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Development of imaging diagnosis system for oral cancer utilizing lesion-integrated nanobubbles and high frequency ultrasound

Research Project

Project/Area Number 22390378
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTohoku University

Principal Investigator

MORI Shiro  東北大学, 病院, 講師 (80230069)

Co-Investigator(Kenkyū-buntansha) ONO Masao  東北大学, 医学系研究科, 教授 (20302218)
Co-Investigator(Renkei-kenkyūsha) KODAMA Tetsuya  東北大学, 医工学研究科, 教授 (40271986)
ONO Masao  東北大学, 医学系研究科, 教授 (20302218)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords口腔癌 / ナノバブル / 超音波 / 転移モデル / リンパ節転移 / 腫瘍血管 / リンパ管 / 画像診断
Research Abstract

The purpose of the present study is to develop a real-time imaging system using high frequency ultrasound and nanobubbles for the diagnosis of oral cancer. In order to evaluate the diagnostic accuracy of the high-frequency ultrasonic imaging analysis for oral cancer, we established a recombinant inbred strain of mouse showing a similar size of lymph node swelling as that of human. As a result, in the metastatic lymph nodes,it became clear that nanobubbles leake and integrate into the perivascular region of the lesion by enhanced permeability and retention (EPR) effect. This finding suggests that the image analysis using high-frequency ultrasound and nanobubbles isextremely useful in diagnosis of the metastatic lesions in the lymph node.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (82 results)

All 2013 2012 2011 2010

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (59 results)

  • [Journal Article] Enhancedsonographic imaging to diagnose lymph node metastasis: importance of bloodvessel volume and density2013

    • Author(s)
      Li Li, Mori S, Kodama M, Sakamoto M, Takahashi S, KodamaT
    • Journal Title

      Cancer Reseach

      Volume: 73 Issue: 7 Pages: 2082-2092

    • DOI

      10.1158/0008-5472.can-12-4200

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mouse model of lymph node metastasis via afferent lymphatic vessels for development of imagingmodalities2013

    • Author(s)
      Li Li, Mori S, Sakamoto M, Takahashi S, Kodama T
    • Journal Title

      PLOS ONE

      Volume: 8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphatic mapping of mice withsystemic lymphoproliferative disorder: usefulness as aninter-lymph node metastasis model of cancer2013

    • Author(s)
      Lenan S, Mori S, Yagishita Y, Okuno T, Hatakeyama Y, Sato T, Kodama T
    • Journal Title

      J Immunol Method

      Volume: 389(1-2) Issue: 1-2 Pages: 69-78

    • DOI

      10.1016/j.jim.2013.01.004

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomics of Vasculitis: Lessons from Mouse Models2013

    • Author(s)
      Nose M, Komori H, Miyazaki T, Mori S
    • Journal Title

      Annals of Vascular Diseases

      Volume: 6 Issue: 1 Pages: 16-21

    • DOI

      10.3400/avd.ra.12.00096

    • NAID

      130004487995

    • ISSN
      1881-641X, 1881-6428
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sjogren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNFreceptor-related protein (GITR)ligand and 4-1BB ligand2013

    • Author(s)
      Saito K, Mori S, Date F, Ono M
    • Journal Title

      Autoimmunity

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sjogren’s syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand2013

    • Author(s)
      Saito K, et al
    • Journal Title

      Autoimmunity

      Volume: accepted

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mouse model of lymph node metastasis via afferent lymphatic vessels for development of imaging modalities2013

    • Author(s)
      Li L, et al
    • Journal Title

      PLOS ONE

      Volume: 8(2):e55797

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sjogren’s syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand2013

    • Author(s)
      Saito K, et al.
    • Journal Title

      Autoimmunity

      Volume: accepted

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of the MEN1 and HRPT2 in jaw tumor and parathyroid adenoma associated with familial hyperparathyroidism2012

    • Author(s)
      Miyashita M, et al
    • Journal Title

      Tohoku University Dental Journal

      Volume: 31 Pages: 52-58

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Volumetric and angiogenicevaluation of antitumor effects with acoustic liposome and high-frequency ultrasound2011

    • Author(s)
      Kodama T, Tomita N, Yagishita Y, Horie S, Funamoto K, Hayase T, Sakamoto M, Mori S
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 6957-6964

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of anti-tumor effects following tumor necrosis factor-alpha gene delivery using nanobubbles and ultrasound2011

    • Author(s)
      Horie S, Watanabe Y, Ono M, Mori S, Kodama T.
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 2082-2089

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy2011

    • Author(s)
      Kuwahara Y, Oikawa T, Ochiai Y, Roudkenar, M Fukumoto, T Shimura, Y Ohtake M H, Ohkubo Y, Mori S, Uchiyama Y, Fukumoto M
    • Journal Title

      Cell Death Dis (2011)

      Volume: 2 Issue: 6 Pages: e177-e177

    • DOI

      10.1038/cddis.2011.56

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Modified High-Density Survival Assay is the Useful Tool to Predict the Effectiveness of Fractioned Radiation Exposure2010

    • Author(s)
      Kuwahara Y, Mori M, Oikawa T, Shimura T, Ohtake Y, Mori S, Ohkubo Y, Fukumoto M
    • Journal Title

      J Radiat Res

      Volume: 51 Pages: 297-302

    • NAID

      10026471144

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of localized gene delivery using a dual-intensity ultyrasound system in the bladder2010

    • Author(s)
      Horie S, Watabnabe Y, Chen R, Mori S, Matsumura Y, Kodama T
    • Journal Title

      Ultrasound Med Biol

      Volume: 36(11) Pages: 1867-1875

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound2010

    • Author(s)
      Kodama T, Aoi A, Watabnabe Y, Horie S, Kodama M, Li L, Chen R, Teramoto N, Morikawa H, Mori S, Fukumoto M
    • Journal Title

      Ultrasound Med Biol

      Volume: 36(7) Pages: 1196-1205

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delivery of Na/I symporter gene into skeletal muscle by using nanobubbles and ultrasound:Visualization of gene expression by positron emission tomography2010

    • Author(s)
      Watanabe Y, Horie S, Funaki Y, Kikuchi Y, Yamazaki H, Ishii K, Mori S, Vassaux G, Kodama T
    • Journal Title

      J Nucl Med

      Volume: 51(6) Pages: 951-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System2010

    • Author(s)
      Tanaka Y, Komori H, Mori S, Soga Y, Tsubaki T, Terada M, Miyazaki T, Fujino T, Nakamura S, Kanno H, Sawasaki T,Endo Y, Nose M
    • Journal Title

      Tohoku J Exp Med

      Volume: 220 (3) Pages: 199-206

    • NAID

      10027083539

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological study on Acoustic liposome using transmission electron microscopy2010

    • Author(s)
      Kodama T, Tomita N, Horie S, Sax N, Iwasaki H, Suzuki R, Maruyama K, Mori S, Fukumoto M
    • Journal Title

      J Electron Microsc

      Volume: 59(3) Pages: 187-196

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological Study on Acoustic Liposome Using Transmission Electron Microscopy2010

    • Author(s)
      Kodama T, et al
    • Journal Title

      J Electron Microsc

      Volume: 59 Pages: 187-196

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System2010

    • Author(s)
      Tanaka Y, et al.
    • Journal Title

      Tohoku J Exp Med

      Volume: 220 Pages: 199-206

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delivery of Na/I symporter gene into skeletal muscle by using nanobubbles and u ltrasound : Visualization of gene expression by positron emission tomography2010

    • Author(s)
      Watanabe Y, et al.
    • Journal Title

      J Nucl Med

      Volume: 51 Pages: 951-958

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of transfection efficiency in skeletal muscle using nano/microbubble s and ultrasound. Ultrasound in Medicine and Biology2010

    • Author(s)
      Kodama T, et al.
    • Journal Title

      Ultrasound Mod Biol

      Volume: 36 Pages: 1196-1205

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of localized gene delivery using a dual intensity ultyrasound syste min the bladder2010

    • Author(s)
      Horie S, et al.
    • Journal Title

      Ultrasoun Mod Biol

      Volume: 36 Pages: 1867-1675

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 超音波と微小気泡によるリンパ管を介したリンパ節内細胞への外来分子導入法の開発2013

    • Author(s)
      加藤茂樹,白井優子,佐藤琢磨,菅崎弘幸,本園千尋,宮澤正顯,森士朗,小玉哲也
    • Organizer
      日本超音波医学会東北地方会第45回学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-10
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Molecualr delivery into lymph nodes using ultrasound and nanobubbles2013

    • Author(s)
      Shirai Y, Kato S, Kanzaki H, Mori S, Kodama T
    • Organizer
      The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore , Singapore.
    • Related Report
      2012 Final Research Report
  • [Presentation] Early diagnosis of lymph nodemetastasis2013

    • Author(s)
      Hasegawa N, Kodama T, Sato T, Kochi T, Mori S
    • Organizer
      The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore , Singapore.
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of contrast-enhanced high-frequencyultrasound for early diagnosis of tumor2013

    • Author(s)
      Yanagisawa Y, Ito K, Noro K, Aoki T, Mori S, Kodama T
    • Organizer
      The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore,Singapore
    • Related Report
      2012 Final Research Report
  • [Presentation] 金ナノロッドを利用した局所的熱療法のリンパ節転移治療への応用2013

    • Author(s)
      奥野竜希,加藤茂樹,畠山友梨子,阪本真弥,森士朗,小玉哲也
    • Organizer
      日本機械学会第25回バイオエンジニアリング講演会
    • Place of Presentation
      筑波
    • Related Report
      2012 Final Research Report
  • [Presentation] 金ナノロッドを利用した局所的熱療法のリンパ節転移治療への応用2013

    • Author(s)
      奥野竜希、他
    • Organizer
      日本機械学会 第25回バイオエンジニアリング講演会
    • Place of Presentation
      筑波
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] Development of contrast-enhanced high-frequency ultrasound for early diagnosis of tumor.2013

    • Author(s)
      Yanagisawa Y, et al
    • Organizer
      The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore, Singapore
    • Related Report
      2012 Annual Research Report
  • [Presentation] Early diagnosis of lymph node metastasis.2013

    • Author(s)
      Hasegawa N, et al
    • Organizer
      The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore, Singapore
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] Molecualr delivery into lymph nodes using ultrasound and nano bubbles.2013

    • Author(s)
      Shirai Y, et al
    • Organizer
      The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore, Singapore
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of contrast-enhanced high-frequency ultrasound for early diagnosis of tumor2013

    • Author(s)
      Yanagisawa Y, et al
    • Organizer
      The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore, Singapore
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecualr delivery into lymph nodes using ultrasound and nano bubbles2013

    • Author(s)
      Shirai Y, et al
    • Organizer
      The 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore, Singapore
    • Related Report
      2011 Annual Research Report
  • [Presentation] プラズモン共鳴を利用した局所的熱療法のリンパ節転移治療への応用2012

    • Author(s)
      奥野竜希,長谷川奈保,畠山友梨子,加藤茂樹,阪本真弥,森士朗,小玉哲也
    • Organizer
      日本バイオマテリアル学会大会シンポジウム2012
    • Place of Presentation
      仙台
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳がんにおける腫瘍周辺上皮組織リンパ管および血管分布に関する研究2012

    • Author(s)
      三浦由宣,佐藤琢磨,阪本真弥,森士朗,小玉哲也
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 二光子顕微鏡をもちいたEPR効果による腫瘍内ナノ粒子流出特性の観察2012

    • Author(s)
      三ヶ田護,サックスニコラ,阪本真弥,森士朗,小玉哲也
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Pressure-driven flow characteristics in the lymphatic vessel for lymphatic drug delivery ststem2012

    • Author(s)
      Hatakeyama Y, Sax N, Kato S, Okuno T, Sakamoto M, Mori S, Kodama T
    • Organizer
      The 9th International Conference on FlowDynamics. Proceedings
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Cancer treatment via the lymphatic vessel using nano/microbubbles2012

    • Author(s)
      Kato S, Nicolas S, Hatakeyama Y, Okuno T, Mori S, Sakamoto M, Kodama T
    • Organizer
      The 9th International Conference on FlowDynamics
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Thermal therapy using plasmonic nano particles for lymph node metastasis2012

    • Author(s)
      Okuno T, Kato S, Hatakeyama Y, Sato T, Sakamoto M, Mori S, Kodama T
    • Organizer
      The 9th International Conference on Flow Dynamics
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] リンパ行性薬剤送達システムの開発2012

    • Author(s)
      畠山友梨子,李麗,サックスニコラ,奥野竜希,加藤茂樹,阪本真弥,森士朗,小玉哲也
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 腫瘍の成長にともなう鼠径リンパ節内の間質液圧特性に関する研究2012

    • Author(s)
      三浦由宣,畠山友梨子,阪本真弥,森士朗,小玉哲也
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 腫瘍移植とEPR効果に関する研究2012

    • Author(s)
      三ヶ田護,サックスニコラ,阪本真弥,森士朗,小玉哲也
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Drug delivery system with acoustic liposomes via the lymphatic vessels2012

    • Author(s)
      Kato S, Horie S, Sakamoto M, Mori S, Kodama T
    • Organizer
      The 8th International Symposium on Cavitation
    • Place of Presentation
      Novotel Clark Quay, Singapore
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Presentation] リンパ行性薬剤送達システム開発のためのリンパ節およびリンパ管内の流動特性2012

    • Author(s)
      畠山梨友子,サックスニコラ,奥野竜希,森士朗,阪本真弥,小玉哲也
    • Organizer
      第28回日本DDS学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Lymphatic network mapping in a novel lymph nodemetastasis model of mice2012

    • Author(s)
      Shao L, Okuno T, Hatakeyama Y, Kato S, Mori S, Kodama T
    • Organizer
      Medical Physics and Biomedical Engineering in Beijing
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Final Research Report
  • [Presentation] Flow characteristics of the lymphatic flow to the axillary lymph node driven by increasing pressures in the inguinal lymph node2012

    • Author(s)
      Hatakeyama Y, Nicolas S, Li L, Kato S, Okuno T, Miura Y, Shao L, Sakamoto M, Mori S, Fujikawa S, Kodama T
    • Organizer
      Medical Physics andBiomedical Engineering
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of the liposomal formuilation on the behavior and physical characteristicsof acoustic liposomes2012

    • Author(s)
      Sax N, Horie S, Li L, Li S, Kochi T, Chen R, Watanabe Y, Yagishita Y, Sakamoto M, Mori S, Kodam T
    • Organizer
      The 19th International Symposium on Nonliner Acoustics
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of the liposomal formuilation on the behavior and physical characteristics of acoustic liposomes2012

    • Author(s)
      Sax N ,et al
    • Organizer
      The 19th International Symposium on Non liner Acoustics
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] Flow characteristics of the lymphatic flow to the axillary lymph node driven by increasing pressures in the inguinal lymph node2012

    • Author(s)
      Hatakeyama Y, at al
    • Organizer
      Medical Physics and Biomedical Engineering in Beijing
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] Lymphatic network mapping in a novel lymph node metastasis model of mice2012

    • Author(s)
      Shao L, et al.
    • Organizer
      Medical Physics and Biomedical Engineering in Beijing
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] 口底に生じた類基底扁平上皮癌の1例2012

    • Author(s)
      阿部慧子、他
    • Organizer
      第61回東北大学歯学会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] リンパ節症を伴い顎下腺および耳下腺に症状のみられたIgG4関連慢性硬化性唾液腺炎の一例2012

    • Author(s)
      栗原 淳、他
    • Organizer
      第61回東北大学歯学会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] Pressure-driven flow characteristics in the lymphatic vessel for lymphatic drug delivery ststem2012

    • Author(s)
      Hatakeyama Y, et al
    • Organizer
      The 9th International Conference on Flow Dynamics
    • Place of Presentation
      Sendai
    • Related Report
      2012 Annual Research Report
  • [Presentation] Drug delivery system with acoustic liposomes via the lymphatic vessels2012

    • Author(s)
      Kato S, et al
    • Organizer
      The 9th International Conference on Flow Dynamics.
    • Place of Presentation
      Sendai
    • Related Report
      2012 Annual Research Report
  • [Presentation] Thermal therapy using plasmonic nano particles for lymph node metastasis2012

    • Author(s)
      Okuno T, et al
    • Organizer
      The 9th International Conference on Flow Dynamics
    • Place of Presentation
      Sendai
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] Lymphatic drainage routes mapping in a novel experimental lymph metastasis model of mice2012

    • Author(s)
      Shao L, et al.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] リンパ節症を伴い顎下腺・耳下腺に症状のみられたIgG4関連慢性硬化性唾液腺炎の1例2012

    • Author(s)
      栗原 淳、 他
    • Organizer
      第57回(公社)日本口腔外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] 当科におけるビスフォスフォネート投与患者の状況2012

    • Author(s)
      大泉丈史、 他
    • Organizer
      第57回(公社)日本口腔外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] プラズモン共鳴を利用した局所的熱療法のリンパ節転移治療への応用2012

    • Author(s)
      奥野竜希, 他
    • Organizer
      日本バイオマテリアル学会大会シンポジウム2012
    • Place of Presentation
      筑波
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pressure-driven flow characteristics in the lymphatic vessel2012

    • Author(s)
      Hatakeyama Y, et al
    • Organizer
      The 9th International Conference on Flow Dynamics
    • Place of Presentation
      Sendai
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cancer treatment via the lymphatic vessel using nano/microbubbles.2012

    • Author(s)
      Kato S, et al
    • Organizer
      The 9th International Conference on Flow Dynamics.
    • Place of Presentation
      Sendai
    • Related Report
      2011 Annual Research Report
  • [Presentation] プラズモン共鳴を利用した局所的熱療法のリンパ節転移治療への応用ラズモン共鳴を利用した局所的熱療法のリンパ節転移治療への応用2012

    • Author(s)
      奥野竜希, 他
    • Organizer
      日本バイオマテリアル学会大会シンポジウム2012
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
  • [Presentation] 超音波とナノバブルを使用した遺伝子導入法およびPETを使用した遺伝子発現の可視化法の開発2011

    • Author(s)
      渡邊夕紀子,堀江佐知子,船木善仁,菊池洋平,山崎浩道,石井慶造,森士朗,小玉哲也
    • Organizer
      第49回日本生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 鼠径リンパ節内の圧力上昇にともなう輸出リンパ管への流出特性2011

    • Author(s)
      畠山友梨子,李麗,サックスニコラ,阪本真弥,森士朗,小玉哲也
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 頭頸部癌遺伝子治療に向けたナノバブルと超音波によるNIS遺伝子導入と^<124>I-PETイメージング2011

    • Author(s)
      渡邊夕紀子,森士朗,堀江佐知子,サックスニコラ,李麗,李深偉,柳下陽子,高地崇,船木善仁,菊池洋平,山崎浩道,石井慶造,阪本真弥,宮下仁,小玉哲也
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 頭頸部癌所属リンパ節転移の診断・治療に向けたリンパ節腫大マウスを用いたリンパ節転移モデルの開発2011

    • Author(s)
      李麗,森士朗,柳下陽子,サックスニコラ,堀江佐知子,渡邊夕紀子,高地崇,李深偉,宮下仁,森川秀広,阪本真弥,小玉哲也
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Contribution ofgenetic and non-genetic factors in the new inbred ankylosis model2011

    • Author(s)
      Yamamura MJ, Iikubo M, Sakamoto M, Mori S, Inui M, Shimoda S, Kobayashi K, Ono M, Sasano T.
    • Organizer
      The 18th International Congress of Dento-Maxillo-Facial Radiology
    • Place of Presentation
      Hiroshima, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノ・マイクロバブルと超音波を用いた口腔癌の遺伝子・治療法を想定た分子導入法の検討(3-B-3-1),プログラム・抄録集180頁2010

    • Author(s)
      大木宏介, 他
    • Organizer
      第55回日本口腔外科学辮会・学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] ナノバブルと高周波超音波による腫瘍血管構築とVEGFの発現に関する分子学的検討2010

    • Author(s)
      宮下仁, 他
    • Organizer
      第55回日本白腔外科学会総会・学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膠原病疾患モデルマウスMcH-1ρr/RA1における唾液腺炎に関する女疫病理学的解析2010

    • Author(s)
      高田陽子, 他
    • Organizer
      第55回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節強直を早期に発症するリコンビナントコンジェニックマウスの免疫病理学的解析2010

    • Author(s)
      稲原英恵, 他
    • Organizer
      第55回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔癌早期診断のためのナノバブルと高周波超音波による腫瘍血管構築画像の病理学的評価2010

    • Author(s)
      柳下陽子, 他
    • Organizer
      第55回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロバブルと高周波超音波を用いた三次元イメージング法による転移リンパ節の血管密度の評価2010

    • Author(s)
      佐藤祥太, 他
    • Organizer
      日本超音波医学会東北地方会第40回学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] がん遺伝子治療に向けた新しいPETレポーター/治療遺伝子の開発2010

    • Author(s)
      渡邊夕紀子, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 三次元高周波超音波およびナノバブルを用いた肝転移の非侵襲的観察2010

    • Author(s)
      陳鋭, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膀胱がん治療に向けた二重超音波照射法の数値的至適化2010

    • Author(s)
      小島貴則, 他
    • Organizer
      第69回日本癌学会学衛総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ナノバブルと超音波を用いたT距-alpha遺伝子導入による抗腫瘍効果の評価2010

    • Author(s)
      堀江佐知子, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo detection of cancer metastases at an early stage by vesse density with ultrasound and nano/microbubbles2010

    • Author(s)
      陳鋭, 他
    • Organizer
      第52回歯科基礎医学会 学術大会ならびに総会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] PET Visualization of Na/I Symporter Gene Expression after Delivery by Nanobubbles and Ultrasound2010

    • Author(s)
      Yukiko Watanabe, et al.
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      yoto
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Longitudinal three-dimentional noninvasive imaging analysis and quantification of ant-tumor effects of TNF-alpha gene for small tumor2010

    • Author(s)
      ISachiko Horie, et al.
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chronological change of ankylosis in the newly developedrecombinant selective-congenic model2010

    • Author(s)
      Yamamura MJ, Iikubo M, Sakamoto M, Kojima I, Mori S, Date F, Shimoda K,Kobayashi K, Ono M, Sasano T.
    • Organizer
      8^<th> Asian congress of OMFR
    • Place of Presentation
      Seoul,Korea
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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