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Reconstruction of Jaw Bone with 3 dimension scaffold treated by functionalized carbon nano-material

Research Project

Project/Area Number 22390361
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthetic dentistry
Research InstitutionHokkaido University

Principal Investigator

YOKOYAMA Atsuro  北海道大学, 大学院・歯学研究科, 教授 (20210627)

Co-Investigator(Kenkyū-buntansha) AKASAKA Tsukasa  北海道大学, 大学院・歯学研究科, 准教授 (00360917)
YAMAMOTO Satoru  北海道大学, 大学院・歯学研究科, 助教 (10344524)
TAKITA Hiroko  北海道大学, 大学院・歯学研究科, 助教 (30125330)
SATO Yoshinori  東北大学, 大学院・環境科学研究科, 准教授 (30374995)
YASUDA Motoaki  北海道大学, 大学院・歯学研究科, 准教授 (90239765)
Co-Investigator(Renkei-kenkyūsha) SHIBA Kiyotaka  癌研究所, タンパク創製研究部, 部長 (40196415)
YUDASAKA Masako  産業技術総合研究所, ナノチューブ応用研 究センター, チーム長 (70159226)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywordsカーボンナノマテリアル / 生体材料 / 骨形成 / b-FGF / スタチン / チタン / カーボンナノ物質 / 長期安定性 / 構造変化 / 3次元スキャホールド / 陽極酸化チタン / 骨芽細胞 / 表面修飾 / カーボンナノチューブ / カーボンナノホーン / 生体適合性 / マクロファージ / グロースファクター
Research Abstract

Functionalized carbon nanomaterials were developed by covalent bond of b-FGF to multiwalled carbon nanotubes and absorption of simvastatin to carbon nanohorns, and effects of them on bone formation were evaluated by animal experiments. Extensive bone formation was observed in the scaffolds with functionalized carbon nanomaterials in comparison with normal carbon nanomaterials. Also, biocompatibility carbon nanomaterials was observed by animal experiments for a long term.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (21 results) Book (1 results)

  • [Journal Article] The effects of the coating of anodized titanium with multi-walled carbon nanotubes on bone foramation.2012

    • Author(s)
      Ioue S.
    • Journal Title

      Key Engineering Materials

      Volume: 529-530 Pages: 621-624

    • DOI

      10.4028/www.scientific.net/kem.529-530.621

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbon nanotube-coating accelerated cell adhesion and proliferation on poly (L-lactide)2012

    • Author(s)
      Hirata E, Akasaka T, UoM, Takita H, Watari F, Yokoyama A
    • Journal Title

      Applied Surface Science

      Volume: (印刷中) Pages: 24-27

    • DOI

      10.1016/j.apsusc.2012.01.012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] nanotube- coati ng of 3D col l agen scaf f ol ds f or bone ti ssue engineering2011

    • Author(s)
      Hi rat a E, Uo M, Taki t a H, Akasaka T, Wat ari F, Yokoyama A. Mul ti wal l ed carbon
    • Journal Title

      Carbon

      Volume: 49 Pages: 3284-91

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carbon nanohorns accel erate bone regenerat i on i n rat cal vari al bone def ect2011

    • Author(s)
      Kasai T, Mat sumura S, Ii zuka T, Shi ba T, Kanamori T, Yudasaka M, Ii j i ma S, Yokoyama A
    • Journal Title

      Nanotechnol ogy

      Volume: 22 Pages: 65102-65102

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mai ntenance of hemi round col oni es and undi f f erent i ated state of mouse induced pluri potent stem cells on carbon nanotube- coated di shes2011

    • Author(s)
      Akasaka T, Yokoyama A, Mat suoka M, Hashi moto T, Wat ari F
    • Journal Title

      Carbon

      Volume: 49 Pages: 2287-2299

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiwalled carbon nanotube-coating of 3D collagen scaffolds for bone tissue engineering2011

    • Author(s)
      Hirata E, UoM, Takita H, Akasaka T, Watari F, Yokoyama A
    • Journal Title

      Carbon

      Volume: 49 Issue: 10 Pages: 3284-3291

    • DOI

      10.1016/j.carbon.2011.04.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toxicity evaluations of various carbon nanomaterials2011

    • Author(s)
      Uo M., 他4名
    • Journal Title

      Dental Materials Journal

      Volume: 30 Issue: 3 Pages: 245-263

    • DOI

      10.4012/dmj.2010-039

    • NAID

      10029136414

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbon nanohorns accelerate bone regeneration in rat calvarial bone deffect2011

    • Author(s)
      Kasai T
    • Journal Title

      NANOTECNOLOGY

      Volume: 22 Pages: 651021-651028

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maintenance of hemiround colonies and undifferentiated state of mouse induced pluripotent stem cells on carbon nanotube-coated dishes2011

    • Author(s)
      Akasaka T
    • Journal Title

      CARBON

      Volume: 49 Pages: 2287-2299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transmission electron microscopic observation of cells cultured on multiwalled carbon nanotube-coated sponges2010

    • Author(s)
      Hirata E
    • Journal Title

      Journal of Electron Microscopy

      Volume: 59 Pages: 447-450

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Functionalization of carbon nanotubes by fibroblast growth factor2012

    • Author(s)
      Hirata E
    • Organizer
      The 2 sympojium of carbon nanoforms
    • Place of Presentation
      産総研(茨城県)
    • Year and Date
      2012-07-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Functionalization of carbon nanotubes by fibroblast growth factor.2012

    • Author(s)
      Hirata E.
    • Organizer
      The 2nd sympojium on Carbon Nanoforms
    • Place of Presentation
      産総研(つくば市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The effect of CNHs adsorbed simvastatin on bone regeneration2012

    • Author(s)
      Yamauchi A.
    • Organizer
      8th Asian Academy of Osseointegration
    • Place of Presentation
      Howard International House (Taiwan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Improvement of osteoconductivity by coating with multi-walled carbon nanotubes on the surface of anodized titanium2012

    • Author(s)
      Inoue S.
    • Organizer
      8th Asian Academy of Osseointegration
    • Place of Presentation
      Howard International House (Taiwan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Carbon nanotubes functionalized by fibroblast growth factor accelerate bone formation2012

    • Author(s)
      Hirata E.
    • Organizer
      8th Asian Academy of Osseointegration
    • Place of Presentation
      Howard International House (Taiwan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Surface modification of Anodized Titanium by Multi-Walled Carbon Nanotubes2012

    • Author(s)
      Inoue S.
    • Organizer
      9th World Biomaterials Congress
    • Place of Presentation
      New International Convention & Exposition Center Chengdu Century City (China)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functionalization of carbon nanotubes by basic-Fibroblast Growth Factor.2012

    • Author(s)
      Hirata. E
    • Organizer
      9th World Biomaterials Congress
    • Place of Presentation
      New International Convention & Exposition Center Chengdu Century City (China)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The effect of CNHs adsorbed simvastatin on bone regeneration2012

    • Author(s)
      Yamauchi A.
    • Organizer
      第43回フラーレン・ナノチューブ・グラフェン総合シンポジウム
    • Place of Presentation
      東北大学川内萩ホール(仙台市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 歯科インプラント用カーボンナノチューブコーティング陽極酸化チタンの開発と観察2011

    • Author(s)
      井上沙織
    • Organizer
      平成23年度日本電子顕微鏡学会北海道支部会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 補綴領域におけるナノテクノロジーの展望2011

    • Author(s)
      横山敦郎
    • Organizer
      日本補綴歯科学会東北・北海道、関越、東関東合同支部会
    • Place of Presentation
      日新潟県歯科医師会館(新潟)
    • Year and Date
      2011-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 補綴領域におけるナノテクノロジーの展望2011

    • Author(s)
      横山敦郎
    • Organizer
      平成23年度日本補綴歯科学会東北・北海道,関越,東関東合同支部会
    • Place of Presentation
      新潟県歯科医師会館(新潟市)(招待講演)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Application of carbon nanotube-coated 3D scaffold for bone tissue engineering2011

    • Author(s)
      平田恵理
    • Organizer
      IDMC2011
    • Place of Presentation
      延世大学(大韓民国)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of the carbon nanotube-coated anodized titanium2011

    • Author(s)
      井上沙織
    • Organizer
      IDMC2011
    • Place of Presentation
      延世大学(大韓民国)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] カーボンナノチューブを修飾した3欠元細胞培養担体の骨再生への応用2011

    • Author(s)
      平田恵理
    • Organizer
      第120回日本補綴歯科学会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2011-05-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] カーボンナノチューブをコートしたコラーゲンスポンジによる骨芽細胞の3次元培養と骨再生への応用2010

    • Author(s)
      平田恵理
    • Organizer
      第32回日本バイオマテリアル学会
    • Place of Presentation
      広島県広島市グランドプリンスホテル広島
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of nanomaterials for bone regeneration2010

    • Author(s)
      横山敦郎
    • Organizer
      The 6^<th> Congress of the Asian Academy of Osseoi ntegration
    • Place of Presentation
      Baek Bum Museum, Seoul (Korea) 招待講演
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of collagen sponge coated with multiwalled carbon nanotubes to 3D cell culturing and bone tissue engineering2010

    • Author(s)
      平田恵理
    • Organizer
      The 6^<th> Congress of the Asian Academy of Osseoi ntegration
    • Place of Presentation
      Baek Bum Museum, Seoul (Korea)
    • Year and Date
      2010-10-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of collagen sponge coated with multiwalled carbon nanotubes to 3D cell culturing and bone tissue engineering2010

    • Author(s)
      笠井孝夫
    • Organizer
      第39回フラーレン・ナノチューブ総合シンポジウム
    • Place of Presentation
      京都府京都大学
    • Year and Date
      2010-09-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] ナノバイオマテリアルの開発と評価における医工連携日本補綴歯科学会2010

    • Author(s)
      横山敦郎
    • Organizer
      第119回学術大会
    • Place of Presentation
      東京ビッグサイト(東京)
    • Year and Date
      2010-06-13
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノバイオマテリアルの開発と評価における医工連携2010

    • Author(s)
      横山敦郎
    • Organizer
      日本補綴歯科学会第119回学術大会
    • Place of Presentation
      東京都東京ビッグサイト 招待講演
    • Year and Date
      2010-06-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] カーボンナノチューブコートした3次元細胞培養用担体の開発と特性評価2010

    • Author(s)
      平田恵理
    • Organizer
      日本補綴歯科学会第119回学術大会
    • Place of Presentation
      東京都東京ビッグサイト
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Book] ナノ材料のリスク評価と安全性対策2010

    • Publisher
      フロンティア
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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