Cancer-targeted liposome coupled to viral proteins for imaging cancer cells
| Project/Area Number |
22390380
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
UZAWA Katsuhiro 千葉大学, 大学院・医学研究院, 准教授 (30302558)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIRASAWA Hiroshi 千葉大学, 大学院・医学研究院, 教授 (00216194)
SAITO Kengo 千葉大学, 大学院・医学研究院, 助教 (70451755)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
|
|---|
| Keywords | 臨床腫瘍学 / リポソーム / シンドビスウイルス / 腫瘍特異的 / 画層診断 / 画像診断 / ハイブリッド型リポソーム / 腫瘍特異的吸着性 / イメージング機器 / 新規増感剤 / 新規造影剤 / 新規ターゲット分子 |
|---|
| Research Abstract |
We developed a novel cancer-targeted liposome coupled to sindbis virus proteins (SIN liposome) on the surface that can be used for imaging tumors and an intra-operative navigation system. The imaging efficacy of this liposome was assessed in a nude mouse bearing a tumor using a clinical CT. CT imaging showed that CT signal increases were detected in tumor site treated with SIN liposomes. Thus, this finding that SIN liposomes selectively fused with a tumor suggested the application of this cancer-targeted liposome to cancer imaging.
|
Report
(4 results)
Research Products
(11 results)
