Development of next-generation artificial tooth root including periodontal ligament
| Project/Area Number |
22390359
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AKAMINE Akifumi 九州大学, 大学院・歯学研究院, 教授 (00117053)
WADA Naohisa 九州大学, 大学病院, 講師 (60380466)
MONNOUCHI Satoshi 九州大学, 大学院・歯学研究院, 助教 (30609558)
友清 淳 九州大学, 大学院・歯学研究院, 助教 (20507777)
藤井 慎介 九州大学, 大学病院, 助教 (60452786)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 歯内療法学 / 歯根膜 / 4-META/MMA-TBBレジン / カルシウム / ハイドロキシアパタイト / 未分化なひと歯根膜細胞 / ヒト歯根膜細胞 / 象牙質タンパク / 未分化なヒト歯根膜細胞 / 人工歯根 / プロテオーム解析 / 炭酸アパタイト |
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| Research Abstract |
In the present study we aimed to develop the next-generation implant close to natural teeth. Our recent study revealed that calcium stimuli promoted the proliferation and osteogenic differentiation of undifferentiated human periodontal ligament (PDL) cell lines. So we prepared the HAp column, and then attached and grew cell lines on its surface. These column-cell complexes were implanted into rat bone cavity. After 4 weeks later, new bone-like tissue and PDL-like fibrous tissues wereformed around HAp columns. We also implanted these complexes into healed bone cavity preparedafter extracting molar of rats. After 4 weeks of implantation, PDL-like fibrous tissues were observed around HAp. These results indicated that implantation using HAp and undifferentiated PDL cells might lead to develop the implants retaining PDL tissues.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] A multipotent clonal human periodontal ligament cell line with neural crest cell phenotypes promotes neurocytic differentiation, migration, and survival2012
Author(s)
Tomokiyo A, Maeda H, Fujii S, Monnouchi S, Wada N, Kono K, Koori K, Yamamoto N, Teramatsu Y, Akamine A
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Journal Title
J Cell Physiol
Volume: 227(5)
Pages: 2040-2050
Related Report
Peer Reviewed
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[Journal Article] Exposure to transforming growth factor-β1 after basic fibroblast growth factor promotes the fibroblastic differentiation of human periodontal ligament stem/progenitor cell lines
Author(s)
Kono K, Maeda H, Fujii S, Tomokiyo A,Yamamoto N, Wada N, Monnouchi S, Teramatsu Y, Hamano S, Koori K, Akamine A
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Related Report
Peer Reviewed
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