Cancer-targeted liposome coupled to viral proteins for imaging cancer cells

• Project/Area Number: 22390380
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Chiba University
• Principal Investigator: UZAWA Katsuhiro 千葉大学, 大学院・医学研究院, 准教授 (30302558)
• Co-Investigator(Kenkyū-buntansha): SHIRASAWA Hiroshi 千葉大学, 大学院・医学研究院, 教授 (00216194) ; SAITO Kengo 千葉大学, 大学院・医学研究院, 助教 (70451755)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
• Keywords: 臨床腫瘍学 / リポソーム / シンドビスウイルス / 腫瘍特異的 / 画層診断 / 画像診断 / ハイブリッド型リポソーム / 腫瘍特異的吸着性 / イメージング機器 / 新規増感剤 / 新規造影剤 / 新規ターゲット分子

Research Abstract

We developed a novel cancer-targeted liposome coupled to sindbis virus proteins (SIN liposome) on the surface that can be used for imaging tumors and an intra-operative navigation system. The imaging efficacy of this liposome was assessed in a nude mouse bearing a tumor using a clinical CT. CT imaging showed that CT signal increases were detected in tumor site treated with SIN liposomes. Thus, this finding that SIN liposomes selectively fused with a tumor suggested the application of this cancer-targeted liposome to cancer imaging.

Research Products

• [Journal Article] Lipocalin-2 is associated with radioresistance in oral cancer and lung cancer cells (2013)
  • Author(s): 椎葉正史、齋藤謙悟、鵜澤一弘
  • Journal Title: International journal of oncology Volume: 42巻 Pages: 1197-1204
  • Peer Reviewed
• [Journal Article] Lipocalin-2 is associated with radioresistance in oral cancer and lung cancer cells. (2013)
  • Author(s): 椎葉正史、齋藤謙悟、鵜澤一弘
  • Journal Title: International journal of oncology Volume: 42 Issue: 4 Pages: 1197-1204
  • DOI: 10.3892/ijo.2013.1815
  • Peer Reviewed
• [Journal Article] Preparation and characterization ofphospholipid-conjugated indocyaninegreen as a near-infrared probe (2012)
  • Author(s): 菅波晃子、 齋藤謙悟、白澤浩
  • Journal Title: Bioorganic& Medicinal Chemistry Letters Volume: 22巻 Pages: 7481-7485
  • Peer Reviewed
• [Journal Article] Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe. (2012)
  • Author(s): 菅波晃子、齋藤謙悟、白澤浩
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 22 Issue: 24 Pages: 7481-7485
  • DOI: 10.1016/j.bmcl.2012.10.044
  • Peer Reviewed
• [Presentation] シスプラチン耐性阻害剤含有腫瘍標的リポソームの効果 (2012)
  • Author(s): 齋藤謙悟
  • Organizer: 第71回日本癌学会
  • Place of Presentation: ロイトン札幌(札幌)
  • Year and Date: 2012-09-21
• [Presentation] The study of cancer-targeted liposome with viral proteins for imaging cancer cells (2011)
  • Author(s): 齋藤謙悟
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-03
• [Presentation] The study of cancer-targeted liposome with viral proteins for imaging cancer cells (2011)
  • Author(s): 齋藤謙悟
  • Organizer: 第69回 日本癌学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-03
• [Presentation] The cancer target therapy by acisplatin-encapsulating liposome with viral proteins (2010)
  • Author(s): 齋藤謙悟
  • Organizer: 第69回 日本癌学会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-09-23
• [Presentation] The cancer target therapy by a cisplatin-encapsulating liposome with viral proteins (2010)
  • Author(s): 齋藤謙悟
  • Organizer: 第69回日本癌学会
  • Place of Presentation: Osaka International conyention Cennter(大阪)
  • Year and Date: 2010-09-23
• [Presentation] シスプラチン耐性阻害剤含有腫瘍標的リポソームの効果
  • Author(s): 齋藤 謙悟
  • Organizer: 第７１回 日本癌学会
  • Place of Presentation: ロイトン札幌（札幌）
• [Patent(Industrial Property Rights)] 腫瘍特異性を有する新型リポソーム (2010)
  • Inventor(s): 鵜澤一弘他
  • Industrial Property Rights Holder: 千葉大学
  • Industrial Property Number: 2010-086071
  • Filing Date: 2010-04-02