Development of cell-based screening system for identifying osteogenesis-targeting compounds
| Project/Area Number |
22390364
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YATANI Hirofumi 大阪大学, 大学院・歯学研究科, 教授 (80174530)
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| Co-Investigator(Kenkyū-buntansha) |
EGUSA Hiroshi 大阪大学, 大学院・歯学研究科, 助教 (30379078)
SAEKI Makio 大阪大学, 大学院・歯学研究科, 講師 (30273692)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUYASU Sho 大阪大学, 歯学部附属病院, 医員 (10711054)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | ケミカルバイオロジー / 小分子化合物 / 骨芽細胞 / 破骨細胞 / 骨組織再生 |
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| Research Abstract |
Small-molecule compounds that potently affect osteoclastogenesis or osteogenesis could form the basis for effective therapeutic strategies for alveolar bone regenerative medicine. In this study, we established osteoclast progenitor cell (NFAT/luciferase reporter cell)- or osteoblast (type I collagen/GFP reporter cell)-based high-throughput screening systems. These screening systems could identify candidates for osteoclastogenesis- or osteogenesis-targeting compounds in reliable manner, thus making it a promising tool for finding novel synthetic regulators of bone formation.
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Report
(4 results)
Research Products
(26 results)
