| Project/Area Number |
22390367
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
|
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOMORI Toshifumi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (00252677)
ASAHINA Izumi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30221039)
KATO Yukio 広島大学, 大学院・医歯薬学総合研究科, 教授 (10112062)
NAGAI Kazuhiro 長崎大学, 病院, 講師 (30304942)
MURATA Hiroshi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (40229993)
|
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| Co-Investigator(Renkei-kenkyūsha) |
SUMITA Yoshinori 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (50456654)
SUEHIRO Fumio 長崎大学, 大学院・医歯薬学総合研究科, 助教 (40524781)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Keywords | 再生医療 / 骨再生 / 幹細胞 / 間葉系幹細胞 / 歯槽骨再生 / 骨増生 |
|---|
| Research Abstract |
We successfully acquired sufficient numbers of stromal cells from 30 patients’ alveolar bone marrow aspirates. We could get enough number of cells for alveolar bone engineering from elderly patients. Low level serum contained medium has higher potential of cell growth and differentiation compared with well-known 10% serum contained medium. Transplantation of alveolar bone marrow stromal cells into mouse showed heterotopic ossification. The cells which have high osteogenic activity in vitro did not show high bone formation in vivo.
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