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Exploration of carbohydrate molecules that regulate malignant behaviors of oral cavity cancer, and application for the development of novel molecular-targeting therapy

Research Project

Project/Area Number 22390379
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionUniversity of Tsukuba

Principal Investigator

ONIZAWA Kojiro  筑波大学, 医学医療系, 教授 (60194578)

Co-Investigator(Kenkyū-buntansha) YAMAGATA Kenji  筑波大学, 医学医療系, 講師 (00420084)
SHODA Junichi  筑波大学, 医学医療系, 教授 (90241827)
TAKEUCHI Kaoru  筑波大学, 医学医療系, 准教授 (00192162)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords口腔癌 / 悪性挙動 / 糖鎖医学 / 糖転移酵素 / 分子標的治療
Research Abstract

The incidence of oral cavity cancers is high in elderly persons, and the number of patients with the cancers will increase in an enlargement of an aging society. It is a well-known fact that oligosaccharide structures are dramatically changed in carcinogenesis including malignant transformation.In this study, the expression levels of N-Acetylglucosaminyltransferase V (GnT-V) in the tissue sections of oral cavity cancers were correlated with the clinicopathological data. The analysis revealed that the deceased GnT-V expression level is an indicator of poorer survival outcome for patients with oral cavity cancers.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (34 results)

All 2013 2012 2011 2010

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (8 results) Book (10 results)

  • [Journal Article] N-acetylglucosamyltransfererase V in oral squamous cell carcinoma correlates with poor prognosis2013

    • Author(s)
      Seto K, Uchida F, Baba O, Yamatoji M, Shonozuka K, Karube R, Warabi E, Yanagawa T, Onizawa K, Miyoshi E, Shoda J, Bukawa H
    • Journal Title

      submitted for publication

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma2013

    • Author(s)
      Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K
    • Journal Title

      Oncology Report

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder2013

    • Author(s)
      Onuki K, Sugiyama H, Ishige K, Kawamoto T,Ota T,Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M,Miyoshi E,Shoda J
    • Journal Title

      J Gastroenterol

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma.2013

    • Author(s)
      Kaori Seto
    • Journal Title

      Oncology Report

      Volume: xx Issue: 6 Pages: 2147-2153

    • DOI

      10.3892/or.2013.2387

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.2013

    • Author(s)
      Kenichiro Onuki
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 4 Pages: 702-714

    • DOI

      10.1007/s00535-013-0813-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biliary tract carcinoma: clinical perspective on molecular targeting strategies for therapeutic options.2012

    • Author(s)
      Shoda J, Ishige K, Sugiyama H, Kawamoto T
    • Journal Title

      JHBPS

      Volume: 19 Pages: 342-353

    • NAID

      10030950703

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amelioration of cisplatin- induced nephrotoxicity in Peroxiredoxin I- deficient mice.2012

    • Author(s)
      Kosuke Okada
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 71 Issue: 2 Pages: 503-509

    • DOI

      10.1007/s00280-012-2046-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of N-acetylglucosaminyltransferase V in intrahepatic cholangiocarcinoma and its association with clinical findings.2012

    • Author(s)
      Kenichiro Onuki
    • Journal Title

      Tokyo Joshi Ikadaigaku Zasshi

      Volume: 82 Pages: 62-69

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biliary tract carcinoma : clinical perspective on molecular targeting2012

    • Author(s)
      Shoda, J., et al.
    • Journal Title

      JHBPS

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells2011

    • Author(s)
      Sugiyama H, Onuki K, Ishige K, Baba N, Ueda T, Matsuda S, Takeuchi K, Onodera M,Nakanuma Y,Yamato M, Yamamoto M, Hyodo I, Shoda J
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 779-789

    • NAID

      10029029679

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potent in vitro and in vivo antitumor activity of sorafenib against2011

    • Author(s)
      Sugiyama,H., et al.
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 779-89

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/2011

    • Author(s)
      Yamanashi, Y., et al.
    • Journal Title

      Gastroenterology

      Volume: 140 Pages: 1664-74

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potent In Vitro and In Vivo Antitumor Activity of Sorafenib Against2011

    • Author(s)
      Sugiyama, H., et al.
    • Journal Title

      J Gastroenterol

      Volume: In pressa

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biliary NPC2 regulates biliary cholesterol secretion via stimulation of2011

    • Author(s)
      Yamanashi, Y., et al.
    • Journal Title

      Gastroenterology

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WFA-positive sialylated MUC1 is a high-sensitivity biliary marker for intrahepatic cholangiocarcinoma2010

    • Author(s)
      MatsudaA, KunoA, KawamotoK, Matsuzaki H, Irimura T, Ikehara Y, Zen Y, Nakanuma Y, YamamotoM, OhkohchiN, Shoda J, HirabayashiJ, Narimatsu H
    • Journal Title

      Hepatology

      Volume: 52 Pages: 174-182

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] WFA-Positive Sialylated MUC1 is a High-Sensitivity Biliary Marker2010

    • Author(s)
      Matsuda, A., et al.
    • Journal Title

      Hepatology

      Volume: 52 Pages: 174-182

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔がんにおける糖転移酵素GnT-Vの機能解析(転移性因子として)2013

    • Author(s)
      内田文彦, 瀬戸佳穂里, 馬場 脩, 大和地正信, 伊藤寛之,山縣憲司, 柳川 徹, 武川寛樹
    • Organizer
      第31回口腔腫瘍学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔がんにおける糖転移酵素GnT-Vの機能解析(転移性因子として)2013

    • Author(s)
      内田文彦
    • Organizer
      第31回口腔腫瘍学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 疾病モデルより解明された肝病態に対する転写因子Nrf2の演じる生体防御機構2012

    • Author(s)
      岡田浩介,蕨 栄治,正田純一
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Nrf2/p62遺伝子二重欠損マウスは脂肪性肝炎を自然発症し,肝腫瘍を発生する2012

    • Author(s)
      岡田浩介,蕨 栄治,徳重克年,石井哲郎,橋本悦子,正田純一
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Final Research Report
  • [Presentation] 胆石の種類と成因.日本胆道学会認定指導医養成講座32012

    • Author(s)
      正田純一
    • Organizer
      第48回日本胆道学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 胆管がんに対するハイブリッドペプチドの新しいバイオ療法 厚生労働科学研究費補助金2012

    • Author(s)
      正田純一
    • Organizer
      難治性疾患克服研究事業「難治性の肝・胆道疾患に関する調査研究」
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 胆嚢癌における糖転移酵素N-アセチルグルコサミン転移酵素V(GnT-V)2011

    • Author(s)
      小貫建一郎, 他
    • Organizer
      日本胆道学会学術集会
    • Place of Presentation
      宮崎
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胆嚢発癌とその癌進展に果たすアラキトン酸代謝活性化の役割2010

    • Author(s)
      川本徹, 他
    • Organizer
      日本肝臓学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-13
    • Related Report
      2010 Annual Research Report
  • [Book] Horizons in Cancer Research. Volume 482013

    • Author(s)
      Junichi Soda
    • Total Pages
      33
    • Publisher
      NOVA Science
    • Related Report
      2012 Annual Research Report
  • [Book] 漢方薬の有効性と医療科学 インチンコウ湯 漢方薬の薬効と薬理 日本伝統医学テキスト,平成22・23年度厚生労働科学研究費補助金 地域医療基盤開発推進研究事業「統合医療を推進するための日本伝統医学の標準化」2012

    • Author(s)
      正田純一,漢方編
    • Related Report
      2012 Final Research Report
  • [Book] Inchinkoto, Clinical efficacy and pharmacology, Textbook of Traditional Japanese Medicine, Health and Labour Sciences Research Grant, Research on the standardization of traditional Japanese Medicine promoting integrated medicine.2012

    • Author(s)
      Shoda J
    • Related Report
      2012 Final Research Report
  • [Book] Gallbladder Cancer Pathogenesis and Molecular Targeting Strategies for Therapeutic Options. Horizons in Cancer Research2012

    • Author(s)
      Shoda J & Yamamoto M
    • Related Report
      2012 Final Research Report
  • [Book] Textbook of Traditional Japanese Medicine2012

    • Author(s)
      Junichi Shoda
    • Total Pages
      5
    • Publisher
      Ministry of Health, Labour and Welfare
    • Related Report
      2012 Annual Research Report
  • [Book] 胆石症・胆道炎・胆道がん 胆石症 概念・定義と疫学2011

    • Author(s)
      正田純一
    • Publisher
      最新医学社(大阪)
    • Related Report
      2012 Final Research Report
  • [Book] 胆道癌発生の分子機序Annual Review消化器20112011

    • Author(s)
      正田純一
    • Publisher
      中外医学社(東京)
    • Related Report
      2011 Annual Research Report
  • [Book] 胆道癌発生の分子機序(Annual Review)(消化器2011)2011

    • Author(s)
      正田純一
    • Publisher
      中外医学社(東京)
    • Related Report
      2010 Annual Research Report
  • [Book] 胆道癌発生の分子機序 Annual Review 消化器 20112010

    • Author(s)
      正田純一
    • Publisher
      中外医学社(東京)
    • Related Report
      2012 Final Research Report
  • [Book] 胆道感染症2010

    • Author(s)
      正田純一
    • Publisher
      南江堂(東京)
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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