Development of tight adhesionsystem for implantable materials and regenerated host tissue.

• Project/Area Number: 22390373
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Okayama University (2011-2012); Osaka University (2010)
• Principal Investigator: MATSUMOTO Takuya 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40324793)
• Co-Investigator(Kenkyū-buntansha): IMAZATO Satoshi 大阪大学, 歯学研究科(研究院), 教授 (80243244)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
• Keywords: 硬組織修復 / 骨 / チタン / ジルコニア / アパタイト / 多孔体 / バイオマテリアル / 細胞操作 / スキャフォールド / 組織工学 / 接着 / ジルコニア/アパタイト複合体 / 多孔質 / 細胞接着 / 骨再生 / タンパク質吸着

Research Abstract

The modification of material surface properties are crucial to achieve the tight adhesion between implanted materials and host tissue. A new synthesis method of hydroxyapatite/zirconia composite porous material and a new surface modification method of titanium material were developed in this study. These materials showed higher biocompatibility and adhesive properties against cells and tissues. Moreover, the combination of bone tissue reconstruction and regeneration for bone tissue defect treatment was succeeded by using the developed materials in this study.

Research Products

• [Journal Article] Porous zirconia/hydroxyapatite scaffolds for bone reconstruction (2012)
  • Author(s): An SH, Matsumoto T, Miyajima H, Nakahira A, Kim KH, Imazato S
  • Journal Title: Dent Mater Volume: 28 Pages: 1221-1232
  • Peer Reviewed
• [Journal Article] In vitro bioactivity evaluation of nano- and micro- crystalline anodic TiO2: HA formation, cellular affinity and organ culture. (2012)
  • Author(s): An SH, Matsumoto T, Sasaki J, Miyajima H, Narayanan R, Imazato S, Kim KH.
  • Journal Title: Mater Sci Eng C Volume: 32 Pages: 2516-2522
  • Peer Reviewed
• [Journal Article] Surface characterization of alkali- and heat-treated Ti with or without prior acid etching. (2012)
  • Author(s): An SH, Matsumoto T, Miyajima H, Sasaki J, Narayanan R, Kim KH.
  • Journal Title: Appl Surf Sci Volume: 258 Pages: 4377-4382
  • Peer Reviewed
• [Journal Article] Porous zirconia/hydroxyapatite scaffolds for bone reconstruction (2012)
  • Author(s): An SH, Matsumoto T, Miyajima H, Nakahira A, Kim KH, Imazato S.
  • Journal Title: Dent Mater Volume: 28 Issue: 12 Pages: 1221-1231
  • DOI: 10.1016/j.dental.2012.09.001
  • Peer Reviewed
• [Journal Article] In vitro bioactivity evaluation of nano- and micro- crystalline anodic TiO2 (2012)
  • Author(s): An SH, Matsumoto T, Sasaki J, Miyajima H, Narayanan R, Imazato S, Kim KH.
  • Journal Title: Mater Sci Eng C Volume: 32 Pages: 2516-2522
  • Peer Reviewed
• [Journal Article] Zirconia-hydroxyapatite composite material with micro porous structure. (2011)
  • Author(s): Matsumoto JT, An SH, Ishimoto T, Nakano T, Matsumoto T, Imazato S.
  • Journal Title: Dent Mater
  • Peer Reviewed
• [Journal Article] Crystallinity of anodic TiO2 nanotubes and bioactivity. (2011)
  • Author(s): An SH, Narayanan R, Matsumoto T, Lee HJ, Kwon TY, Kim KH.
  • Journal Title: J Nanosci Nanotech Volume: 11 Pages: 4910-4918
  • Peer Reviewed
• [Journal Article] Modulation of nanotube formation in apatite single crystal via organic molecule incorporation. (2011)
  • Author(s): Matsumoto T, Uddin MH, An SH, Arakawa K, Taguchi E, Nakahira A, Okazaki M.
  • Journal Title: Mater Chem Phys Volume: 128 Pages: 495-499
  • Peer Reviewed
• [Journal Article] Cell-based fabrication of organic/omprganic composite gel material. (2011)
  • Author(s): Matsumoto T, Mizuno A, Kashiwagi M, Yoshida S, Sasaki J, Nakano T.
  • Journal Title: Materials Volume: 4 Pages: 327-338
  • Peer Reviewed
• [Journal Article] Zirconia-hydroxyapatite composite material with micro porous structure (2011)
  • Author(s): Matsumoto JT, An SH, Ishimoto T, Nakano T, Matsumoto T, Imazato S
  • Journal Title: Dent Mater Volume: 27
  • Peer Reviewed
• [Journal Article] Modulation of nanotube formation in apatite single crystal via organic molecule incorporation (2011)
  • Author(s): Matsumoto T, Uddin MH, An SH, Arakawa K, Taguchi E, Nakahira A, Okazaki M
  • Journal Title: Mater Chem Phys Volume: 128 Pages: 495-499
  • Peer Reviewed
• [Journal Article] Cell-based fabrication of organic/omprganic composite gel material (2011)
  • Author(s): Matsumoto T, Mizuno A, Kashiwagi M, Yoshida S, Sasaki J, Nakano T
  • Journal Title: Materials Volume: 4 Pages: 327-338
  • Peer Reviewed
• [Journal Article] Crystallinity of anodic TiO_2 nanotubes and bioactivity (2011)
  • Author(s): An SH, Narayanan R, Matsumoto T, Lee HJ, Kwon TY, Kim KH
  • Journal Title: J Nanosci Nanotech Volume: 11 Pages: 4910-4918
  • Peer Reviewed
• [Journal Article] Effect of calcium ion concentrations on osteogenic differentiation and hematopietic stem cell niche-related gene expressions in osteoblasts (2010)
  • Author(s): Nakamura S, Matsumoto T, Sasaki J, Egusa H, Lee KY, Nakano T, Sohmura T, Nakahira A
  • Journal Title: Tissue Eng Part A Volume: 16 Pages: 2497-1504
  • Peer Reviewed
• [Journal Article] Apatite containing aspartic acid for selective protein loading (2010)
  • Author(s): Uddin MH, Matsumoto T, Ishihara S, Nakahira A, Okazaki M, Sohmura T.
  • Journal Title: J Dent Res Volume: 89 Pages: 488-492
  • Peer Reviewed
• [Presentation] 石灰化を理解するin vitroの系を作ってみました (2012)
  • Author(s): 松本卓也
  • Organizer: 石灰化を理解するin vitroの系を作ってみました
  • Place of Presentation: 高松
  • Year and Date: 2012-09-08
• [Presentation] Our approach for in vitro tissue synthesis. Biomedial Engineering Seminar (2012)
  • Author(s): Matsumoto T
  • Organizer: Dangkook University
  • Place of Presentation: Daejong, Korea
  • Year and Date: 2012-07-31
• [Presentation] ジルコニア表面のリン酸モノマーによる有機化の検討. (2012)
  • Author(s): 玉田 宜之、長岡 紀幸、早川 聡、入江正郎、西川 悟郎、丸尾 幸憲、吉田 靖弘、松本 卓也、尾坂 明義、皆木 省吾
  • Organizer: 日本歯科理工学会
  • Place of Presentation: 徳島
  • Year and Date: 2012-04-14
• [Presentation] 生体材料を用いた組織周囲環境の構築とin vitro組織形態制御 (2012)
  • Author(s): 松本卓也
  • Organizer: 口腔科学フロンティア研究会
  • Place of Presentation: 大阪大学、大阪
  • Year and Date: 2012-03-03
• [Presentation] In vitro tissue synthesis using engineering approach (2012)
  • Author(s): 松本卓也
  • Organizer: 口腔先端応用科学研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-21
• [Presentation] In vitro tissue synthesis using engineering approach (2012)
  • Author(s): 松本卓也
  • Organizer: 口腔先端応用科学研究会
  • Place of Presentation: 日本大学、東京
  • Year and Date: 2012-01-21
• [Presentation] Our approach for in vitro tissue synthesis. (2012)
  • Author(s): Takuya Matsumoto
  • Organizer: Biomedial Engineering Seminar, Dangkook University
  • Place of Presentation: DaeJong, Korea
  • Invited
• [Presentation] In vitro reproduction of endochondral ossification using 3D cell construct. (2011)
  • Author(s): Matsumoto T
  • Organizer: Gordon Research Conference.
  • Place of Presentation: Holderness, USA
  • Year and Date: 2011-08-02
• [Presentation] In vitro reproduction of endochondral ossification using 3D cell construct (2011)
  • Author(s): Matsumoto T
  • Organizer: Gordon Research Conference
  • Place of Presentation: Holderness, USA
  • Year and Date: 2011-08-02
• [Presentation] Porous Zirconia/Hydroxyapatite Scaffolds for Bone Reconstruction Combined with Bone Regeneration. (2011)
  • Author(s): An SH , Matsumoto T, Miyajima H, Kim KH, Imazato S.
  • Organizer: International Dental Material Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-25
• [Presentation] Porous Zirconia/Hydroxyapatite Scaffolds for Bone Reconstruction Combined with Bone Regeneration (2011)
  • Author(s): An SH, Matsumoto T, Miyajima H, Kim KH, Imazato S
  • Organizer: International Dental Material Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-25
• [Presentation] 生体材料 (2010)
  • Author(s): 松本卓也
  • Organizer: 全国歯科技工士教育協議会顎顔面補綴士養成講座
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2010-10-31
• [Presentation] MSCs combined porous ZrO/HAp scaffold for bone tissue engineering. (2010)
  • Author(s): 安 相〓,宮嶋宏行,松本卓也
  • Organizer: 日本バイオマテリアル学会 第5回関西若手研究発表会.
  • Place of Presentation: 京都
  • Year and Date: 2010-08-06
• [Presentation] MSCs combined porous ZrO/HAp scaffold for bone tissue engineering (2010)
  • Author(s): 安相〓, 宮嶋宏行, 松本卓也
  • Organizer: 日本バイオマテリアル学会第5回関西若手研究発表会
  • Place of Presentation: 京都
  • Year and Date: 2010-08-06
• [Presentation] 荘村泰治異なる配合比を有するZrO2/HAp複合体の生物学的評価 (2010)
  • Author(s): 松本卓也(院生)、松本卓也
  • Organizer: 第55回日本歯科理工学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-17
• [Presentation] モハマッドハフィス ウディン、荘村泰治 アパタイト結晶中での微小孔構造の形成 (2010)
  • Author(s): 松本卓也
  • Organizer: 第55回日本歯科理工学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-17
• [Presentation] 異なる配合比を有するZrO_2/HAp複合体の生物学的評価 (2010)
  • Author(s): 松本卓也(院生)、松本卓也、荘村泰治
  • Organizer: 第55回日本歯科理工学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-17
• [Presentation] アパタイト結晶中での微小孔構造の形成 (2010)
  • Author(s): 松本卓也、モハマッドハフィスウディン、荘村泰治
  • Organizer: 第55回日本歯科理工学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-17
• [Remarks] サイエンスコミュニケーション 「歯科医療と芸術との融合」. 2013年2月1日. 岡山市130名参加