Exploration of carbohydrate molecules that regulate malignant behaviors of oral cavity cancer, and application for the development of novel molecular-targeting therapy
| Project/Area Number |
22390379
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGATA Kenji 筑波大学, 医学医療系, 講師 (00420084)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
TAKEUCHI Kaoru 筑波大学, 医学医療系, 准教授 (00192162)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 口腔癌 / 悪性挙動 / 糖鎖医学 / 糖転移酵素 / 分子標的治療 |
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| Research Abstract |
The incidence of oral cavity cancers is high in elderly persons, and the number of patients with the cancers will increase in an enlargement of an aging society. It is a well-known fact that oligosaccharide structures are dramatically changed in carcinogenesis including malignant transformation.In this study, the expression levels of N-Acetylglucosaminyltransferase V (GnT-V) in the tissue sections of oral cavity cancers were correlated with the clinicopathological data. The analysis revealed that the deceased GnT-V expression level is an indicator of poorer survival outcome for patients with oral cavity cancers.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] N-acetylglucosamyltransfererase V in oral squamous cell carcinoma correlates with poor prognosis2013
Author(s)
Seto K, Uchida F, Baba O, Yamatoji M, Shonozuka K, Karube R, Warabi E, Yanagawa T, Onizawa K, Miyoshi E, Shoda J, Bukawa H
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Journal Title
submitted for publication
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder2013
Author(s)
Onuki K, Sugiyama H, Ishige K, Kawamoto T,Ota T,Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M,Miyoshi E,Shoda J
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Journal Title
J Gastroenterol
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells2011
Author(s)
Sugiyama H, Onuki K, Ishige K, Baba N, Ueda T, Matsuda S, Takeuchi K, Onodera M,Nakanuma Y,Yamato M, Yamamoto M, Hyodo I, Shoda J
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Journal Title
J Gastroenterol
Volume: 46
Pages: 779-789
NAID
Related Report
Peer Reviewed
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[Journal Article] WFA-positive sialylated MUC1 is a high-sensitivity biliary marker for intrahepatic cholangiocarcinoma2010
Author(s)
MatsudaA, KunoA, KawamotoK, Matsuzaki H, Irimura T, Ikehara Y, Zen Y, Nakanuma Y, YamamotoM, OhkohchiN, Shoda J, HirabayashiJ, Narimatsu H
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Journal Title
Hepatology
Volume: 52
Pages: 174-182
Related Report
Peer Reviewed
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