , Selimovic D
  • Journal Title: EUROPEAN JOURNAL OF ORAL SCIENCES Volume: 118 Pages: 590-595
  • Peer Reviewed
• [Presentation] Effect Of Different RDT On μTBS Of Current Adhesive Systems (2013)
  • Author(s): Ting S, Fu J, Pan F, Nakaoki Y, Ikeda T,Tanaka T, Sano H
  • Organizer: International Association for Dental Research 2013
  • Place of Presentation: Washington State Convention Center, Seattle, USA
• [Presentation] Bond durability of four contemporary self-etching systems (2013)
  • Author(s): Fu J, Pan F,Ting S, Ikeda T, Nakaoki Y, Sano H
  • Organizer: International Association for Dental Research 2013
  • Place of Presentation: State Convention Center, Seattle, USA
• [Presentation] Bond durability of four contemporary self-etching system (2012)
  • Author(s): Fu J, Feng P, Ting S, Kakuda S, Nakaoki Y, Ikeda T, Tanaka T Sano H
  • Organizer: The American Association for Dental Research 2012
  • Place of Presentation: Tampa Convention Center, Tampa. USA
• [Presentation] The effects of different coating time on one-and two-step self-etching adhesives (2012)
  • Author(s): Pan F, Ting S, Kakuda S, Nakaoki Y, Ikeda T, Tanaka T, Sano H
  • Organizer: Japan-China Dental Conference 2012
  • Place of Presentation: 四川大学、中国四川
• [Presentation] Bonding performance between Two-step and Newly Developed One-step Self-etching Adhesives (2011)
  • Author(s): Fu J, Pan F, Fukuoka A, Matsuda Y, Ikeda T, Kawamoto C, Inoue S, Kakuda S, Ting S, Tanaka T, Komatsu H, Sano H
  • Organizer: 5th Conseuro Meeting 2011 on Prevention Restoration and Aesthetics
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2011-10-13
• [Presentation] The effect of air-blowing duration on three contemporary all-in-one systems (2011)
  • Author(s): Fu J, Pan F, Ting S, Nakaoki Y, Ikeda T, Tanaka T, Sano H
  • Organizer: 45th Meeting of the Continental European Division of the International Association of Dental Research with the Scandinavian Division
  • Place of Presentation: Semmelweis University, Budapest, Hungary
  • Year and Date: 2011-08-31
• [Presentation] Effect Of Different RDT On μTBS Of Current Adhesive Systems
  • Author(s): Ting Shihchun ,Jiale Fu, Feng Pan,Yasuko Nakaoki, Takatsumi Ikeda, Tanaka Toru, and Hidehiko Sano
  • Organizer: International Association for Dental Research
  • Place of Presentation: Washington State Convention Center (USA)
• [Presentation] Bond durability of four contemporary self-etching systems
  • Author(s): Jiale Fu, Feng Pan, Shihchun Ting, Takatsumi Ikeda, Yasuko Nakaoki, Hidehiko Sano
  • Organizer: International Association for Dental Research
  • Place of Presentation: Washington State Convention Center (USA)